ZNF695

Summary

ZNF695 (zinc finger protein 695, HGNC:30954) is a protein-coding gene on chromosome 1q44, encoding Zinc finger protein 695 (Q8IW36). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 57116 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• MANE Select transcript: NM_020394

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30954
Approved symbol	ZNF695
Name	zinc finger protein 695
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	SBZF3
Ensembl gene	ENSG00000197472
Ensembl biotype	protein_coding
OMIM	616348
Entrez	57116

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 nonsense_mediated_decay, 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000339986, ENST00000366504, ENST00000479214, ENST00000487338, ENST00000491337, ENST00000498046

RefSeq mRNA: 2 — MANE Select: NM_020394 NM_001204221, NM_020394

CCDS: CCDS44344, CCDS55694

Canonical transcript exons

ENST00000339986 — 4 exons

Exon	Start	End
ENSE00001388176	246985323	246988255
ENSE00002129578	246999912	247000074
ENSE00003551699	246999348	246999440
ENSE00003843298	247007906	247008057

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 85.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2009 / max 104.1038, expressed in 1009 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18497	2.2602	823
18496	1.9407	707

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.07	gold quality
ganglionic eminence	UBERON:0004023	77.09	gold quality
ventricular zone	UBERON:0003053	74.85	gold quality
cortical plate	UBERON:0005343	73.83	gold quality
sural nerve	UBERON:0015488	69.78	gold quality
stromal cell of endometrium	CL:0002255	68.69	gold quality
mucosa of transverse colon	UBERON:0004991	67.42	gold quality
placenta	UBERON:0001987	65.44	gold quality
rectum	UBERON:0001052	62.31	gold quality
bone marrow	UBERON:0002371	62.02	gold quality
corpus callosum	UBERON:0002336	61.08	gold quality
duodenum	UBERON:0002114	59.50	gold quality
endometrium	UBERON:0001295	57.01	gold quality
testis	UBERON:0000473	56.97	gold quality
bone marrow cell	CL:0002092	55.79	silver quality
left testis	UBERON:0004533	55.67	gold quality
smooth muscle tissue	UBERON:0001135	55.15	gold quality
right testis	UBERON:0004534	54.35	gold quality
lymph node	UBERON:0000029	54.08	gold quality
vermiform appendix	UBERON:0001154	54.08	gold quality
islet of Langerhans	UBERON:0000006	54.05	gold quality
esophagus mucosa	UBERON:0002469	53.73	gold quality
superior frontal gyrus	UBERON:0002661	52.84	gold quality
blood	UBERON:0000178	52.44	gold quality
calcaneal tendon	UBERON:0003701	52.39	silver quality
colonic epithelium	UBERON:0000397	51.75	gold quality
tonsil	UBERON:0002372	51.06	gold quality
primary visual cortex	UBERON:0002436	51.03	gold quality
prefrontal cortex	UBERON:0000451	50.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

78 targeting ZNF695, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-520F-3P	99.82	71.32	1216
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-132-3P	99.73	70.56	1424
HSA-MIR-212-3P	99.73	70.65	1424
HSA-MIR-7161-5P	99.68	68.92	1592

Literature-anchored findings (GeneRIF, showing 2)

• ZNF695 methylation was associated with the response to definitive chemoradiotherapy in esophageal squamous cell carcinoma. (PMID:25273507)
• Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm. (PMID:36311753)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp738	ENSMUSG00000048280
mus_musculus	Zfp457	ENSMUSG00000055341
mus_musculus	Zfp595	ENSMUSG00000057842
mus_musculus	Zfp953	ENSMUSG00000098905
rattus_norvegicus	AABR07009105.1	ENSRNOG00000053325

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 695 — Q8IW36 (reviewed: Q8IW36)

Alternative names: Zinc finger protein SBZF3

All UniProt accessions (3): Q8IW36, F2Z3A3, F6W2C3

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8IW36-4	4	yes
Q8IW36-1	1
Q8IW36-2	2
Q8IW36-3	3

RefSeq proteins (2): NP_001191150, NP_065127* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (24 total): zinc finger region 13, splice variant 6, sequence variant 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IW36-F1	69.28	0.14

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 57 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, FISCHER_DREAM_TARGETS, chr1q44, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KOYAMA_SEMA3B_TARGETS_DN, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, PRC2_SUZ12_UP.V1_DN, IL2_UP.V1_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, CEBPZ_TARGET_GENES, HSD17B8_TARGET_GENES, LCORL_TARGET_GENES

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

464 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF695	FAM222B	Q8WU58	431
ZNF695	ZNF438	Q7Z4V0	409
ZNF695	KAT8	Q9H7Z6	395
ZNF695	TMEM225B	P0DP42	392
ZNF695	SPMIP3	Q5SVJ3	371
ZNF695	NKAPL	Q5M9Q1	370
ZNF695	TRMT10B	Q6PF06	339
ZNF695	C5orf22	Q49AR2	336
ZNF695	DESI2	Q9BSY9	327
ZNF695	TBC1D3G	Q6DHY5	325
ZNF695	PROSER2	Q86WR7	323
ZNF695	TCF24	Q7RTU0	313
ZNF695	GLCCI1	Q86VQ1	310
ZNF695	THUMPD2	Q9BTF0	310
ZNF695	PIMREG	Q9BSJ6	307

IntAct

10 interactions, top by confidence:

A	B	Type	Score
ZNF695	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	ZNF695	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF695	H2BC21	psi-mi:“MI:0915”(physical association)	0.400
ECE1	ZNF695	psi-mi:“MI:0915”(physical association)	0.370
ZNF695	PDCD5	psi-mi:“MI:0914”(association)	0.350
ZNF695	RTCA	psi-mi:“MI:0914”(association)	0.350
ZNF695	ZNF195	psi-mi:“MI:0914”(association)	0.350

