ZNF707

Summary

ZNF707 (zinc finger protein 707, HGNC:27815) is a protein-coding gene on chromosome 8q24.3, encoding Zinc finger protein 707 (Q96C28). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 286075 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_001100598

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27815
Approved symbol	ZNF707
Name	zinc finger protein 707
Location	8q24.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181135
Ensembl biotype	protein_coding
Entrez	286075

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 22 protein_coding, 8 retained_intron, 7 nonsense_mediated_decay, 4 protein_coding_CDS_not_defined

ENST00000358656, ENST00000418203, ENST00000442058, ENST00000508587, ENST00000525185, ENST00000525538, ENST00000525619, ENST00000525862, ENST00000526315, ENST00000526970, ENST00000527293, ENST00000527561, ENST00000528134, ENST00000528456, ENST00000529833, ENST00000530341, ENST00000530574, ENST00000531254, ENST00000531811, ENST00000531985, ENST00000532003, ENST00000532158, ENST00000532205, ENST00000532486, ENST00000532571, ENST00000533031, ENST00000533254, ENST00000534303, ENST00000534589, ENST00000881543, ENST00000911459, ENST00000911460, ENST00000971400, ENST00000971401, ENST00000971402, ENST00000971403, ENST00000971404, ENST00000971405, ENST00000971406, ENST00000971407, ENST00000971408

RefSeq mRNA: 8 — MANE Select: NM_001100598 NM_001100598, NM_001100599, NM_001288805, NM_001288806, NM_001288807, NM_001288808, NM_001288809, NM_173831

CCDS: CCDS47932

Canonical transcript exons

ENST00000358656 — 6 exons

Exon	Start	End
ENSE00002180200	143693671	143695385
ENSE00002193357	143684479	143684542
ENSE00002528676	143689204	143689301
ENSE00003563709	143690057	143690123
ENSE00003616456	143691600	143691713
ENSE00003789073	143691073	143691199

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 87.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.9546 / max 46.6198, expressed in 1751 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91416	4.7763	1713
91417	1.1783	739

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.86	gold quality
right testis	UBERON:0004534	87.80	gold quality
left testis	UBERON:0004533	87.55	gold quality
testis	UBERON:0000473	86.85	gold quality
granulocyte	CL:0000094	86.79	gold quality
spleen	UBERON:0002106	83.41	gold quality
stromal cell of endometrium	CL:0002255	82.60	gold quality
blood	UBERON:0000178	82.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.80	gold quality
apex of heart	UBERON:0002098	81.47	gold quality
lymph node	UBERON:0000029	80.13	gold quality
skin of leg	UBERON:0001511	79.80	gold quality
zone of skin	UBERON:0000014	79.53	gold quality
sural nerve	UBERON:0015488	79.28	gold quality
skin of abdomen	UBERON:0001416	79.06	gold quality
leukocyte	CL:0000738	78.99	gold quality
monocyte	CL:0000576	78.69	gold quality
right lobe of thyroid gland	UBERON:0001119	78.65	gold quality
mucosa of transverse colon	UBERON:0004991	78.03	gold quality
small intestine	UBERON:0002108	77.87	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.86	gold quality
body of stomach	UBERON:0001161	77.82	gold quality
thyroid gland	UBERON:0002046	77.80	gold quality
left lobe of thyroid gland	UBERON:0001120	77.79	gold quality
left uterine tube	UBERON:0001303	77.70	gold quality
ventricular zone	UBERON:0003053	77.61	gold quality
right adrenal gland cortex	UBERON:0035827	77.59	gold quality
saliva-secreting gland	UBERON:0001044	77.53	gold quality
bone marrow	UBERON:0002371	77.53	gold quality
body of uterus	UBERON:0009853	77.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1715.1	ZNF707	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:22955616

miRNA regulators (miRDB)

