ZNF700

Summary

ZNF700 (zinc finger protein 700, HGNC:25292) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 700 (Q9H0M5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 90592 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• MANE Select transcript: NM_144566

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25292
Approved symbol	ZNF700
Name	zinc finger protein 700
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434I1610
Ensembl gene	ENSG00000196757
Ensembl biotype	protein_coding
Entrez	90592

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000254321, ENST00000482090, ENST00000622593

RefSeq mRNA: 2 — MANE Select: NM_144566 NM_001271848, NM_144566

CCDS: CCDS32915, CCDS74289

Canonical transcript exons

ENST00000254321 — 4 exons

Exon	Start	End
ENSE00001670858	11947181	11947307
ENSE00001813248	11948276	11950763
ENSE00002820298	11947514	11947574
ENSE00003848096	11925107	11925273

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 87.83.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.6401 / max 106.2182, expressed in 1633 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173973	6.6819	1616
173972	1.6083	901
173974	0.9582	472

Top tissues by expression

135 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	87.83	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.53	gold quality
metanephros cortex	UBERON:0010533	87.22	gold quality
body of pancreas	UBERON:0001150	86.93	gold quality
spleen	UBERON:0002106	86.85	gold quality
right lobe of liver	UBERON:0001114	85.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	85.59	gold quality
lower esophagus mucosa	UBERON:0035834	85.49	gold quality
mucosa of transverse colon	UBERON:0004991	85.27	gold quality
transverse colon	UBERON:0001157	85.02	gold quality
endometrium	UBERON:0001295	84.97	gold quality
cortex of kidney	UBERON:0001225	84.68	gold quality
skin of abdomen	UBERON:0001416	84.62	gold quality
zone of skin	UBERON:0000014	84.53	gold quality
calcaneal tendon	UBERON:0003701	84.48	gold quality
skin of leg	UBERON:0001511	84.47	gold quality
small intestine	UBERON:0002108	84.06	gold quality
tonsil	UBERON:0002372	83.66	gold quality
body of stomach	UBERON:0001161	83.60	gold quality
pancreas	UBERON:0001264	83.46	gold quality
right ovary	UBERON:0002118	83.43	gold quality
right adrenal gland cortex	UBERON:0035827	83.05	gold quality
right adrenal gland	UBERON:0001233	83.02	gold quality
esophagus mucosa	UBERON:0002469	82.98	gold quality
left ovary	UBERON:0002119	82.95	gold quality
intestine	UBERON:0000160	82.94	gold quality
bone marrow	UBERON:0002371	82.94	gold quality
thoracic mammary gland	UBERON:0005200	82.93	gold quality
vagina	UBERON:0000996	82.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.28

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2595.1	ZNF700	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

37 targeting ZNF700, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-199A-5P	99.51	69.71	1107
HSA-MIR-199B-5P	99.51	69.74	1098
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-296-3P	99.21	66.56	474
HSA-MIR-376A-3P	99.06	69.17	1128
HSA-MIR-376B-3P	99.06	69.17	1128
HSA-MIR-8066	99.05	68.66	1532
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-548AO-5P	98.55	69.57	1362

Literature-anchored findings (GeneRIF, showing 1)

• High ZNF700 expression is associated with colorectal cancer. (PMID:25875936)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp961	ENSMUSG00000052446
rattus_norvegicus	Zfp617	ENSRNOG00000049856

Paralogs (15): ZNF14 (ENSG00000105708), ZNF57 (ENSG00000171970), ZNF791 (ENSG00000173875), ZNF443 (ENSG00000180855), ZNF101 (ENSG00000181896), ZNF563 (ENSG00000188868), ZNF799 (ENSG00000196466), ZNF441 (ENSG00000197044), ZNF433 (ENSG00000197647), ZNF44 (ENSG00000197857), ZNF823 (ENSG00000197933), ZNF442 (ENSG00000198342), ZNF844 (ENSG00000223547), ZNF709 (ENSG00000242852), ZNF878 (ENSG00000257446)

Protein

Protein identifiers

Zinc finger protein 700 — Q9H0M5 (reviewed: Q9H0M5)

All UniProt accessions (3): Q9H0M5, A0A087WVH9, K7EQV7

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001258777, NP_653167* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (24 total): zinc finger region 18, sequence variant 2, chain 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0M5-F1	72.27	0.03

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 42 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_UP, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, chr19p13, HAMAI_APOPTOSIS_VIA_TRAIL_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, FEV_TARGET_GENES, ZFP91_TARGET_GENES, ZNF350_TARGET_GENES, ZNF513_TARGET_GENES, ZNF561_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

376 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF700	GPBP1L1	Q9HC44	571
ZNF700	ZNF638	Q14966	474
ZNF700	LINC03040	Q8N319	411
ZNF700	ZNF346	Q9UL40	394
ZNF700	BLTP3B	A0JNW5	392
ZNF700	TADA2A	O75478	380
ZNF700	NT5DC1	Q5TFE4	371
ZNF700	NXPE4	Q6UWF7	371
ZNF700	REP15	Q6BDI9	370
ZNF700	FAM53A	Q6NSI3	368
ZNF700	MAST2	Q6P0Q8	350
ZNF700	CTDSPL2	Q05D32	325
ZNF700	TDRP	Q86YL5	323
ZNF700	GALNTL6	Q49A17	311
ZNF700	SCPEP1	Q9HB40	302

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ZNF700	ECE1	psi-mi:“MI:0915”(physical association)	0.370
ECE1	ZNF700	psi-mi:“MI:0915”(physical association)	0.370
pyrD	ZNF700	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (1): ZNF700 (Affinity Capture-RNA)

