ZNF705D

Summary

ZNF705D (zinc finger protein 705D, HGNC:33202) is a protein-coding gene on chromosome 8p23.1, encoding Zinc finger protein 705D (P0CH99). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 728957 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 30 total
• MANE Select transcript: NM_001039615

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33202
Approved symbol	ZNF705D
Name	zinc finger protein 705D
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000215343
Ensembl biotype	protein_coding
Entrez	728957

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000400085

RefSeq mRNA: 1 — MANE Select: NM_001039615 NM_001039615

CCDS: CCDS43712

Canonical transcript exons

ENST00000400085 — 7 exons

Exon	Start	End
ENSE00001619309	12110800	12110895
ENSE00001621663	12108123	12108205
ENSE00001638903	12109900	12110026
ENSE00001698595	12111432	12111514
ENSE00001717624	12112574	12115516
ENSE00001763603	12104389	12104433
ENSE00003968387	12089338	12089643

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 90.23.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.23	gold quality
colonic epithelium	UBERON:0000397	42.32	gold quality
ventricular zone	UBERON:0003053	39.83	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	34.79	gold quality
skeletal muscle tissue	UBERON:0001134	34.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	32.09	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
leukocyte	CL:0000738	30.09	gold quality
prefrontal cortex	UBERON:0000451	29.90	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.80	gold quality
adrenal tissue	UBERON:0018303	28.60	gold quality
endometrium	UBERON:0001295	28.41	silver quality
liver	UBERON:0002107	28.34	gold quality
duodenum	UBERON:0002114	28.14	gold quality
islet of Langerhans	UBERON:0000006	27.72	gold quality
lymph node	UBERON:0000029	27.57	gold quality
testis	UBERON:0000473	27.43	gold quality
placenta	UBERON:0001987	27.37	gold quality
tonsil	UBERON:0002372	27.05	gold quality
left testis	UBERON:0004533	26.99	gold quality
calcaneal tendon	UBERON:0003701	26.94	gold quality
blood	UBERON:0000178	26.86	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

134 targeting ZNF705D, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-15A-5P	99.90	72.80	2787

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 705D — P0CH99 (reviewed: P0CH99)

All UniProt accessions (1): P0CH99

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001034704* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (7 total): zinc finger region 4, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CH99-F1	63.77	0.17

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 25 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, MIR4659A_3P_MIR4659B_3P, MIR6809_3P, MIR3121_3P, MIR6833_3P, MIR6875_3P, MIR7856_5P, MIR4768_5P, MIR10522_5P, MIR3185, MIR6515_3P, MIR1236_3P, MIR12119, MIR3925_3P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

96 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF705D	DEFB135	Q30KP9	654
ZNF705D	DEFB130A	P0DP74	593
ZNF705D	FAM86B2	P0C5J1	481
ZNF705D	KCNA10	Q16322	446
ZNF705D	GOLGA6B	A6NDN3	370
ZNF705D	A0A0G2JN59	A0A0G2JN59	324
ZNF705D	GNA14	O95837	323
ZNF705D	CNMD	O75829	315
ZNF705D	IARS1	P41252	281
ZNF705D	HOXC6	P09630	274
ZNF705D	TNKS	O95271	249
ZNF705D	XKR6	Q5GH73	213
ZNF705D	FOSL2	P15408	212
ZNF705D	CMA1	P23946	202
ZNF705D	CD79B	P40259	193

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ZNF705D	GUCD1	psi-mi:“MI:0915”(physical association)	0.560
CCL26	ZNF705D	psi-mi:“MI:0915”(physical association)	0.370
GUCD1	ZNF705D	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (1): ZNF705D (Two-hybrid)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A7MBI1, A8MUZ8, A8MWA4, B2RXC5, E7ETH6, E9Q8G5, O14628, P0CB33, P0CH99, P0CI00, P21506, P51508, P52744, Q02525, Q0D2J5, Q12901, Q13360, Q15973, Q2M218, Q2VY69, Q4R882, Q5FWF6, Q5HY98, Q5JVG8, Q6P280, Q6V9R5, Q6ZN11, Q6ZN79, Q86XU0, Q8IVC4, Q8IW36, Q8IYX0, Q8N587, Q8N782, Q8N859, Q8NB42, Q8NDP4, Q8NE65

