ZNF587B

Summary

ZNF587B (zinc finger protein 587B, HGNC:37142) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 587B (E7ETH6). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 100293516 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 80 total
• MANE Select transcript: NM_001376223

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37142
Approved symbol	ZNF587B
Name	zinc finger protein 587B
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000269343
Ensembl biotype	protein_coding
Entrez	100293516

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000442832, ENST00000594328, ENST00000594901, ENST00000651253

RefSeq mRNA: 2 — MANE Select: NM_001376223 NM_001204818, NM_001376223

CCDS: CCDS56109, CCDS92699

Canonical transcript exons

ENST00000594901 — 3 exons

Exon	Start	End
ENSE00001469714	57830299	57830564
ENSE00003225176	57840838	57846238
ENSE00003693016	57839023	57839149

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 95.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.5788 / max 224.5924, expressed in 1801 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177799	16.1008	1796
177801	1.5616	542
177800	0.9164	534

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	95.37	gold quality
oocyte	CL:0000023	93.71	gold quality
germinal epithelium of ovary	UBERON:0001304	88.96	gold quality
hair follicle	UBERON:0002073	86.82	gold quality
cervix squamous epithelium	UBERON:0006922	86.49	silver quality
gingival epithelium	UBERON:0001949	86.34	gold quality
colonic epithelium	UBERON:0000397	85.69	gold quality
epithelium of nasopharynx	UBERON:0001951	85.35	gold quality
squamous epithelium	UBERON:0006914	85.02	gold quality
tongue squamous epithelium	UBERON:0006919	84.38	silver quality
mucosa of sigmoid colon	UBERON:0004993	84.16	gold quality
pancreatic ductal cell	CL:0002079	83.81	gold quality
corpus epididymis	UBERON:0004359	83.66	gold quality
esophagus squamous epithelium	UBERON:0006920	83.40	gold quality
gingiva	UBERON:0001828	83.14	gold quality
caput epididymis	UBERON:0004358	83.03	gold quality
nephron tubule	UBERON:0001231	82.62	gold quality
epithelium of esophagus	UBERON:0001976	82.50	gold quality
jejunal mucosa	UBERON:0000399	82.34	gold quality
tonsil	UBERON:0002372	81.98	gold quality
cauda epididymis	UBERON:0004360	81.46	gold quality
oral cavity	UBERON:0000167	81.17	gold quality
palpebral conjunctiva	UBERON:0001812	80.80	gold quality
kidney epithelium	UBERON:0004819	80.55	gold quality
parietal pleura	UBERON:0002400	80.43	gold quality
cervix epithelium	UBERON:0004801	80.42	silver quality
epithelial cell of pancreas	CL:0000083	80.02	silver quality
colonic mucosa	UBERON:0000317	79.89	gold quality
upper leg skin	UBERON:0004262	79.72	gold quality
pleura	UBERON:0000977	79.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.58

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2519.1	ZNF606	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

82 targeting ZNF587B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-577	99.78	69.13	2479

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zfx	ENSDARG00000074453
danio_rerio		ENSDARG00000098424
mus_musculus	Zfy2	ENSMUSG00000000103
mus_musculus	Zfy1	ENSMUSG00000053211
rattus_norvegicus	Zfy1	ENSRNOG00000053042

Paralogs (38): ZFX (ENSG00000005889), ZBTB11 (ENSG00000066422), ZFAT (ENSG00000066827), ZFY (ENSG00000067646), ZNF586 (ENSG00000083828), IKZF5 (ENSG00000095574), ZNF419 (ENSG00000105136), ZNF549 (ENSG00000121406), ZSCAN20 (ENSG00000121903), ZNF304 (ENSG00000131845), PRDM15 (ENSG00000141956), ZNF660 (ENSG00000144792), ZNF711 (ENSG00000147180), ZNF773 (ENSG00000152439), ZNF256 (ENSG00000152454), ZNF837 (ENSG00000152475), ZNF691 (ENSG00000164011), ZNF610 (ENSG00000167554), E4F1 (ENSG00000167967), ZNF562 (ENSG00000171466), ZNF561 (ENSG00000171469), ZNF584 (ENSG00000171574), ZIK1 (ENSG00000171649), ZNF570 (ENSG00000171827), ZSCAN2 (ENSG00000176371), ZNF552 (ENSG00000178935), ZNF154 (ENSG00000179909), ZNF792 (ENSG00000180884), ZNF793 (ENSG00000188227), ZNF548 (ENSG00000188785), ZNF79 (ENSG00000196152), ZNF418 (ENSG00000196724), ZNF772 (ENSG00000197128), ZNF583 (ENSG00000198440), ZNF480 (ENSG00000198464), ZNF551 (ENSG00000204519), ZNF134 (ENSG00000213762), ZNF8 (ENSG00000278129)

