ZNF672

Summary

ZNF672 (zinc finger protein 672, HGNC:26179) is a protein-coding gene on chromosome 1q44, encoding Zinc finger protein 672 (Q499Z4). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Source: NCBI Gene 79894 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 106 total
• MANE Select transcript: NM_024836

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26179
Approved symbol	ZNF672
Name	zinc finger protein 672
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	FLJ22301
Ensembl gene	ENSG00000171161
Ensembl biotype	protein_coding
Entrez	79894

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 21 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000306562, ENST00000423362, ENST00000428515, ENST00000502697, ENST00000505503, ENST00000510904, ENST00000515369, ENST00000906130, ENST00000906131, ENST00000906132, ENST00000906133, ENST00000906134, ENST00000906135, ENST00000906136, ENST00000906137, ENST00000906138, ENST00000906139, ENST00000906140, ENST00000906141, ENST00000933825, ENST00000943081, ENST00000943082, ENST00000943083, ENST00000943084

RefSeq mRNA: 1 — MANE Select: NM_024836 NM_024836

CCDS: CCDS1638

Canonical transcript exons

ENST00000306562 — 4 exons

Exon	Start	End
ENSE00001169362	248847052	248849517
ENSE00001169681	248845566	248845662
ENSE00001169686	248844483	248844636
ENSE00001274553	248838224	248838551

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 92.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2930 / max 216.6662, expressed in 1814 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9656	9.1031	1729
9659	5.7705	1678
9658	2.9109	1402
9660	2.3182	1257
9657	1.1165	594
9661	1.0737	786

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	92.46	gold quality
gastrocnemius	UBERON:0001388	91.12	gold quality
muscle of leg	UBERON:0001383	90.50	gold quality
apex of heart	UBERON:0002098	90.26	gold quality
lower esophagus mucosa	UBERON:0035834	89.21	gold quality
granulocyte	CL:0000094	88.39	gold quality
heart left ventricle	UBERON:0002084	87.47	gold quality
mucosa of transverse colon	UBERON:0004991	87.44	gold quality
muscle organ	UBERON:0001630	87.43	gold quality
right atrium auricular region	UBERON:0006631	87.14	gold quality
cardiac ventricle	UBERON:0002082	87.08	gold quality
leukocyte	CL:0000738	86.18	gold quality
blood	UBERON:0000178	86.18	gold quality
monocyte	CL:0000576	86.14	gold quality
amniotic fluid	UBERON:0000173	86.06	gold quality
mononuclear cell	CL:0000842	85.97	gold quality
tendon of biceps brachii	UBERON:0008188	85.79	gold quality
cortical plate	UBERON:0005343	85.76	gold quality
right lobe of thyroid gland	UBERON:0001119	85.43	gold quality
right lobe of liver	UBERON:0001114	85.35	gold quality
lower esophagus	UBERON:0013473	85.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.28	gold quality
left lobe of thyroid gland	UBERON:0001120	85.19	gold quality
heart	UBERON:0000948	85.01	gold quality
esophagus squamous epithelium	UBERON:0006920	84.83	gold quality
ganglionic eminence	UBERON:0004023	84.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.64	gold quality
cardiac atrium	UBERON:0002081	84.55	gold quality
thyroid gland	UBERON:0002046	84.49	gold quality
esophagus	UBERON:0001043	84.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.21

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2587.1	ZNF672	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605368

miRNA regulators (miRDB)

27 targeting ZNF672, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6755-5P	99.95	65.59	464
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-940	99.37	66.14	2064
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-1253	99.12	67.08	1688
HSA-MIR-4434	99.10	67.01	1984
HSA-MIR-5703	99.10	67.09	2053
HSA-MIR-371A-5P	99.08	66.51	1914
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-6829-5P	98.86	65.12	1480
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-8089	97.74	66.21	1698
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-4667-5P	97.61	66.67	1683
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-4732-3P	97.15	65.45	881
HSA-MIR-10398-5P	97.12	64.94	1051
HSA-MIR-34A-3P	96.80	67.70	805
HSA-MIR-152-5P	96.42	66.59	960

