ZNF664
geneOn this page
Also known as ZFOC1DKFZp761B128
Summary
ZNF664 (zinc finger protein 664, HGNC:25406) is a protein-coding gene on chromosome 12q24.31, encoding Zinc finger protein 664 (Q8N3J9). May be involved in transcriptional regulation.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus.
Source: NCBI Gene 144348 — RefSeq curated summary.
At a glance
- GWAS associations: 67
- Clinical variants (ClinVar): 18 total
- MANE Select transcript:
NM_152437
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:25406 |
| Approved symbol | ZNF664 |
| Name | zinc finger protein 664 |
| Location | 12q24.31 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | ZFOC1, DKFZp761B128 |
| Ensembl gene | ENSG00000179195 |
| Ensembl biotype | protein_coding |
| OMIM | 617890 |
| Entrez | 144348 |
Gene structure
Transcript identifiers
Ensembl transcripts: 60 — 50 protein_coding, 8 protein_coding_CDS_not_defined, 2 retained_intron
ENST00000337815, ENST00000392404, ENST00000537532, ENST00000538932, ENST00000539257, ENST00000539501, ENST00000539644, ENST00000540009, ENST00000540498, ENST00000541448, ENST00000542493, ENST00000542820, ENST00000543017, ENST00000546098, ENST00000901659, ENST00000901660, ENST00000901661, ENST00000901662, ENST00000901663, ENST00000901664, ENST00000901665, ENST00000901666, ENST00000901667, ENST00000901668, ENST00000901669, ENST00000901670, ENST00000901671, ENST00000901672, ENST00000901673, ENST00000901674, ENST00000901675, ENST00000901676, ENST00000901677, ENST00000901678, ENST00000901679, ENST00000901680, ENST00000901681, ENST00000901682, ENST00000901683, ENST00000901684, ENST00000901685, ENST00000901686, ENST00000901687, ENST00000901688, ENST00000901689, ENST00000901690, ENST00000901691, ENST00000901692, ENST00000901693, ENST00000901694, ENST00000901695, ENST00000901696, ENST00000901697, ENST00000915687, ENST00000915688, ENST00000915689, ENST00000915690, ENST00000963055, ENST00000963056, ENST00000963057
RefSeq mRNA: 2 — MANE Select: NM_152437
NM_001204298, NM_152437
CCDS: CCDS9257
Canonical transcript exons
ENST00000337815 — 5 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001285710 | 124011381 | 124011441 |
| ENSE00001285732 | 123988043 | 123988138 |
| ENSE00002318983 | 123973215 | 123973352 |
| ENSE00003624130 | 123973886 | 123974020 |
| ENSE00003841583 | 124011546 | 124015427 |
Expression profiles
Bgee: expression breadth ubiquitous, 255 present calls, max score 99.39.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.1554 / max 333.6317, expressed in 1813 samples.
FANTOM5 promoters (3 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 128613 | 44.1554 | 1813 |
| 128612 | 1.1151 | 694 |
| 128615 | 0.2904 | 93 |
Top tissues by expression
256 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| ileal mucosa | UBERON:0000331 | 99.39 | gold quality |
| secondary oocyte | CL:0000655 | 99.14 | gold quality |
| bronchial epithelial cell | CL:0002328 | 98.90 | gold quality |
| kidney epithelium | UBERON:0004819 | 98.86 | gold quality |
| left ventricle myocardium | UBERON:0006566 | 98.82 | gold quality |
| jejunal mucosa | UBERON:0000399 | 98.78 | gold quality |
| cardiac muscle of right atrium | UBERON:0003379 | 98.78 | gold quality |
| bronchus | UBERON:0002185 | 98.77 | gold quality |
| germinal epithelium of ovary | UBERON:0001304 | 98.27 | gold quality |
| corpus epididymis | UBERON:0004359 | 98.25 | gold quality |
