ZNF605

Summary

ZNF605 (zinc finger protein 605, HGNC:28068) is a protein-coding gene on chromosome 12q24.33, encoding Zinc finger protein 605 (Q86T29). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 100289635 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_183238

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28068
Approved symbol	ZNF605
Name	zinc finger protein 605
Location	12q24.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196458
Ensembl biotype	protein_coding
Entrez	100289635

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 13 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000331711, ENST00000360187, ENST00000381215, ENST00000392321, ENST00000412621, ENST00000539809, ENST00000891951, ENST00000891952, ENST00000891953, ENST00000891954, ENST00000891955, ENST00000920344, ENST00000920345, ENST00000920346, ENST00000957903, ENST00000957904, ENST00000957906

RefSeq mRNA: 2 — MANE Select: NM_183238 NM_001164715, NM_183238

CCDS: CCDS31938, CCDS53850

Canonical transcript exons

ENST00000360187 — 5 exons

Exon	Start	End
ENSE00001470908	132948148	132948270
ENSE00001470909	132956243	132956306
ENSE00002305965	132918306	132927162
ENSE00003493595	132933035	132933155
ENSE00003530841	132945621	132945797

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 86.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6588 / max 110.6103, expressed in 1679 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134262	6.6588	1679

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	86.49	gold quality
oviduct epithelium	UBERON:0004804	86.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.61	gold quality
tibia	UBERON:0000979	83.44	gold quality
calcaneal tendon	UBERON:0003701	83.29	gold quality
cerebellar hemisphere	UBERON:0002245	82.82	gold quality
cerebellar cortex	UBERON:0002129	82.65	gold quality
cerebellum	UBERON:0002037	81.87	gold quality
ganglionic eminence	UBERON:0004023	81.83	gold quality
apex of heart	UBERON:0002098	81.59	gold quality
right lobe of thyroid gland	UBERON:0001119	81.08	gold quality
thyroid gland	UBERON:0002046	81.01	gold quality
left lobe of thyroid gland	UBERON:0001120	80.86	gold quality
adrenal tissue	UBERON:0018303	80.60	gold quality
right uterine tube	UBERON:0001302	80.46	gold quality
adenohypophysis	UBERON:0002196	80.22	gold quality
lower esophagus	UBERON:0013473	80.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	80.07	gold quality
right ovary	UBERON:0002118	79.97	gold quality
fallopian tube	UBERON:0003889	79.92	gold quality
stromal cell of endometrium	CL:0002255	79.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	79.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.75	gold quality
left ovary	UBERON:0002119	79.59	gold quality
pituitary gland	UBERON:0000007	79.35	gold quality
body of uterus	UBERON:0009853	79.04	gold quality
right atrium auricular region	UBERON:0006631	79.00	gold quality
ventricular zone	UBERON:0003053	78.89	gold quality
right adrenal gland	UBERON:0001233	78.82	gold quality
right lobe of liver	UBERON:0001114	78.81	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	16.82
E-GEOD-137537	yes	5.75
E-ANND-3	yes	5.15
E-MTAB-6379	no	253.77
E-MTAB-7303	no	107.57

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

126 targeting ZNF605, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp605	ENSMUSG00000023284
rattus_norvegicus	Zfp605	ENSRNOG00000037428

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 605 — Q86T29 (reviewed: Q86T29)

All UniProt accessions (1): Q86T29

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86T29-1	1	yes
Q86T29-2	2

RefSeq proteins (2): NP_001158187, NP_899061* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (23 total): zinc finger region 17, cross-link 2, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86T29-F1	74.05	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 77, 391

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 53 (showing top): CHANDRAN_METASTASIS_UP, chr12q24, CHANDRAN_METASTASIS_TOP50_UP, ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN, ROESSLER_LIVER_CANCER_METASTASIS_DN, CBX5_TARGET_GENES, E2F5_TARGET_GENES, ZNF197_TARGET_GENES, ZNF22_TARGET_GENES, ZNF350_TARGET_GENES, ZNF711_TARGET_GENES, ZNF766_TARGET_GENES, ZSCAN30_TARGET_GENES, MIR579_3P, MIR664B_3P

GO Biological Process (1): regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

438 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF605	ARMCX4	Q5H9R4	507
ZNF605	YJEFN3	A6XGL0	448
ZNF605	SLF2	Q8IX21	441
ZNF605	M9MMK7	M9MMK7	432
ZNF605	NOAZFP	Q9Y3S2	418
ZNF605	PCMTD1	Q96MG8	417
ZNF605	LINC02881	B7Z368	406
ZNF605	MOCOS	Q96EN8	398
ZNF605	IGSF10	Q6WRI0	397
ZNF605	PCDHGB4	Q9UN71	380
ZNF605	NUDT5	Q9UKK9	378
ZNF605	TMEM178B	H3BS89	372
ZNF605	YIPF4	Q9BSR8	369
ZNF605	CMYA5	Q8N3K9	367
ZNF605	AFG2B	Q9BVQ7	357

IntAct

3 interactions, top by confidence:

A	B	Type	Score
APP	ZNF605	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (2): ZNF605 (Two-hybrid), ZNF605 (Two-hybrid)

