ZNF585B

Summary

ZNF585B (zinc finger protein 585B, HGNC:30948) is a protein-coding gene on chromosome 19q13.12, encoding Zinc finger protein 585B (Q52M93). May be involved in transcriptional regulation.

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 92285 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 109 total
• MANE Select transcript: NM_152279

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30948
Approved symbol	ZNF585B
Name	zinc finger protein 585B
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14928, SZFP41, Zfp27
Ensembl gene	ENSG00000245680
Ensembl biotype	protein_coding
Entrez	92285

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 4 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000392156, ENST00000526705, ENST00000527838, ENST00000531805, ENST00000532828, ENST00000534363, ENST00000586320, ENST00000591273, ENST00000591492, ENST00000905951, ENST00000905952, ENST00000965087

RefSeq mRNA: 1 — MANE Select: NM_152279 NM_152279

CCDS: CCDS12500

Canonical transcript exons

ENST00000532828 — 5 exons

Exon	Start	End
ENSE00002174128	37210441	37210536
ENSE00002956745	37181579	37187244
ENSE00003472336	37189661	37189753
ENSE00003536243	37207040	37207254
ENSE00003557476	37190024	37190150

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 84.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5750 / max 86.1217, expressed in 1438 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180708	4.5750	1438

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	84.27	gold quality
calcaneal tendon	UBERON:0003701	83.51	gold quality
colonic epithelium	UBERON:0000397	82.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.48	gold quality
oocyte	CL:0000023	81.05	gold quality
islet of Langerhans	UBERON:0000006	80.59	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.55	gold quality
right lobe of thyroid gland	UBERON:0001119	80.45	gold quality
adrenal tissue	UBERON:0018303	80.36	gold quality
cerebellar hemisphere	UBERON:0002245	80.25	gold quality
cerebellar cortex	UBERON:0002129	80.21	gold quality
pituitary gland	UBERON:0000007	80.12	gold quality
thyroid gland	UBERON:0002046	79.96	gold quality
left lobe of thyroid gland	UBERON:0001120	79.93	gold quality
left ovary	UBERON:0002119	79.70	gold quality
apex of heart	UBERON:0002098	79.65	gold quality
adenohypophysis	UBERON:0002196	79.52	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.33	gold quality
mucosa of stomach	UBERON:0001199	79.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	79.05	gold quality
lower esophagus	UBERON:0013473	79.03	gold quality
body of uterus	UBERON:0009853	79.01	gold quality
corpus callosum	UBERON:0002336	78.87	gold quality
cerebellum	UBERON:0002037	78.80	gold quality
right ovary	UBERON:0002118	78.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.60	gold quality
endocervix	UBERON:0000458	78.57	gold quality
rectum	UBERON:0001052	78.57	gold quality
stromal cell of endometrium	CL:0002255	78.52	gold quality
cortical plate	UBERON:0005343	78.49	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.95
E-MTAB-7249	no	322.70

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

100 targeting ZNF585B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-383-3P	99.85	65.84	1359

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 585B — Q52M93 (reviewed: Q52M93)

Alternative names: zinc finger protein 41-like protein

All UniProt accessions (7): E9PNT4, E9PQ00, Q52M93, F2Z3L4, K7EL12, K7EP93, K7EPG8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_689492* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (27 total): zinc finger region 21, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q52M93-F1	75.39	0.03

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 76 (showing top): TGCGCANK_UNKNOWN, NRF2_01, CETS1P54_01, SCGGAAGY_ELK1_02, MGGAAGTG_GABP_B, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, RAO_BOUND_BY_SALL4, CSR_EARLY_UP.V1_DN, CBX7_TARGET_GENES, CIITA_TARGET_GENES, FOXJ2_TARGET_GENES, IRF5_TARGET_GENES, KLF7_TARGET_GENES

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), developmental process (GO:0032502), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (2): zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
biological_process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

388 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF585B	OR4D6	Q8NGJ1	451
ZNF585B	GXYLT1	Q4G148	415
ZNF585B	BEAN1	Q3B7T3	321
ZNF585B	MRPL55	Q7Z7F7	320
ZNF585B	ERICH1	Q86X53	311
ZNF585B	SP140L	Q9H930	307
ZNF585B	ZBTB3	Q9H5J0	302
ZNF585B	NOL8	Q76FK4	300
ZNF585B	ZBTB25	P24278	294
ZNF585B	LHFPL3	Q86UP9	290
ZNF585B	C1orf52	Q8N6N3	290
ZNF585B	COG5	Q9UP83	280
ZNF585B	RERGL	Q9H628	270
ZNF585B	INO80E	Q8NBZ0	270
ZNF585B	ZNF385B	Q569K4	269

IntAct

9 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF585B	PCK1	psi-mi:“MI:0915”(physical association)	0.400
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350
ZNF585B	hflC	psi-mi:“MI:0915”(physical association)	0.000
ZNF585B	RIC8A	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): ZNF585B (Affinity Capture-MS), RIC8A (Two-hybrid), ZNF585B (Affinity Capture-RNA), PCK1 (Affinity Capture-MS), ZNF585B (Affinity Capture-MS), ZNF585B (Co-fractionation), ZNF585B (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