15 targeting ZNF707, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-16-1-3P	98.70	69.23	1538
HSA-MIR-4680-3P	98.64	68.60	2093
HSA-MIR-4664-5P	98.17	65.07	1020
HSA-MIR-3921	97.81	67.45	1431
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-342-5P	97.25	64.10	817
HSA-MIR-4653-5P	97.22	67.72	1429
HSA-MIR-939-5P	97.10	65.80	1579
HSA-MIR-1343-5P	96.48	66.06	1506

Cross-species orthologs

0 orthologs

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM4 (ENSG00000110851), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

Zinc finger protein 707 — Q96C28 (reviewed: Q96C28)

All UniProt accessions (10): A0A2R8YE36, E9PHZ0, E9PJ46, E9PKX4, E9PNV7, E9PP66, E9PPS7, E9PQ20, Q96C28, E9PS67

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (8): NP_001094068, NP_001094069, NP_001275734, NP_001275735, NP_001275736, NP_001275737, NP_001275738, NP_776192 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (17 total): zinc finger region 7, compositionally biased region 3, sequence conflict 2, chain 1, domain 1, cross-link 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96C28-F1	69.29	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 144

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 52 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, MCGOWAN_RSP6_TARGETS_DN, NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON, NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, KASLER_HDAC7_TARGETS_1_UP, chr8q24, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, FOXR2_TARGET_GENES, HOXC6_TARGET_GENES, SNIP1_TARGET_GENES, ZNF592_TARGET_GENES, ZNF7_TARGET_GENES, MIR6868_5P, GSE11924_TH2_VS_TH17_CD4_TCELL_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

384 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF707	MRPS14	O60783	567
ZNF707	EMC2	Q15006	500
ZNF707	WDR97	A6NE52	483
ZNF707	C8orf58	Q8NAV2	436
ZNF707	ZC4H2	Q9NQZ6	436
ZNF707	RNF113A	O15541	422
ZNF707	LRRC14	Q15048	394
ZNF707	ADCK5	Q3MIX3	378
ZNF707	SACK1H	Q6ZRV2	371
ZNF707	LRRC24	Q50LG9	370
ZNF707	ANGEL1	Q9UNK9	356
ZNF707	ZDHHC9	Q9Y397	349
ZNF707	RAB5IF	Q9BUV8	348
ZNF707	SDE2	Q6IQ49	322
ZNF707	FBXL6	Q8N531	321

IntAct

42 interactions, top by confidence:

A	B	Type	Score
ZNF707	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	ZNF707	psi-mi:“MI:0915”(physical association)	0.780
MDFI	ZNF707	psi-mi:“MI:0915”(physical association)	0.740
ZNF707	MDFI	psi-mi:“MI:0915”(physical association)	0.740
ZNF707	RALBP1	psi-mi:“MI:0915”(physical association)	0.720
RALBP1	ZNF707	psi-mi:“MI:0915”(physical association)	0.720
ZNF707	KRTAP10-5	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF707	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-5	ZNF707	psi-mi:“MI:0915”(physical association)	0.560
ZNF707	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
STX1A	ZNF707	psi-mi:“MI:0915”(physical association)	0.560
ZNF707	NDEL1	psi-mi:“MI:0915”(physical association)	0.560
CASP8	ZNF707	psi-mi:“MI:0915”(physical association)	0.560
ZNF707	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
LLGL2	RBBP6	psi-mi:“MI:0914”(association)	0.350
CHD8	BLTP3B	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF707	LRP4	psi-mi:“MI:0914”(association)	0.350
ZNF707	MDFI	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (147): ZNF707 (Two-hybrid), ZNF707 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-5 (Two-hybrid), ZNF696 (Affinity Capture-MS), TRIM28 (Affinity Capture-MS), MRPS26 (Affinity Capture-MS), VPRBP (Affinity Capture-MS), ZNF747 (Affinity Capture-MS), ZNF273 (Affinity Capture-MS), ZNF92 (Affinity Capture-MS), ZNF324 (Affinity Capture-MS), C1QBP (Affinity Capture-MS), TOR2A (Affinity Capture-MS), PTCD3 (Affinity Capture-MS)