| lateral globus pallidus | UBERON:0002476 | 98.24 | gold quality |
| mucosa of paranasal sinus | UBERON:0005030 | 98.23 | gold quality |
| pigmented layer of retina | UBERON:0001782 | 98.19 | gold quality |
| epithelium of nasopharynx | UBERON:0001951 | 98.17 | gold quality |
| subthalamic nucleus | UBERON:0001906 | 98.15 | gold quality |
| globus pallidus | UBERON:0001875 | 98.08 | gold quality |
| mucosa of sigmoid colon | UBERON:0004993 | 98.08 | gold quality |
| palpebral conjunctiva | UBERON:0001812 | 98.07 | gold quality |
| caput epididymis | UBERON:0004358 | 98.07 | gold quality |
| C1 segment of cervical spinal cord | UBERON:0006469 | 98.05 | gold quality |
| medial globus pallidus | UBERON:0002477 | 98.04 | gold quality |
| parotid gland | UBERON:0001831 | 98.01 | gold quality |
| inferior vagus X ganglion | UBERON:0005363 | 97.98 | gold quality |
| postcentral gyrus | UBERON:0002581 | 97.91 | gold quality |
| spinal cord | UBERON:0002240 | 97.89 | gold quality |
| visceral pleura | UBERON:0002401 | 97.88 | gold quality |
| parietal pleura | UBERON:0002400 | 97.85 | gold quality |
| duodenum | UBERON:0002114 | 97.84 | gold quality |
| ganglionic eminence | UBERON:0004023 | 97.81 | gold quality |
| colonic mucosa | UBERON:0000317 | 97.76 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 15.74 |
| E-MTAB-6678 | no | 3.33 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
85 targeting ZNF664, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-4476 | 100.00 | 68.18 | 2030 |
| HSA-MIR-6876-5P | 100.00 | 67.68 | 2126 |
| HSA-MIR-3134 | 100.00 | 66.43 | 777 |
| HSA-MIR-4668-3P | 100.00 | 68.74 | 2635 |
| HSA-MIR-340-5P | 100.00 | 72.50 | 4437 |
| HSA-MIR-12118 | 100.00 | 65.88 | 1270 |
| HSA-MIR-4262 | 100.00 | 73.26 | 3931 |
| HSA-MIR-3120-5P | 100.00 | 65.56 | 965 |
| HSA-MIR-3667-3P | 99.99 | 67.17 | 1636 |
| HSA-MIR-4534 | 99.99 | 66.58 | 1907 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-181A-5P | 99.99 | 72.96 | 2995 |
| HSA-MIR-181B-5P | 99.99 | 72.97 | 2996 |
| HSA-MIR-181C-5P | 99.99 | 72.95 | 2996 |
| HSA-MIR-181D-5P | 99.99 | 73.04 | 2997 |
| HSA-MIR-548P | 99.98 | 72.25 | 3784 |
| HSA-MIR-3173-3P | 99.98 | 66.49 | 1217 |
| HSA-MIR-6891-5P | 99.98 | 66.53 | 1372 |
| HSA-MIR-3688-3P | 99.97 | 72.02 | 2834 |
| HSA-MIR-607 | 99.97 | 73.62 | 5593 |
| HSA-MIR-9-3P | 99.96 | 70.88 | 2068 |
| HSA-MIR-495-3P | 99.96 | 72.81 | 4197 |
| HSA-MIR-5688 | 99.96 | 73.23 | 4504 |
| HSA-MIR-551B-5P | 99.96 | 71.28 | 3493 |
| HSA-MIR-4760-3P | 99.93 | 70.50 | 2385 |
| HSA-MIR-3119 | 99.92 | 71.34 | 2390 |
| HSA-MIR-1297 | 99.91 | 73.41 | 3162 |
| HSA-MIR-3671 | 99.90 | 73.04 | 3897 |
| HSA-MIR-182-5P | 99.87 | 74.03 | 2589 |
| HSA-MIR-4503 | 99.85 | 71.45 | 1869 |
Cross-species orthologs
4 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| mus_musculus | Zfp664 | ENSMUSG00000079215 |
| rattus_norvegicus | Zfp664 | ENSRNOG00000064009 |
| drosophila_melanogaster | CG18476 | FBGN0037931 |
| drosophila_melanogaster | CG10669 | FBGN0039329 |
Paralogs (5): ZNF648 (ENSG00000179930), ZNF721 (ENSG00000182903), ZFP62 (ENSG00000196670), ZNF485 (ENSG00000198298), ZNF808 (ENSG00000198482)
Protein
Protein identifiers
Zinc finger protein 664 — Q8N3J9 (reviewed: Q8N3J9)
Alternative names: Zinc finger protein 176, Zinc finger protein from organ of Corti
All UniProt accessions (1): Q8N3J9
UniProt curated annotations — full annotation on UniProt →
Function. May be involved in transcriptional regulation.
Subcellular location. Nucleus.
Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.
RefSeq proteins (2): NP_001191227, NP_689650* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR013087 | Znf_C2H2_type | Domain |
| IPR036236 | Znf_C2H2_sf | Homologous_superfamily |
Pfam: PF00096
UniProt features (16 total): zinc finger region 9, sequence conflict 5, chain 1, cross-link 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q8N3J9-F1 | 91.40 | 0.77 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Post-translational modifications (1): 257
Function
Pathways and Gene Ontology
Reactome pathways
1 pathways
| ID | Pathway |
|---|---|
| R-HSA-212436 | Generic Transcription Pathway |
MSigDB gene sets: 103 (showing top):
AAGTCCA_MIR422B_MIR422A, CTAGGAA_MIR384, SOX9_B1, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX1_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN, TGGNNNNNNKCCAR_UNKNOWN, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GRYDER_PAX3FOXO1_TOP_ENHANCERS, TCCCRNNRTGC_UNKNOWN, chr12q24, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN, ERR1_Q2, STK33_DN
GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)
GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)
GO Cellular Component (1): nucleus (GO:0005634)
Reactome top-level categories
Rollup of top-1 pathways:
| Category | Pathways |
|---|---|
| RNA Polymerase II Transcription | 1 |
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2 |
| DNA-templated transcription | 1 |
| regulation of gene expression | 1 |
| regulation of RNA biosynthetic process | 1 |
| regulation of DNA-templated transcription | 1 |
| transcription by RNA polymerase II | 1 |
| cis-regulatory region sequence-specific DNA binding | 1 |
| chromatin | 1 |
| DNA-binding transcription factor activity | 1 |
| regulation of transcription by RNA polymerase II | 1 |
| transition metal ion binding | 1 |
| nucleic acid binding | 1 |
| binding | 1 |
| cation binding | 1 |
| intracellular membrane-bounded organelle | 1 |
Protein interactions and networks
STRING
562 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| ZNF664 | CCDC92 | Q53HC0 | 797 |
| ZNF664 | DNAH10 | Q8IVF4 | 702 |
| ZNF664 | RFLNA | Q6ZTI6 | 543 |
| ZNF664 | GALNT2 | Q10471 | 448 |
| ZNF664 | NT5DC2 | Q9H857 | 448 |
| ZNF664 | OR56B1 | Q8NGI3 | 447 |
| ZNF664 | SORCS1 | Q8WY21 | 446 |
| ZNF664 | CMIP | Q8IY22 | 442 |
| ZNF664 | C5orf67 | F2Z3F1 | 431 |
| ZNF664 | COBLL1 | Q53SF7 | 419 |
| ZNF664 | TRIB1 | Q96RU8 | 418 |
| ZNF664 | ARL15 | Q9NXU5 | 416 |
| ZNF664 | FOXN3 | O00409 | 413 |
| ZNF664 | TEX19 | Q8NA77 | 398 |
| ZNF664 | SECTM1 | Q8WVN6 | 374 |
IntAct
34 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| MPDZ | SMCHD1 | psi-mi:“MI:0914”(association) | 0.590 |
| CIB3 | ZNF664 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZNF664 | psi-mi:“MI:0915”(physical association) | 0.560 | |
| CABP5 | ZNF664 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZNF664 | ZNF330 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZNF664 | CIB3 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZNF664 | CABP5 | psi-mi:“MI:0915”(physical association) | 0.560 |
| GADD45G | ZNF664 | psi-mi:“MI:0915”(physical association) | 0.560 |
