ZNF576

Summary

ZNF576 (zinc finger protein 576, HGNC:28357) is a protein-coding gene on chromosome 19q13.31, encoding Zinc finger protein 576 (Q9H609). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 79177 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 30 total
• MANE Select transcript: NM_001145347

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28357
Approved symbol	ZNF576
Name	zinc finger protein 576
Location	19q13.31
Locus type	gene with protein product
Status	Approved
Aliases	MGC2508
Ensembl gene	ENSG00000124444
Ensembl biotype	protein_coding
Entrez	79177

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 protein_coding, 1 retained_intron

ENST00000336564, ENST00000391965, ENST00000525771, ENST00000528387, ENST00000529930, ENST00000533118, ENST00000595041, ENST00000895833, ENST00000895834, ENST00000895835, ENST00000895836, ENST00000934409, ENST00000934410, ENST00000934411

RefSeq mRNA: 2 — MANE Select: NM_001145347 NM_001145347, NM_024327

CCDS: CCDS12625

Canonical transcript exons

ENST00000336564 — 3 exons

Exon	Start	End
ENSE00001359388	43598831	43601157
ENSE00002149044	43596595	43596743
ENSE00003621905	43597094	43597193

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 89.78.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8225 / max 71.7681, expressed in 1772 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176203	8.8225	1772
176201	0.6993	440
176202	0.1778	59

Top tissues by expression

274 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	89.78	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.11	gold quality
prefrontal cortex	UBERON:0000451	86.88	gold quality
cerebellar vermis	UBERON:0004720	86.23	silver quality
mucosa of transverse colon	UBERON:0004991	85.03	gold quality
gastrocnemius	UBERON:0001388	83.08	gold quality
muscle of leg	UBERON:0001383	83.00	gold quality
right adrenal gland	UBERON:0001233	82.84	gold quality
apex of heart	UBERON:0002098	82.83	gold quality
right frontal lobe	UBERON:0002810	82.83	gold quality
right lobe of liver	UBERON:0001114	82.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.71	gold quality
cerebellar cortex	UBERON:0002129	82.69	gold quality
cerebellar hemisphere	UBERON:0002245	82.63	gold quality
frontal cortex	UBERON:0001870	82.48	gold quality
cerebellum	UBERON:0002037	82.44	gold quality
left adrenal gland	UBERON:0001234	82.42	gold quality
nucleus accumbens	UBERON:0001882	82.41	gold quality
lateral nuclear group of thalamus	UBERON:0002736	82.41	silver quality
cingulate cortex	UBERON:0003027	82.40	gold quality
anterior cingulate cortex	UBERON:0009835	82.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.31	gold quality
right adrenal gland cortex	UBERON:0035827	82.27	gold quality
left adrenal gland cortex	UBERON:0035825	82.13	gold quality
type B pancreatic cell	CL:0000169	82.08	gold quality
triceps brachii	UBERON:0001509	82.07	gold quality
stromal cell of endometrium	CL:0002255	82.05	gold quality
neocortex	UBERON:0001950	82.00	gold quality
putamen	UBERON:0001874	81.98	gold quality
muscle organ	UBERON:0001630	81.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.69

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

38 targeting ZNF576, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-4708-3P	99.51	67.99	870
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-21-5P	99.46	70.54	1035
HSA-MIR-4652-3P	99.33	70.02	2742
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-3191-5P	99.24	66.52	1722
HSA-MIR-3160-3P	99.07	64.78	955
HSA-MIR-5583-3P	99.06	65.68	1018
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-6796-3P	98.68	65.49	689
HSA-MIR-6852-3P	98.54	67.60	1468
HSA-MIR-518C-5P	98.53	69.20	1640
HSA-MIR-548S	98.50	67.17	1213
HSA-MIR-3928-5P	98.50	67.48	980
HSA-MIR-6806-3P	98.50	67.31	980
HSA-MIR-2681-3P	98.18	65.28	577
HSA-MIR-204-3P	97.80	66.84	1656
HSA-MIR-4646-5P	97.70	66.84	1692
HSA-MIR-3909	97.55	66.78	887
HSA-MIR-4314	97.50	67.30	1369
HSA-MIR-7106-3P	97.33	65.33	644

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	plagx	ENSDARG00000036855
danio_rerio	plagl2	ENSDARG00000076657
drosophila_melanogaster	hb	FBGN0001180
drosophila_melanogaster	CG12391	FBGN0033581
caenorhabditis_elegans		WBGENE00001824
caenorhabditis_elegans		WBGENE00012385

