ZNF615

Summary

ZNF615 (zinc finger protein 615, HGNC:24740) is a protein-coding gene on chromosome 19q13.41, encoding Zinc finger protein 615 (Q8N8J6). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 284370 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 101 total
• MANE Select transcript: NM_001199324

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24740
Approved symbol	ZNF615
Name	zinc finger protein 615
Location	19q13.41
Locus type	gene with protein product
Status	Approved
Aliases	FLJ33710
Ensembl gene	ENSG00000197619
Ensembl biotype	protein_coding
Entrez	284370

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 15 protein_coding, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000376716, ENST00000391795, ENST00000593650, ENST00000594083, ENST00000595114, ENST00000597747, ENST00000597905, ENST00000598071, ENST00000599115, ENST00000599177, ENST00000599631, ENST00000601178, ENST00000602063, ENST00000618487, ENST00000884687, ENST00000946691, ENST00000946692, ENST00000946693, ENST00000946694

RefSeq mRNA: 9 — MANE Select: NM_001199324 NM_001199324, NM_001321317, NM_001321318, NM_001321319, NM_001321320, NM_001321321, NM_001321322, NM_001321323, NM_198480

CCDS: CCDS12846, CCDS59418, CCDS82387

Canonical transcript exons

ENST00000598071 — 7 exons

Exon	Start	End
ENSE00001403271	52003697	52003900
ENSE00001407348	52001813	52001908
ENSE00002526397	52002155	52002281
ENSE00002977615	52008141	52008211
ENSE00003047447	52000346	52000378
ENSE00003190122	51991332	51994837
ENSE00003553191	52007293	52007330

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 89.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.3706 / max 129.1825, expressed in 1448 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182511	5.3706	1448

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	89.95	silver quality
left ventricle myocardium	UBERON:0006566	89.41	gold quality
kidney epithelium	UBERON:0004819	87.09	silver quality
deltoid	UBERON:0001476	86.80	silver quality
tibialis anterior	UBERON:0001385	86.43	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.01	gold quality
calcaneal tendon	UBERON:0003701	84.00	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.72	gold quality
corpus callosum	UBERON:0002336	82.39	gold quality
epithelial cell of pancreas	CL:0000083	82.01	silver quality
cortical plate	UBERON:0005343	81.98	gold quality
ganglionic eminence	UBERON:0004023	81.85	gold quality
colonic epithelium	UBERON:0000397	81.54	gold quality
prostate gland	UBERON:0002367	81.49	gold quality
superficial temporal artery	UBERON:0001614	80.67	silver quality
ventricular zone	UBERON:0003053	80.52	gold quality
upper arm skin	UBERON:0004263	80.33	gold quality
islet of Langerhans	UBERON:0000006	80.07	gold quality
mucosa of paranasal sinus	UBERON:0005030	80.06	silver quality
oviduct epithelium	UBERON:0004804	79.84	gold quality
germinal epithelium of ovary	UBERON:0001304	79.62	silver quality
ileal mucosa	UBERON:0000331	79.53	gold quality
pigmented layer of retina	UBERON:0001782	79.38	gold quality
myocardium	UBERON:0002349	79.07	silver quality
smooth muscle tissue	UBERON:0001135	79.02	gold quality
descending thoracic aorta	UBERON:0002345	78.48	gold quality
popliteal artery	UBERON:0002250	78.41	gold quality
tibial artery	UBERON:0007610	78.40	gold quality
ovary	UBERON:0000992	78.33	gold quality
sural nerve	UBERON:0015488	78.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6142	no	50.16
E-ANND-3	no	4.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): YY1

miRNA regulators (miRDB)

100 targeting ZNF615, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-338-5P	99.92	72.34	2951

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 615 — Q8N8J6 (reviewed: Q8N8J6)

All UniProt accessions (7): A0A0G2JLJ6, Q8N8J6, H9KV89, M0QZR2, M0QZZ4, M0R0F8, M0R130

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8N8J6-1	1	yes
Q8N8J6-2	2
Q8N8J6-3	3

RefSeq proteins (9): NP_001186253, NP_001308246, NP_001308247, NP_001308248, NP_001308249, NP_001308250, NP_001308251, NP_001308252, NP_940882 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF01352

UniProt features (27 total): zinc finger region 19, sequence variant 3, splice variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8J6-F1	73.94	0.20

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 45 (showing top): BASAKI_YBX1_TARGETS_DN, NOUZOVA_TRETINOIN_AND_H4_ACETYLATION, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, CIITA_TARGET_GENES, E2F5_TARGET_GENES, FOXE1_TARGET_GENES, ZNF197_TARGET_GENES, ZNF711_TARGET_GENES, ZNF766_TARGET_GENES, MIR4666A_3P, MIR374A_5P, MIR374B_5P, MIR1323, MIR9_3P, MIR548O_3P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transition metal ion binding	1
DNA binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

