ZNF618

Summary

ZNF618 (zinc finger protein 618, HGNC:29416) is a protein-coding gene on chromosome 9q32, encoding Zinc finger protein 618 (Q5T7W0). Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization.

Enables identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in pericentric heterochromatin.

Source: NCBI Gene 114991 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 147 total
• Druggable target: yes
• MANE Select transcript: NM_001318042

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29416
Approved symbol	ZNF618
Name	zinc finger protein 618
Location	9q32
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1952, NEDD10
Ensembl gene	ENSG00000157657
Ensembl biotype	protein_coding
OMIM	617077
Entrez	114991

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 54 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000288466, ENST00000374124, ENST00000374126, ENST00000452710, ENST00000470105, ENST00000481558, ENST00000615615, ENST00000901577, ENST00000901578, ENST00000901579, ENST00000901580, ENST00000901581, ENST00000901582, ENST00000901583, ENST00000901584, ENST00000901585, ENST00000901586, ENST00000901587, ENST00000901588, ENST00000901589, ENST00000901590, ENST00000901591, ENST00000901592, ENST00000901593, ENST00000901594, ENST00000901595, ENST00000901596, ENST00000901597, ENST00000901598, ENST00000901599, ENST00000901600, ENST00000901601, ENST00000901602, ENST00000901603, ENST00000901604, ENST00000928181, ENST00000928182, ENST00000928183, ENST00000968394, ENST00000968395, ENST00000968396, ENST00000968397, ENST00000968398, ENST00000968399, ENST00000968400, ENST00000968401, ENST00000968402, ENST00000968403, ENST00000968404, ENST00000968405, ENST00000968406, ENST00000968407, ENST00000968408, ENST00000968409, ENST00000968410, ENST00000968411

RefSeq mRNA: 4 — MANE Select: NM_001318042 NM_001318040, NM_001318041, NM_001318042, NM_133374

CCDS: CCDS48008, CCDS83402, CCDS83403

Canonical transcript exons

ENST00000374126 — 15 exons

Exon	Start	End
ENSE00001462548	113998259	113998354
ENSE00003480968	114016695	114016784
ENSE00003492055	114008477	114008554
ENSE00003498174	113969117	113969160
ENSE00003507523	114001996	114002073
ENSE00003524811	114048651	114056593
ENSE00003529036	114047893	114047994
ENSE00003585125	114036300	114036377
ENSE00003590647	114032645	114032728
ENSE00003590843	114008344	114008379
ENSE00003626366	113988321	113988580
ENSE00003636331	114007350	114007439
ENSE00003654547	114002624	114002662
ENSE00003661030	114028733	114028972
ENSE00003932222	113876309	113876413

Expression profiles

Bgee: expression breadth ubiquitous, 222 present calls, max score 97.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.9045 / max 96.6072, expressed in 1538 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98131	4.5402	1464
98132	1.3643	847

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.13	gold quality
pancreatic ductal cell	CL:0002079	96.83	gold quality
oocyte	CL:0000023	95.56	gold quality
kidney epithelium	UBERON:0004819	95.16	gold quality
epithelial cell of pancreas	CL:0000083	93.28	silver quality
buccal mucosa cell	CL:0002336	92.71	gold quality
renal medulla	UBERON:0000362	90.38	gold quality
cardiac muscle of right atrium	UBERON:0003379	89.61	gold quality
left ventricle myocardium	UBERON:0006566	89.20	gold quality
sural nerve	UBERON:0015488	87.90	gold quality
caput epididymis	UBERON:0004358	86.23	gold quality
cauda epididymis	UBERON:0004360	85.67	gold quality
stromal cell of endometrium	CL:0002255	84.93	gold quality
ventricular zone	UBERON:0003053	82.68	gold quality
germinal epithelium of ovary	UBERON:0001304	82.64	gold quality
corpus epididymis	UBERON:0004359	81.84	gold quality
metanephros	UBERON:0000081	81.65	gold quality
pylorus	UBERON:0001166	81.46	gold quality
cortex of kidney	UBERON:0001225	80.94	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.88	gold quality
kidney	UBERON:0002113	80.78	gold quality
tibia	UBERON:0000979	80.44	gold quality
tendon of biceps brachii	UBERON:0008188	80.03	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.65	gold quality
pigmented layer of retina	UBERON:0001782	78.61	gold quality
retina	UBERON:0000966	78.59	gold quality
endometrium	UBERON:0001295	78.42	gold quality
ovary	UBERON:0000992	78.16	gold quality
adult mammalian kidney	UBERON:0000082	78.02	gold quality
epithelium of mammary gland	UBERON:0003244	78.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