Protein

Protein identifiers

Zinc finger protein 587B — E7ETH6 (reviewed: E7ETH6)

All UniProt accessions (4): E7ETH6, A0A494C1I7, M0QY62, M0R1N2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001191747, NP_001363152* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (17 total): zinc finger region 7, cross-link 4, sequence conflict 4, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-E7ETH6-F1	50.77	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 200, 253, 366, 177

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 35 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, URS_ADIPOCYTE_DIFFERENTIATION_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CEBPZ_TARGET_GENES, ELF2_TARGET_GENES, KAT5_TARGET_GENES, NKX2_3_TARGET_GENES, PRKDC_TARGET_GENES, SNAPC4_TARGET_GENES, ZNF350_TARGET_GENES, ZNF561_TARGET_GENES, MIR616_5P, MIR371B_5P

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of DNA-templated transcription (GO:0045892), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
DNA-templated transcription	2
transcription by RNA polymerase II	1
negative regulation of RNA biosynthetic process	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

494 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF587B	USP17L20	D6RJB6	625
ZNF587B	SLFNL1	Q499Z3	505
ZNF587B	M0QYU9	M0QYU9	505
ZNF587B	SMIM7	Q9BQ49	477
ZNF587B	POTEC	B2RU33	445
ZNF587B	SLC35D4	Q24JQ0	417
ZNF587B	SSUH2	Q9Y2M2	398
ZNF587B	SULF1	Q8IWU6	348
ZNF587B	ZMIZ2	Q8NF64	348
ZNF587B	TRAPPC1	Q9Y5R8	307
ZNF587B	NSFL1C	Q9UNZ2	304
ZNF587B	GGNBP2	Q9H3C7	302
ZNF587B	SEMA4G	Q9NTN9	293
ZNF587B	NEXMIF	Q5QGS0	279
ZNF587B	APMAP	Q9HDC9	273

IntAct

5 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
SPDYE4	RPS10-NUDT3	psi-mi:“MI:0914”(association)	0.350
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (10): ZNF587B (Affinity Capture-RNA), ZNF587B (Affinity Capture-MS), ZNF587B (Affinity Capture-MS), ZNF587B (Affinity Capture-MS), ZNF587B (Affinity Capture-MS), ZNF587B (Positive Genetic), ZNF587B (Affinity Capture-MS), ZNF587B (Affinity Capture-MS), ZNF587B (Affinity Capture-RNA), ZNF587B (Two-hybrid)

ESM2 similar proteins: A0JPL0, A6NK53, E7ETH6, E9Q8G5, O14628, P21506, P51508, Q09FC8, Q13360, Q2M218, Q2M3X9, Q2VY69, Q3KQV3, Q3SY52, Q4R882, Q5HY98, Q5REN4, Q5RES8, Q68DI1, Q6NX49, Q6P280, Q6PG37, Q6V9R5, Q6ZMW2, Q7Z340, Q86XU0, Q8IYI8, Q8N587, Q8N720, Q8N859, Q8NB42, Q8NDW4, Q8NEK5, Q8WXB4, Q96MR9, Q96MU6, Q96NG8, Q96NJ3, Q96SR6, Q9BR84

Diamond homologs: A2VDP4, B7Z6K7, D3ZVT0, E7ETH6, E9Q8G5, O43296, O43361, O75290, O75467, O75820, P0CH99, P0CI00, P15621, P17021, P17023, P17024, P17030, P17032, P52740, P52741, Q02525, Q06732, Q08DG8, Q08ER8, Q0VCB0, Q13106, Q13398, Q14587, Q147U1, Q15935, Q2M218, Q2M3X9, Q32M78, Q3KQV3, Q3SY52, Q3V080, Q3ZCX4, Q4R882, Q4V8A8, Q5CZA5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

