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ZNF575

gene
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Also known as FLJ32567

Summary

ZNF575 (zinc finger protein 575, HGNC:27606) is a protein-coding gene on chromosome 19q13.31, encoding Zinc finger protein 575 (Q86XF7). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 284346 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 52 total
  • MANE Select transcript: NM_174945

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:27606
Approved symbolZNF575
Namezinc finger protein 575
Location19q13.31
Locus typegene with protein product
StatusApproved
AliasesFLJ32567
Ensembl geneENSG00000176472
Ensembl biotypeprotein_coding
Entrez284346

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 25 protein_coding, 1 retained_intron

ENST00000314228, ENST00000458714, ENST00000598080, ENST00000600154, ENST00000601282, ENST00000880316, ENST00000880317, ENST00000880318, ENST00000880319, ENST00000880320, ENST00000880321, ENST00000880322, ENST00000880323, ENST00000880324, ENST00000880325, ENST00000880326, ENST00000880327, ENST00000880328, ENST00000880329, ENST00000880330, ENST00000880331, ENST00000880332, ENST00000880333, ENST00000880334, ENST00000970960, ENST00000970961

RefSeq mRNA: 2 — MANE Select: NM_174945 NM_001394237, NM_174945

CCDS: CCDS12623

Canonical transcript exons

ENST00000314228 — 4 exons

ExonStartEnd
ENSE000012908934353318843533521
ENSE000013110654353379543533902
ENSE000030617234353502943536087
ENSE000035308394353433743534501

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 87.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3317 / max 32.6671, expressed in 1137 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
1761961.6623866
1761950.6694387

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
mucosa of transverse colonUBERON:000499187.88gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099183.01gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047380.34gold quality
colonic mucosaUBERON:000031779.52gold quality
tendon of biceps brachiiUBERON:000818879.01silver quality
mucosa of sigmoid colonUBERON:000499378.44silver quality
parotid glandUBERON:000183178.22gold quality
germinal epithelium of ovaryUBERON:000130477.03gold quality
transverse colonUBERON:000115776.45gold quality
gingival epitheliumUBERON:000194975.87gold quality
hindlimb stylopod muscleUBERON:000425275.78gold quality
stromal cell of endometriumCL:000225575.74gold quality
right hemisphere of cerebellumUBERON:001489075.50gold quality
prefrontal cortexUBERON:000045175.32gold quality
primary visual cortexUBERON:000243675.20gold quality
granulocyteCL:000009474.77gold quality
cerebellar hemisphereUBERON:000224574.28gold quality
cerebellar cortexUBERON:000212974.23gold quality
right frontal lobeUBERON:000281074.16gold quality
putamenUBERON:000187474.09gold quality
nucleus accumbensUBERON:000188273.92gold quality
Brodmann (1909) area 9UBERON:001354073.79gold quality
frontal cortexUBERON:000187073.74gold quality
colonUBERON:000115573.64gold quality
neocortexUBERON:000195073.64gold quality
cerebellumUBERON:000203773.62gold quality
anterior cingulate cortexUBERON:000983573.56gold quality
caudate nucleusUBERON:000187373.49gold quality
large intestineUBERON:000005973.48gold quality
cortical plateUBERON:000534373.45gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-MTAB-9543yes2325.37
E-ANND-3no2.34

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting ZNF575, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4776-3P100.0068.731340
HSA-MIR-607799.9968.042299
HSA-MIR-23A-3P99.9574.243163
HSA-MIR-23B-3P99.9574.243163
HSA-MIR-23C99.9573.923192
HSA-MIR-2681-5P99.7567.641655
HSA-MIR-368599.6268.831621
HSA-MIR-1211799.5067.57868
HSA-MIR-29799.4069.581418
HSA-MIR-491-5P99.1365.981468
HSA-MIR-155-3P99.0367.99924
HSA-MIR-392698.9569.261438
HSA-MIR-548S98.5067.171213
HSA-MIR-59598.2567.44699
HSA-MIR-4659B-5P98.0366.84979
HSA-MIR-4659A-5P98.0366.42819
HSA-MIR-892B98.0067.11821
HSA-MIR-3190-3P97.6166.951406
HSA-MIR-6782-3P97.6067.75931
HSA-MIR-939-5P97.1065.801579
HSA-MIR-1343-5P96.4866.061506
HSA-MIR-1211594.1966.37738