192 targeting ZNF618, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4753-3P	99.90	71.03	3786

Literature-anchored findings (GeneRIF, showing 1)

• study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo. (PMID:27129234)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf618	ENSDARG00000071469
mus_musculus	Zfp618	ENSMUSG00000028358
rattus_norvegicus	Zfp618	ENSRNOG00000062890
drosophila_melanogaster	Opbp	FBGN0050443

Paralogs (2): FIZ1 (ENSG00000179943), ZBTB44 (ENSG00000196323)

Protein

Protein identifiers

Zinc finger protein 618 — Q5T7W0 (reviewed: Q5T7W0)

All UniProt accessions (3): B1ALC2, B5MDS3, Q5T7W0

UniProt curated annotations — full annotation on UniProt →

Function. Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization.

Subunit / interactions. Interacts with UHRF2.

Subcellular location. Nucleus. Chromosome.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q5T7W0-1	1	yes
Q5T7W0-2	2
Q5T7W0-3	3
Q5T7W0-4	4

RefSeq proteins (4): NP_001304969, NP_001304970, NP_001304971, NP_588615 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012337	RNaseH-like_sf	Homologous_superfamily
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

UniProt features (26 total): splice variant 6, zinc finger region 4, compositionally biased region 4, cross-link 4, region of interest 4, sequence conflict 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T7W0-F1	65.15	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 1, 63, 81, 239, 437

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 86 (showing top): HORIUCHI_WTAP_TARGETS_DN, KOYAMA_SEMA3B_TARGETS_UP, LIAO_METASTASIS, DODD_NASOPHARYNGEAL_CARCINOMA_UP, JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, GOCC_CHROMOSOMAL_REGION, GOCC_PERICENTRIC_HETEROCHROMATIN, GOCC_HETEROCHROMATIN, GOMF_TRANSCRIPTION_COREGULATOR_BINDING, GOMF_TRANSCRIPTION_FACTOR_BINDING, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN, DURAND_STROMA_S_UP, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, MIR6867_5P, MIR3658

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), chromatin organization (GO:0006325)

GO Molecular Function (7): transcription coregulator binding (GO:0001221), DNA binding (GO:0003677), zinc ion binding (GO:0008270), identical protein binding (GO:0042802), chromatin-protein adaptor activity (GO:0140463), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), pericentric heterochromatin (GO:0005721), chromosome (GO:0005694)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cellular component organization	1
transcription factor binding	1
nucleic acid binding	1
transition metal ion binding	1
protein binding	1
chromatin binding	1
chromatin organization	1
protein-macromolecule adaptor activity	1
binding	1
cation binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1
chromosome, centromeric region	1
heterochromatin	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

622 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF618	SLC12A6	Q9UHW9	564
ZNF618	NUTM1	Q86Y26	528
ZNF618	CHD2	O14647	521
ZNF618	CLVS1	Q8IUQ0	512
ZNF618	N4BP2L1	Q5TBK1	509
ZNF618	BRD9	Q9H8M2	506
ZNF618	TMEM92	Q6UXU6	491
ZNF618	NSD3	Q9BZ95	480
ZNF618	ACIN1	Q9UKV3	479
ZNF618	BRD3	Q15059	471
ZNF618	MBTD1	Q05BQ5	431
ZNF618	SLITRK6	Q9H5Y7	429
ZNF618	PHF14	O94880	428
ZNF618	TRIM28	Q13263	414
ZNF618	ZNF688	P0C7X2	408

IntAct

56 interactions, top by confidence:

A	B	Type	Score
CSNK1A1	FAM83G	psi-mi:“MI:0914”(association)	0.900
CSNK1E	PER2	psi-mi:“MI:0914”(association)	0.850
CSNK1D	PER2	psi-mi:“MI:0914”(association)	0.810
CSNK1D	ZNF618	psi-mi:“MI:0915”(physical association)	0.670
CSNK1E	ZNF618	psi-mi:“MI:0915”(physical association)	0.670
ZNF576	ZBED1	psi-mi:“MI:0914”(association)	0.640
	ZNF618	psi-mi:“MI:0915”(physical association)	0.560
MID1	ZNF618	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	TBC1D13	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	ZNF618	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	DPPA3	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	NTAQ1	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	UBL5	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	UBE2I	psi-mi:“MI:0915”(physical association)	0.560
ZNF618	G3BP2	psi-mi:“MI:0915”(physical association)	0.560
CSNK1E	POTEF	psi-mi:“MI:0914”(association)	0.530
PCNA	ZNF618	psi-mi:“MI:0915”(physical association)	0.370
P		psi-mi:“MI:0914”(association)	0.350
ODF2	ELAPOR2	psi-mi:“MI:0914”(association)	0.350
PER2	CIBAR1	psi-mi:“MI:0914”(association)	0.350
RNF4	KPNA3	psi-mi:“MI:0914”(association)	0.350
FAM110D	NDUFA2	psi-mi:“MI:0914”(association)	0.350
NUBP1	YBEY	psi-mi:“MI:0914”(association)	0.350
SNX24	GAPVD1	psi-mi:“MI:0914”(association)	0.350
	ZNF618	psi-mi:“MI:0915”(physical association)	0.000
CSNK1D	ZNF618	psi-mi:“MI:0915”(physical association)	0.000
MID1	ZNF618	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (51): ZNF618 (Affinity Capture-RNA), ZNF618 (Affinity Capture-RNA), ZNF618 (Affinity Capture-MS), UHRF2 (Affinity Capture-MS), GAPVD1 (Affinity Capture-MS), RPL11 (Affinity Capture-MS), HSPA8 (Affinity Capture-MS), ZNF618 (Affinity Capture-MS), UHRF2 (Affinity Capture-Western), ZNF618 (Affinity Capture-Western), UHRF2 (Reconstituted Complex), ZNF618 (Reconstituted Complex), UHRF2 (Co-localization), ZNF618 (Affinity Capture-MS), ZNF618 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D5NVS8, A1L2U9, A2A891, A4IGQ8, A5PKF5, B1WAZ8, B5XCB8, E1BKK0, F1LMN3, O94972, P23804, P56950, P86174, Q0IH98, Q12766, Q14B70, Q58FA4, Q5NVM3, Q5RET9, Q5T7W0, Q5ZHN5, Q69ZF8, Q6A098, Q6IQ49, Q6IR68, Q6PCX9, Q6TGZ4, Q6YND2, Q6ZU67, Q7YRZ8, Q7Z7J5, Q7ZVU1, Q80YY7, Q8C0R0, Q8C4P0, Q8CII0, Q8K0L9, Q8N680, Q8N8K9, Q93073

Diamond homologs: Q5T7W0, Q80YY7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

147 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	122
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3672 predictions. Top by Δscore:

Variant	Effect	Δscore
9:113876412:AGGTA:A	donor_loss	1.0000
9:113876413:GGTAC:G	donor_loss	1.0000
9:113876414:GTACG:G	donor_loss	1.0000
9:113988317:CCAG:C	acceptor_loss	1.0000
9:113988318:CAGG:C	acceptor_loss	1.0000
9:113988318:CAGGG:C	acceptor_gain	1.0000
9:113988319:A:AG	acceptor_gain	1.0000
9:113988319:AG:A	acceptor_gain	1.0000
9:113988319:AGG:A	acceptor_gain	1.0000
9:113988319:AGGGA:A	acceptor_gain	1.0000
9:113988320:G:A	acceptor_gain	1.0000
9:113988320:G:GA	acceptor_gain	1.0000
9:113988320:GGG:G	acceptor_gain	1.0000
9:113988320:GGGA:G	acceptor_gain	1.0000
9:113988320:GGGAG:G	acceptor_gain	1.0000
9:113988576:CCTTG:C	donor_gain	1.0000
9:113988577:CTTG:C	donor_gain	1.0000
9:113988578:TTG:T	donor_gain	1.0000
9:113988579:TG:T	donor_gain	1.0000
9:113988580:GG:G	donor_gain	1.0000
9:113988581:G:GA	donor_loss	1.0000
9:113988581:G:GG	donor_gain	1.0000
9:113988582:TGAG:T	donor_loss	1.0000
9:113988583:GAGT:G	donor_loss	1.0000
9:114001991:TCCA:T	acceptor_loss	1.0000
9:114001993:CAG:C	acceptor_loss	1.0000
9:114001994:A:AG	acceptor_gain	1.0000
9:114001994:AG:A	acceptor_gain	1.0000
9:114001994:AGG:A	acceptor_gain	1.0000
9:114001995:G:GA	acceptor_gain	1.0000

