ZNF572

Summary

ZNF572 (zinc finger protein 572, HGNC:26758) is a protein-coding gene on chromosome 8q24.13, encoding Zinc finger protein 572 (Q7Z3I7). May be involved in transcriptional regulation.

Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleus.

Source: NCBI Gene 137209 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 81 total — 1 pathogenic
• MANE Select transcript: NM_152412

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26758
Approved symbol	ZNF572
Name	zinc finger protein 572
Location	8q24.13
Locus type	gene with protein product
Status	Approved
Aliases	FLJ38002
Ensembl gene	ENSG00000180938
Ensembl biotype	protein_coding
Entrez	137209

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000319286, ENST00000902451, ENST00000942607, ENST00000942608

RefSeq mRNA: 1 — MANE Select: NM_152412 NM_152412

CCDS: CCDS6354

Canonical transcript exons

ENST00000319286 — 3 exons

Exon	Start	End
ENSE00001239938	124973295	124973416
ENSE00001239945	124976348	124979389
ENSE00001239951	124975606	124975719

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 83.34.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2178 / max 27.0833, expressed in 876 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90524	1.8634	789
90525	0.3544	191

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.14	gold quality
calcaneal tendon	UBERON:0003701	72.06	gold quality
ventricular zone	UBERON:0003053	70.95	gold quality
ganglionic eminence	UBERON:0004023	69.71	gold quality
islet of Langerhans	UBERON:0000006	65.56	gold quality
cortical plate	UBERON:0005343	65.03	gold quality
rectum	UBERON:0001052	64.19	gold quality
smooth muscle tissue	UBERON:0001135	62.75	gold quality
lymph node	UBERON:0000029	62.74	gold quality
right uterine tube	UBERON:0001302	62.72	gold quality
ovary	UBERON:0000992	62.67	gold quality
vermiform appendix	UBERON:0001154	62.35	gold quality
left ovary	UBERON:0002119	62.12	gold quality
popliteal artery	UBERON:0002250	62.12	gold quality
tibial artery	UBERON:0007610	62.10	gold quality
pancreas	UBERON:0001264	62.04	gold quality
right ovary	UBERON:0002118	61.84	gold quality
descending thoracic aorta	UBERON:0002345	61.55	gold quality
colonic epithelium	UBERON:0000397	61.46	gold quality
body of pancreas	UBERON:0001150	61.38	gold quality
body of uterus	UBERON:0009853	60.92	gold quality
left coronary artery	UBERON:0001626	60.89	gold quality
right lobe of thyroid gland	UBERON:0001119	60.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.68	gold quality
lower esophagus	UBERON:0013473	60.67	gold quality
tibial nerve	UBERON:0001323	60.49	gold quality
aorta	UBERON:0000947	60.43	gold quality
metanephros cortex	UBERON:0010533	60.31	gold quality
endometrium	UBERON:0001295	60.25	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-8060	no	80.94
E-ANND-3	no	2.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

81 targeting ZNF572, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514

Cross-species orthologs

0 orthologs

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

Zinc finger protein 572 — Q7Z3I7 (reviewed: Q7Z3I7)

All UniProt accessions (1): Q7Z3I7

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_689625* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (24 total): zinc finger region 12, sequence variant 5, compositionally biased region 2, cross-link 2, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z3I7-F1	66.17	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 5, 6

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 47 (showing top): HATADA_METHYLATED_IN_LUNG_CANCER_DN, GOBP_CYTOKINE_PRODUCTION, RYTTCCTG_ETS2_B, NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, chr8q24, GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, SMCHD1_TARGET_GENES, SNIP1_TARGET_GENES, ZNF830_TARGET_GENES, MIR12123, MIR655_3P

GO Biological Process (3): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of cytokine production (GO:0001817), regulation of immune system process (GO:0002682)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), zinc ion binding (GO:0008270), identical protein binding (GO:0042802), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
cytokine production	1
regulation of gene expression	1
regulation of multicellular organismal process	1
immune system process	1
regulation of biological process	1
cis-regulatory region sequence-specific DNA binding	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transition metal ion binding	1
protein binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