Literature-anchored findings (GeneRIF, showing 1)

  • Results found DNA methylation of the ZNF575 gene in infant cord blood to be associated with maternal antidepressant use in pregnancy in two independent cohorts. This association persists into early childhood. (PMID:30925934)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusZfp575ENSMUSG00000066721
rattus_norvegicusZfp575ENSRNOG00000024065

Paralogs (36): ZBTB32 (ENSG00000011590), SNAI2 (ENSG00000019549), PRDM1 (ENSG00000057657), PRDM6 (ENSG00000061455), ZNF76 (ENSG00000065029), PATZ1 (ENSG00000100105), MAZ (ENSG00000103495), ZBTB16 (ENSG00000109906), ZNF451 (ENSG00000112200), ZBTB45 (ENSG00000119574), ZNF410 (ENSG00000119725), SNAI1 (ENSG00000124216), ZNF384 (ENSG00000126746), ZBTB1 (ENSG00000126804), VEZF1 (ENSG00000136451), PRDM14 (ENSG00000147596), ZNF276 (ENSG00000158805), ZNF362 (ENSG00000160094), ZNF653 (ENSG00000161914), ZNF281 (ENSG00000162702), ZNF148 (ENSG00000163848), ZNF143 (ENSG00000166478), HIC2 (ENSG00000169635), PRDM10 (ENSG00000170325), ZNF296 (ENSG00000170684), ZNF692 (ENSG00000171163), HIC1 (ENSG00000177374), ZBTB18 (ENSG00000179456), ZBTB42 (ENSG00000179627), ZBTB20 (ENSG00000181722), ZBTB7C (ENSG00000184828), SNAI3 (ENSG00000185669), ZFP91 (ENSG00000186660), MTF1 (ENSG00000188786), SCRT2 (ENSG00000215397), SCRT1 (ENSG00000261678)

Protein

Protein identifiers

Zinc finger protein 575 — Q86XF7 (reviewed: Q86XF7)

All UniProt accessions (3): Q86XF7, B3KQ07, M0R087

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001381166, NP_777605* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR013087Znf_C2H2_typeDomain
IPR036236Znf_C2H2_sfHomologous_superfamily
IPR050636C2H2-ZF_domain-containingFamily

Pfam: PF00096

UniProt features (10 total): zinc finger region 6, compositionally biased region 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q86XF7-F175.120.24

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 39 (showing top): RNGTGGGC_UNKNOWN, TGCGCANK_UNKNOWN, CCCNNGGGAR_OLF1_01, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, AR_Q6, EGR_Q6, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, UBN1_TARGET_GENES, ZFP91_TARGET_GENES, ZNF22_TARGET_GENES, ZNF350_TARGET_GENES, ZNF407_TARGET_GENES, ZNF8_TARGET_GENES, MIR6077, MIR3685

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
transition metal ion binding1
nucleic acid binding1
binding1
cation binding1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

338 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF575PHLDB3Q6NSJ2617
ZNF575PRELID3BQ9Y3B1574
ZNF575SLC16A14Q7RTX9503
ZNF575TEX101Q9BY14503
ZNF575BLOC1S6Q9UL45493
ZNF575CMBLQ96DG6492
ZNF575LYPD3O95274468
ZNF575JOSD1Q15040463
ZNF575KCNIP3Q9Y2W7463
ZNF575MALSU1Q96EH3460
ZNF575UBE2BP23567453
ZNF575ETHE1O95571449
ZNF575THOC3Q96J01429
ZNF575RNF208Q9H0X6427
ZNF575GTPBP4Q9BZE4426

IntAct

82 interactions, top by confidence:

ABTypeScore
ZNF575ZRANB1psi-mi:“MI:0915”(physical association)0.560
KRTAP10-8ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575SNX33psi-mi:“MI:0915”(physical association)0.560
TNS2ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575KRTAP2-4psi-mi:“MI:0915”(physical association)0.560
ZNF575ZNF526psi-mi:“MI:0915”(physical association)0.560
ZNF575CARD10psi-mi:“MI:0915”(physical association)0.560
ZNF575MDFIpsi-mi:“MI:0915”(physical association)0.560
KRTAP10-7ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575PICK1psi-mi:“MI:0915”(physical association)0.560
KRTAP6-3ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575KRTAP9-3psi-mi:“MI:0915”(physical association)0.560
KRT40ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575TRIM41psi-mi:“MI:0915”(physical association)0.560
ZNF575KRTAP9-2psi-mi:“MI:0915”(physical association)0.560
KHDRBS3ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575MAPK8IP3psi-mi:“MI:0915”(physical association)0.560
HAP1ZNF575psi-mi:“MI:0915”(physical association)0.560
TP53BP2ZNF575psi-mi:“MI:0915”(physical association)0.560
MYF5ZNF575psi-mi:“MI:0915”(physical association)0.560
HNRNPKZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575KRTAP17-1psi-mi:“MI:0915”(physical association)0.560
KRTAP5-1ZNF575psi-mi:“MI:0915”(physical association)0.560
CYSRT1ZNF575psi-mi:“MI:0915”(physical association)0.560
SPRED2ZNF575psi-mi:“MI:0915”(physical association)0.560
ZNF575ZRANB1psi-mi:“MI:0915”(physical association)0.000
ZNF575KRTAP10-8psi-mi:“MI:0915”(physical association)0.000
ZNF575SNX33psi-mi:“MI:0915”(physical association)0.000
ZNF575TNS2psi-mi:“MI:0915”(physical association)0.000
ZNF575KRTAP2-4psi-mi:“MI:0915”(physical association)0.000

BioGRID (26): ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), ZNF575 (Two-hybrid), KRTAP17-1 (Two-hybrid)

ESM2 similar proteins: A6NM28, A8K8V0, P10075, P28698, P30373, Q0VCC5, Q2TA17, Q3US17, Q499Z4, Q4R3I5, Q4R8S8, Q504L7, Q5R4P8, Q5RJR4, Q5U4E2, Q642B2, Q68H95, Q6DD87, Q6ZMY9, Q6ZN55, Q6ZNH5, Q7L3S4, Q7Z7K2, Q80VM4, Q86XF7, Q8BI73, Q8BIF9, Q8BJ90, Q8BKK5, Q8BY46, Q8JZL0, Q8K2R5, Q8NCA9, Q96BV0, Q96C28, Q96CS4, Q96H86, Q96K58, Q96MX3, Q96SL8

Diamond homologs: Q3TXZ1, Q86XF7, Q9GM03

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 25 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Keratinization927.9×4e-10

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance47
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1022 predictions. Top by Δscore:

VariantEffectΔscore
19:43526199:A:ACdonor_gain1.0000
19:43526200:C:CCdonor_gain1.0000
19:43526657:CAT:Cacceptor_gain1.0000
19:43526195:A:Cdonor_gain0.9900
19:43526200:CGAAG:Cdonor_gain0.9900
19:43526350:C:CCacceptor_gain0.9900
19:43526451:T:TAdonor_gain0.9900
19:43526452:C:Adonor_gain0.9900
19:43526510:CTGA:Cdonor_loss0.9900
19:43526511:TGA:Tdonor_loss0.9900
19:43526512:GACCA:Gdonor_loss0.9900
19:43526513:A:Cdonor_loss0.9900
19:43526514:CCAG:Cdonor_gain0.9900
19:43526660:C:CCacceptor_gain0.9900
19:43526660:CTG:Cacceptor_loss0.9900
19:43526661:T:Aacceptor_loss0.9900
19:43527099:G:Adonor_gain0.9900
19:43527141:G:Cdonor_gain0.9900
19:43533488:G:GTdonor_gain0.9900
19:43534498:GAAG:Gdonor_gain0.9900
19:43534499:AAGGT:Adonor_loss0.9900
19:43534500:AG:Adonor_loss0.9900
19:43534501:GG:Gdonor_loss0.9900
19:43534502:GTG:Gdonor_loss0.9900
19:43526143:C:Adonor_gain0.9800
19:43526346:TTCA:Tacceptor_gain0.9800
19:43526348:CA:Cacceptor_gain0.9800
19:43526513:A:ACdonor_gain0.9800
19:43526514:C:CCdonor_gain0.9800
19:43526541:T:TAdonor_gain0.9800

AlphaMissense

1573 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
19:43535163:T:CF72L0.999
19:43535165:C:AF72L0.999
19:43535165:C:GF72L0.999
19:43535247:T:CF100L0.999
19:43535249:C:AF100L0.999
19:43535249:C:GF100L0.999
19:43535331:T:CF128L0.999
19:43535333:T:AF128L0.999
19:43535333:T:GF128L0.999
19:43535360:C:AH137Q0.999
19:43535360:C:GH137Q0.999
19:43535415:T:CF156L0.999
19:43535417:C:AF156L0.999
19:43535417:C:GF156L0.999
19:43535505:T:CF186L0.999
19:43535507:C:AF186L0.999
19:43535507:C:GF186L0.999
19:43535190:C:AH81N0.998
19:43535274:C:AH109N0.998
19:43535276:C:AH109Q0.998
19:43535276:C:GH109Q0.998
19:43535358:C:AH137N0.998
19:43535442:C:AH165N0.998
19:43535613:T:CF222L0.998
19:43535615:T:AF222L0.998
19:43535615:T:GF222L0.998
19:43535190:C:GH81D0.997
19:43535192:C:AH81Q0.997
19:43535192:C:GH81Q0.997
19:43535247:T:AF100I0.997

dbSNP variants (sampled 300 via entrez): RS1000369944 (19:43534869 G>A), RS1000559241 (19:43533554 G>A), RS1001165854 (19:43532591 A>T), RS1001858346 (19:43530310 C>T), RS1001890979 (19:43533344 G>A), RS1001991347 (19:43536226 A>G), RS1002310633 (19:43530604 G>A), RS1002525607 (19:43533142 C>G,T), RS1003041257 (19:43529815 ACT>A), RS1003529461 (19:43534133 C>G,T), RS1003581865 (19:43531959 T>C), RS1003963865 (19:43534294 A>G), RS1004055593 (19:43535967 A>G), RS1004071666 (19:43533855 G>A), RS1004266629 (19:43531355 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

ChemicalActions (top 5)PubMed papers
pirinixic acidaffects binding, increases activity, increases expression1
sodium arsenitedecreases methylation, increases expression1
butyraldehydedecreases expression1
di-n-butylphosphoric acidaffects expression1
CGP 52608affects binding, increases reaction1
abrinedecreases expression1
jinfukangaffects cotreatment, increases expression1
Resveratrolaffects cotreatment, decreases expression1
Air Pollutantsdecreases expression, increases abundance1
Benzo(a)pyreneincreases methylation1
Cisplatinaffects cotreatment, increases expression1
Pantothenic Aciddecreases expression1
Plant Extractsaffects cotreatment, decreases expression1
Tobacco Smoke Pollutiondecreases expression1
Aflatoxin B1decreases expression1
Antirheumatic Agentsincreases expression1
Cadmium Chlorideincreases expression1
Copper Sulfatedecreases expression1
Particulate Matterdecreases expression, increases abundance1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot