ZNF622

Summary

ZNF622 (zinc finger protein 622, HGNC:30958) is a protein-coding gene on chromosome 5p15.1, encoding Cytoplasmic 60S subunit biogenesis factor ZNF622 (Q969S3). Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. It is a selective cancer dependency (DepMap: 14.9% of cell lines).

Enables preribosome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen.

Source: NCBI Gene 90441 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 77 total
• Cancer dependency (DepMap): dependent in 14.9% of screened cell lines
• MANE Select transcript: NM_033414

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30958
Approved symbol	ZNF622
Name	zinc finger protein 622
Location	5p15.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC2485, MGC17552, ZPR9
Ensembl gene	ENSG00000173545
Ensembl biotype	protein_coding
OMIM	608694
Entrez	90441

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000308683, ENST00000933612, ENST00000933613, ENST00000933614, ENST00000933615, ENST00000933616

RefSeq mRNA: 1 — MANE Select: NM_033414 NM_033414

CCDS: CCDS3886

Canonical transcript exons

ENST00000308683 — 6 exons

Exon	Start	End
ENSE00001208506	16453013	16453156
ENSE00001208510	16458517	16458629
ENSE00001208517	16463108	16463270
ENSE00001208521	16463482	16463742
ENSE00001208523	16451519	16451784
ENSE00001208528	16465041	16465800

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 98.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 31.8767 / max 251.8593, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60998	20.6565	1814
60997	11.2201	1799

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	98.53	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.13	gold quality
myocardium	UBERON:0002349	96.69	gold quality
epithelial cell of pancreas	CL:0000083	94.84	gold quality
amniotic fluid	UBERON:0000173	94.63	gold quality
kidney epithelium	UBERON:0004819	94.54	gold quality
heart right ventricle	UBERON:0002080	94.45	gold quality
apex of heart	UBERON:0002098	94.39	gold quality
heart left ventricle	UBERON:0002084	93.85	gold quality
cardiac ventricle	UBERON:0002082	93.77	gold quality
body of pancreas	UBERON:0001150	93.71	gold quality
pancreas	UBERON:0001264	92.22	gold quality
upper arm skin	UBERON:0004263	92.16	gold quality
heart	UBERON:0000948	91.71	gold quality
tendon of biceps brachii	UBERON:0008188	91.08	gold quality
mucosa of sigmoid colon	UBERON:0004993	91.01	gold quality
gastrocnemius	UBERON:0001388	90.92	gold quality
colonic mucosa	UBERON:0000317	90.84	gold quality
mucosa of transverse colon	UBERON:0004991	90.75	gold quality
islet of Langerhans	UBERON:0000006	90.67	gold quality
cardiac atrium	UBERON:0002081	90.60	gold quality
medial globus pallidus	UBERON:0002477	90.45	gold quality
right atrium auricular region	UBERON:0006631	90.40	gold quality
muscle of leg	UBERON:0001383	90.32	gold quality
endothelial cell	CL:0000115	90.23	gold quality
palpebral conjunctiva	UBERON:0001812	90.10	gold quality
tendon	UBERON:0000043	89.92	gold quality
cartilage tissue	UBERON:0002418	89.92	gold quality
parotid gland	UBERON:0001831	89.85	gold quality
globus pallidus	UBERON:0001875	89.68	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-7052	yes	683.01
E-GEOD-100618	yes	257.78
E-MTAB-6386	no	192.63
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYBL2

miRNA regulators (miRDB)

25 targeting ZNF622, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-646	99.68	67.84	1645
HSA-MIR-4524A-5P	99.57	71.73	1193
HSA-MIR-4524B-5P	99.57	71.68	1195
HSA-MIR-182-3P	99.57	67.57	825
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-6830-3P	98.62	68.07	1760
HSA-MIR-4768-3P	98.16	66.02	2330
HSA-MIR-12126	98.09	64.82	637
HSA-MIR-503-5P	97.87	66.83	575
HSA-MIR-562	97.66	65.63	698
HSA-MIR-597-3P	96.46	68.03	1035