109 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	92
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1128 predictions. Top by Δscore:

Variant	Effect	Δscore
19:37190018:GCTTA:G	donor_loss	1.0000
19:37190019:CTTAC:C	donor_loss	1.0000
19:37190020:TTA:T	donor_loss	1.0000
19:37190022:A:AT	donor_loss	1.0000
19:37190023:C:A	donor_loss	1.0000
19:37190023:CCTA:C	donor_gain	1.0000
19:37190026:A:AC	donor_gain	1.0000
19:37190027:C:CC	donor_gain	1.0000
19:37210485:T:TA	donor_gain	1.0000
19:37210412:A:AC	donor_gain	0.9900
19:37210413:C:CC	donor_gain	0.9900
19:37210483:AGT:A	donor_gain	0.9900
19:37187263:A:T	acceptor_gain	0.9800
19:37190022:A:AC	donor_gain	0.9800
19:37190023:C:CC	donor_gain	0.9800
19:37207178:G:C	donor_gain	0.9800
19:37210405:A:AC	donor_gain	0.9800
19:37210460:T:TA	donor_gain	0.9800
19:37210523:T:TA	donor_gain	0.9800
19:37190152:T:G	acceptor_loss	0.9700
19:37190153:G:C	acceptor_loss	0.9700
19:37210373:C:CT	donor_gain	0.9700
19:37210409:CTGA:C	donor_gain	0.9700
19:37210489:G:T	donor_gain	0.9700
19:37190149:CC:C	acceptor_gain	0.9600
19:37190150:CC:C	acceptor_gain	0.9600
19:37207251:GAACC:G	acceptor_loss	0.9600
19:37207252:AACCT:A	acceptor_loss	0.9600
19:37207253:ACCT:A	acceptor_loss	0.9600
19:37207254:CCTAG:C	acceptor_loss	0.9600

AlphaMissense

5110 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:37185524:A:C	F671L	0.998
19:37185524:A:T	F671L	0.998
19:37185526:A:G	F671L	0.998
19:37185860:G:C	F559L	0.998
19:37185860:G:T	F559L	0.998
19:37185862:A:G	F559L	0.998
19:37185944:A:C	F531L	0.998
19:37185944:A:T	F531L	0.998
19:37185946:A:G	F531L	0.998
19:37186028:G:C	F503L	0.997
19:37186028:G:T	F503L	0.997
19:37186030:A:G	F503L	0.997
19:37185356:A:C	F727L	0.996
19:37185356:A:T	F727L	0.996
19:37185358:A:G	F727L	0.996
19:37185608:A:C	F643L	0.996
19:37185608:A:T	F643L	0.996
19:37185610:A:G	F643L	0.996
19:37185771:C:G	R589P	0.996
19:37185776:G:C	F587L	0.996
19:37185776:G:T	F587L	0.996
19:37185778:A:G	F587L	0.996
19:37186112:G:C	F475L	0.996
19:37186112:G:T	F475L	0.996
19:37186114:A:G	F475L	0.996
19:37185440:G:C	F699L	0.995
19:37185440:G:T	F699L	0.995
19:37185442:A:G	F699L	0.995
19:37185692:A:C	F615L	0.995
19:37185692:A:T	F615L	0.995

dbSNP variants (sampled 300 via entrez): RS1000047061 (19:37195425 C>T), RS1000340447 (19:37183438 G>A,T), RS1000450952 (19:37190488 G>C), RS1000470024 (19:37190785 C>T), RS1000501323 (19:37190571 T>C,G), RS1000590677 (19:37196906 A>C,G), RS1000622238 (19:37195689 T>C), RS1000647071 (19:37203023 A>G), RS1000666358 (19:37189257 C>T), RS1000696364 (19:37202729 G>A), RS1000738952 (19:37190764 C>T), RS1001137949 (19:37201670 A>G), RS1001187740 (19:37188932 GTTC>G), RS1001226366 (19:37183218 T>C), RS1001235688 (19:37190089 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001762_406	Obesity-related traits	5.000000e-06
GCST007387_24	Insomnia symptoms (never/rarely vs. sometimes/usually)	5.000000e-08
GCST007388_16	Insomnia symptoms (never/rarely vs. usually)	8.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003939	energy intake
EFO:0007876	insomnia measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Air Pollutants	increases expression, affects expression, increases abundance	2
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
terbufos	increases methylation	1
tobacco tar	decreases expression	1
nickel sulfate	decreases expression	1
avobenzone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	increases expression, affects cotreatment	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Doxorubicin	decreases expression	1
Fonofos	increases methylation	1
Methotrexate	increases expression	1
Ozone	affects expression, increases abundance	1
Parathion	increases methylation	1
Plant Extracts	affects cotreatment, increases expression	1
Valproic Acid	decreases expression	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD31	HEK293 eGFP-ZNF585B	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.