ZNF705A

Summary

ZNF705A (zinc finger protein 705A, HGNC:32281) is a protein-coding gene on chromosome 12p13.31, encoding Zinc finger protein 705A (Q6ZN79). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus.

Source: NCBI Gene 440077 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_001004328

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32281
Approved symbol	ZNF705A
Name	zinc finger protein 705A
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ16353
Ensembl gene	ENSG00000196946
Ensembl biotype	protein_coding
Entrez	440077

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000359286, ENST00000396570, ENST00000398526, ENST00000610508

RefSeq mRNA: 1 — MANE Select: NM_001004328 NM_001004328

CCDS: CCDS31737

Canonical transcript exons

ENST00000396570 — 6 exons

Exon	Start	End
ENSE00001552676	8176999	8180046
ENSE00001744452	8175860	8175942
ENSE00001752668	8174326	8174452
ENSE00001790546	8172555	8172637
ENSE00001797998	8175228	8175323
ENSE00002243773	8157015	8157092

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 46.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0538 / max 8.9228, expressed in 27 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123957	0.0538	27

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	46.44	gold quality
right testis	UBERON:0004534	46.28	gold quality
testis	UBERON:0000473	46.23	gold quality
placenta	UBERON:0001987	40.40	gold quality
bone marrow cell	CL:0002092	37.96	gold quality
blood	UBERON:0000178	37.25	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
lymph node	UBERON:0000029	36.65	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	35.11	gold quality
tonsil	UBERON:0002372	34.25	gold quality
right coronary artery	UBERON:0001625	34.08	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.66	gold quality
prefrontal cortex	UBERON:0000451	32.23	gold quality
muscle tissue	UBERON:0002385	32.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
vermiform appendix	UBERON:0001154	32.02	gold quality
liver	UBERON:0002107	31.79	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
gall bladder	UBERON:0002110	30.81	gold quality
urinary bladder	UBERON:0001255	30.45	gold quality
leukocyte	CL:0000738	30.44	silver quality
monocyte	CL:0000576	30.17	silver quality
endometrium	UBERON:0001295	30.15	gold quality
calcaneal tendon	UBERON:0003701	30.07	gold quality
right lobe of liver	UBERON:0001114	29.95	gold quality
islet of Langerhans	UBERON:0000006	29.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

150 targeting ZNF705A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 705A — Q6ZN79 (reviewed: Q6ZN79)

All UniProt accessions (3): J3KPU9, Q6ZN79, U3KQ42

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001004328* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (9 total): sequence variant 4, zinc finger region 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZN79-F1	64.50	0.11

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 32 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, MAFG_TARGET_GENES, MIR6809_3P, MIR3121_3P, MIR182_5P, MIR6833_3P, MIR218_5P, MIR519E_5P, MIR515_5P, MIR10522_5P, MIR3185, MIR6515_3P, MIR1236_3P, MIR12119

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

138 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF705A	CLEC2L	P0C7M8	446
ZNF705A	TGIF2LX	Q8IUE1	434
ZNF705A	MORN1	Q5T089	422
ZNF705A	CHLSN	Q9BRJ6	418
ZNF705A	SLC9D1	Q6UWJ1	417
ZNF705A	SFSWAP	Q12872	380
ZNF705A	ATP5MJ	P56378	371
ZNF705A	USP43	Q70EL4	367
ZNF705A	MRI1	Q9BV20	348
ZNF705A	SRPRB	Q9Y5M8	336
ZNF705A	DCBLD2	Q96PD2	294
ZNF705A	COL22A1	Q8NFW1	274
ZNF705A	NEUROG1	Q92886	274
ZNF705A	FNIP1	Q8TF40	274
ZNF705A	KRT2	P35908	272

IntAct

0 interactions, top by confidence:

BioGRID (1): CCT8 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A2K5V015, A1YIY0, A8MUZ8, A8MWA4, B8JI71, O08569, P01133, P0DJ43, P14370, P14585, P17630, P19070, P48357, P82279, P97435, Q07444, Q0D2K5, Q28066, Q28660, Q29RU2, Q4KUS1, Q5G872, Q5R6R1, Q5RCW9, Q5T1H1, Q5UKY4, Q5Z5Q3, Q60736, Q63515, Q63722, Q6DFV8, Q6GMZ9, Q6V0K7, Q6ZN79, Q7TSY4, Q811Q4, Q8N2E2, Q8VHS2, Q90Y54, Q95MI4

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

735 predictions. Top by Δscore:

Variant	Effect	Δscore
12:8174324:A:AG	acceptor_gain	1.0000
12:8174325:G:GG	acceptor_gain	1.0000
12:8174325:GAAGA:G	acceptor_gain	1.0000
12:8174452:GGTG:G	donor_loss	1.0000
12:8174453:G:C	donor_loss	1.0000
12:8174453:G:GG	donor_gain	1.0000
12:8174454:T:TC	donor_loss	1.0000
12:8174455:GA:G	donor_loss	1.0000
12:8175223:AACAG:A	acceptor_gain	1.0000
12:8175226:AG:A	acceptor_gain	1.0000
12:8175227:GG:G	acceptor_gain	1.0000
12:8175322:AGGT:A	donor_loss	1.0000
12:8175324:G:GG	donor_gain	1.0000
12:8175849:A:AG	acceptor_gain	1.0000
12:8175858:A:AG	acceptor_gain	1.0000
12:8175859:G:GA	acceptor_gain	1.0000
12:8175859:GA:G	acceptor_gain	1.0000
12:8175859:GAC:G	acceptor_gain	1.0000
12:8175859:GACA:G	acceptor_gain	1.0000
12:8175939:AATGG:A	donor_loss	1.0000
12:8175941:TGGT:T	donor_loss	1.0000
12:8175943:G:C	donor_loss	1.0000
12:8175943:G:GG	donor_gain	1.0000
12:8175944:TAAGT:T	donor_loss	1.0000
12:8174319:GTTTT:G	acceptor_loss	0.9900
12:8174320:TTTTA:T	acceptor_loss	0.9900
12:8174321:TTTA:T	acceptor_loss	0.9900
12:8174322:TTA:T	acceptor_loss	0.9900
12:8174324:AGA:A	acceptor_loss	0.9900
12:8174325:G:GT	acceptor_loss	0.9900

AlphaMissense

1379 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:8174441:T:C	L43P	0.971
12:8174452:G:T	G47W	0.971
12:8177246:G:C	R189P	0.961
12:8174360:T:C	F16S	0.960
12:8174374:T:A	W21R	0.960
12:8174374:T:C	W21R	0.960
12:8174376:G:C	W21C	0.958
12:8174376:G:T	W21C	0.958
12:8177262:C:A	H194Q	0.952
12:8177262:C:G	H194Q	0.952
12:8174407:T:G	Y32D	0.951
12:8175228:G:T	G47V	0.951
12:8174423:T:C	L37P	0.948
12:8174338:T:C	F9L	0.943
12:8174340:T:A	F9L	0.943
12:8174340:T:G	F9L	0.943
12:8174359:T:C	F16L	0.929
12:8174361:C:A	F16L	0.929
12:8174361:C:G	F16L	0.929
12:8174350:G:C	A13P	0.925
12:8174426:A:T	E38V	0.921
12:8174400:A:C	R29S	0.919
12:8174400:A:T	R29S	0.919
12:8177274:G:C	R198S	0.917
12:8177274:G:T	R198S	0.917
12:8177286:T:G	C202W	0.916
12:8177284:T:C	C202R	0.912
12:8174430:T:A	N39K	0.911
12:8174430:T:G	N39K	0.911
12:8177295:T:G	C205W	0.909

dbSNP variants (sampled 300 via entrez): RS1000063691 (12:8159023 T>C,G), RS1000148053 (12:8159543 A>C), RS1000519791 (12:8159386 C>T), RS1001108239 (12:8166234 T>C), RS1001219429 (12:8163070 C>T), RS1001324634 (12:8156082 G>A), RS1001458392 (12:8172901 C>T), RS1001546764 (12:8158429 T>C), RS1001851865 (12:8159008 T>C), RS1001885594 (12:8173216 A>G,T), RS1001911872 (12:8173520 C>A,T), RS1002069988 (12:8156382 T>C), RS1002127028 (12:8161231 C>G), RS1002152633 (12:8179836 T>C), RS1002430717 (12:8167285 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation	1
sodium arsenite	increases expression	1
theaflavin-3,3’-digallate	affects expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.