ZNF598

Summary

ZNF598 (zinc finger protein 598, E3 ubiquitin ligase, HGNC:28079) is a protein-coding gene on chromosome 16p13.3, encoding E3 ubiquitin-protein ligase ZNF598 (Q86UK7). E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains.

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development.

Source: NCBI Gene 90850 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 107 total
• MANE Select transcript: NM_178167

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28079
Approved symbol	ZNF598
Name	zinc finger protein 598, E3 ubiquitin ligase
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ00086, HEL2
Ensembl gene	ENSG00000167962
Ensembl biotype	protein_coding
OMIM	617508
Entrez	90850

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 retained_intron, 2 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000561787, ENST00000562103, ENST00000562988, ENST00000564556, ENST00000564824, ENST00000565396, ENST00000567008, ENST00000567625, ENST00000652647

RefSeq mRNA: 3 — MANE Select: NM_178167 NM_001405664, NM_001405665, NM_178167

Canonical transcript exons

ENST00000562103 — 14 exons

Exon	Start	End
ENSE00001162532	2002521	2002732
ENSE00003470214	2002206	2002423
ENSE00003476341	1999496	2000256
ENSE00003478990	2001004	2001191
ENSE00003498397	2003616	2003728
ENSE00003515147	2002991	2003120
ENSE00003539059	1998965	1999121
ENSE00003571304	1998702	1998852
ENSE00003578363	2000391	2000481
ENSE00003582616	2001583	2001700
ENSE00003593941	1997655	1998585
ENSE00003843810	2009524	2009622
ENSE00003849555	2009736	2009821
ENSE00003849732	2009624	2009734

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 94.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.4086 / max 85.6499, expressed in 1683 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155897	2.7737	1480
155896	2.6350	1316

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	94.33	gold quality
body of pancreas	UBERON:0001150	94.27	gold quality
skin of abdomen	UBERON:0001416	94.00	gold quality
sural nerve	UBERON:0015488	93.06	gold quality
lower esophagus mucosa	UBERON:0035834	92.82	gold quality
minor salivary gland	UBERON:0001830	92.22	gold quality
granulocyte	CL:0000094	91.93	gold quality
adenohypophysis	UBERON:0002196	91.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.52	gold quality
right lobe of liver	UBERON:0001114	91.47	gold quality
zone of skin	UBERON:0000014	91.44	gold quality
mucosa of transverse colon	UBERON:0004991	91.29	gold quality
left uterine tube	UBERON:0001303	91.25	gold quality
body of stomach	UBERON:0001161	91.08	gold quality
apex of heart	UBERON:0002098	90.96	gold quality
gastrocnemius	UBERON:0001388	90.77	gold quality
transverse colon	UBERON:0001157	90.75	gold quality
cerebellar hemisphere	UBERON:0002245	90.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.59	gold quality
ectocervix	UBERON:0012249	90.58	gold quality
pituitary gland	UBERON:0000007	90.55	gold quality
esophagus mucosa	UBERON:0002469	90.55	gold quality
saliva-secreting gland	UBERON:0001044	90.52	gold quality
mucosa of stomach	UBERON:0001199	90.52	gold quality
cerebellar cortex	UBERON:0002129	90.45	gold quality
mouth mucosa	UBERON:0003729	90.38	gold quality
spleen	UBERON:0002106	90.37	gold quality
left testis	UBERON:0004533	90.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.35	gold quality
lower esophagus	UBERON:0013473	90.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

40 targeting ZNF598, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-518A-5P	99.70	69.01	2209
HSA-MIR-527	99.70	69.01	2209
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-5697	99.39	67.74	1249
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-4635	98.74	67.63	1339

Literature-anchored findings (GeneRIF, showing 8)

