ZNF705B

Summary

ZNF705B (zinc finger protein 705B, HGNC:32284) is a protein-coding gene on chromosome 8p23.1, encoding Zinc finger protein 705B (P0CI00). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 100132396 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 16 total
• MANE Select transcript: NM_001193630

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32284
Approved symbol	ZNF705B
Name	zinc finger protein 705B
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000215356
Ensembl biotype	protein_coding
Entrez	100132396

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000400120

RefSeq mRNA: 1 — MANE Select: NM_001193630 NM_001193630

CCDS: CCDS55194

Canonical transcript exons

ENST00000400120 — 7 exons

Exon	Start	End
ENSE00001600461	7950033	7950128
ENSE00001608227	7930287	7930436
ENSE00001653900	7926337	7926397
ENSE00001694929	7949129	7949255
ENSE00001698841	7951807	7952413
ENSE00001741433	7947351	7947433
ENSE00001802252	7950665	7950747

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 83.98.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.98	silver quality
left testis	UBERON:0004533	39.05	gold quality
testis	UBERON:0000473	38.99	gold quality
bone marrow cell	CL:0002092	38.72	gold quality
ganglionic eminence	UBERON:0004023	37.28	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
tonsil	UBERON:0002372	33.69	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
right testis	UBERON:0004534	33.15	gold quality
bone marrow	UBERON:0002371	33.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
urinary bladder	UBERON:0001255	28.88	gold quality
liver	UBERON:0002107	28.60	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
right coronary artery	UBERON:0001625	27.42	gold quality
islet of Langerhans	UBERON:0000006	26.88	gold quality
blood	UBERON:0000178	26.58	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
leukocyte	CL:0000738	25.74	gold quality
monocyte	CL:0000576	25.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 705B — P0CI00 (reviewed: P0CI00)

All UniProt accessions (1): P0CI00

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001180559* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (7 total): zinc finger region 4, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CI00-F1	62.32	0.10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 5 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, chr8p23

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

160 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF705B	ATP6AP1L	Q52LC2	479
ZNF705B	PHYHD1	Q5SRE7	419
ZNF705B	ACY3	Q96HD9	400
ZNF705B	ARHGAP28	Q9P2N2	398
ZNF705B	ARHGAP42	A6NI28	370
ZNF705B	SYNE3	Q6ZMZ3	368
ZNF705B	PRAG1	Q86YV5	348
ZNF705B	ASPNAT	Q8N9F0	348
ZNF705B	EDARADD	Q8WWZ3	323
ZNF705B	ABCB9	Q9NP78	320
ZNF705B	KANK2	Q63ZY3	312
ZNF705B	GJC2	Q5T442	278
ZNF705B	HOXD8	P13378	277
ZNF705B	PI16	Q6UXB8	276
ZNF705B	ZHX2	Q9Y6X8	272

IntAct

0 interactions, top by confidence:

BioGRID (2): CCT8 (Cross-Linking-MS (XL-MS)), ZNF705G (Reconstituted Complex)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A7MBI1, A8MUZ8, A8MWA4, B2RXC5, E7ETH6, E9Q8G5, O14628, P0CB33, P0CH99, P0CI00, P21506, P51508, P52744, Q02525, Q0D2J5, Q12901, Q13360, Q15973, Q2M218, Q2VY69, Q4R882, Q5FWF6, Q5HY98, Q5JVG8, Q6P280, Q6V9R5, Q6ZN11, Q6ZN79, Q86XU0, Q8IVC4, Q8IW36, Q8IYX0, Q8N587, Q8N782, Q8N859, Q8NB42, Q8NDP4, Q8NE65

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	15
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

910 predictions. Top by Δscore:

Variant	Effect	Δscore
8:7949125:TTA:T	acceptor_loss	1.0000
8:7949126:TA:T	acceptor_loss	1.0000
8:7949127:A:AC	acceptor_loss	1.0000
8:7949127:A:AG	acceptor_gain	1.0000
8:7949128:G:GG	acceptor_gain	1.0000
8:7949128:GGAGA:G	acceptor_gain	1.0000
8:7949253:TCG:T	donor_gain	1.0000
8:7949254:CGG:C	donor_loss	1.0000
8:7949256:G:GG	donor_gain	1.0000
8:7949256:GT:G	donor_loss	1.0000
8:7950028:AACAG:A	acceptor_gain	1.0000
8:7950031:A:AG	acceptor_gain	1.0000
8:7950031:AG:A	acceptor_gain	1.0000
8:7950032:G:GG	acceptor_gain	1.0000
8:7950032:GG:G	acceptor_gain	1.0000
8:7950126:CAGG:C	donor_loss	1.0000
8:7950654:A:AG	acceptor_gain	1.0000
8:7950663:A:AG	acceptor_gain	1.0000
8:7950664:G:GT	acceptor_gain	1.0000
8:7950664:GA:G	acceptor_gain	1.0000
8:7950664:GAC:G	acceptor_gain	1.0000
8:7950664:GACA:G	acceptor_gain	1.0000
8:7950748:G:GG	donor_gain	1.0000
8:7947431:CTA:C	donor_gain	0.9900
8:7947434:G:GG	donor_gain	0.9900
8:7949121:T:A	acceptor_gain	0.9900
8:7949127:AG:A	acceptor_gain	0.9900
8:7949128:GG:G	acceptor_gain	0.9900
8:7949128:GGA:G	acceptor_gain	0.9900
8:7949251:CCTCG:C	donor_gain	0.9900

AlphaMissense

2009 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:7952113:T:C	F209L	0.996
8:7952115:C:A	F209L	0.996
8:7952115:C:G	F209L	0.996
8:7952197:T:C	F237L	0.992
8:7952199:T:A	F237L	0.992
8:7952199:T:G	F237L	0.992
8:7952154:C:A	H222Q	0.979
8:7952154:C:G	H222Q	0.979
8:7949244:T:C	L43P	0.977
8:7952114:T:C	F209S	0.977
8:7949179:G:C	W21C	0.976
8:7949179:G:T	W21C	0.976
8:7949255:G:T	G47W	0.975
8:7949177:T:A	W21R	0.973
8:7949177:T:C	W21R	0.973
8:7949163:T:C	F16S	0.972
8:7952132:T:C	L215P	0.972
8:7952054:G:C	R189P	0.968
8:7952070:C:A	H194Q	0.967
8:7952070:C:G	H194Q	0.967
8:7949210:T:G	Y32D	0.964
8:7949226:T:C	L37P	0.964
8:7952113:T:A	F209I	0.964
8:7950033:G:T	G47V	0.961
8:7949141:T:C	F9L	0.960
8:7949143:T:A	F9L	0.960
8:7949143:T:G	F9L	0.960
8:7952142:T:A	H218Q	0.960
8:7952142:T:G	H218Q	0.960
8:7952198:T:C	F237S	0.959

dbSNP variants (sampled 300 via entrez): RS1000081281 (8:7936661 G>A), RS1001205100 (8:7930647 T>C,G), RS1002158477 (8:7928000 G>A,C), RS1002614999 (8:7938578 G>A,T), RS1003931956 (8:7939851 T>A), RS1004061170 (8:7946899 A>C), RS1004434240 (8:7941366 A>G,T), RS1005717648 (8:7932690 C>A,G,T), RS1006164487 (8:7933720 A>G), RS1007419816 (8:7925848 A>G,T), RS1009504743 (8:7934779 G>T), RS1009535972 (8:7936621 C>G), RS1011270317 (8:7927310 C>A,G), RS1011657799 (8:7926138 T>A,G), RS1014111730 (8:7938868 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	decreases methylation	1
2-palmitoylglycerol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.