| VWCE | ZNF316 | psi-mi:“MI:0914”(association) | 0.530 |
| IGFBP1 | SUSD5 | psi-mi:“MI:0914”(association) | 0.530 |
| RETN | GLI4 | psi-mi:“MI:0914”(association) | 0.530 |
| RGS20 | PGP | psi-mi:“MI:0914”(association) | 0.350 |
| ZNF227 | ZNF664 | psi-mi:“MI:0914”(association) | 0.350 |
| NOTCH2 | ZNF320 | psi-mi:“MI:0914”(association) | 0.350 |
| LTBP2 | ZNF320 | psi-mi:“MI:0914”(association) | 0.350 |
| FBLN2 | ZNF316 | psi-mi:“MI:0914”(association) | 0.350 |
| ST14 | LIPT2 | psi-mi:“MI:0914”(association) | 0.350 |
| ZNF664 | GAPDHS | psi-mi:“MI:0914”(association) | 0.350 |
| TRAK1 | PEX14 | psi-mi:“MI:0914”(association) | 0.350 |
| LY6H | NXPH4 | psi-mi:“MI:0914”(association) | 0.350 |
| NFIB | psi-mi:“MI:0914”(association) | 0.350 | |
| ZNF330 | ZNF664 | psi-mi:“MI:0915”(physical association) | 0.000 |
| GADD45G | ZNF664 | psi-mi:“MI:0915”(physical association) | 0.000 |
BioGRID (32): ZNF664 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS), ZNF664 (Two-hybrid), ZNF664 (Two-hybrid), ZNF664 (Two-hybrid), ZNF664 (Two-hybrid), KRTAP10-1 (Two-hybrid), ZNF664 (Affinity Capture-RNA), ZNF664 (Affinity Capture-MS), STRIP1 (Affinity Capture-MS), ZNF664 (Affinity Capture-MS)
ESM2 similar proteins: O73694, P18712, P18717, P18719, P18720, P18721, P18722, P18724, P18727, P18730, P18731, P18732, P18734, P18735, P18738, P18740, P18741, P18742, P18743, P18744, P18750, P24399, P26634, P26635, P31507, P31508, P31509, Q01779, Q01792, Q01793, Q01797, Q01799, Q01800, Q01871, Q01872, Q02025, Q02026, Q02027, Q02034, Q02035
Diamond homologs: Q4VA44, Q5RAM9, Q60493, Q8N3J9
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
18 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 17 |
| Likely benign | 1 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
1338 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 12:123974018:CAGGT:C | donor_loss | 1.0000 |
| 12:123974019:AGG:A | donor_loss | 1.0000 |
| 12:123974020:GGT:G | donor_loss | 1.0000 |
| 12:123976224:G:GT | donor_gain | 1.0000 |
| 12:123973301:G:T | donor_gain | 0.9900 |
| 12:123973350:GGA:G | donor_gain | 0.9900 |
| 12:123973351:GAG:G | donor_gain | 0.9900 |
| 12:123973353:G:GG | donor_gain | 0.9900 |
| 12:123974018:CAGG:C | donor_loss | 0.9900 |
| 12:123974021:GT:G | donor_loss | 0.9900 |
| 12:123974021:GTA:G | donor_loss | 0.9900 |
| 12:123974022:T:G | donor_loss | 0.9900 |
| 12:123976203:T:G | donor_gain | 0.9900 |
| 12:124011379:A:AG | acceptor_gain | 0.9900 |
| 12:124011380:G:GG | acceptor_gain | 0.9900 |
| 12:123973351:GA:G | donor_gain | 0.9800 |
| 12:123976224:G:T | donor_gain | 0.9800 |
| 12:123976239:G:T | donor_gain | 0.9800 |
| 12:123989289:T:G | acceptor_gain | 0.9800 |
| 12:124011437:AAAAG:A | donor_loss | 0.9800 |
| 12:124011438:AAAG:A | donor_loss | 0.9800 |
| 12:124011439:AAGG:A | donor_loss | 0.9800 |
| 12:124011440:AG:A | donor_loss | 0.9800 |
| 12:124011440:AGG:A | donor_loss | 0.9800 |
| 12:124011441:G:GT | donor_loss | 0.9800 |
| 12:124011441:GG:G | donor_loss | 0.9800 |
| 12:124011442:G:T | donor_loss | 0.9800 |
| 12:124011443:T:G | donor_loss | 0.9800 |
| 12:123973399:G:GT | donor_gain | 0.9700 |
| 12:123973400:G:T | donor_gain | 0.9700 |
AlphaMissense
1787 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 12:124012514:T:C | F124L | 0.998 |
| 12:124012516:T:A | F124L | 0.998 |
| 12:124012516:T:G | F124L | 0.998 |
| 12:124012598:T:C | F152L | 0.998 |
| 12:124012600:C:A | F152L | 0.998 |
| 12:124012600:C:G | F152L | 0.998 |
| 12:124012682:T:C | F180L | 0.998 |
| 12:124012684:C:A | F180L | 0.998 |
| 12:124012684:C:G | F180L | 0.998 |
| 12:124012766:T:C | F208L | 0.997 |
| 12:124012768:C:A | F208L | 0.997 |
| 12:124012768:C:G | F208L | 0.997 |
| 12:124012430:T:C | F96L | 0.996 |
| 12:124012432:C:A | F96L | 0.996 |
| 12:124012432:C:G | F96L | 0.996 |
| 12:124012850:T:C | F236L | 0.996 |
| 12:124012852:C:A | F236L | 0.996 |
| 12:124012852:C:G | F236L | 0.996 |
| 12:124012709:C:G | H189D | 0.993 |
| 12:124012449:T:C | L102P | 0.992 |
| 12:124012515:T:C | F124S | 0.992 |
| 12:124012533:T:C | L130P | 0.992 |
| 12:124012701:T:C | L186P | 0.992 |
| 12:124012711:C:A | H189Q | 0.992 |
| 12:124012711:C:G | H189Q | 0.992 |
| 12:124012683:T:C | F180S | 0.991 |
| 12:124012543:T:A | H133Q | 0.990 |
| 12:124012543:T:G | H133Q | 0.990 |
| 12:124012599:T:C | F152S | 0.990 |
| 12:124012617:T:C | L158P | 0.990 |
dbSNP variants (sampled 300 via entrez): RS1000005912 (12:123978645 C>G), RS1000106696 (12:123978301 T>C), RS1000145084 (12:124013947 A>C,G), RS1000227671 (12:123990088 A>G,T), RS1000317136 (12:123977860 A>G), RS1000351428 (12:123973221 TC>T,TCC), RS1000491757 (12:124007879 G>A), RS1000508148 (12:123982925 C>T), RS1000515484 (12:123989140 A>G), RS1000582197 (12:123990520 C>T), RS1000604963 (12:123995163 C>T), RS1000642259 (12:123988936 C>T), RS1000686141 (12:123982776 A>G), RS1000693148 (12:123989245 C>T), RS1000741109 (12:123982629 G>A)
Disease associations
OMIM: gene MIM:617890 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
67 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST000755_47 | HDL cholesterol | 3.000000e-10 |
| GCST000758_20 | Triglycerides | 1.000000e-08 |
| GCST001523_44 | Visceral adipose tissue adjusted for BMI | 9.000000e-06 |
| GCST001524_26 | Visceral adipose tissue/subcutaneous adipose tissue ratio | 7.000000e-06 |
| GCST002216_10 | Triglycerides | 2.000000e-08 |
| GCST002223_66 | HDL cholesterol | 8.000000e-10 |
| GCST002233_8 | Adiponectin levels | 2.000000e-07 |
| GCST002399_1 | Clubfoot | 2.000000e-07 |
| GCST002782_127 | Waist-to-hip ratio adjusted for body mass index | 7.000000e-15 |
| GCST002782_128 | Waist-to-hip ratio adjusted for body mass index | 7.000000e-14 |
| GCST002782_129 | Waist-to-hip ratio adjusted for body mass index | 6.000000e-14 |
| GCST002782_130 | Waist-to-hip ratio adjusted for body mass index | 2.000000e-13 |
| GCST004064_51 | Waist-hip ratio | 1.000000e-09 |
| GCST004064_73 | Waist-hip ratio | 2.000000e-06 |
| GCST004232_10 | HDL cholesterol levels | 1.000000e-34 |
| GCST004234_12 | HDL cholesterol levels | 6.000000e-10 |
| GCST004237_10 | Triglyceride levels | 2.000000e-11 |
| GCST004505_3 | Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) | 3.000000e-08 |
| GCST004505_4 | Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) | 3.000000e-09 |
| GCST005956_10 | Waist-to-hip ratio adjusted for BMI | 6.000000e-08 |
| GCST005958_11 | Waist-to-hip ratio adjusted for BMI (age >50) | 4.000000e-07 |
| GCST005962_22 | Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) | 1.000000e-08 |
| GCST009107_2 | Body mass index variance | 1.000000e-10 |
| GCST009380_5 | Type 2 diabetes (adjusted for BMI) | 2.000000e-08 |
| GCST009380_6 | Type 2 diabetes (adjusted for BMI) | 2.000000e-06 |
| GCST009404_21 | Optic cup area | 1.000000e-10 |
| GCST009602_23 | Metabolic syndrome | 4.000000e-10 |
| GCST009723_71 | Vertical cup-disc ratio (adjusted for vertical disc diameter) | 2.000000e-09 |
| GCST009724_100 | Vertical cup-disc ratio (multi-trait analysis) | 2.000000e-14 |
| GCST010002_177 | Refractive error | 4.000000e-08 |
EFO canonical traits (15, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0004612 | high density lipoprotein cholesterol measurement |
| EFO:0004530 | triglyceride measurement |
| EFO:0004340 | body mass index |
| EFO:0004767 | visceral:subcutaneous adipose tissue ratio |
| EFO:0004502 | adiponectin measurement |
| EFO:0007788 | BMI-adjusted waist-hip ratio |
| EFO:0004343 | waist-hip ratio |
| EFO:0004318 | smoking behavior |
| EFO:0008007 | age at assessment |
| EFO:0008343 | sex interaction measurement |
| EFO:0000195 | metabolic syndrome |
| EFO:0006939 | cup-to-disc ratio measurement |
| EFO:0004995 | lean body mass |
| EFO:0007789 | BMI-adjusted waist circumference |
| EFO:0008039 | BMI-adjusted hip circumference |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
26 total (human), top 26 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| sodium arsenite | increases abundance, increases expression, decreases expression | 3 |
| entinostat | decreases expression, affects cotreatment | 2 |
| Valproic Acid | decreases expression, decreases methylation | 2 |
| Cyclosporine | increases expression, increases methylation | 2 |
| Cadmium Chloride | decreases expression, increases expression | 2 |
| aristolochic acid I | decreases expression | 1 |
| TAK-243 | increases sumoylation | 1 |
| triphenyl phosphate | affects expression | 1 |
| cobaltous chloride | decreases expression | 1 |
| manganese chloride | increases abundance, increases expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| K 7174 | increases expression | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | affects cotreatment, decreases expression | 1 |
| ICG 001 | increases expression | 1 |
| dorsomorphin | affects cotreatment, decreases expression | 1 |
| 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid | increases expression | 1 |
| Sunitinib | increases expression | 1 |
| Arsenic | increases abundance, increases expression | 1 |
| Atrazine | decreases expression | 1 |
| Benzo(a)pyrene | decreases methylation | 1 |
| Diethylstilbestrol | decreases expression | 1 |
| Doxorubicin | decreases expression | 1 |
| Manganese | increases abundance, increases expression | 1 |
| Tretinoin | decreases expression | 1 |
| Triiodothyronine | increases expression | 1 |
| Antirheumatic Agents | increases expression | 1 |
Cellosaurus cell lines
1 cell lines: 1 transformed cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_HD38 | HEK293 eGFP-ZNF664 | Transformed cell line | Female |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): familial clubfoot with or without associated lower limb anomalies