ZNF697

Summary

ZNF697 (zinc finger protein 697, HGNC:32034) is a protein-coding gene on chromosome 1p12, encoding Zinc finger protein 697 (Q5TEC3). RNA-interacting protein with a high number of miRNA targets.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 90874 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_001080470

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32034
Approved symbol	ZNF697
Name	zinc finger protein 697
Location	1p12
Locus type	gene with protein product
Status	Approved
Aliases	MGC45731
Ensembl gene	ENSG00000143067
Ensembl biotype	protein_coding
OMIM	620981
Entrez	90874

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000421812, ENST00000887271

RefSeq mRNA: 1 — MANE Select: NM_001080470 NM_001080470

CCDS: CCDS44202

Canonical transcript exons

ENST00000421812 — 3 exons

Exon	Start	End
ENSE00001689226	119647691	119648266
ENSE00001733724	119625875	119626137
ENSE00002177000	119619377	119624116

Expression profiles

Bgee: expression breadth ubiquitous, 207 present calls, max score 90.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8947 / max 101.2652, expressed in 1641 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14080	8.2897	1628
14079	0.6050	346

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cartilage tissue	UBERON:0002418	90.11	gold quality
kidney epithelium	UBERON:0004819	87.38	gold quality
cortical plate	UBERON:0005343	86.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.86	gold quality
pancreatic ductal cell	CL:0002079	81.10	silver quality
placenta	UBERON:0001987	80.98	gold quality
tibialis anterior	UBERON:0001385	80.68	silver quality
left ventricle myocardium	UBERON:0006566	80.29	silver quality
islet of Langerhans	UBERON:0000006	80.22	gold quality
cardiac muscle of right atrium	UBERON:0003379	80.11	silver quality
ganglionic eminence	UBERON:0004023	79.44	gold quality
stromal cell of endometrium	CL:0002255	78.92	gold quality
parotid gland	UBERON:0001831	78.87	gold quality
secondary oocyte	CL:0000655	77.03	gold quality
visceral pleura	UBERON:0002401	76.93	gold quality
skin of hip	UBERON:0001554	76.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.92	gold quality
ileal mucosa	UBERON:0000331	75.80	gold quality
kidney	UBERON:0002113	75.16	gold quality
germinal epithelium of ovary	UBERON:0001304	74.80	silver quality
myocardium	UBERON:0002349	74.77	silver quality
parietal pleura	UBERON:0002400	74.33	gold quality
adult mammalian kidney	UBERON:0000082	74.26	gold quality
metanephros	UBERON:0000081	74.13	gold quality
monocyte	CL:0000576	73.86	gold quality
oocyte	CL:0000023	73.37	gold quality
leukocyte	CL:0000738	73.33	gold quality
sperm	CL:0000019	73.14	silver quality
tendon of biceps brachii	UBERON:0008188	72.80	silver quality
metanephros cortex	UBERON:0010533	72.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

144 targeting ZNF697, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548P	99.98	72.25	3784
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-5688	99.96	73.23	4504
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp697	ENSMUSG00000050064
rattus_norvegicus	Zfp697	ENSRNOG00000065357

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

Zinc finger protein 697 — Q5TEC3 (reviewed: Q5TEC3)

All UniProt accessions (1): Q5TEC3

UniProt curated annotations — full annotation on UniProt →

Function. RNA-interacting protein with a high number of miRNA targets. Acts as a damage-induced regulator of muscle remodeling by mediating the interferon gamma response in muscle cells.

Subcellular location. Nucleus.

Induction. Expression is transiently elevated during intense exercise and recovery from muscle atrophy or injury.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001073939* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050331	Zinc_finger_PRDM4/PRDM1/PRDM14	Family

Pfam: PF00096

UniProt features (19 total): zinc finger region 11, compositionally biased region 4, chain 1, region of interest 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5TEC3-F1	65.99	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 102 (showing top): GOBP_RESPONSE_TO_PEPTIDE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, DODD_NASOPHARYNGEAL_CARCINOMA_UP, chr1p12, GOBP_RESPONSE_TO_TYPE_II_INTERFERON, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, GOMF_MIRNA_BINDING, YOSHIMURA_MAPK8_TARGETS_DN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_3, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, CSR_EARLY_UP.V1_UP, GOMF_REGULATORY_RNA_BINDING

