ZNF525

Summary

ZNF525 (zinc finger protein 525, HGNC:29423) is a protein-coding gene on chromosome 19q13.42, encoding Zinc finger protein 525 (Q8N782). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 170958 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 8 total
• MANE Select transcript: NM_001348156

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29423
Approved symbol	ZNF525
Name	zinc finger protein 525
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1979
Ensembl gene	ENSG00000203326
Ensembl biotype	protein_coding
Entrez	170958

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000467003, ENST00000474037, ENST00000475179, ENST00000491101, ENST00000497729, ENST00000593918, ENST00000600148, ENST00000601790, ENST00000867656, ENST00000929074, ENST00000950057

RefSeq mRNA: 2 — MANE Select: NM_001348156 NM_001348156, NM_001348157

CCDS: CCDS86802, CCDS86803

Canonical transcript exons

ENST00000474037 — 4 exons

Exon	Start	End
ENSE00001893737	53380722	53386590
ENSE00003515279	53372215	53372296
ENSE00003671754	53375770	53375896
ENSE00003822848	53365705	53365759

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 86.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.3438 / max 57.4145, expressed in 1190 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177324	3.3438	1190

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	86.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.61	gold quality
adrenal tissue	UBERON:0018303	82.61	gold quality
endometrium	UBERON:0001295	82.03	gold quality
right testis	UBERON:0004534	81.38	gold quality
granulocyte	CL:0000094	80.36	gold quality
left ovary	UBERON:0002119	80.08	gold quality
ovary	UBERON:0000992	79.95	gold quality
tonsil	UBERON:0002372	79.65	gold quality
prostate gland	UBERON:0002367	79.57	gold quality
testis	UBERON:0000473	79.56	gold quality
left testis	UBERON:0004533	79.55	gold quality
lymph node	UBERON:0000029	79.51	gold quality
right ovary	UBERON:0002118	79.37	gold quality
cortical plate	UBERON:0005343	79.37	gold quality
body of pancreas	UBERON:0001150	79.23	gold quality
pancreas	UBERON:0001264	78.51	gold quality
cortex of kidney	UBERON:0001225	77.96	gold quality
fundus of stomach	UBERON:0001160	77.71	gold quality
skin of abdomen	UBERON:0001416	77.71	gold quality
spleen	UBERON:0002106	77.64	gold quality
zone of skin	UBERON:0000014	77.59	gold quality
islet of Langerhans	UBERON:0000006	77.55	gold quality
vagina	UBERON:0000996	77.43	gold quality
skin of leg	UBERON:0001511	77.36	gold quality
right adrenal gland	UBERON:0001233	77.30	gold quality
stomach	UBERON:0000945	77.28	gold quality
cerebellar cortex	UBERON:0002129	77.26	gold quality
cerebellar hemisphere	UBERON:0002245	77.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.42

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (11): ZNF761 (ENSG00000160336), ZNF701 (ENSG00000167562), ZNF816 (ENSG00000180257), ZNF766 (ENSG00000196214), ZNF765 (ENSG00000196417), ZNF860 (ENSG00000197385), ZNF813 (ENSG00000198346), ZNF468 (ENSG00000204604), ZNF888 (ENSG00000213793), ZNF578 (ENSG00000258405), (ENSG00000269825)

Protein

Protein identifiers

Zinc finger protein 525 — Q8N782 (reviewed: Q8N782)

All UniProt accessions (5): E7ENB8, E7EUL5, Q8N782, J3KR62, M0QZA4

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001335085, NP_001335086 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (11 total): zinc finger region 9, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N782-F1	63.24	0.07

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 14 (showing top): MODULE_151, MODULE_114, GEORGES_TARGETS_OF_MIR192_AND_MIR215, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF274_TARGET_GENES, MANNO_MIDBRAIN_NEUROTYPES_HNBGABA, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, MODULE_83, SU_HO_FOETAL_FEMUR_C2_HYPERTROPHIC_CHONDROCYTE, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, chr19q13

GO Biological Process (3): regulation of DNA-templated transcription (GO:0006355), regulation of gene expression (GO:0010468), negative regulation of macromolecule biosynthetic process (GO:0010558)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleoplasm (GO:0005654), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of macromolecule biosynthetic process	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
gene expression	1
macromolecule biosynthetic process	1
negative regulation of biosynthetic process	1
negative regulation of macromolecule metabolic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

