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ZNF679

gene
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Also known as MGC42415

Summary

ZNF679 (zinc finger protein 679, HGNC:28650) is a protein-coding gene on chromosome 7q11.21, encoding Zinc finger protein 679 (Q8IYX0). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 168417 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 77 total
  • MANE Select transcript: NM_153363

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:28650
Approved symbolZNF679
Namezinc finger protein 679
Location7q11.21
Locus typegene with protein product
StatusApproved
AliasesMGC42415
Ensembl geneENSG00000197123
Ensembl biotypeprotein_coding
Entrez168417

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000255746, ENST00000421025

RefSeq mRNA: 1 — MANE Select: NM_153363 NM_153363

CCDS: CCDS47592

Canonical transcript exons

ENST00000421025 — 5 exons

ExonStartEnd
ENSE000014809466424902864249156
ENSE000016348386422847464228652
ENSE000016374706426589664266931
ENSE000025047336426022164260347
ENSE000025163466426083464260929

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 79.64.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047379.64gold quality
right testisUBERON:000453448.93gold quality
testisUBERON:000047348.54gold quality
left testisUBERON:000453347.61gold quality
sural nerveUBERON:001548845.39gold quality
ventricular zoneUBERON:000305340.47silver quality
colonic epitheliumUBERON:000039737.20gold quality
cortical plateUBERON:000534336.47gold quality
bone marrow cellCL:000209236.16gold quality
skeletal muscle tissueUBERON:000113433.38gold quality
right uterine tubeUBERON:000130233.20gold quality
hindlimb stylopod muscleUBERON:000425232.15gold quality
bone marrowUBERON:000237131.74gold quality
muscle tissueUBERON:000238531.06gold quality
monocyteCL:000057630.33gold quality
leukocyteCL:000073830.08gold quality
stromal cell of endometriumCL:000225529.87gold quality
prefrontal cortexUBERON:000045129.71gold quality
liverUBERON:000210729.63gold quality
tonsilUBERON:000237229.20gold quality
lymph nodeUBERON:000002928.67gold quality
duodenumUBERON:000211428.14gold quality
urinary bladderUBERON:000125527.81silver quality
cortex of kidneyUBERON:000122527.58gold quality
bloodUBERON:000017826.66gold quality
vermiform appendixUBERON:000115426.42gold quality
gall bladderUBERON:000211025.98gold quality
olfactory segment of nasal mucosaUBERON:000538625.89gold quality
placentaUBERON:000198725.81gold quality
muscle of legUBERON:000138325.67gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes2.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 679 — Q8IYX0 (reviewed: Q8IYX0)

All UniProt accessions (1): Q8IYX0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_699194* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001909KRABDomain
IPR013087Znf_C2H2_typeDomain
IPR036051KRAB_dom_sfHomologous_superfamily
IPR036236Znf_C2H2_sfHomologous_superfamily
IPR050527

Pfam: PF00096, PF01352, PF13894

UniProt features (16 total): zinc finger region 9, sequence variant 4, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8IYX0-F170.410.37

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-212436Generic Transcription Pathway

MSigDB gene sets: 18 (showing top): chr7q11, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, GSE10240_CTRL_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN, NOTCH3_TARGET_GENES, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, PULVER_FOREY_PERTURB_ACCUMULATION_S, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, GSE32423_IL7_VS_IL7_IL4_MEMORY_CD8_TCELL_UP, GSE32423_IL7_VS_IL4_MEMORY_CD8_TCELL_UP, GSE369_SOCS3_KO_VS_IFNG_KO_LIVER_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE8621_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
RNA Polymerase II Transcription1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
transition metal ion binding1
nucleic acid binding1
binding1
cation binding1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

164 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF679OR52E4Q8NGH9535
ZNF679TRIM60Q495X7499
ZNF679SPIDRQ14159455
ZNF679FNTAP49354425
ZNF679HGSNATQ68CP4425
ZNF679HOOK3Q86VS8418
ZNF679POMKQ9H5K3373
ZNF679MCM4P33991372
ZNF679LRFN1Q9P244370
ZNF679SIPA1L2Q9P2F8370
ZNF679MAP1SQ66K74364
ZNF679UBE3AP78355362
ZNF679DHFRP00374361
ZNF679PRKDCP78527353
ZNF679DHFR2Q86XF0352
ZNF679BPY2O14599352

IntAct

19 interactions, top by confidence:

ABTypeScore
ZNF679MDFIpsi-mi:“MI:0915”(physical association)0.670
MDFIZNF679psi-mi:“MI:0915”(physical association)0.670
ZNF679KRTAP10-5psi-mi:“MI:0915”(physical association)0.560
ZNF679psi-mi:“MI:0915”(physical association)0.560
KRTAP10-5ZNF679psi-mi:“MI:0915”(physical association)0.560
ZNF679psi-mi:“MI:0915”(physical association)0.560
KRTAP10-6ZNF679psi-mi:“MI:0915”(physical association)0.560
ZNF679LXNpsi-mi:“MI:0915”(physical association)0.560
ZNF679TP53psi-mi:“MI:0915”(physical association)0.370
INSRBLTP3Bpsi-mi:“MI:0914”(association)0.350
ZNF679KRTAP10-6psi-mi:“MI:0915”(physical association)0.000
LXNZNF679psi-mi:“MI:0915”(physical association)0.000
ZNF679MDFIpsi-mi:“MI:0915”(physical association)0.000

