ZNF585A

Summary

ZNF585A (zinc finger protein 585A, HGNC:26305) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 585A (Q6P3V2). May be involved in transcriptional regulation.

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 199704 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 79 total
• MANE Select transcript: NM_001288800

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26305
Approved symbol	ZNF585A
Name	zinc finger protein 585A
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ23765, Zfp27
Ensembl gene	ENSG00000196967
Ensembl biotype	protein_coding
Entrez	199704

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000292841, ENST00000356958, ENST00000392157, ENST00000587817, ENST00000588354, ENST00000588723, ENST00000896007, ENST00000935500, ENST00000971112, ENST00000971113

RefSeq mRNA: 3 — MANE Select: NM_001288800 NM_001288800, NM_152655, NM_199126

CCDS: CCDS12499, CCDS74353

Canonical transcript exons

ENST00000292841 — 5 exons

Exon	Start	End
ENSE00000000352	37172627	37172695
ENSE00001298137	37145540	37153606
ENSE00003540534	37156229	37156355
ENSE00003683517	37155865	37155957
ENSE00003689678	37169839	37170054

Expression profiles

Bgee: expression breadth ubiquitous, 238 present calls, max score 93.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.5321 / max 110.7990, expressed in 1704 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180706	10.4622	1704
180705	0.0639	18
180704	0.0060	3

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	93.58	gold quality
endothelial cell	CL:0000115	91.17	gold quality
sperm	CL:0000019	90.64	gold quality
secondary oocyte	CL:0000655	89.37	gold quality
oocyte	CL:0000023	89.17	gold quality
granulocyte	CL:0000094	86.51	gold quality
islet of Langerhans	UBERON:0000006	86.13	gold quality
leukocyte	CL:0000738	85.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.85	gold quality
monocyte	CL:0000576	85.70	gold quality
Brodmann (1909) area 23	UBERON:0013554	85.51	gold quality
left adrenal gland cortex	UBERON:0035825	84.15	gold quality
left adrenal gland	UBERON:0001234	83.61	gold quality
right adrenal gland	UBERON:0001233	83.40	gold quality
adenohypophysis	UBERON:0002196	83.32	gold quality
right adrenal gland cortex	UBERON:0035827	83.08	gold quality
calcaneal tendon	UBERON:0003701	83.04	gold quality
adrenal tissue	UBERON:0018303	82.86	gold quality
adrenal cortex	UBERON:0001235	82.69	gold quality
left ventricle myocardium	UBERON:0006566	82.57	silver quality
pituitary gland	UBERON:0000007	82.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.29	gold quality
pancreas	UBERON:0001264	82.25	gold quality
middle temporal gyrus	UBERON:0002771	82.22	gold quality
primary visual cortex	UBERON:0002436	81.98	gold quality
mucosa of transverse colon	UBERON:0004991	81.83	gold quality
body of pancreas	UBERON:0001150	81.75	gold quality
left lobe of thyroid gland	UBERON:0001120	81.60	gold quality
adrenal gland	UBERON:0002369	81.59	gold quality
ventricular zone	UBERON:0003053	81.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.59

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

125 targeting ZNF585A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-8485	100.00	77.57	4731
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-539-5P	99.93	70.30	2855

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 585A — Q6P3V2 (reviewed: Q6P3V2)

All UniProt accessions (4): A0A0C4DFY4, Q6P3V2, K7ELR3, K7EN80

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6P3V2-1	1	yes
Q6P3V2-2	2

RefSeq proteins (3): NP_001275729, NP_689868, NP_954577 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (29 total): zinc finger region 22, splice variant 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P3V2-F1	76.35	0.14

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 59 (showing top): MAYBURD_RESPONSE_TO_L663536_DN, NRF2_01, CETS1P54_01, SCGGAAGY_ELK1_02, MGGAAGTG_GABP_B, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZWANG_EGF_INTERVAL_DN, GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_129_MOUSE_DN, CIITA_TARGET_GENES, E2F5_TARGET_GENES, FOXE1_TARGET_GENES, FOXJ2_TARGET_GENES, ZNF197_TARGET_GENES, ZNF558_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (2): zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

342 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF585A	RNF214	Q8ND24	476
ZNF585A	MITD1	Q8WV92	401
ZNF585A	DBF4B	Q8NFT6	397
ZNF585A	BEAN1	Q3B7T3	378
ZNF585A	MRPL55	Q7Z7F7	377
ZNF585A	ZBTB3	Q9H5J0	361
ZNF585A	C1orf52	Q8N6N3	350
ZNF585A	ZBTB25	P24278	346
ZNF585A	COG5	Q9UP83	327
ZNF585A	YY1AP1	Q9H869	321
ZNF585A	CCNDBP1	O95273	318
ZNF585A	MTMR7	Q9Y216	314
ZNF585A	PRPF38A	Q8NAV1	307
ZNF585A	AKR7A3	O95154	297
ZNF585A	INS-IGF2	F8WCM5	285

IntAct

3 interactions, top by confidence:

A	B	Type	Score
ZNF585A	CHTOP	psi-mi:“MI:0915”(physical association)	0.400
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350