BioGRID (33): ZNF695 (Two-hybrid), ZYG11A (Affinity Capture-MS), SAV1 (Affinity Capture-MS), TRIM24 (Affinity Capture-MS), HECTD1 (Affinity Capture-MS), STK3 (Affinity Capture-MS), TRIM28 (Affinity Capture-MS), ACTB (Affinity Capture-MS), TUBB3 (Affinity Capture-MS), STK4 (Affinity Capture-MS), TUBA1A (Affinity Capture-MS), ZNF695 (Two-hybrid), ZNF695 (Proximity Label-MS), ZNF695 (Affinity Capture-MS), ACTB (Affinity Capture-MS)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

624 predictions. Top by Δscore:

Variant	Effect	Δscore
1:246988251:CAAAA:C	acceptor_gain	1.0000
1:246988256:C:CC	acceptor_gain	1.0000
1:246999345:TAC:T	donor_loss	1.0000
1:246999346:ACCT:A	donor_loss	1.0000
1:246999347:CCTGA:C	donor_loss	1.0000
1:246999910:A:AC	donor_gain	1.0000
1:246999911:C:CC	donor_gain	1.0000
1:246988252:AAAA:A	acceptor_gain	0.9900
1:246988253:AAA:A	acceptor_gain	0.9900
1:246988254:AA:A	acceptor_gain	0.9900
1:246999440:CCTG:C	acceptor_loss	0.9900
1:246999441:C:CA	acceptor_loss	0.9900
1:246999442:T:A	acceptor_loss	0.9900
1:246999911:CT:C	donor_gain	0.9900
1:246999987:C:A	donor_gain	0.9900
1:247007901:CTCA:C	donor_loss	0.9900
1:247007902:TCA:T	donor_loss	0.9900
1:247007903:CAC:C	donor_loss	0.9900
1:247007904:ACCA:A	donor_loss	0.9900
1:247007905:C:G	donor_loss	0.9900
1:246999443:G:C	acceptor_loss	0.9800
1:247000075:C:A	acceptor_loss	0.9800
1:247007899:CACT:C	donor_loss	0.9800
1:247007900:ACTC:A	donor_loss	0.9800
1:246988254:AAC:A	acceptor_loss	0.9700
1:246988255:ACTGG:A	acceptor_loss	0.9700
1:246999441:C:CC	acceptor_gain	0.9700
1:247004750:TAACA:T	acceptor_gain	0.9700
1:246999446:T:TC	acceptor_gain	0.9600
1:246999986:T:TA	donor_gain	0.9600

AlphaMissense

3447 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:246987264:A:C	F417L	0.994
1:246987264:A:T	F417L	0.994
1:246987266:A:G	F417L	0.994
1:246987096:A:C	F473L	0.992
1:246987096:A:T	F473L	0.992
1:246987098:A:G	F473L	0.992
1:246987180:A:C	F445L	0.992
1:246987180:A:T	F445L	0.992
1:246987182:A:G	F445L	0.992
1:246987348:A:C	F389L	0.991
1:246987348:A:T	F389L	0.991
1:246987350:A:G	F389L	0.991
1:246987432:A:C	F361L	0.984
1:246987432:A:T	F361L	0.984
1:246987434:A:G	F361L	0.984
1:246987516:A:C	F333L	0.979
1:246987516:A:T	F333L	0.979
1:246987518:A:G	F333L	0.979
1:246987012:A:C	F501L	0.978
1:246987012:A:T	F501L	0.978
1:246987014:A:G	F501L	0.978
1:246987155:G:C	H454D	0.976
1:246987237:A:C	H426Q	0.975
1:246987237:A:T	H426Q	0.975
1:246987225:A:C	H430Q	0.974
1:246987225:A:T	H430Q	0.974
1:246987153:A:C	H454Q	0.973
1:246987153:A:T	H454Q	0.973
1:246987141:A:C	H458Q	0.970
1:246987141:A:T	H458Q	0.970

dbSNP variants (sampled 300 via entrez): RS1000020620 (1:246992688 T>A,C), RS1000027617 (1:246974943 C>G), RS1000086045 (1:246954757 A>T), RS1000117712 (1:246963696 C>T), RS1000136358 (1:246992415 G>A), RS1000170340 (1:246971461 T>A), RS1000187684 (1:247008294 G>A,C), RS1000190435 (1:246976923 A>C), RS1000284549 (1:246998619 A>G), RS1000331268 (1:246966209 T>C), RS1000433933 (1:246971588 C>A,T), RS1000622801 (1:247003105 T>C), RS1000639626 (1:246984188 A>C), RS1000668029 (1:246945749 G>A,C,T), RS1000704799 (1:246982653 G>A)

Disease associations

OMIM: gene MIM:616348 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST009391_357	Metabolite levels	3.000000e-06
GCST009391_362	Metabolite levels	2.000000e-06
GCST009391_904	Metabolite levels	7.000000e-07
GCST012490_273	Femur bone mineral density x serum urate levels interaction	3.000000e-09
GCST012490_296	Femur bone mineral density x serum urate levels interaction	8.000000e-10

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0010434	triacylglycerol 56:7 measurement
EFO:0010435	triacylglycerol 56:8 measurement
EFO:0010442	triacylglycerol 58:8 measurement
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Cadmium Chloride	decreases expression, increases expression	2
TAK-243	increases sumoylation	1
methylmercuric chloride	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	increases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	affects methylation	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
dorsomorphin	decreases expression, affects cotreatment	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	affects methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Methapyrilene	decreases methylation	1
Methylcholanthrene	affects binding, increases reaction	1
Testosterone	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	increases expression	1
Particulate Matter	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.