737 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57819941:CTCAG:C	donor_loss	0.9900
19:57819943:CAG:C	donor_loss	0.9900
19:57830560:CTCAG:C	donor_loss	0.9900
19:57830561:TCAGG:T	donor_loss	0.9900
19:57830562:CAGGT:C	donor_loss	0.9900
19:57830563:AG:A	donor_loss	0.9900
19:57830564:GG:G	donor_loss	0.9900
19:57830565:G:GA	donor_loss	0.9900
19:57839146:CTGGG:C	donor_loss	0.9800
19:57839147:TGGG:T	donor_loss	0.9800
19:57839147:TGGGT:T	donor_loss	0.9800
19:57839148:GGGTA:G	donor_loss	0.9800
19:57839149:GGT:G	donor_loss	0.9800
19:57839150:GT:G	donor_loss	0.9800
19:57839150:GTA:G	donor_loss	0.9800
19:57839151:T:G	donor_loss	0.9800
19:57839151:TAAGT:T	donor_loss	0.9800
19:57839152:AAGTT:A	donor_loss	0.9800
19:57840832:TTTCA:T	acceptor_loss	0.9800
19:57840833:TTCAG:T	acceptor_loss	0.9800
19:57840834:TCA:T	acceptor_loss	0.9800
19:57840835:CA:C	acceptor_loss	0.9800
19:57840836:A:T	acceptor_loss	0.9800
19:57840837:G:GA	acceptor_loss	0.9800
19:57830454:GA:G	donor_gain	0.9700
19:57839148:GG:G	donor_gain	0.9600
19:57839149:GG:G	donor_gain	0.9600
19:57840837:GGTT:G	acceptor_gain	0.9600
19:57829008:G:GT	donor_gain	0.9500
19:57839150:G:GG	donor_gain	0.9500

AlphaMissense

4235 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57841509:T:C	F279L	0.996
19:57841511:T:A	F279L	0.996
19:57841511:T:G	F279L	0.996
19:57841677:T:C	F335L	0.996
19:57841679:T:A	F335L	0.996
19:57841679:T:G	F335L	0.996
19:57841761:T:C	F363L	0.996
19:57841763:T:A	F363L	0.996
19:57841763:T:G	F363L	0.996
19:57841425:T:C	F251L	0.989
19:57841427:T:A	F251L	0.989
19:57841427:T:G	F251L	0.989
19:57841593:T:C	F307L	0.988
19:57841595:T:A	F307L	0.988
19:57841595:T:G	F307L	0.988
19:57841711:G:C	R346P	0.986
19:57841704:C:G	H344D	0.983
19:57841538:T:A	H288Q	0.982
19:57841538:T:G	H288Q	0.982
19:57841708:A:C	Q345P	0.982
19:57841768:G:C	R365P	0.982
19:57839057:T:C	F24S	0.981
19:57841683:T:C	S337P	0.981
19:57841706:T:A	H344Q	0.981
19:57841706:T:G	H344Q	0.981
19:57841620:C:G	H316D	0.980
19:57841618:G:C	R315P	0.979
19:57841696:T:C	L341P	0.977
19:57841536:C:G	H288D	0.976
19:57841718:C:A	H348Q	0.976

dbSNP variants (sampled 300 via entrez): RS1000292881 (19:57830984 A>G), RS1000293255 (19:57841976 A>G), RS1000457341 (19:57837138 C>A), RS1000636782 (19:57831747 C>G,T), RS1001194557 (19:57838072 G>C), RS1001690086 (19:57846596 C>T), RS1001962175 (19:57841446 A>G), RS1002106867 (19:57845554 C>T), RS1002409069 (19:57837915 C>T), RS1002470212 (19:57831541 C>T), RS1002523072 (19:57842283 T>C,G), RS1002563998 (19:57845229 C>T), RS1002583009 (19:57840394 C>CA), RS1002590933 (19:57835940 G>C), RS1002643162 (19:57835560 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
trichostatin A	affects expression	1
sodium arsenite	decreases expression, increases abundance	1
ferrous chloride	decreases expression	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
avobenzone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Arsenic	decreases expression, increases abundance	1
Estradiol	increases expression	1
Methotrexate	decreases expression	1
Niclosamide	decreases expression	1
Ozone	increases abundance, affects cotreatment, increases oxidation	1
Potassium Chloride	decreases expression, decreases response to substance	1
Dronabinol	decreases expression, decreases response to substance	1
Thiram	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	increases expression	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	increases expression	1
Lactic Acid	increases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.