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-14k9.3	ENSDARG00000045595
mus_musculus	Zfp672	ENSMUSG00000049755
rattus_norvegicus	Zfp672	ENSRNOG00000002713

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 672 — Q499Z4 (reviewed: Q499Z4)

All UniProt accessions (3): D6RD56, D6RH11, Q499Z4

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_079112* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13894

UniProt features (16 total): zinc finger region 14, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q499Z4-F1	76.42	0.26

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 73 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, APPIERTO_RESPONSE_TO_FENRETINIDE_UP, chr1q44, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GCM_USP6, WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, BARX1_TARGET_GENES, CEBPZ_TARGET_GENES, CIITA_TARGET_GENES, FEV_TARGET_GENES, ID1_TARGET_GENES

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

532 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF672	HAUS5	O94927	617
ZNF672	SPMIP3	Q5SVJ3	604
ZNF672	MYBPC2	Q14324	512
ZNF672	PGBD2	Q6P3X8	473
ZNF672	SH3BP5L	Q7L8J4	433
ZNF672	RAB4B	P22750	422
ZNF672	DESI2	Q9BSY9	418
ZNF672	RFX5	P48382	410
ZNF672	CCDC34	Q96HJ3	386
ZNF672	GALNT16	Q8N428	379
ZNF672	TP53TG3	Q9ULZ0	370
ZNF672	SNRNP48	Q6IEG0	369
ZNF672	CCSER1	Q9C0I3	344
ZNF672	DMRTA2	Q96SC8	333
ZNF672	CORO7	P57737	319

IntAct

18 interactions, top by confidence:

A	B	Type	Score
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
REPIN1	IPO8	psi-mi:“MI:0914”(association)	0.640
NOTCH2NLC	ZNF672	psi-mi:“MI:0915”(physical association)	0.560
ZNF672	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-6	ZNF672	psi-mi:“MI:0915”(physical association)	0.560
REPIN1	SET	psi-mi:“MI:0914”(association)	0.530
NOTCH2	ZNF316	psi-mi:“MI:0914”(association)	0.530
REPIN1		psi-mi:“MI:0914”(association)	0.350
REPIN1	POTEB	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
	NFIB	psi-mi:“MI:0914”(association)	0.350
ZNF672	NOTCH2NLC	psi-mi:“MI:0915”(physical association)	0.000
ZNF672	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.000
ZNF672	KRTAP10-6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (12): ZNF672 (Affinity Capture-RNA), ZNF672 (Affinity Capture-MS), KRTAP10-6 (Two-hybrid), KRTAP2-3 (Two-hybrid), KRTAP2-4 (Two-hybrid), NOTCH2NL (Two-hybrid), NBPF19 (Two-hybrid), ZNF672 (Affinity Capture-MS), ZNF672 (Affinity Capture-MS), ZNF672 (Affinity Capture-MS), ZNF672 (Affinity Capture-MS), ZNF672 (Proximity Label-MS)

ESM2 similar proteins: A3KN32, A6NFI3, A6NM28, A8K8V0, O75467, O95201, P10075, P28698, P30373, P52736, Q07230, Q0VCC5, Q14929, Q16587, Q17QR7, Q3TDE8, Q3US17, Q499Z4, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q642B2, Q68H95, Q6AW86, Q6DD87, Q6PGE4, Q6ZMY9, Q6ZNH5, Q7L3S4, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BJ90, Q8BKK5, Q8JZL0, Q8N393, Q8NCA9, Q96BV0

Diamond homologs: Q499Z4, Q642B2, Q99LH4, G5EFF4, O15391, O57415, O95125, O95863, P22227, P25490, P31509, Q00899, Q02026, Q02027, Q02085, Q22024, Q3B7M4, Q3TTC2, Q3UH06, Q3US17, Q504L7, Q7TSH3, Q8BI66, Q8ST83, Q8TF50, Q92618, Q92766, Q96MM3, Q99M85, Q9BV97, Q9BWW7, Q9ER74, Q9NSC2, Q9UDV6, Q6DCW1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

106 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	97
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

