ZNF589

Summary

ZNF589 (zinc finger protein 589, HGNC:16747) is a protein-coding gene on chromosome 3p21.31, encoding Zinc finger protein 589 (Q86UQ0). May play a role in hematopoietic stem/progenitor cell differentiation.

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 51385 — RefSeq curated summary.

At a glance

• Gene–disease (curated): complex neurodevelopmental disorder (Limited, GenCC)
• GWAS associations: 7
• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_016089

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16747
Approved symbol	ZNF589
Name	zinc finger protein 589
Location	3p21.31
Locus type	gene with protein product
Status	Approved
Aliases	SZF1
Ensembl gene	ENSG00000164048
Ensembl biotype	protein_coding
OMIM	616702
Entrez	51385

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000354698, ENST00000412564, ENST00000427617, ENST00000440261, ENST00000448461, ENST00000454212, ENST00000457782, ENST00000929429

RefSeq mRNA: 1 — MANE Select: NM_016089 NM_016089

CCDS: CCDS43085

Canonical transcript exons

ENST00000354698 — 4 exons

Exon	Start	End
ENSE00001424309	48267915	48270990
ENSE00001658729	48247625	48247677
ENSE00003592808	48260813	48260939
ENSE00003844129	48241104	48241214

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 96.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.4584 / max 185.4348, expressed in 1695 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36570	8.3893	1433
36569	3.1013	1184
36571	0.9678	457

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	96.35	gold quality
spleen	UBERON:0002106	87.95	gold quality
granulocyte	CL:0000094	87.39	gold quality
cortical plate	UBERON:0005343	87.15	gold quality
right lobe of thyroid gland	UBERON:0001119	87.07	gold quality
lower esophagus mucosa	UBERON:0035834	86.80	gold quality
cerebellar hemisphere	UBERON:0002245	86.77	gold quality
ganglionic eminence	UBERON:0004023	86.64	gold quality
cerebellar cortex	UBERON:0002129	86.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.44	gold quality
left lobe of thyroid gland	UBERON:0001120	86.25	gold quality
thyroid gland	UBERON:0002046	85.32	gold quality
ventricular zone	UBERON:0003053	85.20	gold quality
monocyte	CL:0000576	85.12	gold quality
mononuclear cell	CL:0000842	85.09	gold quality
cerebellum	UBERON:0002037	84.86	gold quality
leukocyte	CL:0000738	84.84	gold quality
prostate gland	UBERON:0002367	84.13	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.92	gold quality
right ovary	UBERON:0002118	83.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.61	gold quality
left ovary	UBERON:0002119	83.22	gold quality
right lung	UBERON:0002167	83.10	gold quality
right adrenal gland cortex	UBERON:0035827	83.05	gold quality
right adrenal gland	UBERON:0001233	82.86	gold quality
left uterine tube	UBERON:0001303	82.34	gold quality
mucosa of stomach	UBERON:0001199	82.18	gold quality
lymph node	UBERON:0000029	81.91	gold quality
skin of leg	UBERON:0001511	81.90	gold quality
left adrenal gland	UBERON:0001234	81.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.65

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

84 targeting ZNF589, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-3975	99.62	65.97	697
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-199A-5P	99.51	69.71	1107

Literature-anchored findings (GeneRIF, showing 2)

• The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system (PMID:26738774)
• A heterochromatin inducing protein differentially recognizes self versus foreign genomes. (PMID:33730092)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300), ZNF70 (ENSG00000187792)

Protein

Protein identifiers

Zinc finger protein 589 — Q86UQ0 (reviewed: Q86UQ0)

Alternative names: Stem cell zinc finger protein 1

All UniProt accessions (5): B4DQF9, C9J1J1, C9JGA6, Q86UQ0, F8VZ09

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Subunit / interactions. Interacts with TRIM28.

Subcellular location. Nucleus.

Tissue specificity. Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.

Domain organisation. The KRAB domain mediates interaction with TRIM28.