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 14.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• ZPR9 plays an important role in modulation of the transactivation by B-MYB and cellular growth of neuroblastoma cells (PMID:12645566)
• ZPR9 was found to physically interact with ASK1 through a disulfide linkage;ZPR9 functions as a novel positive regulator of ASK1. (PMID:21771788)
• Results from a study on gene expression variability markers in early-stage human embryos shows that ZNF622 is a putative expression variability marker for the 3-day, 8-cell embryo stage. (PMID:26288249)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf622	ENSDARG00000014692
mus_musculus	Zfp622	ENSMUSG00000052253
rattus_norvegicus	Zfp622l1	ENSRNOG00000010589
rattus_norvegicus		ENSRNOG00000065109
drosophila_melanogaster	CG6769	FBGN0030878
caenorhabditis_elegans		WBGENE00015809

Protein

Protein identifiers

Cytoplasmic 60S subunit biogenesis factor ZNF622 — Q969S3 (reviewed: Q969S3)

Alternative names: Zinc finger protein 622, Zinc finger-like protein 9

All UniProt accessions (1): Q969S3

UniProt curated annotations — full annotation on UniProt →

Function. Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.

Subunit / interactions. Homo- and heterodimer. Associates with pre-60S ribosomal particles. Interacts with MELK and MYBL2. Interacts with DNAJC21.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.

Post-translational modifications. Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus. Ubiquitinated by HECTD1, leading to its degradation.

Similarity. Belongs to the REI1 family.

RefSeq proteins (1): NP_219482* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003604	Matrin/U1-like-C_Znf_C2H2	Domain
IPR013087	Znf_C2H2_type	Domain
IPR022755	Znf_C2H2_jaz	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR040025	Znf622/Rei1/Reh1	Family
IPR041661	ZN622/Rei1/Reh1_Znf-C2H2	Domain

Pfam: PF12171, PF12756

UniProt features (9 total): zinc finger region 2, compositionally biased region 2, modified residue 2, initiator methionine 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9GMO	ELECTRON MICROSCOPY	2.59
6LQM	ELECTRON MICROSCOPY	3.09
6LSR	ELECTRON MICROSCOPY	3.13

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969S3-F1	73.05	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 276

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 131 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, GOBP_RIBOSOME_BIOGENESIS, GOBP_REGULATION_OF_PHOSPHORYLATION, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, GOBP_APOPTOTIC_SIGNALING_PATHWAY, WANG_LMO4_TARGETS_DN, GOBP_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS, GOBP_JNK_CASCADE, MARTIN_VIRAL_GPCR_SIGNALING_DN

GO Biological Process (7): intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631), positive regulation of kinase activity (GO:0033674), ribosomal large subunit biogenesis (GO:0042273), positive regulation of apoptotic process (GO:0043065), positive regulation of MAPK cascade (GO:0043410), positive regulation of JNK cascade (GO:0046330), ribosome biogenesis (GO:0042254)

GO Molecular Function (6): RNA binding (GO:0003723), zinc ion binding (GO:0008270), preribosome binding (GO:1990275), nucleic acid binding (GO:0003676), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (7): nucleoplasm (GO:0005654), nucleolus (GO:0005730), Golgi apparatus (GO:0005794), cytosol (GO:0005829), preribosome, large subunit precursor (GO:0030687), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ribonucleoprotein complex biogenesis	2
binding	2
nuclear lumen	2
cytoplasm	2
intracellular membrane-bounded organelle	2
intrinsic apoptotic signaling pathway	1
kinase activity	1
positive regulation of phosphorylation	1
positive regulation of catalytic activity	1
regulation of kinase activity	1
ribosome biogenesis	1
apoptotic process	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
MAPK cascade	1
regulation of MAPK cascade	1
positive regulation of intracellular signal transduction	1
JNK cascade	1
positive regulation of MAPK cascade	1
regulation of JNK cascade	1
nucleic acid binding	1
transition metal ion binding	1
ribonucleoprotein complex binding	1
cation binding	1
intracellular membraneless organelle	1
endomembrane system	1
preribosome	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1812 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF622	MELK	Q14680	958
ZNF622	MYBL2	P10244	914
ZNF622	PA2G4	Q9UQ80	641
ZNF622	RSL24D1	Q9UHA3	487
ZNF622	ZNF593	O00488	483
ZNF622	NMD3	Q96D46	478
ZNF622	LSG1	Q9H089	473
ZNF622	CRLS1	Q9UJA2	468
ZNF622	MRTO4	Q9UKD2	468
ZNF622	HSPA8	P11142	449
ZNF622	EIF6	P56537	449
ZNF622	DNAJC21	Q5F1R6	449
ZNF622	SAFB2	Q14151	445
ZNF622	TXN	P10599	439
ZNF622	LY6H	O94772	438