• ZNF598, RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated quality control pathways. (PMID:28132843)
• The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrate ribosome quality control of premature polyadenylated mRNAs. (PMID:28685749)
• findings reveal distinct functions for ZNF598 and its downstream RPS targets, one that negatively regulates ISG expression and infection by a range of viruses while the other is positively exploited by poxviruses. (PMID:29719242)
• ZNF598 is a tristetraprolin-like factor that can contribute to the regulation of the inflammatory potential of cytokine-producing cells (PMID:30917308)
• Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I. (PMID:31433974)
• Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. (PMID:32657267)
• ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. (PMID:34551427)
• A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. (PMID:36302773)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf598	ENSDARG00000014945
mus_musculus	Zfp598	ENSMUSG00000041130
rattus_norvegicus	Zfp598	ENSRNOG00000012434
drosophila_melanogaster	CG11414	FBGN0035024
caenorhabditis_elegans		WBGENE00016888

Protein

Protein identifiers

E3 ubiquitin-protein ligase ZNF598 — Q86UK7 (reviewed: Q86UK7)

Alternative names: Zinc finger protein 598

All UniProt accessions (3): H3BPF3, H3BPG6, H3BR87

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains. ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs. Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation. Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and ‘Lys-63’-linked polyubiquitination of RPS20/uS10. Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides. E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3. Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs. Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression. (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10. Poxvirus encoding mRNAs contain unusual 5’ poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts.

Subunit / interactions. Interacts with the E2 ubiquitin-conjugating enzyme UBE2D3. Component of the 4EHP-GYF2 complex, at least composed of EIF4E2, GIGYF2 and ZNF598.

Subcellular location. Cytoplasm. Cytosol.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the ZNF598/HEL2 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q86UK7-1	1	yes
Q86UK7-2	2
Q86UK7-3	3
Q86UK7-4	4

RefSeq proteins (3): NP_001392593, NP_001392594, NP_835461* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001841	Znf_RING	Domain
IPR013087	Znf_C2H2_type	Domain
IPR041888	RING-HC_ZNF598/HEL2	Domain
IPR044288	ZNF598/HEL2	Family
IPR056437	Znf-C2H2_ZNF598/HEL2	Domain
IPR057634	PAH_ZNF598/HEL2	Domain
IPR059042	Znf_C2H2_ZNF598	Domain

Pfam: PF23202, PF23208, PF23230, PF25447

UniProt features (29 total): compositionally biased region 9, splice variant 6, modified residue 4, sequence variant 4, zinc finger region 2, region of interest 2, chain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UK7-F1	63.98	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 306, 437, 428, 431

Mutagenesis-validated functional residues (1):

Position	Phenotype
29	abolishes e3 ubiquitin-protein ligase activity, leading to enhanced readthrough on the poly(a)-stall sequences.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA

MSigDB gene sets: 122 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_TRANSLATIONAL_INITIATION, GOBP_NEGATIVE_REGULATION_OF_TRANSLATION, GOBP_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_PROTEIN_MONOUBIQUITINATION, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_PROTEIN_POLYUBIQUITINATION, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS, GOBP_TRANSLATIONAL_ELONGATION, GOBP_PROTEIN_K63_LINKED_UBIQUITINATION, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEIN_CATABOLIC_PROCESS

GO Biological Process (6): protein monoubiquitination (GO:0006513), protein ubiquitination (GO:0016567), negative regulation of translational initiation (GO:0045947), protein K63-linked ubiquitination (GO:0070534), rescue of stalled cytosolic ribosome (GO:0072344), ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)