AlphaMissense

6274 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:113988541:T:C	C100R	1.000
9:113988542:G:A	C100Y	1.000
9:113988543:C:G	C100W	1.000
9:114002007:T:A	C149S	1.000
9:114002007:T:C	C149R	1.000
9:114002008:G:A	C149Y	1.000
9:114002008:G:C	C149S	1.000
9:114002009:C:G	C149W	1.000
9:114002016:T:A	C152S	1.000
9:114002016:T:C	C152R	1.000
9:114002017:G:A	C152Y	1.000
9:114002017:G:C	C152S	1.000
9:114002017:G:T	C152F	1.000
9:114002018:T:G	C152W	1.000
9:114002028:T:C	Y156H	1.000
9:114002028:T:G	Y156D	1.000
9:114002029:A:G	Y156C	1.000
9:114002043:T:C	C161R	1.000
9:114002044:G:A	C161Y	1.000
9:114002045:C:G	C161W	1.000
9:114002046:T:C	F162L	1.000
9:114002047:T:C	F162S	1.000
9:114002048:C:A	F162L	1.000
9:114002048:C:G	F162L	1.000
9:114002055:C:A	H165N	1.000
9:114002055:C:G	H165D	1.000
9:114002055:C:T	H165Y	1.000
9:114002056:A:G	H165R	1.000
9:114002057:C:A	H165Q	1.000
9:114002057:C:G	H165Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000001308 (9:114053722 C>T), RS1000013461 (9:113992290 G>A), RS1000015881 (9:113970507 C>T), RS1000041080 (9:114030918 C>G), RS1000046537 (9:113906209 C>G), RS1000053152 (9:113922802 A>G), RS1000068322 (9:113881863 T>C), RS1000075804 (9:113905948 C>A,T), RS1000122069 (9:113987249 T>A), RS1000128523 (9:113948742 T>C,G), RS1000141398 (9:114025828 A>C), RS1000150119 (9:113966304 A>G), RS1000180986 (9:114054321 A>C,G), RS1000187357 (9:113888241 C>A), RS1000200267 (9:113931639 G>A)

Disease associations

OMIM: gene MIM:617077 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST003560_4	Coronary artery aneurysm in Kawasaki disease	2.000000e-07
GCST005648_6	Serum metabolite concentrations in chronic kidney disease	2.000000e-08
GCST006629_71	Pulse pressure	9.000000e-17
GCST006987_2	Neutrophil level response to clozapine in treatment-resistant schizophrenia	9.000000e-09
GCST007204_4	Low density lipoprotein cholesterol levels	9.000000e-06
GCST007267_125	Systolic blood pressure	2.000000e-10
GCST007269_107	Pulse pressure	5.000000e-16
GCST007324_117	Adventurousness	2.000000e-08
GCST007325_242	General risk tolerance (MTAG)	2.000000e-09
GCST007576_231	Chronotype	7.000000e-09
GCST008529_30	Tea consumption	4.000000e-06
GCST012170_12	Cognitive function in longevity	8.000000e-06
GCST012490_268	Femur bone mineral density x serum urate levels interaction	2.000000e-08

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0004833	neutrophil count
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0006335	systolic blood pressure
EFO:0008579	risk-taking behaviour
EFO:0008328	chronotype measurement
EFO:0010091	tea consumption measurement
EFO:0008354	cognitive function measurement
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725046 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	8
Benzo(a)pyrene	affects methylation, decreases expression	3
bisphenol A	decreases methylation, increases expression, affects cotreatment	2
sodium arsenite	decreases expression, increases expression	2
(+)-JQ1 compound	decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Cyclosporine	decreases expression, increases methylation	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
beta-lapachone	decreases expression	1
mono-(2-ethylhexyl)phthalate	decreases methylation, increases abundance	1
butyraldehyde	decreases expression	1
tobacco tar	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
beta-methylcholine	affects expression	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cisplatin	increases expression	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697554	Binding	Inhibition of ZNF618 (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.