ZNF708

Summary

ZNF708 (zinc finger protein 708, HGNC:12945) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 708 (P17019). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus.

Source: NCBI Gene 7562 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total
• MANE Select transcript: NM_021269

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12945
Approved symbol	ZNF708
Name	zinc finger protein 708
Location	19p12
Locus type	gene with protein product
Status	Approved
Aliases	KOX8
Ensembl gene	ENSG00000182141
Ensembl biotype	protein_coding
Entrez	7562

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000356929, ENST00000598046, ENST00000601295, ENST00000602023, ENST00000718342

RefSeq mRNA: 3 — MANE Select: NM_021269 NM_001297560, NM_001297561, NM_021269

CCDS: CCDS32980

Canonical transcript exons

ENST00000356929 — 4 exons

Exon	Start	End
ENSE00001714924	21310501	21310627
ENSE00004034823	21329210	21329410
ENSE00004034824	21309246	21309341
ENSE00004034826	21291160	21294739

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 84.43.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.3337 / max 1519.6763, expressed in 1737 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180211	8.1116	1472
180210	5.9004	1468
180209	2.2363	838
208745	0.4563	216
180207	0.3861	87
180208	0.2429	21

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	84.43	gold quality
calcaneal tendon	UBERON:0003701	83.73	gold quality
adrenal tissue	UBERON:0018303	83.14	gold quality
colonic epithelium	UBERON:0000397	83.00	gold quality
ganglionic eminence	UBERON:0004023	82.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.88	gold quality
bone marrow cell	CL:0002092	81.53	gold quality
corpus callosum	UBERON:0002336	81.21	gold quality
sural nerve	UBERON:0015488	80.75	gold quality
spinal cord	UBERON:0002240	79.67	gold quality
oviduct epithelium	UBERON:0004804	79.66	gold quality
ventricular zone	UBERON:0003053	78.30	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.51	gold quality
vermiform appendix	UBERON:0001154	77.20	gold quality
islet of Langerhans	UBERON:0000006	77.04	gold quality
leukocyte	CL:0000738	76.81	gold quality
left ovary	UBERON:0002119	76.65	gold quality
monocyte	CL:0000576	76.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.35	gold quality
prefrontal cortex	UBERON:0000451	75.99	gold quality
buccal mucosa cell	CL:0002336	75.98	silver quality
tendon	UBERON:0000043	75.91	gold quality
ovary	UBERON:0000992	75.69	gold quality
tibial nerve	UBERON:0001323	75.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.26	gold quality
lymph node	UBERON:0000029	75.25	gold quality
body of pancreas	UBERON:0001150	74.75	gold quality
right ovary	UBERON:0002118	74.63	gold quality
pancreas	UBERON:0001264	74.56	gold quality
rectum	UBERON:0001052	74.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.35

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1730.1	ZNF708	More than 3 adjacent zinc fingers
MA1730.2	ZNF708	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:28273063

miRNA regulators (miRDB)

96 targeting ZNF708, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 708 — P17019 (reviewed: P17019)

Alternative names: Zinc finger protein 15, Zinc finger protein 15-like 1, Zinc finger protein KOX8

All UniProt accessions (4): P17019, M0QYN4, M0R1G3, M0R2V2

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (3): NP_001284489, NP_001284490, NP_067092* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (22 total): zinc finger region 15, sequence variant 4, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17019-F1	76.11	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 544

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins

MSigDB gene sets: 98 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, chr19p12, HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS, GCNP_SHH_UP_EARLY.V1_UP, REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY

GO Biological Process (1): regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Regulation of endogenous retroelements	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

602 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF708	SREK1IP1	Q8N9Q2	453
ZNF708	SFXN3	Q9BWM7	452
ZNF708	CREG2	Q8IUH2	449
ZNF708	KRTAP19-2	Q3LHN2	447
ZNF708	LEMD3	Q9Y2U8	426
ZNF708	KIAA1958	Q8N8K9	420
ZNF708	WIPF1	O43516	412
ZNF708	P2RX1	P51575	405
ZNF708	OR51A2	Q8NGJ7	399
ZNF708	OR4C5	Q8NGB2	397
ZNF708	GNG12	Q9UBI6	394
ZNF708	DNAAF8	Q8IYS4	393
ZNF708	PDE6B	P35913	376
ZNF708	POMZP3	Q6PJE2	375
ZNF708	SIX4	Q9UIU6	366

