ZNF670

Summary

ZNF670 (zinc finger protein 670, HGNC:28167) is a protein-coding gene on chromosome 1q44, encoding Zinc finger protein 670 (Q9BS34). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lipid metabolic process. Predicted to be active in nucleus.

Source: NCBI Gene 93474 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_033213

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28167
Approved symbol	ZNF670
Name	zinc finger protein 670
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	MGC12466
Ensembl gene	ENSG00000277462
Ensembl biotype	protein_coding
Entrez	93474

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000366503, ENST00000908465, ENST00000908466

RefSeq mRNA: 2 — MANE Select: NM_033213 NM_001204220, NM_033213

CCDS: CCDS31087

Canonical transcript exons

ENST00000366503 — 4 exons

Exon	Start	End
ENSE00000961401	247034637	247038427
ENSE00001441870	247078594	247078811
ENSE00002344844	247038810	247038870
ENSE00002373108	247039411	247039537

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 82.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.5911 / max 68.3181, expressed in 1351 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18498	3.5911	1351
18499	0.8772	520

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	82.37	gold quality
sperm	CL:0000019	81.27	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.86	gold quality
secondary oocyte	CL:0000655	78.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.63	gold quality
ganglionic eminence	UBERON:0004023	78.52	gold quality
ventricular zone	UBERON:0003053	74.70	gold quality
Brodmann (1909) area 23	UBERON:0013554	72.29	gold quality
germinal epithelium of ovary	UBERON:0001304	71.30	gold quality
middle temporal gyrus	UBERON:0002771	71.24	silver quality
islet of Langerhans	UBERON:0000006	70.83	gold quality
stromal cell of endometrium	CL:0002255	69.44	gold quality
smooth muscle tissue	UBERON:0001135	68.30	gold quality
primary visual cortex	UBERON:0002436	67.99	gold quality
cerebellar cortex	UBERON:0002129	67.69	gold quality
cerebellum	UBERON:0002037	67.63	gold quality
cerebellar hemisphere	UBERON:0002245	67.57	gold quality
epithelial cell of pancreas	CL:0000083	66.89	gold quality
oocyte	CL:0000023	66.51	silver quality
cartilage tissue	UBERON:0002418	66.40	gold quality
palpebral conjunctiva	UBERON:0001812	66.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.90	gold quality
occipital lobe	UBERON:0002021	65.51	gold quality
body of uterus	UBERON:0009853	65.37	gold quality
prefrontal cortex	UBERON:0000451	65.24	gold quality
lymph node	UBERON:0000029	64.82	gold quality
rectum	UBERON:0001052	64.74	gold quality
gall bladder	UBERON:0002110	64.73	gold quality
pancreas	UBERON:0001264	64.65	gold quality
endometrium	UBERON:0001295	64.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.29

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

105 targeting ZNF670, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-153-5P	99.89	73.86	6317
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-3941	99.86	70.54	2735
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514

Cross-species orthologs

0 orthologs

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391)

Protein

Protein identifiers

Zinc finger protein 670 — Q9BS34 (reviewed: Q9BS34)

All UniProt accessions (1): Q9BS34

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001191149, NP_149990* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (12 total): zinc finger region 9, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BS34-F1	68.20	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 281

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 53 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP, GOBP_LIPID_METABOLIC_PROCESS, chr1q44, GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, JOHNSTONE_PARVB_TARGETS_3_DN, WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, PCGF1_TARGET_GENES, SNIP1_TARGET_GENES, ZNF350_TARGET_GENES, ZNF597_TARGET_GENES

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), lipid metabolic process (GO:0006629), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
primary metabolic process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

224 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF670	TBC1D3G	Q6DHY5	474
ZNF670	SH3BP5L	Q7L8J4	398
ZNF670	TBC1D3H	P0C7X1	348
ZNF670	PIGW	Q7Z7B1	316
ZNF670	TBC1D3D	A0A087WVF3	305
ZNF670	ZNHIT3	Q15649	305
ZNF670	DDX52	Q9Y2R4	297
ZNF670	TADA2A	O75478	295
ZNF670	STRN3	Q13033	288
ZNF670	PAFAH1B3	Q15102	285
ZNF670	LRRC8C	Q8TDW0	272
ZNF670	TFB2M	Q9H5Q4	258
ZNF670	PTGDS	P41222	257
ZNF670	A0A087WT91	A0A087WT91	248
ZNF670	C17orf78	Q8N4C9	244

IntAct

91 interactions, top by confidence:

A	B	Type	Score
ZNF670	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.720
ZNF670	TRIM41	psi-mi:“MI:0915”(physical association)	0.720
ZNF670	OPTN	psi-mi:“MI:0915”(physical association)	0.720
TRIM41	ZNF670	psi-mi:“MI:0915”(physical association)	0.720
OPTN	ZNF670	psi-mi:“MI:0915”(physical association)	0.720
CCNDBP1	ZNF670	psi-mi:“MI:0915”(physical association)	0.720
ZNF670	MDFI	psi-mi:“MI:0915”(physical association)	0.700
MDFI	ZNF670	psi-mi:“MI:0915”(physical association)	0.700
CSNK2A2	ZNF670	psi-mi:“MI:0915”(physical association)	0.670
KRTAP10-5	ZNF670	psi-mi:“MI:0915”(physical association)	0.560
ZNF670	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
ZNF670	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
TSGA10	ZNF670	psi-mi:“MI:0915”(physical association)	0.560
	ZNF670	psi-mi:“MI:0915”(physical association)	0.560
ZNF670	KRTAP10-5	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF670	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF670	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (32): ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-5 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Proximity Label-MS), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid), ZNF670 (Two-hybrid)