GO Molecular Function (8): RNA binding (GO:0003723), zinc ion binding (GO:0008270), ribosome binding (GO:0043022), ubiquitin protein ligase activity (GO:0061630), protein-RNA adaptor activity (GO:0140517), stalled ribosome sensor activity (GO:0170011), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): cytosol (GO:0005829), cytosolic ribosome (GO:0022626), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Ribosome-associated quality control	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein ubiquitination	1
protein modification by small protein conjugation	1
translational initiation	1
regulation of translational initiation	1
negative regulation of translation	1
protein polyubiquitination	1
cytoplasmic translational elongation	1
ribosome disassembly	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
nucleic acid binding	1
transition metal ion binding	1
ribonucleoprotein complex binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
protein-macromolecule adaptor activity	1
ribosome binding	1
molecular sensor activity	1
catalytic activity	1
cation binding	1
cytoplasm	1
cytosol	1
ribosome	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1864 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF598	GIGYF2	Q6Y7W6	929
ZNF598	GIGYF1	O75420	895
ZNF598	EIF4E2	O60573	854
ZNF598	LTN1	O94822	815
ZNF598	ASCC3	Q8N3C0	812
ZNF598	NEMF	O60524	795
ZNF598	RPS20	P17075	794
ZNF598	RACK1	P25388	785
ZNF598	RPS10	P46783	744
ZNF598	ASCC2	Q9H1I8	715
ZNF598	EIF4E	P06730	712
ZNF598	ABCE1	P61221	699
ZNF598	PELO	Q9BRX2	692
ZNF598	EDF1	O60869	662
ZNF598	RPS3	P23396	648

IntAct

63 interactions, top by confidence:

A	B	Type	Score
STK25	STRN	psi-mi:“MI:0914”(association)	0.900
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
EIF4E2	GIGYF1	psi-mi:“MI:0914”(association)	0.730
RACK1	RIOK3	psi-mi:“MI:0914”(association)	0.640
GIGYF1	ZNF598	psi-mi:“MI:0915”(physical association)	0.560
ZNF598	YWHAE	psi-mi:“MI:0915”(physical association)	0.560
UBE2L3	UBOX5	psi-mi:“MI:0914”(association)	0.550
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
KBTBD7	PLD2	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
SLC31A1	C2orf72	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
DIS3L	EIF4E2	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
GIGYF2	ZNF598	psi-mi:“MI:0915”(physical association)	0.400
SFN	ZNF598	psi-mi:“MI:0915”(physical association)	0.400
PRPF40A	ZNF598	psi-mi:“MI:0915”(physical association)	0.400
SF1	U2SURP	psi-mi:“MI:0914”(association)	0.350
FOXS1	DDX39A	psi-mi:“MI:0914”(association)	0.350
TANK	CNOT1	psi-mi:“MI:0914”(association)	0.350
TNIP2	CHUK	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
rep	EIF3F	psi-mi:“MI:0914”(association)	0.350

BioGRID (516): ZNF598 (Affinity Capture-MS), ZNF598 (Co-fractionation), ZNF598 (Co-fractionation), ZNF598 (Affinity Capture-MS), ZNF598 (Proximity Label-MS), ZNF598 (Proximity Label-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS), ZNF598 (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RQ45, A0A1B0GWB2, A2A9T0, A6QPA0, A7MCY6, D3ZFB6, E9PUL5, E9Q0B3, F5GYI3, F5H4A9, J3QNX5, O70142, P0C1G7, P81408, P97764, P98077, Q148V8, Q15654, Q2KI80, Q3SX26, Q3SZL6, Q4V9L6, Q5FVJ4, Q5FW56, Q5RAC1, Q5T7N3, Q6DG50, Q6PAJ3, Q6PJ61, Q6ZMQ8, Q6ZNR0, Q6ZRV2, Q75VX8, Q7Z6L0, Q86UK7, Q86VE0, Q8BGW2, Q8BRJ3, Q8BX43, Q8C0R7

Diamond homologs: Q6PFK1, Q80YR4, Q86UK7, Q05580, Q76PD2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	ZNF598	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 86 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the ternary complex, and subsequently, the 43S complex	6	21.6×	4e-05
SARS-CoV-1-host interactions	7	20.5×	2e-05
Translation initiation complex formation	6	19.0×	4e-05
Ribosomal scanning and start codon recognition	6	19.0×	4e-05
SARS-CoV-1 Infection	7	16.6×	3e-05
SARS-CoV-2-host interactions	7	13.9×	4e-05
Formation of a pool of free 40S subunits	6	11.2×	4e-04
G2/M Checkpoints	5	11.2×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
translational initiation	7	31.8×	1e-06
negative regulation of translation	7	17.4×	5e-05
cytoplasmic translation	5	11.7×	9e-03
intracellular protein localization	8	10.6×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

107 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	75
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2305 predictions. Top by Δscore:

Variant	Effect	Δscore
16:1998696:CCTGA:C	donor_loss	1.0000
16:1998697:CTGA:C	donor_loss	1.0000
16:1998698:TGACC:T	donor_loss	1.0000
16:1998699:GACCT:G	donor_loss	1.0000
16:1998700:A:AG	donor_loss	1.0000
16:1998701:C:CA	donor_loss	1.0000
16:1998713:C:CA	donor_gain	1.0000
16:1998714:C:A	donor_gain	1.0000
16:1998848:TGGGT:T	acceptor_gain	1.0000
16:1998851:GT:G	acceptor_gain	1.0000
16:1998853:C:CC	acceptor_gain	1.0000
16:1998861:C:CT	acceptor_gain	1.0000
16:1998862:A:T	acceptor_gain	1.0000
16:2000252:GGGCG:G	acceptor_gain	1.0000
16:2000253:GGCG:G	acceptor_gain	1.0000
16:2000255:CG:C	acceptor_gain	1.0000
16:2000257:C:CC	acceptor_gain	1.0000
16:2000261:G:GC	acceptor_gain	1.0000
16:2000407:AC:A	donor_gain	1.0000
16:2000408:C:CA	donor_gain	1.0000
16:2001187:CTTCC:C	acceptor_gain	1.0000
16:2001190:CC:C	acceptor_gain	1.0000
16:2001191:CC:C	acceptor_gain	1.0000
16:2001192:C:CC	acceptor_gain	1.0000
16:2001192:C:T	acceptor_gain	1.0000
16:2001593:T:TA	donor_gain	1.0000
16:2001600:T:TA	donor_gain	1.0000
16:2001698:CCC:C	acceptor_gain	1.0000
16:2001699:CCC:C	acceptor_gain	1.0000
16:2001701:C:CC	acceptor_gain	1.0000

AlphaMissense

5873 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000226821 (16:2005283 A>G), RS1000291395 (16:2007724 T>A), RS1000472053 (16:2004227 G>A,C), RS1000600131 (16:2005440 G>A), RS1000697397 (16:2009506 G>A,T), RS1000705858 (16:2009288 C>T), RS1001033742 (16:2011195 C>A), RS1001253558 (16:2002130 G>A,C,T), RS1001817883 (16:2010142 A>G), RS1001885414 (16:1999097 T>C), RS1001908491 (16:2008799 A>T), RS1001932145 (16:2010397 G>A), RS1001960836 (16:2008590 A>C,G), RS1001989757 (16:1997516 T>C), RS1002099761 (16:2001906 C>T)

Disease associations

OMIM: gene MIM:617508 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	affects expression, increases abundance, increases expression	2
Particulate Matter	increases abundance, increases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
bufotalin	increases expression	1
propylparaben	increases expression	1
lead acetate	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cupric chloride	increases expression	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Caffeine	decreases phosphorylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Ivermectin	decreases expression	1
Ozone	affects expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	increases abundance, increases expression, affects cotreatment	1
Ribonucleotides	affects binding	1
Smoke	increases expression	1
Dronabinol	increases expression	1
Thiram	increases expression	1

Cellosaurus cell lines

2 cell lines: 1 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C7XZ	HAP1 ZNF598 (-)	Cancer cell line	Male
CVCL_F1PP	HyCyte HEK293T KO-hZNF598	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.