IntAct

18 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF708	KRT8	psi-mi:“MI:0915”(physical association)	0.400
ECE1	ZNF708	psi-mi:“MI:0915”(physical association)	0.370
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL27A	ZNF320	psi-mi:“MI:0914”(association)	0.350
PURG	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZKSCAN8	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ANKRD36B	CCDC66	psi-mi:“MI:0914”(association)	0.350
RPL36	GTPBP10	psi-mi:“MI:0914”(association)	0.350
ANOS1	ZNF724	psi-mi:“MI:0914”(association)	0.350
ZNF543	TRIM24	psi-mi:“MI:0914”(association)	0.350
ZNF653	URB1	psi-mi:“MI:0914”(association)	0.350
ZNF708	OCM2	psi-mi:“MI:0914”(association)	0.350
TIMM50	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (20): ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-RNA), ZNF708 (Proximity Label-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), TOR2A (Affinity Capture-MS), GJD4 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), OCM2 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS), ZNF708 (Affinity Capture-MS)

ESM2 similar proteins: A6NDX5, A6NK75, A6NNF4, A6NP11, B4DXR9, B7Z6K7, C9JN71, O43361, O75290, O75373, P0CJ79, P0DKX0, P17019, P17021, P17035, P17039, P35789, Q02386, Q03938, Q08AN1, Q13106, Q15928, Q3ZCX4, Q5R9F0, Q5SXM1, Q68EA5, Q6P9A1, Q6PDB4, Q6ZN06, Q6ZN08, Q6ZNG1, Q76KX8, Q86V71, Q86XN6, Q8IYB9, Q8N4W9, Q8NEP9, Q8TBZ8, Q8TC21, Q8TF32

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	66
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

969 predictions. Top by Δscore:

Variant	Effect	Δscore
19:21294735:CATAG:C	acceptor_gain	1.0000
19:21309241:CCTA:C	donor_loss	1.0000
19:21309244:A:AT	donor_loss	1.0000
19:21309245:C:T	donor_loss	1.0000
19:21309343:T:C	acceptor_loss	1.0000
19:21310493:AT:A	donor_gain	1.0000
19:21310540:T:A	donor_gain	1.0000
19:21294737:TAG:T	acceptor_gain	0.9900
19:21294739:GC:G	acceptor_loss	0.9900
19:21294740:C:A	acceptor_loss	0.9900
19:21294740:C:CC	acceptor_gain	0.9900
19:21294741:T:C	acceptor_loss	0.9900
19:21309339:TAC:T	acceptor_gain	0.9900
19:21310494:T:C	donor_gain	0.9900
19:21329204:TCTCA:T	donor_loss	0.9900
19:21329205:CTCA:C	donor_loss	0.9900
19:21329206:TCAC:T	donor_loss	0.9900
19:21329207:CACCA:C	donor_loss	0.9900
19:21329208:ACCA:A	donor_loss	0.9900
19:21329209:C:T	donor_loss	0.9900
19:21329244:G:C	donor_gain	0.9900
19:21294736:ATAG:A	acceptor_gain	0.9800
19:21329222:T:TA	donor_gain	0.9800
19:21294738:AG:A	acceptor_gain	0.9700
19:21301970:C:CT	donor_gain	0.9700
19:21301971:T:TT	donor_gain	0.9700
19:21309342:C:CC	acceptor_gain	0.9700
19:21309344:G:C	acceptor_loss	0.9700
19:21310493:A:AC	donor_gain	0.9700
19:21311755:C:CT	acceptor_gain	0.9700

AlphaMissense

3757 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000022648 (19:21295889 T>C), RS1000044199 (19:21318924 G>A,C), RS1000237470 (19:21299983 C>T), RS1000296168 (19:21314544 A>G), RS1000352718 (19:21307622 G>A,T), RS1000379690 (19:21300918 C>T), RS1000525710 (19:21301041 T>A), RS1000542945 (19:21319353 T>C), RS1000555095 (19:21301456 T>C), RS1000602920 (19:21326802 C>T), RS1000671301 (19:21320570 G>T), RS1000717802 (19:21307390 C>T), RS1000986530 (19:21325653 T>C), RS1000995735 (19:21293920 G>A), RS1001053834 (19:21295563 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, affects expression, decreases expression	4
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	decreases methylation	1
perfluorooctane sulfonic acid	decreases expression	1
pentabromodiphenyl ether	decreases expression	1
K 7174	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methapyrilene	increases methylation	1
Methyl Methanesulfonate	increases expression	1
Quercetin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vanadates	decreases expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Aflatoxin B1	increases methylation	1
Aflatoxin M1	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.