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), response to type II interferon (GO:0034341)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), miRNA binding (GO:0035198), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
response to cytokine	1
innate immune response	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
regulatory RNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

244 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF697	B3KSW5	B3KSW5	542
ZNF697	GAPVD1	Q14C86	480
ZNF697	ZFYVE16	Q7Z3T8	476
ZNF697	Q6IQ01	Q6IQ01	448
ZNF697	ANKRA2	Q9H9E1	420
ZNF697	ZBTB21	Q9ULJ3	412
ZNF697	ZZZ3	Q8IYH5	410
ZNF697	ZNF608	Q9ULD9	407
ZNF697	MT1M	Q8N339	353
ZNF697	MT1H	P80294	325
ZNF697	INKA1	Q96EL1	323
ZNF697	ADAM30	Q9UKF2	312
ZNF697	PPP1R3F	Q6ZSY5	306
ZNF697	ZBED4	O75132	306
ZNF697	SLC15A5	A6NIM6	305

IntAct

21 interactions, top by confidence:

A	B	Type	Score
ZNF697	DNM2	psi-mi:“MI:0915”(physical association)	0.560
ZNF697		psi-mi:“MI:0915”(physical association)	0.560
ZNF697	GRN	psi-mi:“MI:0915”(physical association)	0.560
ZNF697	WFS1	psi-mi:“MI:0915”(physical association)	0.560
ZNF697	GDAP1	psi-mi:“MI:0915”(physical association)	0.560
HTT	ZNF697	psi-mi:“MI:0915”(physical association)	0.560
CCL1	ZNF697	psi-mi:“MI:0915”(physical association)	0.370
SCRIB	C1orf226	psi-mi:“MI:0914”(association)	0.350

BioGRID (16): ZNF697 (Two-hybrid), ZNF697 (Two-hybrid), ZNF697 (Two-hybrid), KRT40 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-5 (Two-hybrid), KRTAP10-8 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZNF697 (Two-hybrid), ZNF697 (Affinity Capture-MS), ZNF697 (Affinity Capture-RNA), ZNF697 (Affinity Capture-MS), ZNF697 (Affinity Capture-MS), ZNF697 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2CE44, A6NFI3, A6NM28, A8K8V0, O15370, O70218, O95201, P0CJ78, P10075, P10754, P28698, P70338, Q04890, Q07120, Q14V87, Q19A40, Q569E7, Q58DK7, Q5DWN0, Q5FWU5, Q5RJR4, Q5T619, Q5TEC3, Q6DD87, Q6IQX8, Q6PD29, Q6PGE4, Q6ZMY9, Q7Z7K2, Q80VM4, Q8BIF9, Q8JZL0, Q8N8E2, Q8NAF0, Q8NCA9, Q8TD94, Q8WUU4, Q96C55, Q96H86, Q96MX3

Diamond homologs: P0CG23, Q3US17, Q569E7, Q5TEC3, Q96MX3, P18714, P18715, P18718, P18724, P18725, P18731, P18735, P18737, P18738, P18740, P18747, P52742, Q01611, Q02085, Q3MJ62, Q6A085, Q6DD87, Q7L3S4, Q7TNU6, Q8BIF9, Q8BJ90, Q9UC06, Q9UEG4, A1L1L7, A1YEV9, A1YG26, A2T712, A2T7L7, O60304, P18716, P18719, P18729, P18730, P18736, P18741

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	89
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

810 predictions. Top by Δscore:

Variant	Effect	Δscore
1:119624113:CCCT:C	acceptor_gain	1.0000
1:119624114:CCTC:C	acceptor_gain	1.0000
1:119624117:C:CC	acceptor_gain	1.0000
1:119625870:CTCAC:C	donor_loss	1.0000
1:119625872:CACC:C	donor_loss	1.0000
1:119625873:ACCTG:A	donor_loss	1.0000
1:119626102:C:T	acceptor_gain	1.0000
1:119626145:A:T	acceptor_gain	1.0000
1:119636229:AG:A	donor_gain	1.0000
1:119624112:CCCCT:C	acceptor_gain	0.9900
1:119624113:CCCTC:C	acceptor_gain	0.9900
1:119624114:CCT:C	acceptor_gain	0.9900
1:119624115:CT:C	acceptor_gain	0.9900
1:119624115:CTC:C	acceptor_gain	0.9900
1:119624116:TC:T	acceptor_loss	0.9900
1:119624116:TCT:T	acceptor_gain	0.9900
1:119624117:C:A	acceptor_gain	0.9900
1:119624117:CTGCA:C	acceptor_loss	0.9900
1:119624123:C:CT	acceptor_gain	0.9900
1:119624124:A:T	acceptor_gain	0.9900
1:119625899:C:A	donor_gain	0.9900
1:119626102:C:CT	acceptor_gain	0.9900
1:119626103:A:T	acceptor_gain	0.9900
1:119626135:TCC:T	acceptor_gain	0.9900
1:119626136:CC:C	acceptor_gain	0.9900
1:119626136:CCC:C	acceptor_gain	0.9900
1:119626137:CC:C	acceptor_gain	0.9900
1:119626138:C:CC	acceptor_gain	0.9900
1:119626144:C:CT	acceptor_gain	0.9900
1:119626144:C:T	acceptor_gain	0.9900

AlphaMissense

3629 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:119622837:A:C	F502L	1.000
1:119622837:A:T	F502L	1.000
1:119622839:A:G	F502L	1.000
1:119622889:C:G	R485P	1.000
1:119622921:G:C	F474L	1.000
1:119622921:G:T	F474L	1.000
1:119622923:A:G	F474L	1.000
1:119623005:G:C	F446L	1.000
1:119623005:G:T	F446L	1.000
1:119623007:A:G	F446L	1.000
1:119623089:G:C	F418L	1.000
1:119623089:G:T	F418L	1.000
1:119623091:A:G	F418L	1.000
1:119623173:G:C	F390L	1.000
1:119623173:G:T	F390L	1.000
1:119623175:A:G	F390L	1.000
1:119623257:G:C	F362L	1.000
1:119623257:G:T	F362L	1.000
1:119623259:A:G	F362L	1.000
1:119623449:G:C	F298L	1.000
1:119623449:G:T	F298L	1.000
1:119623451:A:G	F298L	1.000
1:119623506:G:C	H279Q	1.000
1:119623506:G:T	H279Q	1.000
1:119623508:G:C	H279D	1.000
1:119623508:G:T	H279N	1.000
1:119623533:G:C	F270L	1.000
1:119623533:G:T	F270L	1.000
1:119623534:A:G	F270S	1.000
1:119623535:A:G	F270L	1.000

dbSNP variants (sampled 300 via entrez): RS1000017137 (1:119628067 G>A,C,T), RS1000071970 (1:119628266 T>C), RS1000209155 (1:119630376 C>T), RS1000234723 (1:119642312 G>A), RS1000252699 (1:119622602 G>T), RS1000282753 (1:119629016 C>G), RS1000301032 (1:119622743 T>C), RS1000388104 (1:119648510 A>G), RS1000460290 (1:119648721 T>C), RS1000615532 (1:119641382 A>G), RS1000641503 (1:119624185 C>T), RS1000742770 (1:119647367 T>C), RS1000773838 (1:119647579 C>G), RS1001145602 (1:119628416 A>G), RS1001238595 (1:119647404 G>C,T)

Disease associations

OMIM: gene MIM:620981 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004757_2	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis	3.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs10494227	Efficacy	3	interferon beta-1a;interferon beta-1b	Multiple Sclerosis

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10494227	ZNF697	3	2.50	1	interferon beta-1a;interferon beta-1b

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	3
Acetaminophen	increases expression	2
Smoke	decreases expression, increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
TAK-243	increases sumoylation	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
trichostatin A	affects expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	decreases expression	1
perfluorooctanoic acid	decreases expression	1
ferrous chloride	increases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Allergens	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Calcitriol	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD40	HEK293 eGFP-ZNF697	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.