ESM2 similar proteins: A3KN32, A6NM28, A8K8V0, E9PYI1, O75467, O95201, P10072, P10075, P10078, P10754, P28698, P30373, P52736, Q0VCC5, Q14929, Q16587, Q17QR7, Q29RZ4, Q3KNW1, Q3TDE8, Q3US17, Q58DK7, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMY9, Q7Z398, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BKK5, Q8JZL0, Q8N393, Q8R0T2

Diamond homologs: A1L1L7, A3KN32, A3KN36, A6NFI3, A6NM28, A6NN14, A6QLU5, A7MBI1, A8K8V0, A8MTY0, A8MWA4, B4DU55, C9JBD0, G3X9G7, O60765, O75290, O94892, O95780, P0C7X2, P10072, P15622, P16373, P16374, P17023, P17032, P17097, P17098, P21506, P52742, P59923, Q06730, Q08DG8, Q16587, Q29RZ4, Q2TL60, Q3V080, Q49AA0, Q4R6C2, Q4V8A8, Q5FWF6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1492 predictions. Top by Δscore:

Variant	Effect	Δscore
8:143691593:T:TA	acceptor_gain	1.0000
8:143691598:AGGAT:A	acceptor_loss	1.0000
8:143691711:CAGGT:C	donor_loss	1.0000
8:143691712:AGGT:A	donor_loss	1.0000
8:143691713:GGT:G	donor_loss	1.0000
8:143691715:T:G	donor_loss	1.0000
8:143707660:A:AC	donor_gain	1.0000
8:143707661:C:CC	donor_gain	1.0000
8:143684539:TGTGG:T	donor_loss	0.9900
8:143684540:GTG:G	donor_gain	0.9900
8:143684540:GTGGT:G	donor_loss	0.9900
8:143684542:GGT:G	donor_loss	0.9900
8:143684543:G:GG	donor_gain	0.9900
8:143684543:G:T	donor_loss	0.9900
8:143684544:TGAG:T	donor_loss	0.9900
8:143684545:GAGT:G	donor_loss	0.9900
8:143690055:A:AG	acceptor_gain	0.9900
8:143690056:G:GG	acceptor_gain	0.9900
8:143691043:T:TA	acceptor_gain	0.9900
8:143691231:GG:G	donor_gain	0.9900
8:143691232:GG:G	donor_gain	0.9900
8:143691595:AGAAG:A	acceptor_gain	0.9900
8:143691596:GAAGG:G	acceptor_gain	0.9900
8:143691598:AG:A	acceptor_gain	0.9900
8:143691599:GG:G	acceptor_gain	0.9900
8:143691599:GGA:G	acceptor_gain	0.9900
8:143691599:GGAT:G	acceptor_gain	0.9900
8:143691709:GCCAG:G	donor_gain	0.9900
8:143691714:G:GG	donor_gain	0.9900
8:143693665:CCACA:C	acceptor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000241539 (8:143692411 G>A), RS1000448772 (8:143687371 T>C), RS1000698235 (8:143693092 C>T), RS1000711878 (8:143685983 C>A,T), RS1000783699 (8:143686132 C>G), RS1001396684 (8:143688554 A>G), RS1001449381 (8:143688827 G>A,C), RS1002226508 (8:143683258 T>C), RS1003173283 (8:143684280 T>C), RS1003585209 (8:143694910 T>C), RS1003634985 (8:143684379 G>A,C), RS1003738272 (8:143689882 A>G), RS1003843498 (8:143686496 C>A,G,T), RS1004297039 (8:143686819 T>C), RS1004691754 (8:143690819 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
beta-lapachone	decreases expression	1
sodium arsenite	increases expression	1
manganese chloride	increases abundance, increases expression	1
cupric oxide	increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Manganese	increases abundance, increases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1
Urethane	increases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases expression	1
Copper Sulfate	increases expression	1
Vitamin K 3	affects expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD41	HEK293 eGFP-ZNF707	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.