ZNF705G

Summary

ZNF705G (zinc finger protein 705G, HGNC:37134) is a protein-coding gene on chromosome 8p23.1, encoding Putative zinc finger protein 705G (A8MUZ8). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 100131980 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 91 total
• MANE Select transcript: NM_001164457

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37134
Approved symbol	ZNF705G
Name	zinc finger protein 705G
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000215372
Ensembl biotype	protein_coding
Entrez	100131980

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000400156

RefSeq mRNA: 1 — MANE Select: NM_001164457 NM_001164457

CCDS: CCDS47773

Canonical transcript exons

ENST00000400156 — 7 exons

Exon	Start	End
ENSE00001621164	7381452	7381601
ENSE00001647348	7359619	7359701
ENSE00001663100	7361110	7361236
ENSE00001681972	7385498	7385558
ENSE00001774873	7360237	7360332
ENSE00001793543	7362935	7363017
ENSE00002171194	7355517	7358560

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 40.27.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	40.27	gold quality
right testis	UBERON:0004534	37.57	gold quality
ganglionic eminence	UBERON:0004023	37.22	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
left testis	UBERON:0004533	35.78	gold quality
testis	UBERON:0000473	35.70	gold quality
skeletal muscle tissue	UBERON:0001134	34.95	gold quality
muscle tissue	UBERON:0002385	33.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
monocyte	CL:0000576	32.13	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
mucosa of stomach	UBERON:0001199	31.73	gold quality
leukocyte	CL:0000738	31.72	gold quality
prefrontal cortex	UBERON:0000451	30.27	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
right uterine tube	UBERON:0001302	29.21	gold quality
tonsil	UBERON:0002372	28.60	gold quality
liver	UBERON:0002107	28.29	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.59	gold quality
lymph node	UBERON:0000029	27.57	gold quality
primary visual cortex	UBERON:0002436	27.42	gold quality
smooth muscle tissue	UBERON:0001135	27.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.32	gold quality
blood	UBERON:0000178	27.07	gold quality
corpus callosum	UBERON:0002336	27.06	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Putative zinc finger protein 705G — A8MUZ8 (reviewed: A8MUZ8)

All UniProt accessions (1): A8MUZ8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001157929* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (6 total): zinc finger region 4, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MUZ8-F1	67.40	0.15

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 24 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GSE26928_NAIVE_VS_EFF_MEMORY_CD4_TCELL_UP, GSE26928_NAIVE_VS_CXCR5_POS_CD4_TCELL_UP, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, GSE2770_IL12_AND_TGFB_VS_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE1112_OT1_CD8AB_VS_HY_CD8AA_THYMOCYTE_RTOC_CULTURE_UP, GSE1740_UNSTIM_VS_IFNA_STIMULATED_MCSF_DERIVED_MACROPHAGE_UP, GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_0.8H_UP, GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_12H_DN, chr8p23, GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

84 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF705G	SPATA31A6	Q5VVP1	599
ZNF705G	ANKRD20A4P	Q4UJ75	581
ZNF705G	ENPP7	Q6UWV6	541
ZNF705G	BET1L	Q9NYM9	380
ZNF705G	DNAJC8	O75937	377
ZNF705G	LRRC37A3	O60309	374
ZNF705G	EME2	A4GXA9	367
ZNF705G	WDR3	Q9UNX4	348
ZNF705G	CETN1	Q12798	269
ZNF705G	SF3B3	Q15393	245
ZNF705G	CETN2	P41208	212
ZNF705G	IARS1	P41252	211
ZNF705G	TNKS	O95271	203
ZNF705G	HLA-DQA2	P01906	160
ZNF705G	HLA-DQB1	P01917	145

IntAct

0 interactions, top by confidence:

BioGRID (2): CCT8 (Cross-Linking-MS (XL-MS)), ZNF705G (Reconstituted Complex)

ESM2 similar proteins: A0A2K5V015, A1YIY0, A8MUZ8, A8MWA4, B8JI71, O08569, P01133, P0DJ43, P14370, P14585, P17630, P19070, P48357, P82279, P97435, Q07444, Q0D2K5, Q28066, Q28660, Q29RU2, Q4KUS1, Q5G872, Q5R6R1, Q5RCW9, Q5T1H1, Q5UKY4, Q5Z5Q3, Q60736, Q63515, Q63722, Q6DFV8, Q6GMZ9, Q6V0K7, Q6ZN79, Q7TSY4, Q811Q4, Q8N2E2, Q8VHS2, Q90Y54, Q95MI4