ESM2 similar proteins: A1L1L7, A2VDP4, A6NHJ4, D3ZVT0, E9PW05, O60765, P08042, P17014, P18723, P52738, P85977, Q02975, Q06730, Q0VGE8, Q2KI58, Q2M3W8, Q2TL60, Q2VY69, Q3MIS6, Q4V8A8, Q5R4K8, Q5VIY5, Q61751, Q61967, Q6GQR8, Q6P2D0, Q6PF04, Q7L2R6, Q7Z3I7, Q86Y25, Q8BFS8, Q8BQC8, Q8BZ89, Q8N184, Q8N782, Q8N823, Q8N8J6, Q8R1D1, Q8TF47, Q8WTR7

Diamond homologs: A0JPK3, A2RRD8, A2VDQ7, A3KN32, A8MUZ8, A8MWA4, C9JN71, E9QAG8, O60384, O60765, O75820, P0CH99, P0CI00, P10076, P10755, P15621, P16374, P16415, P17017, P17024, P51523, P52737, P52740, Q06730, Q06732, Q08AG5, Q0D2J5, Q13106, Q13360, Q15928, Q15935, Q15973, Q32M78, Q3KP31, Q4R4C7, Q4R6J4, Q4R882, Q5R9F0, Q5RC79, Q5REI6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 32 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
DNA damage response	6	11.5×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

648 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247038425:CTG:C	acceptor_gain	1.0000
1:247038805:ATTAC:A	donor_loss	1.0000
1:247038806:TTACC:T	donor_loss	1.0000
1:247038807:TACC:T	donor_loss	1.0000
1:247038808:ACCT:A	donor_loss	1.0000
1:247038809:C:CT	donor_loss	1.0000
1:247038868:TTC:T	acceptor_gain	1.0000
1:247038869:TC:T	acceptor_gain	1.0000
1:247038869:TCCTA:T	acceptor_loss	1.0000
1:247038870:CC:C	acceptor_gain	1.0000
1:247038870:CCTAA:C	acceptor_loss	1.0000
1:247038871:C:CC	acceptor_gain	1.0000
1:247038871:CTAAA:C	acceptor_loss	1.0000
1:247038872:T:C	acceptor_loss	1.0000
1:247038878:G:C	acceptor_gain	1.0000
1:247038878:G:GC	acceptor_gain	1.0000
1:247039405:TCTTA:T	donor_loss	1.0000
1:247039406:CTTA:C	donor_loss	1.0000
1:247039407:TTAC:T	donor_loss	1.0000
1:247039408:TA:T	donor_loss	1.0000
1:247039410:C:A	donor_loss	1.0000
1:247039410:CCTA:C	donor_gain	1.0000
1:247039547:C:CT	acceptor_gain	1.0000
1:247039551:CATA:C	acceptor_gain	1.0000
1:247039552:A:C	acceptor_gain	1.0000
1:247039554:A:C	acceptor_gain	1.0000
1:247078591:CACC:C	donor_loss	1.0000
1:247038423:GACTG:G	acceptor_gain	0.9900
1:247038426:TG:T	acceptor_gain	0.9900
1:247038428:C:CC	acceptor_gain	0.9900

AlphaMissense

2594 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247037833:G:C	F262L	0.996
1:247037833:G:T	F262L	0.996
1:247037835:A:G	F262L	0.996
1:247037917:G:C	F234L	0.993
1:247037917:G:T	F234L	0.993
1:247037919:A:G	F234L	0.993
1:247037749:A:C	F290L	0.992
1:247037749:A:T	F290L	0.992
1:247037751:A:G	F290L	0.992
1:247037665:G:C	F318L	0.990
1:247037665:G:T	F318L	0.990
1:247037667:A:G	F318L	0.990
1:247037581:A:C	F346L	0.989
1:247037581:A:T	F346L	0.989
1:247037583:A:G	F346L	0.989
1:247038001:G:C	F206L	0.989
1:247038001:G:T	F206L	0.989
1:247038003:A:G	F206L	0.989
1:247037497:G:C	F374L	0.986
1:247037497:G:T	F374L	0.986
1:247037499:A:G	F374L	0.986
1:247037828:C:G	R264P	0.986
1:247037878:A:C	H247Q	0.983
1:247037878:A:T	H247Q	0.983
1:247037962:A:C	H219Q	0.983
1:247037962:A:T	H219Q	0.983
1:247037834:A:G	F262S	0.979
1:247037890:A:C	H243Q	0.976
1:247037890:A:T	H243Q	0.976
1:247037900:A:G	L240P	0.976

dbSNP variants (sampled 300 via entrez): RS1000024522 (1:247036897 C>A), RS1000025141 (1:247073649 A>T), RS1000083209 (1:247041219 G>T), RS1000085854 (1:247078928 G>A), RS1000220611 (1:247047573 G>C), RS1000268047 (1:247078775 G>A), RS1000369684 (1:247050006 T>A,C), RS1000380833 (1:247071864 T>TC), RS1000429722 (1:247064623 T>G), RS1000443679 (1:247050357 T>C), RS1000558391 (1:247054006 T>C,G), RS1000639158 (1:247066492 G>A), RS1000692248 (1:247042471 T>C,G), RS1000704246 (1:247048555 G>A), RS1000759629 (1:247064916 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001692_1	Response to taxane treatment (docetaxel)	2.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases abundance, increases palmitoylation, increases expression, decreases reaction	3
methylmercuric chloride	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
bisphenol A	decreases expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
avobenzone	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
jinfukang	decreases expression, affects cotreatment	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Arbutin	increases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cisplatin	affects cotreatment, decreases expression	1
Dinitrofluorobenzene	increases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Oxazolone	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Aflatoxin M1	decreases expression	1
Copper Sulfate	increases expression	1
S-Nitrosoglutathione	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW75	HEK293 eGFP-ZNF670	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.