ZNF671

Summary

ZNF671 (zinc finger protein 671, HGNC:26279) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 671 (Q8TAW3). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 79891 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 78 total
• MANE Select transcript: NM_024833

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26279
Approved symbol	ZNF671
Name	zinc finger protein 671
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	FLJ23506
Ensembl gene	ENSG00000083814
Ensembl biotype	protein_coding
Entrez	79891

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000317398, ENST00000594803, ENST00000596939, ENST00000599961, ENST00000600125, ENST00000601584, ENST00000910306, ENST00000925804

RefSeq mRNA: 3 — MANE Select: NM_024833 NM_001321375, NM_001321376, NM_024833

CCDS: CCDS12961

Canonical transcript exons

ENST00000317398 — 4 exons

Exon	Start	End
ENSE00003064423	57727391	57727624
ENSE00003479369	57719751	57721697
ENSE00003680923	57723214	57723340
ENSE00003718867	57722316	57722438

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 86.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.1457 / max 69.9185, expressed in 1338 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182912	3.7617	1298
182913	0.3840	195

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	86.76	gold quality
cerebellar cortex	UBERON:0002129	86.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.26	gold quality
cortical plate	UBERON:0005343	85.45	gold quality
cerebellum	UBERON:0002037	85.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.07	gold quality
ganglionic eminence	UBERON:0004023	84.95	gold quality
apex of heart	UBERON:0002098	84.93	gold quality
ventricular zone	UBERON:0003053	82.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.26	gold quality
granulocyte	CL:0000094	81.90	gold quality
spleen	UBERON:0002106	81.25	gold quality
right lobe of thyroid gland	UBERON:0001119	80.76	gold quality
adenohypophysis	UBERON:0002196	80.23	gold quality
left lobe of thyroid gland	UBERON:0001120	79.54	gold quality
right adrenal gland	UBERON:0001233	79.16	gold quality
pituitary gland	UBERON:0000007	78.92	gold quality
right adrenal gland cortex	UBERON:0035827	78.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.80	gold quality
lower esophagus	UBERON:0013473	78.74	gold quality
thyroid gland	UBERON:0002046	78.53	gold quality
left adrenal gland cortex	UBERON:0035825	78.29	gold quality
left adrenal gland	UBERON:0001234	78.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	78.12	gold quality
gastrocnemius	UBERON:0001388	77.90	gold quality
leukocyte	CL:0000738	77.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	77.87	gold quality
lymph node	UBERON:0000029	77.73	gold quality
muscle of leg	UBERON:0001383	77.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.68	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6386	no	123.68
E-ANND-3	no	3.40

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
CDKN2A

miRNA regulators (miRDB)

32 targeting ZNF671, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-3679-3P	99.64	69.88	1599
HSA-MIR-4753-5P	99.54	68.51	1356
HSA-MIR-5007-3P	99.51	68.14	1242
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-6738-3P	99.03	67.14	1326
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-3074-5P	98.82	66.56	1414
HSA-MIR-4656	98.79	66.22	1306
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-5581-3P	98.55	70.31	1161
HSA-MIR-6881-5P	98.16	67.38	665
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-4669	97.94	62.71	224
HSA-MIR-4675	97.69	64.82	774
HSA-MIR-3620-5P	97.42	63.95	792
HSA-MIR-4286	97.20	64.37	1587
HSA-MIR-3667-5P	97.16	64.87	591
HSA-MIR-6872-3P	97.08	66.99	750

Literature-anchored findings (GeneRIF, showing 6)

• Data show that ZNF671, an epigenetically silenced tumor suppressor, represents a potential predictor for urothelial carcinoma (UC) relapse and non-invasive biomarker that could assist in UC clinical decision-making. (PMID:26320192)
• In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes. (PMID:28716111)
• Data show that mRNA and protein expression of ZNF671 are down-regulated in nasopharyngeal cancer (NPC) tissues and cell lines. Its downregulation promotes NPC cell proliferation and tumorigenicity by facilitating cell cycle progression. These results suggest that ZNF671 is a potential tumor suppressor which epigenetically silenced by promoter methylation in NPC. (PMID:29052525)
• ZNF671 functions as a tumor suppressor in ovarian cancer. (PMID:30633424)
• Zinc finger protein 671 has a cancer-inhibiting function in colorectal carcinoma via the deactivation of Notch signaling. (PMID:36436566)
• Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma. (PMID:37215982)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf574	ENSDARG00000087074
drosophila_melanogaster	CG11902	FBGN0028647
drosophila_melanogaster	CG11696	FBGN0030314
drosophila_melanogaster	CG10631	FBGN0032817

Paralogs (7): ZNF710 (ENSG00000140548), ZNF212 (ENSG00000170260), ZNF366 (ENSG00000178175), ZNF662 (ENSG00000182983), ZNF667 (ENSG00000198046), ZNF783 (ENSG00000204946), ZNF865 (ENSG00000261221)

Protein

Protein identifiers

Zinc finger protein 671 — Q8TAW3 (reviewed: Q8TAW3)

All UniProt accessions (3): Q8TAW3, M0QX87, M0R091

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (3): NP_001308304, NP_001308305, NP_079109* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (14 total): zinc finger region 10, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TAW3-F1	63.43	0.25

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 51 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP, CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, HATADA_METHYLATED_IN_LUNG_CANCER_UP, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN, VERHAAK_GLIOBLASTOMA_CLASSICAL, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, NOTCH_DN.V1_UP, KRAS.600.LUNG.BREAST_UP.V1_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, TRIP13_TARGET_GENES, ZNF282_TARGET_GENES, GSE10325_CD4_TCELL_VS_LUPUS_CD4_TCELL_UP, GSE10325_BCELL_VS_LUPUS_BCELL_UP

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of DNA-templated transcription (GO:0045892), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	3
DNA-templated transcription	2
transcription by RNA polymerase II	1
negative regulation of RNA biosynthetic process	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

492 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF671	RXFP3	Q9NSD7	607
ZNF671	ASTN1	O14525	582
ZNF671	TAFA4	Q96LR4	479
ZNF671	FAM78A	Q5JUQ0	479
ZNF671	TTLL12	Q14166	457
ZNF671	DLX1	P56177	445
ZNF671	ZNF395	Q9H8N7	426
ZNF671	RIMS4	Q9H426	419
ZNF671	ALKAL1	Q6UXT8	418
ZNF671	PCDHAC1	Q9H158	399
ZNF671	PRAC1	Q96KF2	395
ZNF671	SHISA3	A0PJX4	393
ZNF671	ANKRD13B	Q86YJ7	393
ZNF671	RUBCNL	Q9H714	392
ZNF671	CCDC134	Q9H6E4	386

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ZNF671	MAPK6	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (4): ZNF671 (Two-hybrid), ZNF671 (Affinity Capture-RNA), ZNF671 (Cross-Linking-MS (XL-MS)), ZNF671 (Two-hybrid)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A1YF12, A1YG88, A2T759, B2RUI1, D3ZVT0, O43296, P0CG31, P10072, P17020, P17097, P51814, Q08ER8, Q13398, Q14590, Q3KQV3, Q3SY52, Q4V8A8, Q571J5, Q5CZA5, Q5RBX0, Q5RCD9, Q5RCX4, Q61116, Q61967, Q68DY9, Q6NX49, Q6PK81, Q80YP6, Q86UD4, Q8BFS8, Q8BV42, Q8IVP9, Q8IZ26, Q8NEK5, Q8TAU3, Q8TAW3, Q8TF47, Q8WTR7

Diamond homologs: A6NFI3, A6NM28, A6QLU5, A7MBI1, A8MQ14, B4DU55, O43296, O75290, O75467, O95125, O95780, P0C7X2, P0DKX0, P15622, P17014, P17023, P17031, P17032, P17097, P21506, P51508, P51523, P51814, P52736, P52738, Q02525, Q06730, Q06732, Q08DG8, Q08ER8, Q14586, Q14929, Q16587, Q29RZ4, Q2M3X9, Q3ZCX4, Q49AA0, Q4V8A8, Q5CZA5, Q5FWF6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

78 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	72
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