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

91 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	82
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

981 predictions. Top by Δscore:

Variant	Effect	Δscore
8:7359612:AACTT:A	donor_loss	1.0000
8:7359613:ACTTA:A	donor_loss	1.0000
8:7359614:CTTAC:C	donor_loss	1.0000
8:7359615:TTACC:T	donor_loss	1.0000
8:7359616:TAC:T	donor_loss	1.0000
8:7359617:A:AC	donor_gain	1.0000
8:7359618:C:CC	donor_gain	1.0000
8:7359698:CTGT:C	acceptor_gain	1.0000
8:7359699:TGTC:T	acceptor_loss	1.0000
8:7359711:T:TC	acceptor_gain	1.0000
8:7360235:A:AC	donor_gain	1.0000
8:7360236:C:CC	donor_gain	1.0000
8:7361103:GACTC:G	donor_loss	1.0000
8:7361104:ACTCA:A	donor_loss	1.0000
8:7361105:CTCAC:C	donor_loss	1.0000
8:7361106:TCA:T	donor_loss	1.0000
8:7361107:CACCG:C	donor_loss	1.0000
8:7361108:A:AC	donor_gain	1.0000
8:7361108:ACCGA:A	donor_loss	1.0000
8:7361109:C:CA	donor_gain	1.0000
8:7361232:TTCTT:T	acceptor_gain	1.0000
8:7361234:CTT:C	acceptor_gain	1.0000
8:7361237:C:CC	acceptor_gain	1.0000
8:7359617:AC:A	donor_gain	0.9900
8:7359618:CC:C	donor_gain	0.9900
8:7359618:CCA:C	donor_gain	0.9900
8:7359699:TGT:T	acceptor_gain	0.9900
8:7359700:GT:G	acceptor_gain	0.9900
8:7359702:C:CC	acceptor_gain	0.9900
8:7359711:T:C	acceptor_gain	0.9900

AlphaMissense

2010 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:7358252:G:C	F209L	0.977
8:7358252:G:T	F209L	0.977
8:7358254:A:G	F209L	0.977
8:7361121:A:G	L43P	0.964
8:7361202:A:G	F16S	0.964
8:7358000:G:C	F293L	0.954
8:7358000:G:T	F293L	0.954
8:7358002:A:G	F293L	0.954
8:7361201:G:C	F16L	0.954
8:7361201:G:T	F16L	0.954
8:7361203:A:G	F16L	0.954
8:7361155:A:C	Y32D	0.945
8:7361188:A:G	W21R	0.945
8:7361188:A:T	W21R	0.945
8:7361139:A:G	L37P	0.944
8:7361186:C:A	W21C	0.943
8:7361186:C:G	W21C	0.943
8:7361212:C:G	A13P	0.941
8:7361222:A:C	F9L	0.932
8:7361222:A:T	F9L	0.932
8:7361224:A:G	F9L	0.932
8:7358168:A:C	F237L	0.924
8:7358168:A:T	F237L	0.924
8:7358170:A:G	F237L	0.924
8:7361162:T:A	R29S	0.914
8:7361162:T:G	R29S	0.914
8:7358313:C:G	R189P	0.907
8:7361142:A:G	M36T	0.904
8:7361136:T:A	E38V	0.902
8:7361132:A:C	N39K	0.886

dbSNP variants (sampled 300 via entrez): RS1000241593 (8:7385269 A>C), RS1000260179 (8:7365646 A>C,T), RS1000396493 (8:7366297 G>A,T), RS1000651979 (8:7387276 G>A,T), RS1000696810 (8:7385720 C>G,T), RS1000888004 (8:7356899 G>A), RS1001931488 (8:7362771 C>A,T), RS1001961199 (8:7382170 C>T), RS1002067415 (8:7363152 A>C), RS1002310736 (8:7380783 G>A,C), RS1002598813 (8:7357049 T>A), RS1002631886 (8:7369930 T>A,C,G), RS1002734777 (8:7357528 T>A), RS1002920113 (8:12357739 C>G), RS1002979941 (8:7369273 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	decreases phosphorylation	1
Tetrachlorodibenzodioxin	decreases expression, increases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.