692 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248844627:G:GT	donor_gain	1.0000
1:248845555:ACT:A	acceptor_gain	1.0000
1:248845555:ACTG:A	acceptor_gain	1.0000
1:248845557:T:TA	acceptor_gain	1.0000
1:248845558:G:A	acceptor_gain	1.0000
1:248838535:G:GT	donor_gain	0.9900
1:248838538:G:GT	donor_gain	0.9900
1:248844631:G:GT	donor_gain	0.9900
1:248844632:A:T	donor_gain	0.9900
1:248845544:A:AG	acceptor_gain	0.9900
1:248845550:T:G	acceptor_gain	0.9900
1:248845555:A:AG	acceptor_gain	0.9900
1:248845555:ACTGG:A	acceptor_gain	0.9900
1:248845556:C:G	acceptor_gain	0.9900
1:248838368:A:T	donor_gain	0.9800
1:248838552:G:GG	donor_gain	0.9800
1:248838552:G:GA	donor_loss	0.9700
1:248838553:T:TC	donor_loss	0.9700
1:248844624:A:AG	donor_gain	0.9700
1:248844627:G:T	donor_gain	0.9700
1:248844628:A:T	donor_gain	0.9700
1:248845549:A:AG	acceptor_gain	0.9700
1:248838554:GAGGG:G	donor_loss	0.9600
1:248838827:GC:G	donor_gain	0.9600
1:248845545:C:G	acceptor_gain	0.9600
1:248845565:GCAC:G	acceptor_gain	0.9500
1:248838367:G:GT	donor_gain	0.9400
1:248842297:GTGCC:G	donor_gain	0.9400
1:248842298:TGCCT:T	donor_gain	0.9400
1:248839202:G:GT	donor_gain	0.9300

AlphaMissense

2917 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248848316:T:C	F348L	1.000
1:248848318:C:A	F348L	1.000
1:248848318:C:G	F348L	1.000
1:248848400:T:C	F376L	1.000
1:248848402:C:A	F376L	1.000
1:248848402:C:G	F376L	1.000
1:248847925:C:A	H217Q	0.999
1:248847925:C:G	H217Q	0.999
1:248847980:T:C	F236L	0.999
1:248847981:T:C	F236S	0.999
1:248847982:C:A	F236L	0.999
1:248847982:C:G	F236L	0.999
1:248848064:T:C	F264L	0.999
1:248848066:C:A	F264L	0.999
1:248848066:C:G	F264L	0.999
1:248848148:T:C	F292L	0.999
1:248848150:C:A	F292L	0.999
1:248848150:C:G	F292L	0.999
1:248848232:T:C	F320L	0.999
1:248848234:C:A	F320L	0.999
1:248848234:C:G	F320L	0.999
1:248848266:G:C	R331P	0.999
1:248848273:C:A	H333Q	0.999
1:248848273:C:G	H333Q	0.999
1:248848317:T:C	F348S	0.999
1:248847923:C:A	H217N	0.998
1:248847923:C:G	H217D	0.998
1:248847937:C:A	H221Q	0.998
1:248847937:C:G	H221Q	0.998
1:248848007:C:A	H245N	0.998

dbSNP variants (sampled 300 via entrez): RS1000038682 (1:248841069 T>C), RS1000358394 (1:248849310 C>T), RS1000967767 (1:248844109 A>G), RS1001336152 (1:248840981 T>C), RS1001429295 (1:248841762 A>G), RS1001452097 (1:248847153 C>T), RS1001940995 (1:248841528 C>A), RS1002236097 (1:248845361 G>T), RS1002545474 (1:248842979 C>A,T), RS1002616199 (1:248849160 G>C), RS1003009908 (1:248842304 A>C,G), RS1003592623 (1:248837943 G>C), RS1003796626 (1:248836640 T>C), RS1004079650 (1:248837000 A>G), RS1004174850 (1:248843195 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009560_3	Decreased low contrast letter acuity in multiple sclerosis	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008385	visual acuity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	decreases expression	2
GSK-J4	decreases expression	1
FR900359	decreases phosphorylation	1
TAK-243	increases sumoylation	1
bisphenol A	decreases methylation	1
dimethylselenide	increases expression, increases oxidation	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	affects expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
diallyl trisulfide	increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Ethanol	affects cotreatment, decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Cisplatin	increases expression	1
Demecolcine	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.