BioGRID (5): CHTOP (Proximity Label-MS), ZNF585A (Affinity Capture-MS), ZNF585A (Affinity Capture-RNA), ZNF585A (Affinity Capture-RNA), ZNF585A (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	67
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1206 predictions. Top by Δscore:

Variant	Effect	Δscore
19:37127119:A:AG	acceptor_gain	1.0000
19:37127120:T:G	acceptor_gain	1.0000
19:37127124:TCAG:T	acceptor_loss	1.0000
19:37127124:TCAGA:T	acceptor_gain	1.0000
19:37127125:CAGA:C	acceptor_gain	1.0000
19:37127126:A:AG	acceptor_gain	1.0000
19:37127127:G:GC	acceptor_gain	1.0000
19:37127127:GA:G	acceptor_gain	1.0000
19:37127127:GAC:G	acceptor_gain	1.0000
19:37127127:GACT:G	acceptor_gain	1.0000
19:37127127:GACTT:G	acceptor_gain	1.0000
19:37156223:GCTTA:G	donor_loss	1.0000
19:37156224:CTTA:C	donor_loss	1.0000
19:37156225:TTACC:T	donor_loss	1.0000
19:37156227:A:AC	donor_gain	1.0000
19:37156227:ACC:A	donor_loss	1.0000
19:37156228:C:CC	donor_gain	1.0000
19:37156228:C:CG	donor_loss	1.0000
19:37156228:CCTA:C	donor_gain	1.0000
19:37156231:A:AC	donor_gain	1.0000
19:37156232:C:CC	donor_gain	1.0000
19:37127122:TTTCA:T	acceptor_gain	0.9900
19:37127123:TTCA:T	acceptor_gain	0.9900
19:37127126:AGA:A	acceptor_gain	0.9900
19:37127127:G:C	acceptor_gain	0.9900
19:37156353:TCCCT:T	acceptor_loss	0.9900
19:37156355:CCT:C	acceptor_loss	0.9900
19:37156356:C:CC	acceptor_gain	0.9900
19:37156356:CTGT:C	acceptor_loss	0.9900
19:37156357:T:A	acceptor_loss	0.9900

AlphaMissense

5116 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:37152306:G:C	F531L	0.999
19:37152306:G:T	F531L	0.999
19:37152308:A:G	F531L	0.999
19:37152138:G:C	F587L	0.998
19:37152138:G:T	F587L	0.998
19:37152140:A:G	F587L	0.998
19:37152222:G:C	F559L	0.998
19:37152222:G:T	F559L	0.998
19:37152224:A:G	F559L	0.998
19:37151718:A:C	F727L	0.997
19:37151718:A:T	F727L	0.997
19:37151720:A:G	F727L	0.997
19:37151802:G:C	F699L	0.997
19:37151802:G:T	F699L	0.997
19:37151804:A:G	F699L	0.997
19:37151886:A:C	F671L	0.997
19:37151886:A:T	F671L	0.997
19:37151888:A:G	F671L	0.997
19:37151970:A:C	F643L	0.997
19:37151970:A:T	F643L	0.997
19:37151972:A:G	F643L	0.997
19:37152289:A:G	L537P	0.997
19:37152474:G:C	F475L	0.997
19:37152474:G:T	F475L	0.997
19:37152476:A:G	F475L	0.997
19:37152726:G:C	F391L	0.997
19:37152726:G:T	F391L	0.997
19:37152728:A:G	F391L	0.997
19:37151770:C:G	R710P	0.996
19:37151861:G:C	H680D	0.996

dbSNP variants (sampled 300 via entrez): RS1000091038 (19:37167995 T>C), RS1000223814 (19:37155470 G>A,T), RS1000274262 (19:37151329 A>C), RS1000512090 (19:37150396 AG>A), RS1000583601 (19:37151551 G>C,T), RS1000599630 (19:37147604 T>C), RS1000887198 (19:37163727 A>G), RS1000918390 (19:37163511 C>T), RS1001064646 (19:37170379 G>A), RS1001090170 (19:37156712 A>G), RS1001115778 (19:37157233 T>C), RS1001269564 (19:37163072 A>AC), RS1001289284 (19:37146729 T>C), RS1001712510 (19:37158816 A>G), RS1001840335 (19:37156646 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST004639_17	Prudent dietary pattern	3.000000e-06
GCST008058_86	Estimated glomerular filtration rate	2.000000e-21
GCST008059_100	Estimated glomerular filtration rate	2.000000e-21
GCST90020024_566	A body shape index	6.000000e-09
GCST90020025_1646	Waist-to-hip ratio adjusted for BMI	5.000000e-09
GCST90020027_317	Waist-hip index	3.000000e-08
GCST90020028_1330	Hip circumference adjusted for BMI	2.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases abundance, increases expression, decreases expression	3
Smoke	decreases expression, increases abundance	2
Valproic Acid	decreases expression, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
tobacco tar	decreases expression	1
nickel sulfate	decreases expression	1
beta-methylcholine	affects expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Coal	increases abundance, decreases expression	1
Doxorubicin	decreases expression	1
Thiram	increases expression	1
Urethane	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.