773 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57723208:CCTTA:C	donor_loss	1.0000
19:57723209:CTTAC:C	donor_loss	1.0000
19:57723210:TTA:T	donor_loss	1.0000
19:57723211:TAC:T	donor_loss	1.0000
19:57723212:A:AC	donor_gain	1.0000
19:57723212:AC:A	donor_gain	1.0000
19:57723213:C:CC	donor_gain	1.0000
19:57723213:CC:C	donor_gain	1.0000
19:57723336:CAGCC:C	acceptor_gain	1.0000
19:57723337:AGCC:A	acceptor_gain	1.0000
19:57723338:GCC:G	acceptor_gain	1.0000
19:57723338:GCCC:G	acceptor_loss	1.0000
19:57723339:CC:C	acceptor_gain	1.0000
19:57723339:CCC:C	acceptor_gain	1.0000
19:57723339:CCCT:C	acceptor_loss	1.0000
19:57723340:CC:C	acceptor_gain	1.0000
19:57723341:C:CC	acceptor_gain	1.0000
19:57723341:CTGC:C	acceptor_loss	1.0000
19:57723342:T:A	acceptor_loss	1.0000
19:57722311:CTCA:C	donor_loss	0.9900
19:57722312:TCACC:T	donor_loss	0.9900
19:57722313:CACCA:C	donor_loss	0.9900
19:57722314:A:T	donor_loss	0.9900
19:57722436:TTC:T	acceptor_gain	0.9900
19:57722439:C:CC	acceptor_gain	0.9900
19:57723207:ACCTT:A	donor_loss	0.9900
19:57723213:CCCA:C	donor_gain	0.9900
19:57723341:C:T	acceptor_gain	0.9900
19:57723345:A:T	acceptor_gain	0.9900
19:57723347:C:CT	acceptor_gain	0.9900

AlphaMissense

3535 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57720706:G:C	F460L	0.999
19:57720706:G:T	F460L	0.999
19:57720708:A:G	F460L	0.999
19:57720784:A:C	F434L	0.999
19:57720784:A:T	F434L	0.999
19:57720786:A:G	F434L	0.999
19:57720538:G:C	F516L	0.998
19:57720538:G:T	F516L	0.998
19:57720540:A:G	F516L	0.998
19:57720622:G:C	F488L	0.998
19:57720622:G:T	F488L	0.998
19:57720624:A:G	F488L	0.998
19:57720868:G:C	F406L	0.998
19:57720868:G:T	F406L	0.998
19:57720870:A:G	F406L	0.998
19:57720767:A:G	L440P	0.997
19:57720836:C:G	R417P	0.997
19:57720605:A:G	L494P	0.996
19:57721204:G:C	F294L	0.996
19:57721204:G:T	F294L	0.996
19:57721206:A:G	F294L	0.996
19:57720679:G:C	H469Q	0.995
19:57720679:G:T	H469Q	0.995
19:57720689:A:G	L466P	0.995
19:57720785:A:G	F434S	0.995
19:57720935:A:G	L384P	0.995
19:57720539:A:G	F516S	0.994
19:57721019:A:G	L356P	0.994
19:57723259:A:C	Y74D	0.994
19:57720595:G:C	H497Q	0.993

dbSNP variants (sampled 300 via entrez): RS1000261499 (19:57725576 C>G,T), RS1000287748 (19:57723726 C>A,G,T), RS1000663031 (19:57720411 C>G,T), RS1000798392 (19:57720122 A>G), RS1001343179 (19:57724824 C>T), RS1002004554 (19:57721508 A>G), RS1002029518 (19:57726374 AATCAG>A), RS1002039484 (19:57728428 A>G), RS1002531634 (19:57726248 GGAGGTA>G), RS1002711684 (19:57725525 G>A,T), RS1002800399 (19:57723514 CCCA>C), RS1003171436 (19:57720591 T>A,C,G), RS1003325868 (19:57727430 G>A,T), RS1003717254 (19:57726904 T>C), RS1004033434 (19:57729134 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	decreases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
N-((3,5-difluorophenyl)acetyl)alanyl-2-phenylglycine-1,1-dimethylethyl ester	affects expression, decreases reaction	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
terbufos	increases methylation	1
butyraldehyde	increases expression	1
potassium chromate(VI)	increases expression	1
maleic acid	increases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
MRK 003	decreases expression	1
Oxaliplatin	increases response to substance	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Decitabine	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Amphotericin B	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Cyclophosphamide	decreases expression	1
Fonofos	increases methylation	1
Ethyl Methanesulfonate	increases expression	1
Gentamicins	decreases expression	1
Methyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.