356 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF525	CCNI2	Q6ZMN8	431
ZNF525	FAM24B	Q8N5W8	418
ZNF525	CT45A3	P0DMU6	400
ZNF525	CT45A10	P0DMU9	371
ZNF525	CT45A5	P0DMU8	368
ZNF525	OR51B5	Q9H339	348
ZNF525	MCMDC2	Q4G0Z9	348
ZNF525	CEP15	Q9HBI5	323
ZNF525	DPY19L1	Q2PZI1	321
ZNF525	M1AP	Q8TC57	320
ZNF525	CPPED1	Q9BRF8	312
ZNF525	SAC3D1	A6NKF1	308
ZNF525	M9MMK7	M9MMK7	298
ZNF525	BZW2	Q9Y6E2	289
ZNF525	RPP25	Q9BUL9	282

IntAct

3 interactions, top by confidence:

A	B	Type	Score
CUL4A	HAX1	psi-mi:“MI:0914”(association)	0.350
CUL5	DDX3X	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

8 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

735 predictions. Top by Δscore:

Variant	Effect	Δscore
19:53375768:AG:A	acceptor_gain	1.0000
19:53375769:GG:G	acceptor_gain	1.0000
19:53375857:G:T	donor_gain	1.0000
19:53375895:GG:G	donor_gain	1.0000
19:53375896:GG:G	donor_gain	1.0000
19:53375925:G:GT	donor_gain	1.0000
19:53375925:G:T	donor_gain	1.0000
19:53365755:GGCGC:G	donor_gain	0.9900
19:53365756:GCGC:G	donor_gain	0.9900
19:53365756:GCGCG:G	donor_gain	0.9900
19:53365758:GC:G	donor_gain	0.9900
19:53365760:G:GG	donor_gain	0.9900
19:53365925:TTTA:T	donor_gain	0.9900
19:53372211:TCAG:T	acceptor_loss	0.9900
19:53372212:CAG:C	acceptor_loss	0.9900
19:53372213:A:AG	acceptor_gain	0.9900
19:53372213:AG:A	acceptor_gain	0.9900
19:53372213:AGG:A	acceptor_loss	0.9900
19:53372214:G:C	acceptor_loss	0.9900
19:53372214:G:GG	acceptor_gain	0.9900
19:53372214:GG:G	acceptor_gain	0.9900
19:53372214:GGATT:G	acceptor_gain	0.9900
19:53372292:CTCAG:C	donor_loss	0.9900
19:53372293:TCAG:T	donor_loss	0.9900
19:53372295:AGGT:A	donor_loss	0.9900
19:53372296:GGT:G	donor_loss	0.9900
19:53372298:T:A	donor_loss	0.9900
19:53375765:TTCA:T	acceptor_loss	0.9900
19:53375766:TCAG:T	acceptor_loss	0.9900
19:53375768:AGGGT:A	acceptor_loss	0.9900

AlphaMissense

3220 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000501860 (19:53383941 C>T), RS1000552464 (19:53384235 G>A), RS1000804240 (19:53378771 G>A), RS1000819338 (19:53386302 C>A), RS1001036792 (19:53373085 T>C), RS1001125634 (19:53386527 G>C), RS1001163266 (19:53378200 T>C), RS1001362299 (19:53368077 G>T), RS1001413668 (19:53363778 T>G), RS1001425668 (19:53367093 A>C,G), RS1001466181 (19:53364006 C>T), RS1001530035 (19:53372823 A>G), RS1001561947 (19:53385411 T>C), RS1001685869 (19:53377817 C>T), RS1001711728 (19:53367919 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	increases expression, increases methylation	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases methylation	1
nonanal	increases methylation	1
n-hexanal	increases methylation	1
arsenite	affects binding, decreases reaction	1
caprylic aldehyde	increases methylation	1
pentanal	increases methylation	1
heptanal	increases methylation	1
tanespimycin	affects cotreatment, increases expression	1
VER 155008	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	increases expression	1
Phthalic Acids	increases methylation	1
Smoke	decreases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.