Paralogs (29): ZNF446 (ENSG00000083838), REST (ENSG00000084093), ZNF174 (ENSG00000103343), OVOL3 (ENSG00000105261), PLAGL1 (ENSG00000118495), ZSCAN18 (ENSG00000121413), OVOL2 (ENSG00000125850), PLAGL2 (ENSG00000126003), ZSCAN5A (ENSG00000131848), ZSCAN29 (ENSG00000140265), ZSCAN32 (ENSG00000140987), ZSCAN1 (ENSG00000152467), ZNF18 (ENSG00000154957), ZKSCAN2 (ENSG00000155592), ZNF496 (ENSG00000162714), ZNF202 (ENSG00000166261), ZNF641 (ENSG00000167528), ZNF444 (ENSG00000167685), SCAND1 (ENSG00000171222), ZNF274 (ENSG00000171606), ZNF131 (ENSG00000172262), OVOL1 (ENSG00000172818), ZNF518A (ENSG00000177853), ZNF518B (ENSG00000178163), PLAG1 (ENSG00000181690), ZSCAN5B (ENSG00000197213), ZNF770 (ENSG00000198146), PEG3 (ENSG00000198300), ZSCAN5C (ENSG00000204532)

Protein

Protein identifiers

Zinc finger protein 576 — Q9H609 (reviewed: Q9H609)

All UniProt accessions (1): Q9H609

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001138819, NP_077303 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050888	ZnF_C2H2-type_TF	Family

Pfam: PF00096, PF13912

UniProt features (8 total): zinc finger region 4, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H609-F1	75.36	0.19

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 71 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, ATF_B, XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN, AP2_Q3, KOYAMA_SEMA3B_TARGETS_UP, CREB_Q3, ATF_01, CREBP1CJUN_01, CREB_01, TGACGTCA_ATF3_Q6, STEIN_ESRRA_TARGETS_UP, EIF4E_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, COBLL1_TARGET_GENES, CREB3L4_TARGET_GENES

GO Biological Process (1): regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transcription cis-regulatory region binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

498 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF576	SEC22B	O75396	328
ZNF576	CCDC90B	Q9GZT6	323
ZNF576	RPL6	Q02878	312
ZNF576	ELOVL1	Q9BW60	305
ZNF576	GOLM1	Q8NBJ4	275
ZNF576	TMOD4	Q9NZQ9	272
ZNF576	FAHD2A	Q96GK7	249
ZNF576	FAHD2B	Q6P2I3	249
ZNF576	ACVR1B	P36896	237
ZNF576	AICDA	Q9GZX7	235
ZNF576	WRNIP1	Q96S55	232
ZNF576	BOLA1	Q9Y3E2	232
ZNF576	PHTF1	Q9UMS5	228
ZNF576	CLK2	P49760	223
ZNF576	HEBP2	Q9Y5Z4	216

IntAct

45 interactions, top by confidence:

A	B	Type	Score
AP4B1	ZNF576	psi-mi:“MI:0915”(physical association)	0.780
ZNF576	AP4B1	psi-mi:“MI:0915”(physical association)	0.780
ZNF576	SH3GLB1	psi-mi:“MI:0915”(physical association)	0.720
SH3GLB1	ZNF576	psi-mi:“MI:0915”(physical association)	0.720
ZNF576	ZBED1	psi-mi:“MI:0914”(association)	0.640
KRT15	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
ZNF576	TLE5	psi-mi:“MI:0915”(physical association)	0.560
TLE5	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
PPP1R27	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
ZNF576	PICK1	psi-mi:“MI:0915”(physical association)	0.560
ARPC3	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
VBP1	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
MAGEA4	ZNF576	psi-mi:“MI:0915”(physical association)	0.560
RBBP6	HNRNPC	psi-mi:“MI:0914”(association)	0.530
RARG	ZNF576	psi-mi:“MI:0915”(physical association)	0.370
SUOX	ZNF576	psi-mi:“MI:0915”(physical association)	0.370
ZNF576	MAPKAPK5	psi-mi:“MI:0915”(physical association)	0.370
ZNF576	GAPDHS	psi-mi:“MI:0914”(association)	0.350

BioGRID (39): ZNF576 (Two-hybrid), ZNF576 (Two-hybrid), ZNF576 (Two-hybrid), ZNF576 (Two-hybrid), POGZ (Affinity Capture-MS), ZNF618 (Affinity Capture-MS), AJUBA (Affinity Capture-MS), ZBTB40 (Affinity Capture-MS), ZBED1 (Affinity Capture-MS), ZBTB10 (Affinity Capture-MS), LIMD1 (Affinity Capture-MS), RBBP6 (Affinity Capture-MS), PDLIM7 (Affinity Capture-MS), ZBTB33 (Affinity Capture-MS), ZNF446 (Affinity Capture-MS)