370 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF572	WASHC5	Q12768	594
ZNF572	SREK1IP1	Q8N9Q2	528
ZNF572	CREG2	Q8IUH2	496
ZNF572	FAM222B	Q8WU58	489
ZNF572	SFXN3	Q9BWM7	450
ZNF572	LRATD2	Q96KN1	448
ZNF572	SSC4D	Q8WTU2	437
ZNF572	LEMD3	Q9Y2U8	435
ZNF572	SREK1	Q8WXA9	435
ZNF572	RMDN2	Q96LZ7	430
ZNF572	WIPF1	O43516	426
ZNF572	P2RX1	P51575	418
ZNF572	SQLE	Q14534	411
ZNF572	MTSS1	O43312	406
ZNF572	FAM24B	Q8N5W8	404

IntAct

313 interactions, top by confidence:

A	B	Type	Score
YJU2B	ZNF572	psi-mi:“MI:0915”(physical association)	0.720
KRTAP10-8	ZNF572	psi-mi:“MI:0915”(physical association)	0.720
TRIM54	ZNF572	psi-mi:“MI:0915”(physical association)	0.720
ZNF572	YJU2B	psi-mi:“MI:0915”(physical association)	0.720
ZNF572	LZTS2	psi-mi:“MI:0915”(physical association)	0.720
ZNF572	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.720
ZNF572	TRIM54	psi-mi:“MI:0915”(physical association)	0.720
LZTS2	ZNF572	psi-mi:“MI:0915”(physical association)	0.720
CARD9	ZNF572	psi-mi:“MI:0915”(physical association)	0.670
ZNF572	CARD9	psi-mi:“MI:0915”(physical association)	0.670
FSD2	ZNF572	psi-mi:“MI:0915”(physical association)	0.600
ZNF572		psi-mi:“MI:0915”(physical association)	0.600

BioGRID (70): ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid), ZNF572 (Two-hybrid)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A6QLU5, B2RUI1, D3ZVT0, O14709, O43296, O75123, P10072, P15621, P17020, P17097, P51814, P85977, Q08ER8, Q0VGE8, Q14590, Q32KN0, Q3KQV3, Q4V8A8, Q5CZA5, Q5RBX0, Q5RCD9, Q5VIY5, Q61116, Q61967, Q6GQR8, Q6P9A3, Q6ZMS4, Q7TSH9, Q7TSI0, Q7Z3I7, Q86UD4, Q86WZ6, Q8BFS8, Q8IZ26, Q8N9F8, Q8TAF7

Diamond homologs: B1H2Q6, G5EGB2, O15535, O75290, P17026, P18724, P18741, P18747, P52742, Q15937, Q17895, Q1LZC0, Q3MJ62, Q4R7X8, Q5R4X5, Q6A085, Q7Z3I7, Q8BGV5, Q8TBZ5, Q91VW9, Q969J2, Q9BRR0, Q9ERU2, Q9ERU3, Q9UEG4, Q9Z1D9, Q9Z2K3, A1L1L7, A1YEV9, A1YG26, A2T712, A2T7L7, O60304, P18714, P18715, P18716, P18719, P18729, P18730, P18731

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

81 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	72
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
687465	GRCh37/hg19 8q24.13-24.21(chr8:123074293-131113892)x1	Pathogenic

SpliceAI

330 predictions. Top by Δscore:

Variant	Effect	Δscore
8:124975600:CCACA:C	acceptor_loss	1.0000
8:124975601:CACAG:C	acceptor_loss	1.0000
8:124975602:ACAG:A	acceptor_gain	1.0000
8:124975603:CAGGG:C	acceptor_loss	1.0000
8:124975604:A:AG	acceptor_gain	1.0000
8:124975604:A:C	acceptor_loss	1.0000
8:124975604:AG:A	acceptor_gain	1.0000
8:124975605:G:GG	acceptor_gain	1.0000
8:124975605:G:T	acceptor_loss	1.0000
8:124975605:GG:G	acceptor_gain	1.0000
8:124975715:CACAG:C	donor_loss	1.0000
8:124975716:ACAG:A	donor_loss	1.0000
8:124975717:CAGGT:C	donor_loss	1.0000
8:124975718:AGGT:A	donor_loss	1.0000
8:124975719:GGTGA:G	donor_loss	1.0000
8:124975720:GTG:G	donor_loss	1.0000
8:124975721:T:A	donor_loss	1.0000
8:124975604:AGG:A	acceptor_gain	0.9900
8:124975605:GGG:G	acceptor_gain	0.9900
8:124975605:GGGT:G	acceptor_gain	0.9900
8:124975696:A:T	donor_gain	0.9900
8:124973417:G:GG	donor_gain	0.9800
8:124975602:ACAGG:A	acceptor_gain	0.9800
8:124975605:GGGTT:G	acceptor_gain	0.9800
8:124975602:A:AG	acceptor_gain	0.9700
8:124975694:G:GT	donor_gain	0.9700
8:124973412:GAACA:G	donor_gain	0.9600
8:124973687:G:GT	donor_gain	0.9600
8:124976347:GGA:G	acceptor_gain	0.9600
8:124973878:ATTTT:A	donor_gain	0.9400

AlphaMissense

3592 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:124977109:T:C	F281L	0.999
8:124977111:T:A	F281L	0.999
8:124977111:T:G	F281L	0.999
8:124977143:G:C	R292P	0.999
8:124976773:T:C	F169L	0.998
8:124976775:T:A	F169L	0.998
8:124976775:T:G	F169L	0.998
8:124976857:T:C	F197L	0.998
8:124976859:C:A	F197L	0.998
8:124976859:C:G	F197L	0.998
8:124976941:T:C	F225L	0.998
8:124976943:C:A	F225L	0.998
8:124976943:C:G	F225L	0.998
8:124977025:T:C	F253L	0.998
8:124977027:C:A	F253L	0.998
8:124977027:C:G	F253L	0.998
8:124977529:T:C	F421L	0.998
8:124977531:C:A	F421L	0.998
8:124977531:C:G	F421L	0.998
8:124976792:T:C	L175P	0.997
8:124976876:T:C	L203P	0.997
8:124976960:T:C	L231P	0.997
8:124977054:T:A	H262Q	0.997
8:124977054:T:G	H262Q	0.997
8:124977128:T:C	L287P	0.997
8:124977138:C:A	H290Q	0.997
8:124977138:C:G	H290Q	0.997
8:124977140:A:C	Q291P	0.997
8:124977193:T:C	F309L	0.997
8:124977195:T:A	F309L	0.997

dbSNP variants (sampled 300 via entrez): RS1000045801 (8:124972648 C>T), RS1000312373 (8:124972854 A>G), RS1000537200 (8:124977836 C>T), RS1000849748 (8:124976971 C>T), RS1000923137 (8:124977371 A>G), RS1001171740 (8:124972133 A>G), RS1003469734 (8:124977488 C>G), RS1003672421 (8:124976098 A>T), RS1003845809 (8:124979344 G>T), RS1004318751 (8:124977973 A>G), RS1004504564 (8:124973281 A>T), RS1004621951 (8:124978712 G>A), RS1005322639 (8:124979593 C>T), RS1005376273 (8:124979386 T>C), RS1005631247 (8:124972021 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_894	Metabolite levels	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010440	triacylglycerol 58:6 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, affects cotreatment	2
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
propionaldehyde	increases expression	1
arsenite	increases methylation	1
sodium arsenite	increases expression	1
potassium chromate(VI)	increases expression	1
ferrous chloride	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	affects cotreatment, increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Catechin	affects cotreatment, increases expression	1
Dexamethasone	increases expression, affects cotreatment	1
Succimer	increases expression, affects cotreatment	1
Gold	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Potassium Chloride	decreases response to substance, decreases expression	1
Dronabinol	decreases expression, decreases response to substance	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
Vanadates	decreases expression	1
1-Methyl-3-isobutylxanthine	increases expression, affects cotreatment	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1
Particulate Matter	decreases expression	1
Magnetite Nanoparticles	affects cotreatment, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD29	HEK293 eGFP-ZNF572	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.