ESM2 similar proteins: A6NK75, A6NNF4, A6NP11, A8MTY0, A8MUV8, B4DXR9, C9JN71, O75346, O75373, O95780, P0CJ79, P0DKX0, P0DPD5, P17019, P17035, P35789, Q03923, Q03938, Q08AN1, Q14593, Q15928, Q3SXZ3, Q3ZCX4, Q5MCW4, Q5R9S5, Q5RER9, Q68DY1, Q6JLC9, Q6ZMV8, Q6ZN06, Q6ZN08, Q6ZNA1, Q76KX8, Q86T29, Q86V71, Q8IYN0, Q8N4W9, Q8N7M2, Q8NEM1, Q8TD23

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1180 predictions. Top by Δscore:

Variant	Effect	Δscore
12:132933029:TCTTA:T	donor_loss	1.0000
12:132933030:CTTA:C	donor_loss	1.0000
12:132933031:TTA:T	donor_loss	1.0000
12:132933032:T:TG	donor_loss	1.0000
12:132933033:A:AC	donor_gain	1.0000
12:132933033:A:AG	donor_loss	1.0000
12:132933033:AC:A	donor_gain	1.0000
12:132933034:C:CC	donor_gain	1.0000
12:132933034:CC:C	donor_gain	1.0000
12:132948147:CA:C	donor_gain	1.0000
12:132956241:ACC:A	donor_gain	1.0000
12:132956242:CCC:C	donor_gain	1.0000
12:132928335:AAAT:A	donor_gain	0.9900
12:132928336:A:C	donor_gain	0.9900
12:132928376:T:TA	donor_gain	0.9900
12:132936523:T:C	acceptor_gain	0.9900
12:132936525:G:C	acceptor_gain	0.9900
12:132948125:T:TA	donor_gain	0.9900
12:132956062:T:TA	donor_gain	0.9900
12:132933153:TAT:T	acceptor_gain	0.9800
12:132933153:TATC:T	acceptor_loss	0.9800
12:132933154:ATC:A	acceptor_loss	0.9800
12:132933155:TC:T	acceptor_loss	0.9800
12:132933157:T:G	acceptor_loss	0.9800
12:132933159:GAAAA:G	acceptor_loss	0.9800
12:132936523:T:TC	acceptor_gain	0.9800
12:132948147:CACT:C	donor_gain	0.9800
12:132948187:G:C	donor_gain	0.9800
12:132956236:C:CA	donor_gain	0.9800
12:132956237:CCTTA:C	donor_loss	0.9800

AlphaMissense

4300 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:132925757:A:C	F514L	0.997
12:132925757:A:T	F514L	0.997
12:132925759:A:G	F514L	0.997
12:132925673:A:C	F542L	0.996
12:132925673:A:T	F542L	0.996
12:132925675:A:G	F542L	0.996
12:132926513:G:C	F262L	0.996
12:132926513:G:T	F262L	0.996
12:132926515:A:G	F262L	0.996
12:132926597:A:C	F234L	0.996
12:132926597:A:T	F234L	0.996
12:132926599:A:G	F234L	0.996
12:132926681:A:C	F206L	0.996
12:132926681:A:T	F206L	0.996
12:132926683:A:G	F206L	0.996
12:132926261:G:C	F346L	0.995
12:132926261:G:T	F346L	0.995
12:132926263:A:G	F346L	0.995
12:132925505:G:C	F598L	0.994
12:132925505:G:T	F598L	0.994
12:132925507:A:G	F598L	0.994
12:132925841:G:C	F486L	0.994
12:132925841:G:T	F486L	0.994
12:132925843:A:G	F486L	0.994
12:132925925:G:C	F458L	0.994
12:132925925:G:T	F458L	0.994
12:132925927:A:G	F458L	0.994
12:132926160:A:G	L380P	0.994
12:132926429:G:C	F290L	0.994
12:132926429:G:T	F290L	0.994

dbSNP variants (sampled 300 via entrez): RS1000018757 (12:132934567 G>A), RS1000070213 (12:132952185 G>A,C), RS1000173422 (12:132954221 C>T), RS1000266719 (12:132954119 T>C), RS1000447676 (12:132950294 A>C), RS1000533272 (12:132929885 T>C), RS1000756595 (12:132923145 G>A), RS1000882103 (12:132950455 G>A,T), RS1000898926 (12:132946435 C>G,T), RS1000929610 (12:132946631 A>T), RS1000966164 (12:132930158 G>C), RS1001089019 (12:132941228 A>G), RS1001213753 (12:132944290 C>A,T), RS1001290106 (12:132949923 T>C), RS1001291130 (12:132940957 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010002_179	Refractive error	1.000000e-12
GCST90002390_182	Mean corpuscular hemoglobin	6.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, decreases methylation, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Valproic Acid	affects expression, decreases expression	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
avobenzone	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Succimer	increases expression, affects cotreatment	1
Doxorubicin	decreases expression	1
Methapyrilene	decreases methylation	1
Nicotine	increases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	decreases expression	1
Magnetite Nanoparticles	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.