ZNF674-AS1

Summary

ZNF674-AS1 (ZNF674 antisense RNA 1, HGNC:44266) is a long non-coding RNA gene on chromosome Xp11.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44266
Approved symbol	ZNF674-AS1
Name	ZNF674 antisense RNA 1
Location	Xp11.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230844
Ensembl biotype	lncRNA
Entrez	401588
RNAcentral	URS000075D439 — lncRNA, 2148 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000421685, ENST00000609887, ENST00000657382, ENST00000838386, ENST00000838387, ENST00000838388, ENST00000838389, ENST00000838390, ENST00000838391, ENST00000838392, ENST00000838393, ENST00000838394, ENST00000838396, ENST00000838397, ENST00000838398, ENST00000838399, ENST00000838400, ENST00000838401, ENST00000838402, ENST00000838403, ENST00000838404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421685 — 2 exons

Exon	Start	End
ENSE00001666404	46545493	46545627
ENSE00001688866	46546466	46548408

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 91.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8674 / max 67.7696, expressed in 1540 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196122	2.4828	1361
196123	1.0246	545
196121	0.3599	125

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	91.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.32	gold quality
oviduct epithelium	UBERON:0004804	83.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.95	gold quality
adenohypophysis	UBERON:0002196	77.40	gold quality
islet of Langerhans	UBERON:0000006	75.57	gold quality
pituitary gland	UBERON:0000007	75.54	gold quality
monocyte	CL:0000576	74.64	gold quality
ganglionic eminence	UBERON:0004023	74.41	gold quality
leukocyte	CL:0000738	73.94	gold quality
left ovary	UBERON:0002119	73.74	gold quality
cortical plate	UBERON:0005343	73.53	gold quality
gastrocnemius	UBERON:0001388	73.19	gold quality
left lobe of thyroid gland	UBERON:0001120	73.16	gold quality
right ovary	UBERON:0002118	72.95	gold quality
cerebellar hemisphere	UBERON:0002245	72.66	gold quality
muscle of leg	UBERON:0001383	72.59	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.58	gold quality
cerebellar cortex	UBERON:0002129	72.51	gold quality
thyroid gland	UBERON:0002046	72.47	gold quality
body of uterus	UBERON:0009853	72.19	gold quality
right lobe of thyroid gland	UBERON:0001119	72.06	gold quality
epithelial cell of pancreas	CL:0000083	71.84	gold quality
bone marrow cell	CL:0002092	71.75	silver quality
tibial artery	UBERON:0007610	71.75	gold quality
popliteal artery	UBERON:0002250	71.73	gold quality
smooth muscle tissue	UBERON:0001135	71.72	gold quality
fallopian tube	UBERON:0003889	71.65	gold quality
stromal cell of endometrium	CL:0002255	71.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• data suggest that ZNF674-AS1 may play some role during cancer occurrence and progression and may be a new biomarker for Human Hepatocellular Carcinoma. (PMID:27896271)
• ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells. (PMID:33618674)
• Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7. (PMID:35802620)
• LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma. (PMID:38177154)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.