ZNF567

Summary

ZNF567 (zinc finger protein 567, HGNC:28696) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 567 (Q8N184). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 163081 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001322917

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28696
Approved symbol	ZNF567
Name	zinc finger protein 567
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	MGC45586
Ensembl gene	ENSG00000189042
Ensembl biotype	protein_coding
Entrez	163081

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 28 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000360729, ENST00000536254, ENST00000585696, ENST00000588311, ENST00000589264, ENST00000590392, ENST00000591308, ENST00000682579, ENST00000910217, ENST00000910218, ENST00000910219, ENST00000910220, ENST00000910221, ENST00000910223, ENST00000910225, ENST00000910227, ENST00000915754, ENST00000915755, ENST00000915756, ENST00000915757, ENST00000915758, ENST00000915759, ENST00000915760, ENST00000915761, ENST00000915762, ENST00000941119, ENST00000941120, ENST00000941121, ENST00000941122, ENST00000941123

RefSeq mRNA: 28 — MANE Select: NM_001322917 NM_001300979, NM_001322911, NM_001322912, NM_001322913, NM_001322914, NM_001322915, NM_001322916, NM_001322917, NM_001322918, NM_001322919, NM_001322920, NM_001363651, NM_001387759, NM_001387760, NM_001387761, NM_001387762, NM_001387763, NM_001387764, NM_001387765, NM_001387766, NM_001387767, NM_001387768, NM_001387769, NM_001387770, NM_001387771, NM_001387772, NM_001387773, NM_152603

CCDS: CCDS12495, CCDS74349, CCDS86756

Canonical transcript exons

ENST00000682579 — 6 exons

Exon	Start	End
ENSE00001258376	36712781	36712867
ENSE00002937680	36687612	36687634
ENSE00003578490	36694802	36694876
ENSE00003668707	36712386	36712512
ENSE00003916164	36718948	36721336
ENSE00003918311	36689397	36689497

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 91.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.2309 / max 65.0649, expressed in 1104 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175523	2.2309	1104

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	91.07	gold quality
epithelial cell of pancreas	CL:0000083	89.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.35	gold quality
calcaneal tendon	UBERON:0003701	83.21	gold quality
germinal epithelium of ovary	UBERON:0001304	81.83	gold quality
ventricular zone	UBERON:0003053	79.63	gold quality
cortical plate	UBERON:0005343	79.39	gold quality
buccal mucosa cell	CL:0002336	79.27	gold quality
placenta	UBERON:0001987	79.25	gold quality
thymus	UBERON:0002370	79.25	gold quality
palpebral conjunctiva	UBERON:0001812	78.78	gold quality
ganglionic eminence	UBERON:0004023	78.51	gold quality
left testis	UBERON:0004533	78.51	gold quality
cartilage tissue	UBERON:0002418	78.44	gold quality
right testis	UBERON:0004534	78.31	gold quality
testis	UBERON:0000473	78.23	gold quality
islet of Langerhans	UBERON:0000006	78.02	gold quality
lymph node	UBERON:0000029	77.86	gold quality
sperm	CL:0000019	77.45	gold quality
Brodmann (1909) area 23	UBERON:0013554	77.32	gold quality
skin of hip	UBERON:0001554	77.22	gold quality
smooth muscle tissue	UBERON:0001135	77.18	gold quality
stromal cell of endometrium	CL:0002255	76.63	gold quality
adrenal tissue	UBERON:0018303	76.41	gold quality
right adrenal gland cortex	UBERON:0035827	76.35	gold quality
cerebellar cortex	UBERON:0002129	76.13	gold quality
cerebellar hemisphere	UBERON:0002245	76.12	gold quality
pigmented layer of retina	UBERON:0001782	75.95	gold quality
sural nerve	UBERON:0015488	75.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.72

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

48 targeting ZNF567, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-3941	99.86	70.54	2735
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-4696	99.48	67.48	1040

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG14442	FBGN0029893
drosophila_melanogaster	CG14440	FBGN0029894

Paralogs (11): IKZF2 (ENSG00000030419), ZNF821 (ENSG00000102984), ZNF639 (ENSG00000121864), IKZF4 (ENSG00000123411), ZNF382 (ENSG00000161298), IKZF3 (ENSG00000161405), ZNF613 (ENSG00000176024), IKZF1 (ENSG00000185811), ZNF649 (ENSG00000198093), ZNF564 (ENSG00000249709), ZNF350 (ENSG00000256683)

Protein

Protein identifiers

Zinc finger protein 567 — Q8N184 (reviewed: Q8N184)

All UniProt accessions (4): F8WEL6, Q8N184, K7EMD5, K7ESK1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8N184-3	3	yes
Q8N184-1	1
Q8N184-2	2

RefSeq proteins (28): NP_001287908, NP_001309840, NP_001309841, NP_001309842, NP_001309843, NP_001309844, NP_001309845, NP_001309846, NP_001309847, NP_001309848, NP_001309849, NP_001350580, NP_001374688, NP_001374689, NP_001374690, NP_001374691, NP_001374692, NP_001374693, NP_001374694, NP_001374695, NP_001374696, NP_001374697, NP_001374698, NP_001374699, NP_001374700, NP_001374701, NP_001374702, NP_689816 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (25 total): zinc finger region 15, cross-link 5, splice variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N184-F1	70.85	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 173, 202, 217, 233, 447

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 54 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP, JOHNSTONE_PARVB_TARGETS_3_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CSHL1_TARGET_GENES, SALL4_TARGET_GENES, ZNF26_TARGET_GENES, ZNF486_TARGET_GENES, MIR4795_3P, MIR6809_3P, MIR539_5P, MIR548L

GO Biological Process (4): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355), regulation of macromolecule metabolic process (GO:0060255), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
regulation of metabolic process	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
macromolecule metabolic process	1
primary metabolic process	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

472 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF567	N4BP2	Q86UW6	543
ZNF567	SYCE1L	A8MT33	490
ZNF567	ZWILCH	Q9H900	486
ZNF567	ETFB	P38117	472
ZNF567	URB2	Q14146	430
ZNF567	SPEF1	Q9Y4P9	430
ZNF567	PRDX6	P30041	427
ZNF567	DENND2C	Q68D51	419
ZNF567	OSBPL7	Q9BZF2	397
ZNF567	TMEM131L	A2VDJ0	394
ZNF567	CTTNBP2NL	Q9P2B4	375
ZNF567	RNF144A	P50876	375
ZNF567	FCSK	Q8N0W3	368
ZNF567	LNPK	Q9C0E8	367
ZNF567	DHX35	Q9H5Z1	364

IntAct

19 interactions, top by confidence:

A	B	Type	Score
MAP3K20	ZNF567	psi-mi:“MI:0915”(physical association)	0.780
ZNF567	MAP3K20	psi-mi:“MI:0915”(physical association)	0.780
ZNF567	MAP3K20	psi-mi:“MI:0915”(physical association)	0.670
MAP3K20	ZNF567	psi-mi:“MI:0915”(physical association)	0.670
FAM9B	ZNF567	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF567	HSPD1	psi-mi:“MI:0915”(physical association)	0.400
PCBD1	ZNF567	psi-mi:“MI:0915”(physical association)	0.370
C9orf72	CHD2	psi-mi:“MI:0914”(association)	0.350
ZNF567	IPO8	psi-mi:“MI:0914”(association)	0.350
ZNF567	MAP3K20	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): ZNF567 (Two-hybrid), FAM9B (Two-hybrid), ZNF567 (Two-hybrid), ZAK (Two-hybrid), ZNF567 (Affinity Capture-RNA), ZNF567 (Two-hybrid), ZNF567 (Proximity Label-MS), ZNF567 (Proximity Label-MS), ZNF567 (Affinity Capture-RNA), ZNF567 (Affinity Capture-MS), ZNF567 (Affinity Capture-MS), ZNF567 (Proximity Label-MS), ZNF567 (Positive Genetic), ZNF567 (Affinity Capture-MS), ZNF567 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1135 predictions. Top by Δscore:

Variant	Effect	Δscore
19:36712509:GTGG:G	donor_gain	1.0000
19:36712510:TGG:T	donor_gain	1.0000
19:36712511:GG:G	donor_gain	1.0000
19:36712511:GGG:G	donor_gain	1.0000
19:36712512:GG:G	donor_gain	1.0000
19:36712513:G:GC	donor_loss	1.0000
19:36712513:G:GG	donor_gain	1.0000
19:36712514:T:G	donor_loss	1.0000
19:36712773:C:G	acceptor_gain	1.0000
19:36712777:TCA:T	acceptor_loss	1.0000
19:36712778:CAG:C	acceptor_loss	1.0000
19:36712779:A:AG	acceptor_gain	1.0000
19:36712779:AG:A	acceptor_gain	1.0000
19:36712779:AGG:A	acceptor_gain	1.0000
19:36712779:AGGG:A	acceptor_loss	1.0000
19:36712779:AGGGT:A	acceptor_gain	1.0000
19:36712780:G:A	acceptor_gain	1.0000
19:36712780:G:GA	acceptor_gain	1.0000
19:36712780:GGG:G	acceptor_gain	1.0000
19:36712780:GGGT:G	acceptor_gain	1.0000
19:36712780:GGGTG:G	acceptor_gain	1.0000
19:36712866:GG:G	donor_gain	1.0000
19:36712867:GG:G	donor_gain	1.0000
19:36687692:G:GT	donor_gain	0.9900
19:36689496:GT:G	donor_gain	0.9900
19:36694796:CCTTA:C	acceptor_loss	0.9900
19:36694797:CTTA:C	acceptor_loss	0.9900
19:36694799:TA:T	acceptor_loss	0.9900
19:36694800:A:AT	acceptor_loss	0.9900
19:36694801:G:A	acceptor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000058603 (19:36681365 G>A), RS1000097529 (19:36712308 A>G), RS1000145452 (19:36727757 T>C), RS1000257595 (19:36706191 A>G), RS1000302185 (19:36727541 G>A), RS1000341319 (19:36693259 T>C,G), RS1000369494 (19:36675042 T>A,G), RS1000439115 (19:36688806 C>A), RS1000444800 (19:36688546 G>A,T), RS1000515902 (19:36687122 A>C), RS1000547163 (19:36687405 A>C), RS1000632125 (19:36694798 T>C,G), RS1000682160 (19:36680287 A>C,T), RS1000736765 (19:36672568 C>T), RS1000776040 (19:36693803 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, increases expression	2
trichostatin A	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	decreases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
lei gong teng	increases expression	1
epigallocatechin gallate	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Clorgyline	increases expression	1
Coal	decreases expression, increases abundance	1
Succimer	increases expression, affects cotreatment	1
Dimethyl Sulfoxide	increases expression	1
Estradiol	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Oxazolone	increases expression	1
Smoke	decreases expression, increases abundance	1
Urethane	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.