IntAct

110 interactions, top by confidence:

A	B	Type	Score
MAP3K5	MAP2K3	psi-mi:“MI:0914”(association)	0.760
MAP3K5	YWHAB	psi-mi:“MI:0914”(association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MAP3K5	TXN	psi-mi:“MI:0914”(association)	0.680
MAP3K5	ZNF622	psi-mi:“MI:0915”(physical association)	0.660
ZNF622	MAP3K5	psi-mi:“MI:0915”(physical association)	0.660
MAP3K5	ZNF622	psi-mi:“MI:0407”(direct interaction)	0.660
ZNF622	MAP3K5	psi-mi:“MI:0407”(direct interaction)	0.660
ZNF622	MAP3K5	psi-mi:“MI:0217”(phosphorylation reaction)	0.660
YAF2	E2F6	psi-mi:“MI:0914”(association)	0.640
PRPF31	PRPF4	psi-mi:“MI:0914”(association)	0.640
BEND7	ZNF622	psi-mi:“MI:0915”(physical association)	0.560
MACROH2A1	ZNF622	psi-mi:“MI:0915”(physical association)	0.560
CAVIN1	ZZEF1	psi-mi:“MI:0914”(association)	0.530
EZR	BCR	psi-mi:“MI:0914”(association)	0.480
ZNF622	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
HMGB2	ZNF622	psi-mi:“MI:0915”(physical association)	0.370
	ZNF622	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (176): MRTO4 (Co-fractionation), ZNF622 (Co-fractionation), ZNF622 (Reconstituted Complex), ZNF622 (Proximity Label-MS), ZNF622 (Proximity Label-MS), ZNF622 (Proximity Label-MS), ZNF622 (Proximity Label-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS), ZNF622 (Affinity Capture-MS)

ESM2 similar proteins: A1CFJ6, A1CYJ1, A2QGZ1, A3LU29, A4R9U5, A5DFT1, A5DYR5, A6RC73, A6RNR4, A6RVU0, A6SK81, A6ZQU8, A7E664, A7EGB5, A7EPT0, A7TP28, B8MSM6, C5P263, P0CP24, P0CP25, P0CS78, P0CS79, P40007, Q0CDP3, Q0UBQ5, Q1DLJ4, Q1EBC4, Q4IPB3, Q4PII9, Q4SQ06, Q4W9V0, Q4WIK9, Q4WNY4, Q59YD8, Q5AVK6, Q5AWM5, Q5B4T5, Q5BEG5, Q6BWR0, Q6CE60

Diamond homologs: G0S920, O59811, Q58CQ5, Q7TM96, Q80UU1, Q90Y35, Q91VY9, Q969S3, Q9H8Y5, Q9HET8, O74977, P38344, Q66H85, Q04311, Q06709, Q8H1G5, Q9ZQ18

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
MAP3K5	up-regulates	ZNF622	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 117 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	5	19.8×	1e-04
Cap-dependent Translation Initiation	5	19.8×	1e-04
SARS-CoV-1 modulates host translation machinery	5	19.8×	1e-04
Eukaryotic Translation Elongation	5	17.9×	2e-04
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5	17.4×	2e-04
Influenza Viral RNA Transcription and Replication	6	16.6×	5e-05
SARS-CoV-1-host interactions	7	15.8×	1e-05
SRP-dependent cotranslational protein targeting to membrane	12	15.4×	7e-09

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	10	18.7×	1e-07
regulation of alternative mRNA splicing, via spliceosome	5	12.3×	7e-03
translation	8	8.3×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

618 predictions. Top by Δscore:

Variant	Effect	Δscore
5:16453008:TGTAC:T	donor_loss	1.0000
5:16453009:GTACC:G	donor_loss	1.0000
5:16453010:TACCT:T	donor_loss	1.0000
5:16453011:A:C	donor_loss	1.0000
5:16453012:C:CT	donor_loss	1.0000
5:16453154:CAC:C	acceptor_gain	1.0000
5:16453157:C:CA	acceptor_loss	1.0000
5:16453157:C:CC	acceptor_gain	1.0000
5:16453158:T:A	acceptor_loss	1.0000
5:16458510:CACTT:C	donor_loss	1.0000
5:16458511:ACTTA:A	donor_loss	1.0000
5:16458512:CTTAC:C	donor_loss	1.0000
5:16458513:TTA:T	donor_loss	1.0000
5:16458514:TACC:T	donor_loss	1.0000
5:16458515:A:AC	donor_gain	1.0000
5:16458515:ACCAG:A	donor_loss	1.0000
5:16458516:C:CC	donor_gain	1.0000
5:16458516:C:G	donor_loss	1.0000
5:16458625:TACTC:T	acceptor_gain	1.0000
5:16458627:CTC:C	acceptor_gain	1.0000
5:16458629:CCTA:C	acceptor_loss	1.0000
5:16458630:C:CC	acceptor_gain	1.0000
5:16458630:CTAT:C	acceptor_loss	1.0000
5:16463102:GCTTA:G	donor_loss	1.0000
5:16463103:CTTAC:C	donor_loss	1.0000
5:16463104:TTACC:T	donor_loss	1.0000
5:16463105:TACC:T	donor_loss	1.0000
5:16463106:A:AC	donor_gain	1.0000
5:16463106:ACCTA:A	donor_loss	1.0000
5:16463107:C:CC	donor_gain	1.0000

AlphaMissense

3185 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:16463244:A:G	C305R	0.998
5:16465525:G:C	F47L	0.998
5:16465525:G:T	F47L	0.998
5:16465526:A:G	F47S	0.998
5:16465527:A:G	F47L	0.998
5:16465571:A:G	L32P	0.998
5:16465573:G:C	N31K	0.998
5:16465573:G:T	N31K	0.998
5:16465587:A:G	W27R	0.998
5:16465587:A:T	W27R	0.998
5:16465641:A:G	C9R	0.998
5:16463187:G:C	H324D	0.997
5:16463234:C:G	C308S	0.997
5:16463235:A:T	C308S	0.997
5:16463242:G:C	C305W	0.997
5:16465640:C:T	C9Y	0.997
5:16465650:A:G	C6R	0.997
5:16463167:G:C	H330Q	0.996
5:16463167:G:T	H330Q	0.996
5:16463185:A:C	H324Q	0.996
5:16463185:A:T	H324Q	0.996
5:16463235:A:G	C308R	0.996
5:16463243:C:T	C305Y	0.996
5:16465565:C:G	R34P	0.996
5:16465584:G:C	H28D	0.996
5:16465585:C:A	W27C	0.996
5:16465585:C:G	W27C	0.996
5:16465639:G:C	C9W	0.996
5:16465640:C:A	C9F	0.996
5:16465648:G:C	C6W	0.996

dbSNP variants (sampled 300 via entrez): RS1000081874 (5:16456032 G>A), RS1000254191 (5:16454157 A>G), RS1000909423 (5:16461826 G>C), RS1000950932 (5:16455011 A>T), RS1001085413 (5:16454765 T>C), RS1001167717 (5:16456751 G>A), RS1001305412 (5:16456510 A>C), RS1002077343 (5:16462268 A>C), RS1002165238 (5:16455290 G>A), RS1002281554 (5:16459952 G>A), RS1002314056 (5:16459516 T>C,G), RS1002797209 (5:16465349 A>C), RS1002840167 (5:16458657 T>C), RS1002988725 (5:16462869 C>A), RS1003107031 (5:16451970 C>T)

Disease associations

OMIM: gene MIM:608694 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003025_12	Attention function in attention deficit hyperactive disorder	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007636	attention function measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases activity, increases expression	3
Valproic Acid	affects cotreatment, increases expression	3
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, increases methylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
butyraldehyde	increases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
licochalcone B	increases expression	1
PCI 5002	increases expression, affects cotreatment	1
Resveratrol	increases expression, affects cotreatment	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Copper	affects binding, decreases expression	1
Disulfiram	decreases expression, affects binding	1
Hydralazine	affects cotreatment, increases expression	1
Methyl Methanesulfonate	increases expression	1
Phenobarbital	affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2LW	Abcam HeLa ZNF622 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.