ESM2 similar proteins: A6NDX5, A6NK75, A6NNF4, A6NP11, B4DXR9, B7Z6K7, C9JN71, O43361, O75290, O75373, P0CJ79, P0DKX0, P17019, P17021, P17035, P17039, P35789, Q02386, Q03938, Q08AN1, Q13106, Q15928, Q3ZCX4, Q5R9F0, Q5SXM1, Q68EA5, Q6P9A1, Q6PDB4, Q6ZN06, Q6ZN08, Q6ZNG1, Q76KX8, Q86V71, Q86XN6, Q8IYB9, Q8N4W9, Q8NEP9, Q8TBZ8, Q8TC21, Q8TF32

Diamond homologs: A2RRD8, A6NFI3, A6NM28, A8MUZ8, A8MWA4, B2RUI1, B4DU55, E9Q8G5, O43296, O43361, O75467, O75820, P0CH99, P0CI00, P10078, P16373, P16374, P17021, P17023, P17032, P17097, P17098, P21506, P51786, P52740, Q06732, Q08ER8, Q13106, Q13360, Q13398, Q14592, Q147U1, Q32M78, Q3KQV3, Q3MIS6, Q3SY52, Q571J5, Q5CZA5, Q5HY98, Q5R7I8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

822 predictions. Top by Δscore:

Variant	Effect	Δscore
19:11948266:T:G	acceptor_gain	1.0000
19:11948272:ACAG:A	acceptor_gain	1.0000
19:11948273:CA:C	acceptor_loss	1.0000
19:11948274:A:AG	acceptor_gain	1.0000
19:11948274:AG:A	acceptor_gain	1.0000
19:11948275:G:GG	acceptor_gain	1.0000
19:11948275:G:GT	acceptor_gain	1.0000
19:11948275:GG:G	acceptor_gain	1.0000
19:11948275:GGA:G	acceptor_gain	1.0000
19:11948275:GGAGT:G	acceptor_gain	1.0000
19:11947163:A:AG	acceptor_gain	0.9900
19:11947163:ACAT:A	acceptor_gain	0.9900
19:11947164:C:G	acceptor_gain	0.9900
19:11947165:AT:A	acceptor_gain	0.9900
19:11947165:ATGT:A	acceptor_gain	0.9900
19:11947166:T:G	acceptor_gain	0.9900
19:11947304:ATAGG:A	donor_loss	0.9900
19:11947305:TAGGT:T	donor_loss	0.9900
19:11947306:AGGT:A	donor_loss	0.9900
19:11947307:GGTA:G	donor_loss	0.9900
19:11947308:G:C	donor_loss	0.9900
19:11947308:G:GG	donor_gain	0.9900
19:11947309:T:A	donor_loss	0.9900
19:11948265:A:AG	acceptor_gain	0.9900
19:11948265:AT:A	acceptor_gain	0.9900
19:11948266:T:TA	acceptor_gain	0.9900
19:11948272:A:AG	acceptor_gain	0.9900
19:11948273:C:G	acceptor_gain	0.9900
19:11948273:CAGG:C	acceptor_gain	0.9900
19:11948274:AGGA:A	acceptor_gain	0.9900

AlphaMissense

4976 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:11949825:T:C	F601L	0.994
19:11949827:C:A	F601L	0.994
19:11949827:C:G	F601L	0.994
19:11948799:T:C	F259L	0.992
19:11948801:T:A	F259L	0.992
19:11948801:T:G	F259L	0.992
19:11949909:T:C	F629L	0.992
19:11949911:C:A	F629L	0.992
19:11949911:C:G	F629L	0.992
19:11949741:T:C	F573L	0.991
19:11949743:C:A	F573L	0.991
19:11949743:C:G	F573L	0.991
19:11949657:T:C	F545L	0.986
19:11949659:C:A	F545L	0.986
19:11949659:C:G	F545L	0.986
19:11950077:T:C	F685L	0.985
19:11950079:C:A	F685L	0.985
19:11950079:C:G	F685L	0.985
19:11949915:T:C	S631P	0.984
19:11949928:T:C	L635P	0.983
19:11949993:T:C	F657L	0.982
19:11949995:C:A	F657L	0.982
19:11949995:C:G	F657L	0.982
19:11949387:T:C	F455L	0.980
19:11949389:C:A	F455L	0.980
19:11949389:C:G	F455L	0.980
19:11949747:T:C	S575P	0.980
19:11948967:T:C	F315L	0.979
19:11948969:T:A	F315L	0.979
19:11948969:T:G	F315L	0.979

dbSNP variants (sampled 300 via entrez): RS1000057418 (19:11945987 G>C), RS1000118339 (19:11941121 G>A), RS1000430019 (19:11945837 G>C), RS1000536597 (19:11923777 G>A,C), RS1000541068 (19:11941326 C>A), RS1000969615 (19:11923507 C>A), RS1001063807 (19:11929263 A>G), RS1001164018 (19:11928203 C>G,T), RS1001295190 (19:11926216 T>C,G), RS1001338425 (19:11934988 T>C,G), RS1001362078 (19:11951248 T>C), RS1001530813 (19:11942847 T>C), RS1001549126 (19:11929032 C>T), RS1001666042 (19:11951026 C>T), RS1001690762 (19:11923475 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002337_47	Amyotrophic lateral sclerosis (sporadic)	4.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression	2
aristolochic acid I	decreases expression	1
TAK-243	increases sumoylation	1
trichostatin A	affects expression	1
sodium arsenite	increases expression	1
aflatoxin B2	increases methylation	1
Temozolomide	increases expression	1
Leflunomide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzene	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Cisplatin	increases expression	1
Estradiol	affects expression	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects cotreatment, decreases expression	1
Quercetin	decreases expression	1
Theophylline	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	increases methylation	1
Lactic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.