ZNF573

Summary

ZNF573 (zinc finger protein 573, HGNC:26420) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 573 (Q86YE8). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 126231 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 105 total
• MANE Select transcript: NM_001172690

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26420
Approved symbol	ZNF573
Name	zinc finger protein 573
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ30921
Ensembl gene	ENSG00000189144
Ensembl biotype	protein_coding
Entrez	126231

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 14 protein_coding, 7 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay

ENST00000339503, ENST00000378445, ENST00000392138, ENST00000480587, ENST00000489148, ENST00000494605, ENST00000536220, ENST00000585724, ENST00000586155, ENST00000586785, ENST00000587684, ENST00000588218, ENST00000588443, ENST00000589435, ENST00000589632, ENST00000590674, ENST00000591516, ENST00000909374, ENST00000909375, ENST00000909376, ENST00000909377, ENST00000909378, ENST00000920807, ENST00000959119, ENST00000959120

RefSeq mRNA: 5 — MANE Select: NM_001172690 NM_001172689, NM_001172690, NM_001172691, NM_001172692, NM_152360

CCDS: CCDS12508, CCDS59381

Canonical transcript exons

ENST00000536220 — 5 exons

Exon	Start	End
ENSE00002257745	37779544	37779586
ENSE00003505155	37738302	37740194
ENSE00003566888	37770005	37770097
ENSE00003571774	37773661	37773751
ENSE00003581540	37771564	37771696

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 93.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.3906 / max 157.8898, expressed in 1374 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180734	4.1996	1355
180735	0.1509	52
180736	0.0401	10

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nipple	UBERON:0002030	93.07	gold quality
endothelial cell	CL:0000115	92.79	gold quality
secondary oocyte	CL:0000655	91.44	gold quality
visceral pleura	UBERON:0002401	90.44	gold quality
renal medulla	UBERON:0000362	89.99	gold quality
pylorus	UBERON:0001166	89.91	gold quality
oocyte	CL:0000023	89.63	gold quality
urethra	UBERON:0000057	89.26	gold quality
cerebellar vermis	UBERON:0004720	88.32	gold quality
parietal pleura	UBERON:0002400	88.21	gold quality
cardia of stomach	UBERON:0001162	87.97	gold quality
inferior vagus X ganglion	UBERON:0005363	87.92	gold quality
adrenal tissue	UBERON:0018303	87.62	gold quality
pleura	UBERON:0000977	87.57	gold quality
corpus callosum	UBERON:0002336	87.20	gold quality
buccal mucosa cell	CL:0002336	86.54	silver quality
colonic epithelium	UBERON:0000397	86.49	gold quality
ventral tegmental area	UBERON:0002691	86.34	gold quality
trigeminal ganglion	UBERON:0001675	85.97	gold quality
calcaneal tendon	UBERON:0003701	85.83	gold quality
germinal epithelium of ovary	UBERON:0001304	85.77	gold quality
skin of hip	UBERON:0001554	85.66	gold quality
sperm	CL:0000019	85.44	gold quality
subthalamic nucleus	UBERON:0001906	84.84	gold quality
Brodmann (1909) area 23	UBERON:0013554	84.67	gold quality
dorsal root ganglion	UBERON:0000044	84.37	gold quality
superior surface of tongue	UBERON:0007371	84.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.88	gold quality
penis	UBERON:0000989	83.88	gold quality
left testis	UBERON:0004533	83.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting ZNF573, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-20A-3P	99.44	69.10	1575
HSA-MIR-3160-5P	99.28	69.07	1938
HSA-MIR-5585-3P	98.25	67.41	941
HSA-MIR-4700-3P	97.74	68.64	1014
HSA-MIR-6511A-3P	97.60	66.61	713
HSA-MIR-6511B-3P	97.60	66.61	713
HSA-MIR-4680-5P	96.43	67.15	893
HSA-MIR-4513	95.04	67.06	727
HSA-MIR-6855-3P	95.04	66.57	725

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 573 — Q86YE8 (reviewed: Q86YE8)

All UniProt accessions (7): A0A0A0MRV5, Q86YE8, K7EL03, K7EM14, K7EM47, K7EQQ2, K7ERS7

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q86YE8-1	1	yes
Q86YE8-2	2
Q86YE8-3	3
Q86YE8-4	4

RefSeq proteins (5): NP_001166160, NP_001166161, NP_001166162, NP_001166163, NP_689573 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13912

UniProt features (31 total): zinc finger region 19, splice variant 4, sequence conflict 4, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86YE8-F1	75.63	0.02

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 69 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP, RATTENBACHER_BOUND_BY_CELF1, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, BAHD1_TARGET_GENES, E2F5_TARGET_GENES, H1_6_TARGET_GENES, ZBTB12_TARGET_GENES, ZIM3_TARGET_GENES, ZNF22_TARGET_GENES, ZNF30_TARGET_GENES, ZNF331_TARGET_GENES, ZNF436_TARGET_GENES

GO Biological Process (4): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355), regulation of macromolecule metabolic process (GO:0060255), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of metabolic process	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
macromolecule metabolic process	1
primary metabolic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

506 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF573	MCTP2	Q6DN12	491
ZNF573	UNC80	Q8N2C7	483
ZNF573	CMC2	Q9NRP2	476
ZNF573	MAST4	O15021	476
ZNF573	TP53I11	O14683	476
ZNF573	COL19A1	Q14993	469
ZNF573	ABCA13	Q86UQ4	452
ZNF573	A0A087WVV2	A0A087WVV2	447
ZNF573	IFT81	Q8WYA0	445
ZNF573	GDAP1	Q8TB36	443
ZNF573	SRPK2	P78362	437
ZNF573	GABRA5	P31644	429
ZNF573	NUTM1	Q86Y26	425
ZNF573	ZNF462	Q96JM2	419
ZNF573	PPP3CA	Q08209	404