534 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF615	CCDC158	Q5M9N0	419
ZNF615	C5orf63	A6NC05	377
ZNF615	SPATA12	Q7Z6I5	376
ZNF615	CEACAM18	A8MTB9	375
ZNF615	CCDC59	Q9P031	358
ZNF615	SDR42E1	Q8WUS8	355
ZNF615	ANKMY2	Q8IV38	348
ZNF615	GIN1	Q9NXP7	333
ZNF615	ANKRD33B	A6NCL7	325
ZNF615	WDR36	Q8NI36	311
ZNF615	SERPINB12	Q96P63	307
ZNF615	GARIN6	Q8NEG0	293
ZNF615	ANKRD49	Q8WVL7	289
ZNF615	THSD7B	Q9C0I4	288
ZNF615	TUBD1	Q9UJT1	286

IntAct

2 interactions, top by confidence:

A	B	Type	Score
FYN	ZNF615	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): ZNF615 (Affinity Capture-RNA), ZNF615 (Proximity Label-MS), ZNF615 (Affinity Capture-MS), ZNF615 (Affinity Capture-MS), ZNF615 (Affinity Capture-MS), ZNF615 (Cross-Linking-MS (XL-MS)), ZNF615 (Proximity Label-MS)

ESM2 similar proteins: A2VDP4, A6NHJ4, O94892, P0CJ79, P17014, P17021, P17025, P17032, P17035, P18733, P51508, P51814, Q06730, Q06732, Q09FC8, Q0VGE8, Q14586, Q32M78, Q3MIS6, Q5JVG2, Q5R4K8, Q5R9S5, Q5RBQ3, Q5RCJ2, Q5RER9, Q5TYW1, Q5VIY5, Q6P560, Q6PDB4, Q6ZMW2, Q6ZN06, Q6ZNA1, Q76KX8, Q7L2R6, Q86Y25, Q8N184, Q8N823, Q8N883, Q8N8J6, Q8NEP9

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

101 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	91
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1118 predictions. Top by Δscore:

Variant	Effect	Δscore
19:51994838:C:CC	acceptor_gain	1.0000
19:52001810:CA:C	donor_loss	1.0000
19:52001811:A:AC	donor_gain	1.0000
19:52001812:C:CC	donor_gain	1.0000
19:52001812:C:T	donor_loss	1.0000
19:52001905:TACC:T	acceptor_gain	1.0000
19:52001906:ACC:A	acceptor_gain	1.0000
19:52001907:CC:C	acceptor_gain	1.0000
19:52001907:CCC:C	acceptor_gain	1.0000
19:52001907:CCCTG:C	acceptor_loss	1.0000
19:52001908:CCTG:C	acceptor_gain	1.0000
19:52001909:C:CC	acceptor_gain	1.0000
19:52001910:T:A	acceptor_loss	1.0000
19:52001914:CA:C	acceptor_gain	1.0000
19:52001915:A:AC	acceptor_gain	1.0000
19:52001915:A:C	acceptor_gain	1.0000
19:52002150:CTCA:C	donor_loss	1.0000
19:52002151:TCA:T	donor_loss	1.0000
19:52002153:A:AC	donor_gain	1.0000
19:52002153:A:AG	donor_loss	1.0000
19:52002153:AC:A	donor_gain	1.0000
19:52002154:C:CC	donor_gain	1.0000
19:52002154:CC:C	donor_gain	1.0000
19:52002154:CCCA:C	donor_gain	1.0000
19:52002157:A:AC	donor_gain	1.0000
19:52002158:C:CC	donor_gain	1.0000
19:52002159:TGC:T	donor_gain	1.0000
19:52002161:C:CT	donor_gain	1.0000
19:52002162:C:CT	donor_gain	1.0000
19:52002193:T:TA	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000050007 (19:52006617 T>C), RS1000236821 (19:51995109 C>A,T), RS1000534207 (19:51994169 G>A), RS1001159209 (19:52001332 A>G), RS1001224813 (19:52006911 G>A), RS1001247757 (19:52009362 G>A,T), RS1001250272 (19:52002793 A>G), RS1001383853 (19:52000831 T>C), RS1001396448 (19:52001646 T>A,C,G), RS1001572860 (19:52006732 A>G), RS1001904145 (19:51995285 T>G), RS1001990285 (19:51991029 G>A,T), RS1002172539 (19:52008056 C>T), RS1002238717 (19:51998193 T>C), RS1002305230 (19:52004485 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007277_24	Tourette syndrome	9.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	increases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
dicrotophos	decreases expression	1
urushiol	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
arsenite	affects binding, decreases reaction	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
perfluorohexanesulfonic acid	decreases expression	1
abrine	increases expression	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cadmium	increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Urethane	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.