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

669 predictions. Top by Δscore:

Variant	Effect	Δscore
8:12109894:TTTTA:T	acceptor_loss	1.0000
8:12109895:TTTA:T	acceptor_loss	1.0000
8:12109897:TA:T	acceptor_loss	1.0000
8:12109898:A:AG	acceptor_gain	1.0000
8:12109899:G:GG	acceptor_gain	1.0000
8:12109899:GGA:G	acceptor_gain	1.0000
8:12109899:GGAGA:G	acceptor_gain	1.0000
8:12110024:TCG:T	donor_gain	1.0000
8:12110025:CGG:C	donor_loss	1.0000
8:12110027:G:C	donor_loss	1.0000
8:12110027:G:GG	donor_gain	1.0000
8:12110028:TGAG:T	donor_loss	1.0000
8:12110795:AACAG:A	acceptor_gain	1.0000
8:12110798:AG:A	acceptor_gain	1.0000
8:12110799:GG:G	acceptor_gain	1.0000
8:12110894:AGGT:A	donor_loss	1.0000
8:12110896:G:GG	donor_gain	1.0000
8:12110897:T:G	donor_loss	1.0000
8:12111421:A:AG	acceptor_gain	1.0000
8:12111430:A:AG	acceptor_gain	1.0000
8:12111431:G:GA	acceptor_gain	1.0000
8:12111431:GA:G	acceptor_gain	1.0000
8:12111431:GAC:G	acceptor_gain	1.0000
8:12111431:GACA:G	acceptor_gain	1.0000
8:12111511:AATGG:A	donor_loss	1.0000
8:12111512:ATGG:A	donor_loss	1.0000
8:12111513:TG:T	donor_gain	1.0000
8:12111513:TGG:T	donor_loss	1.0000
8:12111514:GG:G	donor_gain	1.0000
8:12111514:GGT:G	donor_loss	1.0000

AlphaMissense

2009 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:12112880:T:C	F209L	0.995
8:12112882:C:A	F209L	0.995
8:12112882:C:G	F209L	0.995
8:12112964:T:C	F237L	0.991
8:12112966:T:A	F237L	0.991
8:12112966:T:G	F237L	0.991
8:12110015:T:C	L43P	0.985
8:12112881:T:C	F209S	0.980
8:12109948:T:A	W21R	0.977
8:12109948:T:C	W21R	0.977
8:12109950:G:C	W21C	0.977
8:12109950:G:T	W21C	0.977
8:12112921:C:A	H222Q	0.977
8:12112921:C:G	H222Q	0.977
8:12110026:G:T	G47W	0.976
8:12112899:T:C	L215P	0.975
8:12109934:T:C	F16S	0.974
8:12113132:T:C	F293L	0.974
8:12113134:C:A	F293L	0.974
8:12113134:C:G	F293L	0.974
8:12109997:T:C	L37P	0.972
8:12112837:C:A	H194Q	0.970
8:12112837:C:G	H194Q	0.970
8:12112821:G:C	R189P	0.963
8:12112880:T:A	F209I	0.963
8:12109933:T:C	F16L	0.961
8:12109935:C:A	F16L	0.961
8:12109935:C:G	F16L	0.961
8:12109981:T:G	Y32D	0.959
8:12110800:G:T	G47V	0.958

dbSNP variants (sampled 300 via entrez): RS1001257641 (8:12093862 C>G,T), RS1001287453 (8:12094692 C>A), RS1002262109 (8:12100095 G>A), RS1002289714 (8:12102761 G>A,C), RS1003265028 (8:12112076 AT>A), RS1003296159 (8:12114538 G>A,T), RS1005216193 (8:12091379 A>T), RS1006217197 (8:12098971 G>A), RS1006415327 (8:12099809 A>G), RS1007205104 (8:12105455 G>A,C), RS1007404537 (8:12108589 T>C), RS1009385728 (8:12091003 T>C,G), RS1009435456 (8:12089189 G>C), RS1009977286 (8:12098888 G>A), RS1010862822 (8:12095638 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.