Miscellaneous. Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q86UQ0-1	1	yes
Q86UQ0-2	2, SZF1-2
Q86UQ0-3	3, SZF1-1

RefSeq proteins (1): NP_057173* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR048414	PDRM9-like_Znf-C2H2	Domain

Pfam: PF00096, PF01352, PF21225

UniProt features (14 total): zinc finger region 4, splice variant 3, sequence variant 2, chain 1, domain 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UQ0-F1	54.47	0.06

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 190

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 88 (showing top): LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, BENPORATH_ES_1, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, WANG_CISPLATIN_RESPONSE_AND_XPC_UP, LU_EZH2_TARGETS_UP, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, ZWANG_DOWN_BY_2ND_EGF_PULSE, chr3p21, GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, E2F5_TARGET_GENES, KAT5_TARGET_GENES, ZBTB18_TARGET_GENES

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), zinc ion binding (GO:0008270), DNA binding (GO:0003677), sequence-specific DNA binding (GO:0043565), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
negative regulation of transcription by RNA polymerase II	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transition metal ion binding	1
nucleic acid binding	1
DNA binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

394 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF589	MAN1A1	P33908	432
ZNF589	DNAJC13	O75165	406
ZNF589	CLVS1	Q8IUQ0	394
ZNF589	N4BP2L1	Q5TBK1	392
ZNF589	C1orf167	Q5SNV9	369
ZNF589	TMEM92	Q6UXU6	358
ZNF589	CCT8	P50990	352
ZNF589	ZNF618	Q5T7W0	348
ZNF589	FOXI2	Q6ZQN5	348
ZNF589	C7orf25	Q9BPX7	348
ZNF589	ERC1	Q8IUD2	337
ZNF589	VPS13C	Q709C8	315
ZNF589	CDC42BPA	Q5VT25	314
ZNF589	TIGD4	Q8IY51	314
ZNF589	PTK7	Q13308	313

IntAct

6 interactions, top by confidence:

A	B	Type	Score
RBPJ	NOTCH1	psi-mi:“MI:0914”(association)	0.910
POLR2E	POLR3A	psi-mi:“MI:0914”(association)	0.870
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
CBX1	EXOC5	psi-mi:“MI:0914”(association)	0.350
MFAP4	PEX1	psi-mi:“MI:0914”(association)	0.350

BioGRID (25): ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-RNA), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-RNA), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS), ZNF589 (Affinity Capture-MS)

ESM2 similar proteins: A0JPK3, A1YFX5, A2RQG7, A7KBS4, F4JUI3, G3X9G7, O49498, P03131, P04605, P04614, P05909, P0C1K0, P11332, P12453, P18098, P24109, P35965, P98182, Q09424, Q0VCB0, Q19203, Q2YDJ5, Q3UZB0, Q567C6, Q5BI31, Q5EXX3, Q5M948, Q62396, Q6AXY9, Q6PB60, Q6PI77, Q71HP2, Q74124, Q7JUR5, Q7Z142, Q7Z2Y5, Q80YD3, Q86UQ0, Q8C0P7, Q8C6P8

Diamond homologs: A0A163UT06, A2AGX3, A6QPM3, B1AUS7, E9Q3T6, O60224, O75626, P0C6Y7, P52736, Q13029, Q16384, Q16385, Q3UZD5, Q5R5M1, Q60636, Q63755, Q6P2A1, Q6PGE4, Q7RTT6, Q80V63, Q86UQ0, Q8BZ97, Q8TD17, Q96EQ9, Q99909, Q9GZV8, Q9NQV5, Q9NQV7, Q9NQV8, Q9NQW5, Q9NQX0, Q9QZP2, Q9UDV7, Q9UKN5, Q9ULD5, A2VDP4, A3KN32, A3KN36, A6NM28, A6QLU5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1437 predictions. Top by Δscore:

Variant	Effect	Δscore
3:48247676:TGGTG:T	donor_loss	1.0000
3:48247678:G:A	donor_loss	1.0000
3:48247679:T:G	donor_loss	1.0000
3:48260938:GG:G	donor_gain	1.0000
3:48260939:GG:G	donor_gain	1.0000
3:48260940:G:GA	donor_loss	1.0000
3:48260940:G:GG	donor_gain	1.0000
3:48260941:T:A	donor_loss	1.0000
3:48295070:CTCA:C	donor_loss	1.0000
3:48295071:TCA:T	donor_loss	1.0000
3:48295073:A:AC	donor_gain	1.0000
3:48295073:A:T	donor_loss	1.0000
3:48295073:AC:A	donor_gain	1.0000
3:48295074:C:CA	donor_loss	1.0000
3:48295074:C:CC	donor_gain	1.0000
3:48295074:CC:C	donor_gain	1.0000
3:48295074:CCCGA:C	donor_gain	1.0000
3:48295231:GCCCG:G	acceptor_gain	1.0000
3:48295232:CCCG:C	acceptor_gain	1.0000
3:48295232:CCCGC:C	acceptor_gain	1.0000
3:48295233:CCG:C	acceptor_gain	1.0000
3:48295233:CCGC:C	acceptor_gain	1.0000
3:48295234:CG:C	acceptor_gain	1.0000
3:48295234:CGC:C	acceptor_gain	1.0000
3:48295236:C:CC	acceptor_gain	1.0000
3:48295236:CT:C	acceptor_loss	1.0000
3:48295238:G:C	acceptor_gain	1.0000
3:48295238:G:GC	acceptor_gain	1.0000
3:48295243:C:CT	acceptor_gain	1.0000
3:48295244:A:T	acceptor_gain	1.0000