IntAct

5 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (7): ZNF573 (Affinity Capture-MS), ZNF573 (Affinity Capture-MS), ZNF573 (Affinity Capture-RNA), ZNF573 (Affinity Capture-RNA), ZNF573 (Affinity Capture-MS), ZNF573 (Affinity Capture-MS), ZNF573 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0JPL0, A1L1L7, A2A761, A2VDP4, A3KN36, A6QLU5, A6QPT6, A7MBI1, A8MT65, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, O95780, P10076, P17014, P17023, P17025, P17030, P17032, P17098, P51523, P51814, P52736, P52742, P58317, Q02975, Q06730, Q06732, Q08DG8, Q0VCB0, Q13360, Q14584, Q14587, Q14590, Q147U1, Q16587, Q29RZ4, Q2M218

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

105 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

987 predictions. Top by Δscore:

Variant	Effect	Δscore
19:37758745:G:C	donor_gain	1.0000
19:37770099:T:C	acceptor_gain	0.9900
19:37771705:CCA:C	acceptor_gain	0.9900
19:37773659:A:AC	donor_gain	0.9900
19:37773660:C:CC	donor_gain	0.9900
19:37773660:CA:C	donor_gain	0.9900
19:37740193:ATC:A	acceptor_loss	0.9800
19:37740195:C:A	acceptor_loss	0.9800
19:37740195:C:CC	acceptor_gain	0.9800
19:37749198:A:C	acceptor_gain	0.9800
19:37770058:A:T	acceptor_gain	0.9800
19:37770099:T:TC	acceptor_gain	0.9800
19:37773660:CACA:C	donor_gain	0.9800
19:37773660:CACAG:C	donor_gain	0.9800
19:37770101:A:C	acceptor_gain	0.9700
19:37771706:CA:C	acceptor_gain	0.9700
19:37740201:C:CT	acceptor_gain	0.9600
19:37771562:AC:A	donor_gain	0.9600
19:37771563:CC:C	donor_gain	0.9600
19:37773655:ACTT:A	donor_loss	0.9600
19:37773656:CT:C	donor_loss	0.9600
19:37773657:T:TA	donor_loss	0.9600
19:37773658:T:TC	donor_loss	0.9600
19:37773659:A:C	donor_loss	0.9600
19:37773660:C:CA	donor_loss	0.9600
19:37740190:CAAAT:C	acceptor_gain	0.9500
19:37740197:G:C	acceptor_loss	0.9500
19:37749196:A:C	acceptor_gain	0.9500
19:37770023:C:A	donor_gain	0.9500
19:37770097:CCT:C	acceptor_gain	0.9500

AlphaMissense

4447 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:37738633:G:C	F619L	0.994
19:37738633:G:T	F619L	0.994
19:37738635:A:G	F619L	0.994
19:37739725:A:C	F255L	0.993
19:37739725:A:T	F255L	0.993
19:37739727:A:G	F255L	0.993
19:37739809:A:C	F227L	0.992
19:37739809:A:T	F227L	0.992
19:37739811:A:G	F227L	0.992
19:37739641:A:C	F283L	0.991
19:37739641:A:T	F283L	0.991
19:37739643:A:G	F283L	0.991
19:37738969:A:C	F507L	0.990
19:37738969:A:T	F507L	0.990
19:37738971:A:G	F507L	0.990
19:37739221:A:C	F423L	0.990
19:37739221:A:T	F423L	0.990
19:37739223:A:G	F423L	0.990
19:37738717:A:C	F591L	0.989
19:37738717:A:T	F591L	0.989
19:37738719:A:G	F591L	0.989
19:37738801:A:C	F563L	0.988
19:37738801:A:T	F563L	0.988
19:37738803:A:G	F563L	0.988
19:37739389:A:C	F367L	0.988
19:37739389:A:T	F367L	0.988
19:37739391:A:G	F367L	0.988
19:37739557:A:C	F311L	0.988
19:37739557:A:T	F311L	0.988
19:37739559:A:G	F311L	0.988

dbSNP variants (sampled 300 via entrez): RS1000029789 (19:37753870 A>G), RS1000110596 (19:37757483 T>C,G), RS1000119704 (19:37776239 A>G), RS1000155632 (19:37760833 A>G), RS1000173103 (19:37770219 A>T), RS1000208358 (19:37761055 G>A), RS1000382180 (19:37768349 G>A), RS1000464790 (19:37754128 A>T), RS1000650167 (19:37775767 C>T), RS1000875519 (19:37744116 T>A,C), RS1000976223 (19:37740922 T>C), RS1001071045 (19:37755646 G>A), RS1001125445 (19:37747894 T>G), RS1001141949 (19:37741332 A>G,T), RS1001158892 (19:37762204 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_55	Refractive error	7.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
(+)-JQ1 compound	decreases expression	2
Acetaminophen	decreases expression, increases expression	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Ozone	affects cotreatment, decreases expression, increases abundance, affects expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	affects cotreatment, decreases methylation	1
methacrylaldehyde	decreases expression, increases abundance, affects cotreatment	1
beta-methylcholine	affects expression	1
avobenzone	decreases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	decreases methylation, increases methylation, affects cotreatment	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Atrazine	decreases expression	1
Cisplatin	decreases expression	1
Dietary Carbohydrates	increases expression	1
Gallic Acid	increases expression	1
Hydrogen Peroxide	affects expression	1
Methyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.