ZNF561-AS1

Summary

ZNF561-AS1 (ZNF561 antisense RNA 1, HGNC:27613) is a long non-coding RNA gene on chromosome 19p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27613
Approved symbol	ZNF561-AS1
Name	ZNF561 antisense RNA 1
Location	19p13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267106
Ensembl biotype	lncRNA
Entrez	284385
RNAcentral	URS000075C770 — lncRNA, 1834 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 lncRNA

ENST00000585797, ENST00000586614, ENST00000586943, ENST00000587536, ENST00000588765, ENST00000591056, ENST00000591932, ENST00000592851, ENST00000652061, ENST00000652787, ENST00000661696, ENST00000686350, ENST00000686891, ENST00000687622, ENST00000688502, ENST00000689621, ENST00000690668, ENST00000690762, ENST00000691650, ENST00000691807, ENST00000691984, ENST00000692217, ENST00000692903, ENST00000692996, ENST00000724285, ENST00000724286, ENST00000724287, ENST00000724288, ENST00000724289, ENST00000724290, ENST00000724291

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585797 — 3 exons

Exon	Start	End
ENSE00003755134	9632228	9632417
ENSE00004046844	9621479	9621645
ENSE00004046851	9633460	9635446

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 81.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2211 / max 36.1110, expressed in 1583 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173704	3.0408	1450
173702	0.9400	629
173703	0.2403	98

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.68	gold quality
endothelial cell	CL:0000115	78.55	gold quality
islet of Langerhans	UBERON:0000006	78.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.21	gold quality
stromal cell of endometrium	CL:0002255	77.60	gold quality
ventricular zone	UBERON:0003053	75.45	gold quality
superficial temporal artery	UBERON:0001614	75.14	gold quality
mucosa of paranasal sinus	UBERON:0005030	75.14	gold quality
ganglionic eminence	UBERON:0004023	74.18	gold quality
cortical plate	UBERON:0005343	73.59	gold quality
thymus	UBERON:0002370	73.57	silver quality
ascending aorta	UBERON:0001496	73.15	gold quality
thoracic aorta	UBERON:0001515	73.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.89	gold quality
spinal cord	UBERON:0002240	72.71	gold quality
left coronary artery	UBERON:0001626	72.67	gold quality
aorta	UBERON:0000947	72.66	gold quality
coronary artery	UBERON:0001621	72.66	gold quality
cardia of stomach	UBERON:0001162	72.46	silver quality
descending thoracic aorta	UBERON:0002345	72.43	gold quality
putamen	UBERON:0001874	72.34	gold quality
popliteal artery	UBERON:0002250	72.31	gold quality
tibial artery	UBERON:0007610	72.29	gold quality
right coronary artery	UBERON:0001625	72.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.17	gold quality
lower esophagus	UBERON:0013473	72.14	gold quality
adult mammalian kidney	UBERON:0000082	72.07	gold quality
smooth muscle tissue	UBERON:0001135	71.88	gold quality
amygdala	UBERON:0001876	71.87	gold quality
nucleus accumbens	UBERON:0001882	71.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p/miR-128-5p-SRSF6 axis. (PMID:33622363)
• ZNF561-AS1 Regulates Cell Proliferation and Apoptosis in Myocardial Infarction Through miR-223-3p/NLRP3 Axis. (PMID:35997481)
• ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D. (PMID:36308081)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.