AlphaMissense

2381 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:48268544:T:C	F285L	0.999
3:48268546:T:A	F285L	0.999
3:48268546:T:G	F285L	0.999
3:48268460:T:C	F257L	0.998
3:48268462:T:A	F257L	0.998
3:48268462:T:G	F257L	0.998
3:48268628:T:C	F313L	0.998
3:48268630:T:A	F313L	0.998
3:48268630:T:G	F313L	0.998
3:48268712:T:C	F341L	0.998
3:48268714:T:A	F341L	0.998
3:48268714:T:G	F341L	0.998
3:48268545:T:C	F285S	0.996
3:48268629:T:C	F313S	0.995
3:48268713:T:C	F341S	0.995
3:48268573:C:A	H294Q	0.994
3:48268573:C:G	H294Q	0.994
3:48268461:T:C	F257S	0.993
3:48268487:C:G	H266D	0.993
3:48268571:C:G	H294D	0.993
3:48268731:T:C	L347P	0.993
3:48268741:C:A	H350Q	0.993
3:48268741:C:G	H350Q	0.993
3:48268489:C:A	H266Q	0.992
3:48268489:C:G	H266Q	0.992
3:48268491:A:C	Q267P	0.992
3:48268655:C:G	H322D	0.992
3:48268657:T:A	H322Q	0.992
3:48268657:T:G	H322Q	0.992
3:48268659:A:C	Q323P	0.992

dbSNP variants (sampled 300 via entrez): RS1000096079 (3:48263703 G>T), RS1000116200 (3:48258818 G>A,C), RS1000166995 (3:48252624 T>TC), RS1000252678 (3:48258266 C>T), RS1000321688 (3:48260490 C>T), RS1000373611 (3:48245618 G>A), RS1000419319 (3:48268163 A>G,T), RS1000437948 (3:48252005 C>T), RS1000454968 (3:48260379 A>G), RS1000536478 (3:48265027 G>A,T), RS1000588375 (3:48259931 A>T), RS1000682493 (3:48253716 A>C), RS1000707299 (3:48246909 C>T), RS1000746465 (3:48252353 G>A), RS1000945818 (3:48247125 C>T)

Disease associations

OMIM: gene MIM:616702 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
complex neurodevelopmental disorder	Limited	Autosomal recessive

Mondo (1): complex neurodevelopmental disorder (MONDO:0100038)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST006231_20	Mean arterial pressure	1.000000e-06
GCST006941_60	Irritable mood	1.000000e-09
GCST010698_80	Subcortical volume (min-P)	3.000000e-24
GCST010699_110	Brain morphology (min-P)	4.000000e-08
GCST010701_52	Cortical surface area (MOSTest)	1.000000e-16
GCST010702_36	Subcortical volume (MOSTest)	1.000000e-10
GCST010703_262	Brain morphology (MOSTest)	2.000000e-13

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0006340	mean arterial pressure
EFO:0009594	irritability measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
entinostat	increases expression, affects cotreatment	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	2
Cisplatin	affects cotreatment, increases expression, decreases expression	2
Ozone	affects cotreatment, decreases expression, increases abundance, affects expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
FR900359	increases phosphorylation	1
methylmercuric chloride	decreases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
geraniol	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
azoxystrobin	decreases expression	1
deguelin	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment, increases expression	1
dorsomorphin	decreases expression, affects cotreatment, increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
jinfukang	increases expression, affects cotreatment	1
Vorinostat	increases expression	1
Leflunomide	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants, Occupational	affects expression, increases abundance, increases expression	1
Antimycin A	decreases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	decreases expression	1
Curcumin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	affects expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HA05	K562 eGFP-ZNF589	Cancer cell line	Female
CVCL_TZ40	HAP1 ZNF589 (-) 1	Cancer cell line	Male
CVCL_TZ41	HAP1 ZNF589 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT06310681	Not specified	COMPLETED	Pilot Testing of a Co-adapted Group Programme for Parents/Carers of Children With Complex Neurodisability
NCT07303049	Not specified	NOT_YET_RECRUITING	Cognitive Benefit of Intensive Rehabilitation Using Rhythmic Music Training in Children With Complex Neurodevelopmental Disorder