BioGRID (8): KRTAP10-5 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF679 (Two-hybrid), ZNF679 (Two-hybrid), ZNF679 (Two-hybrid), ZNF679 (Two-hybrid), ZNF679 (Two-hybrid), ZNF679 (Positive Genetic)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance71
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

768 predictions. Top by Δscore:

VariantEffectΔscore
7:64260216:TTCA:Tacceptor_loss1.0000
7:64260219:AGG:Aacceptor_gain1.0000
7:64260220:G:Aacceptor_loss1.0000
7:64260220:GGG:Gacceptor_gain1.0000
7:64260344:CTGGG:Cdonor_loss1.0000
7:64260346:GG:Gdonor_gain1.0000
7:64260346:GGGT:Gdonor_loss1.0000
7:64260347:GG:Gdonor_gain1.0000
7:64260348:G:GAdonor_loss1.0000
7:64260349:T:Adonor_loss1.0000
7:64260824:A:AGacceptor_gain1.0000
7:64260826:T:Gacceptor_gain1.0000
7:64260827:A:AGacceptor_gain1.0000
7:64260828:A:Gacceptor_gain1.0000
7:64260831:CAGGT:Cacceptor_loss1.0000
7:64260832:A:ATacceptor_loss1.0000
7:64260833:GGT:Gacceptor_gain1.0000
7:64260927:CAGG:Cdonor_loss1.0000
7:64260928:AGGT:Adonor_loss1.0000
7:64260930:G:Tdonor_loss1.0000
7:64265893:CAGTT:Cacceptor_loss1.0000
7:64265894:A:AGacceptor_gain1.0000
7:64265895:G:GAacceptor_gain1.0000
7:64265895:GT:Gacceptor_gain1.0000
7:64265895:GTT:Gacceptor_gain1.0000
7:64265895:GTTA:Gacceptor_gain1.0000
7:64265895:GTTAT:Gacceptor_gain1.0000
7:64260219:A:AGacceptor_gain0.9900
7:64260219:AG:Aacceptor_gain0.9900
7:64260220:G:GAacceptor_gain0.9900

AlphaMissense

2727 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:64266462:T:CF277L0.992
7:64266464:T:AF277L0.992
7:64266464:T:GF277L0.992
7:64266378:T:CF249L0.989
7:64266380:T:AF249L0.989
7:64266380:T:GF249L0.989
7:64266546:T:CF305L0.986
7:64266548:T:AF305L0.986
7:64266548:T:GF305L0.986
7:64266630:T:CF333L0.986
7:64266632:T:AF333L0.986
7:64266632:T:GF333L0.986
7:64266714:T:CF361L0.985
7:64266716:T:AF361L0.985
7:64266716:T:GF361L0.985
7:64260254:T:CF25L0.977
7:64260256:C:AF25L0.977
7:64260256:C:GF25L0.977
7:64266469:G:CR279P0.967
7:64260255:T:CF25S0.961
7:64266798:T:CF389L0.959
7:64266800:T:AF389L0.959
7:64266800:T:GF389L0.959
7:64266565:T:CL311P0.952
7:64260271:G:CW30C0.949
7:64260271:G:TW30C0.949
7:64260233:T:CF18L0.947
7:64260235:C:AF18L0.947
7:64260235:C:GF18L0.947
7:64266587:T:AH318Q0.946

dbSNP variants (sampled 300 via entrez): RS1000008336 (7:64234018 G>C), RS1000123796 (7:64230771 T>C,G), RS1000186964 (7:64247083 C>T), RS1000296975 (7:64252642 T>C), RS1000372389 (7:64241572 T>A,C), RS1000508942 (7:64233747 T>C), RS1000518646 (7:64264685 G>T), RS1000695195 (7:64254305 T>G), RS1000700600 (7:64258949 T>C,G), RS1000752881 (7:64258515 A>G), RS1000785456 (7:64258724 T>C), RS1000789604 (7:64238989 C>T), RS1000841838 (7:64238793 G>A), RS1000879202 (7:64237399 C>T), RS1000973467 (7:64237125 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST000635_15Response to statin therapy8.000000e-06
GCST007843_11Rheumatoid arthritis1.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyrenedecreases methylation, increases expression2
bisphenol Aaffects cotreatment, increases methylation1
nickel sulfateincreases expression1
ICG 001decreases expression1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic aciddecreases expression1
Fulvestrantaffects cotreatment, increases methylation1
Arsenicincreases methylation1
Aflatoxin B1decreases methylation1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot