ZNF70

gene
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Also known as Cos17MGC48959

Summary

ZNF70 (zinc finger protein 70, HGNC:13140) is a protein-coding gene on chromosome 22q11.23, encoding Zinc finger protein 70 (Q9UC06). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and megasporocyte nucleus.

Source: NCBI Gene 7621 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 88 total
  • MANE Select transcript: NM_021916

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:13140
Approved symbolZNF70
Namezinc finger protein 70
Location22q11.23
Locus typegene with protein product
StatusApproved
AliasesCos17, MGC48959
Ensembl geneENSG00000187792
Ensembl biotypeprotein_coding
OMIM194544
Entrez7621

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000341976, ENST00000871908, ENST00000871909, ENST00000871910, ENST00000964215

RefSeq mRNA: 1 — MANE Select: NM_021916 NM_021916

CCDS: CCDS13812

Canonical transcript exons

ENST00000341976 — 2 exons

ExonStartEnd
ENSE000013832352373868223745219
ENSE000014000172375071123751112

Expression profiles

Bgee: expression breadth ubiquitous, 200 present calls, max score 81.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3817 / max 146.6726, expressed in 1659 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
1933285.80751455
1933270.4625276
1933260.111667

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
tibiaUBERON:000097981.77gold quality
tibialis anteriorUBERON:000138580.29silver quality
corpus epididymisUBERON:000435977.53gold quality
pigmented layer of retinaUBERON:000178277.10gold quality
ileal mucosaUBERON:000033176.43gold quality
parietal pleuraUBERON:000240076.23gold quality
stromal cell of endometriumCL:000225575.88gold quality
visceral pleuraUBERON:000240174.61gold quality
secondary oocyteCL:000065574.50silver quality
germinal epithelium of ovaryUBERON:000130473.60silver quality
caput epididymisUBERON:000435873.57gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047372.12gold quality
ventricular zoneUBERON:000305371.87gold quality
bone marrow cellCL:000209271.65silver quality
palpebral conjunctivaUBERON:000181271.36gold quality
lower lobe of lungUBERON:000894971.13gold quality
bronchial epithelial cellCL:000232870.95gold quality
cortical plateUBERON:000534370.69gold quality
ganglionic eminenceUBERON:000402370.55gold quality
bronchusUBERON:000218570.23gold quality
calcaneal tendonUBERON:000370170.19gold quality
muscle of legUBERON:000138369.75gold quality
gastrocnemiusUBERON:000138869.72gold quality
hindlimb stylopod muscleUBERON:000425269.19gold quality
sural nerveUBERON:001548869.09gold quality
ovaryUBERON:000099269.02gold quality
oviduct epitheliumUBERON:000480468.88gold quality
descending thoracic aortaUBERON:000234568.83gold quality
right ovaryUBERON:000211868.51gold quality
cartilage tissueUBERON:000241868.43silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-MTAB-6379no9.04
E-ANND-3no4.21

Regulation

Is transcription factor: yes

JASPAR motifs

MotifNameFamily
MA2565.1ZNF70More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605368

miRNA regulators (miRDB)

62 targeting ZNF70, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-373-5P99.9875.364753
HSA-MIR-616-5P99.9875.584775
HSA-MIR-6783-3P99.8967.922059
HSA-MIR-1343-3P99.8966.781815
HSA-MIR-449699.8868.892236
HSA-MIR-6780A-5P99.8866.692776
HSA-MIR-221-5P99.8665.451052
HSA-MIR-807399.8665.211118
HSA-MIR-132399.8369.892471
HSA-MIR-4659A-3P99.8072.624248
HSA-MIR-4659B-3P99.8072.624248
HSA-MIR-1273H-5P99.7766.322471
HSA-MIR-498-5P99.7669.641807
HSA-MIR-548O-3P99.7469.302228
HSA-MIR-4524A-3P99.7266.852406
HSA-MIR-30B-3P99.7065.762325
HSA-MIR-3689A-3P99.7065.732306
HSA-MIR-3689B-3P99.7065.712311
HSA-MIR-3689C99.7065.712311
HSA-MIR-6779-5P99.7065.762363
HSA-MIR-452-5P99.6569.631762
HSA-MIR-4676-3P99.6569.311733
HSA-MIR-892C-3P99.6569.381745
HSA-MIR-466399.6265.33957
HSA-MIR-4743-3P99.6268.122095
HSA-MIR-105-5P99.5469.242060
HSA-MIR-7853-5P99.5469.302055
HSA-MIR-1212399.5271.792990

Literature-anchored findings (GeneRIF, showing 3)

  • We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee (PMID:27353377)
  • miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation. (PMID:32053575)
  • ZNF70 regulates IL-1beta secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer. (PMID:38000525)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
drosophila_melanogasterCG2712FBGN0024975
drosophila_melanogasterPhsFBGN0036522
drosophila_melanogasterCG3281FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 70Q9UC06 (reviewed: Q9UC06)

Alternative names: Zinc finger protein N27C7-1

All UniProt accessions (1): Q9UC06

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_068735* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR013087Znf_C2H2_typeDomain
IPR036236Znf_C2H2_sfHomologous_superfamily

Pfam: PF00096, PF13465

UniProt features (13 total): zinc finger region 11, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9UC06-F171.850.42

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-212436Generic Transcription Pathway

MSigDB gene sets: 40 (showing top): AP2_Q3, ZHAN_MULTIPLE_MYELOMA_CD1_UP, HEN1_01, ELK1_01, CETS1P54_01, SENESE_HDAC3_TARGETS_DN, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, SCGGAAGY_ELK1_02, HNF4ALPHA_Q6, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CIITA_TARGET_GENES, FOXD2_TARGET_GENES, ID1_TARGET_GENES, MIR1323

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), megasporocyte nucleus (GO:0043076)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
RNA Polymerase II Transcription1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
regulation of DNA-templated transcription1
transcription by RNA polymerase II1
transcription cis-regulatory region binding1
chromatin1
RNA polymerase II transcription regulatory region sequence-specific DNA binding1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
transition metal ion binding1
nucleic acid binding1
binding1
cation binding1
intracellular membrane-bounded organelle1
intracellular anatomical structure1
cellular anatomical structure1
nucleus1

Protein interactions and networks

STRING

438 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF70C9JR48C9JR48930
ZNF70DRICH1Q6PGQ1581
ZNF70LRRC75BQ2VPJ9571
ZNF70C22orf15Q8WYQ4527
ZNF70WDTC1Q8N5D0493
ZNF70RNF126Q9BV68474
ZNF70DNASE2O00115454
ZNF70RGL4Q8IZJ4447
ZNF70DEFA4P12838444
ZNF70PGAM5Q96HS1416
ZNF70CD37P11049412
ZNF70KIAA1671Q9BY89410
ZNF70CCDC34Q96HJ3406
ZNF70TICAM1Q8IUC6400
ZNF70GUCD1Q96NT3393

IntAct

39 interactions, top by confidence:

ABTypeScore
H1-1RRP8psi-mi:“MI:0914”(association)0.640
ZNF71NVLpsi-mi:“MI:0914”(association)0.530
RPL30RRP8psi-mi:“MI:0914”(association)0.530
E4F1ZBTB24psi-mi:“MI:0914”(association)0.530
THAP3CASC3psi-mi:“MI:0914”(association)0.530
NIFKRSL1D1psi-mi:“MI:0914”(association)0.530
H1-1SURF6psi-mi:“MI:0914”(association)0.530
ZNF70ZFP64psi-mi:“MI:0915”(physical association)0.370
ZC3H3ANKHD1psi-mi:“MI:0914”(association)0.350
DGCR8MPHOSPH10psi-mi:“MI:0914”(association)0.350
NIFKRRP8psi-mi:“MI:0914”(association)0.350
SRP14RPSA2psi-mi:“MI:0914”(association)0.350
RPS19ZNF320psi-mi:“MI:0914”(association)0.350
RPL36GTPBP10psi-mi:“MI:0914”(association)0.350
RPL28GTPBP10psi-mi:“MI:0914”(association)0.350
PRR3ZNF316psi-mi:“MI:0914”(association)0.350
CBX6ZNF316psi-mi:“MI:0914”(association)0.350
RPS6CCDC85Cpsi-mi:“MI:0914”(association)0.350
RPL19psi-mi:“MI:0914”(association)0.350
RPL17psi-mi:“MI:0914”(association)0.350
UTP23psi-mi:“MI:0914”(association)0.350
SRSF4psi-mi:“MI:0914”(association)0.350
RPS13KIF2Apsi-mi:“MI:0914”(association)0.350
RPL23AMPHOSPH10psi-mi:“MI:0914”(association)0.350
ZBTB47MPHOSPH10psi-mi:“MI:0914”(association)0.350

BioGRID (48): ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-RNA), ZNF70 (Reconstituted Complex), ZNF70 (Affinity Capture-MS), ZNF70 (Affinity Capture-MS)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A3KN32, B2RUI1, O43296, O75123, P10072, P17020, P17097, P51814, P52736, P52740, Q07230, Q08ER8, Q13398, Q14590, Q32KN0, Q3KQV3, Q3MIS6, Q4V8A8, Q5CZA5, Q5RBQ3, Q5RBX0, Q5RCD9, Q5RCX4, Q6GQR8, Q6NX45, Q6P9A3, Q6PK81, Q7TSH9, Q7TSI0, Q7Z7L9, Q86UD4, Q8BFS8, Q8BLB0, Q8IVP9, Q8IZ26, Q8N9F8

Diamond homologs: P18714, P18715, P18718, P18724, P18725, P18731, P18735, P18737, P18738, P18740, P18747, P52742, Q01611, Q02085, Q3MJ62, Q569E7, Q5TEC3, Q6A085, Q6DD87, Q7L3S4, Q7TNU6, Q8BIF9, Q8BJ90, Q9UC06, Q9UEG4, A2ANX9, B0YDH7, O15391, O57311, O57415, O60315, O60481, O62836, O73689, O95409, P03001, P08048, P0C6P6, P10925, P17010

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 45 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Peptide chain elongation1048.8×7e-14
Viral mRNA Translation1048.8×7e-14
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA1048.3×7e-14
Selenocysteine synthesis1046.2×8e-14
Eukaryotic Translation Termination1046.2×8e-14
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)1045.3×8e-14
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA1045.3×8e-14
Nonsense-Mediated Decay (NMD)544.8×6e-07

GO biological processes:

GO termPartnersFoldFDR
cytoplasmic translation1147.4×5e-14
ribosomal small subunit biogenesis526.5×6e-05
translation1023.9×6e-10
rRNA processing516.5×3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

88 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance80
Likely benign0
Benign3

Top pathogenic / likely-pathogenic (0)

SpliceAI

261 predictions. Top by Δscore:

VariantEffectΔscore
22:23743655:T:TAdonor_gain0.9800
22:23745216:CAAT:Cacceptor_gain0.9800
22:23745218:ATC:Aacceptor_loss0.9700
22:23745219:TCTGA:Tacceptor_loss0.9700
22:23745220:C:CCacceptor_gain0.9700
22:23745220:C:CGacceptor_loss0.9700
22:23745221:T:Cacceptor_loss0.9700
22:23745215:ACAAT:Aacceptor_gain0.9200
22:23745216:CAATC:Cacceptor_gain0.9200
22:23745222:G:Cacceptor_loss0.9200
22:23743729:TGGAG:Tdonor_gain0.9000
22:23745217:AAT:Aacceptor_gain0.9000
22:23745232:C:CTacceptor_loss0.9000
22:23745227:GAAAA:Gacceptor_loss0.8900
22:23745223:AAAA:Aacceptor_loss0.8500
22:23750973:CCACT:Cdonor_loss0.8500
22:23750974:CACTC:Cdonor_loss0.8500
22:23750975:ACTCA:Adonor_loss0.8500
22:23750976:CTCA:Cdonor_loss0.8500
22:23750977:TCA:Tdonor_loss0.8500
22:23750978:CA:Cdonor_loss0.8500
22:23750979:AC:Adonor_loss0.8500
22:23750980:CC:Cdonor_loss0.8500
22:23743609:A:ATdonor_gain0.8300
22:23745218:AT:Aacceptor_gain0.8300
22:23745233:A:Tacceptor_loss0.8300
22:23750997:CAGCT:Cdonor_loss0.8300
22:23750998:AGCTC:Adonor_loss0.8300
22:23750999:GCTCA:Gdonor_loss0.8300
22:23751000:CT:Cdonor_loss0.8300

AlphaMissense

2984 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
22:23744106:G:CF345L0.999
22:23744106:G:TF345L0.999
22:23744108:A:GF345L0.999
22:23744190:G:CF317L0.999
22:23744190:G:TF317L0.999
22:23744192:A:GF317L0.999
22:23744526:G:CF205L0.999
22:23744526:G:TF205L0.999
22:23744528:A:GF205L0.999
22:23744610:G:CF177L0.999
22:23744610:G:TF177L0.999
22:23744612:A:GF177L0.999
22:23743941:G:CF400L0.998
22:23743941:G:TF400L0.998
22:23743943:A:GF400L0.998
22:23744022:A:CF373L0.998
22:23744022:A:TF373L0.998
22:23744024:A:GF373L0.998
22:23744074:C:GR356P0.998
22:23744274:A:CF289L0.998
22:23744274:A:TF289L0.998
22:23744276:A:GF289L0.998
22:23744694:G:CF149L0.998
22:23744694:G:TF149L0.998
22:23744696:A:GF149L0.998
22:23744089:A:GL351P0.997
22:23744173:A:GL323P0.997
22:23744358:G:CF261L0.997
22:23744358:G:TF261L0.997
22:23744360:A:GF261L0.997

dbSNP variants (sampled 300 via entrez): RS1000295292 (22:23740955 C>A), RS1000402895 (22:23750991 G>A), RS1000406583 (22:23752297 C>T), RS1000423977 (22:23746891 G>C), RS1000465349 (22:23751137 C>G), RS1000663575 (22:23740096 C>G), RS1001007253 (22:23745879 G>A,C), RS1001435996 (22:23749961 A>G,T), RS1001670451 (22:23739018 C>T), RS1001945846 (22:23743964 T>C), RS1002373452 (22:23741503 A>G), RS1002406070 (22:23748267 T>A), RS1002438610 (22:23748622 G>A), RS1002505908 (22:23744955 A>T), RS1002543817 (22:23742567 T>C,G)

Disease associations

OMIM: gene MIM:194544 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST008839_314Height8.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteincreases expression2
Air Pollutantsaffects expression, increases abundance, decreases expression2
Smokedecreases expression, increases abundance2
Valproic Acidincreases expression2
aristolochic acid Idecreases expression1
GSK-J4decreases expression1
bisphenol Faffects cotreatment, increases expression1
dicrotophosincreases expression1
triphenyl phosphateaffects expression1
bisphenol Aaffects cotreatment, increases expression1
avobenzonedecreases expression1
di-n-butylphosphoric acidaffects expression1
CGP 52608affects binding, increases reaction1
abrinedecreases expression1
Sunitinibincreases expression1
Arsenic Trioxidedecreases expression1
Acetaminophenincreases expression1
Arsenicaffects methylation1
Cisplatindecreases expression1
Dexamethasoneaffects cotreatment, increases expression1
Doxorubicindecreases expression1
Estradiolincreases expression1
Indomethacinaffects cotreatment, increases expression1
Ozoneaffects expression, increases abundance1
Tetrachlorodibenzodioxinaffects expression1
Tobacco Smoke Pollutiondecreases expression1
Urethaneaffects expression1
1-Methyl-3-isobutylxanthineaffects cotreatment, increases expression1
Aflatoxin B1increases methylation1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_A8J4SEES3-1V human ZNF70, clone1Embryonic stem cellMale
CVCL_A8J5SEES3-1V human ZNF70, clone2Embryonic stem cellMale
CVCL_A8J6SEES3-1V human ZNF70, clone3Embryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.