ESM2 similar proteins: A2A5K6, A6QR00, D4A8X0, E9Q6W4, G3V893, O15015, O15156, O95863, P0CJ78, P10074, Q02085, Q13105, Q29RK0, Q3U3I9, Q4R8S8, Q504L7, Q5EBL2, Q5F293, Q5R4P8, Q5RJR4, Q60821, Q66K89, Q6DD87, Q6GL52, Q6NV66, Q6PGE4, Q6YND2, Q6ZN55, Q80VM4, Q8BI66, Q8BI69, Q8BIF9, Q8BY46, Q8CCE9, Q8CJ78, Q8JZL0, Q8N1W2, Q8NCA9, Q8TF50, Q8WUU4

Diamond homologs: O70237, Q5RJR4, Q8JZL0, Q9H609

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	25
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

918 predictions. Top by Δscore:

Variant	Effect	Δscore
19:43597182:G:GT	donor_gain	1.0000
19:43597189:CATCT:C	donor_gain	1.0000
19:43597190:ATCT:A	donor_gain	1.0000
19:43597191:TCT:T	donor_gain	1.0000
19:43597192:CT:C	donor_gain	1.0000
19:43597193:TGTG:T	donor_loss	1.0000
19:43597194:G:GA	donor_loss	1.0000
19:43597194:G:GG	donor_gain	1.0000
19:43597195:TGAG:T	donor_loss	1.0000
19:43597198:G:GG	donor_gain	1.0000
19:43599208:G:GT	donor_gain	1.0000
19:43596477:G:GT	donor_gain	0.9900
19:43596502:GAC:G	donor_gain	0.9900
19:43596504:C:CG	donor_gain	0.9900
19:43596504:C:G	donor_gain	0.9900
19:43596583:GCT:G	donor_gain	0.9900
19:43596586:G:GG	donor_gain	0.9900
19:43596591:G:GT	donor_gain	0.9900
19:43596616:G:GT	donor_gain	0.9900
19:43596742:GG:G	donor_gain	0.9900
19:43596743:GG:G	donor_gain	0.9900
19:43597093:GAA:G	acceptor_gain	0.9900
19:43597196:GAGTA:G	donor_loss	0.9900
19:43597197:A:AG	donor_gain	0.9900
19:43597197:AGTA:A	donor_loss	0.9900
19:43598829:A:AG	acceptor_gain	0.9900
19:43598830:G:GG	acceptor_gain	0.9900
19:43598947:G:GT	donor_gain	0.9900
19:43596494:GGCCC:G	donor_gain	0.9800
19:43596509:T:TA	donor_gain	0.9800

AlphaMissense

1121 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:43598872:T:C	F43L	0.997
19:43598874:C:A	F43L	0.997
19:43598874:C:G	F43L	0.997
19:43598962:T:C	C73R	0.997
19:43598983:T:C	F80L	0.997
19:43598985:C:A	F80L	0.997
19:43598985:C:G	F80L	0.997
19:43599199:T:C	F152L	0.997
19:43599201:T:A	F152L	0.997
19:43599201:T:G	F152L	0.997
19:43598964:C:G	C73W	0.996
19:43599106:T:C	F121L	0.996
19:43599108:T:A	F121L	0.996
19:43599108:T:G	F121L	0.996
19:43599010:C:A	H89N	0.995
19:43599010:C:G	H89D	0.995
19:43599085:T:C	C114R	0.995
19:43599133:C:G	H130D	0.995
19:43598984:T:C	F80S	0.994
19:43599002:T:C	L86P	0.994
19:43599012:C:A	H89Q	0.994
19:43599012:C:G	H89Q	0.994
19:43598860:T:A	C39S	0.993
19:43598861:G:C	C39S	0.993
19:43598916:C:A	H57Q	0.993
19:43598916:C:G	H57Q	0.993
19:43598956:T:C	F71L	0.993
19:43598958:C:A	F71L	0.993
19:43598958:C:G	F71L	0.993
19:43599133:C:A	H130N	0.993

dbSNP variants (sampled 300 via entrez): RS1000301047 (19:43596524 T>G), RS1000761553 (19:43601050 C>A,G,T), RS1001605966 (19:43598033 A>G), RS1004602656 (19:43598482 A>C), RS1004888059 (19:43597778 T>G), RS1004940607 (19:43597489 G>A), RS1005384753 (19:43595758 GC>G), RS1005800021 (19:43594661 C>T), RS1006397261 (19:43594670 AG>A,AGG), RS1007417887 (19:43596082 G>A,T), RS1007468673 (19:43595867 G>A,C), RS1007843469 (19:43600782 C>A), RS1009141701 (19:43596817 T>G), RS1009382980 (19:43597566 CAA>C), RS1009792789 (19:43596539 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90000025_569	Appendicular lean mass	1.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic Trioxide	decreases reaction, affects binding	1
Diazinon	increases methylation	1
Lead	increases expression	1
Phthalic Acids	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Quercetin	decreases phosphorylation	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.