ZNF710

Summary

ZNF710 (zinc finger protein 710, HGNC:25352) is a protein-coding gene on chromosome 15q26.1, encoding Zinc finger protein 710 (Q8N1W2). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 374655 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 93 total
• MANE Select transcript: NM_198526

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25352
Approved symbol	ZNF710
Name	zinc finger protein 710
Location	15q26.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp547K1113, FLJ37393, FLJ00306
Ensembl gene	ENSG00000140548
Ensembl biotype	protein_coding
Entrez	374655

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000268154, ENST00000558883, ENST00000559360, ENST00000559419, ENST00000560908, ENST00000865313, ENST00000865314, ENST00000932450, ENST00000932451, ENST00000932452, ENST00000932453, ENST00000951122, ENST00000951123

RefSeq mRNA: 1 — MANE Select: NM_198526 NM_198526

CCDS: CCDS10358

Canonical transcript exons

ENST00000268154 — 5 exons

Exon	Start	End
ENSE00001035698	90073071	90073262
ENSE00001182721	90074116	90074290
ENSE00001182726	90067110	90068595
ENSE00001258195	90001324	90001614
ENSE00001258203	90079660	90082191

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 96.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.6792 / max 72.4292, expressed in 1432 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148394	2.2001	889
148395	1.0608	762
148393	0.1911	98
148396	0.1709	67
148410	0.0271	2
148411	0.0226	4
207647	0.0065	1

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cervix squamous epithelium	UBERON:0006922	96.26	gold quality
type B pancreatic cell	CL:0000169	93.83	silver quality
tongue squamous epithelium	UBERON:0006919	93.14	silver quality
olfactory bulb	UBERON:0002264	92.33	gold quality
lower esophagus mucosa	UBERON:0035834	92.08	gold quality
monocyte	CL:0000576	91.84	gold quality
mononuclear cell	CL:0000842	91.82	gold quality
leukocyte	CL:0000738	91.69	gold quality
cervix epithelium	UBERON:0004801	91.46	gold quality
body of pancreas	UBERON:0001150	90.41	gold quality
granulocyte	CL:0000094	89.03	gold quality
blood	UBERON:0000178	87.91	gold quality
epithelium of nasopharynx	UBERON:0001951	87.62	gold quality
buccal mucosa cell	CL:0002336	86.92	gold quality
hair follicle	UBERON:0002073	86.27	silver quality
vena cava	UBERON:0004087	86.18	silver quality
pharyngeal mucosa	UBERON:0000355	86.13	gold quality
ventricular zone	UBERON:0003053	85.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.85	gold quality
embryo	UBERON:0000922	84.90	gold quality
pancreas	UBERON:0001264	84.85	gold quality
ganglionic eminence	UBERON:0004023	84.84	gold quality
esophagus mucosa	UBERON:0002469	84.78	gold quality
cortical plate	UBERON:0005343	84.65	gold quality
cardia of stomach	UBERON:0001162	84.27	gold quality
body of tongue	UBERON:0011876	83.99	gold quality
subthalamic nucleus	UBERON:0001906	83.97	gold quality
pancreatic ductal cell	CL:0002079	83.96	silver quality
squamous epithelium	UBERON:0006914	83.79	gold quality
inferior vagus X ganglion	UBERON:0005363	83.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

203 targeting ZNF710, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-6077	99.99	68.04	2299
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-507	99.97	70.11	1915
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-548AE-3P	99.93	72.66	4867

Literature-anchored findings (GeneRIF, showing 1)

• Overexpression of antisense long noncoding RNA ZNF710AS1202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression. (PMID:32236626)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf710b	ENSDARG00000005549
danio_rerio	znf710a	ENSDARG00000014680
rattus_norvegicus	Zfp710	ENSRNOG00000014278
drosophila_melanogaster	CG11902	FBGN0028647
drosophila_melanogaster	CG11696	FBGN0030314
drosophila_melanogaster	CG10631	FBGN0032817

Paralogs (7): ZNF671 (ENSG00000083814), ZNF212 (ENSG00000170260), ZNF366 (ENSG00000178175), ZNF662 (ENSG00000182983), ZNF667 (ENSG00000198046), ZNF783 (ENSG00000204946), ZNF865 (ENSG00000261221)

Protein

Protein identifiers

Zinc finger protein 710 — Q8N1W2 (reviewed: Q8N1W2)

All UniProt accessions (4): Q8N1W2, H0YKZ0, H0YLC4, H0YLZ7

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_940928* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050457	ZnFinger_BTB_dom_contain	Family

Pfam: PF00096, PF13912

UniProt features (17 total): zinc finger region 11, cross-link 3, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N1W2-F1	61.08	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 110, 113, 377

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 184 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, GCM_MAP4K4, MORF_FLT1, GCANCTGNY_MYOD_Q6, AREB6_03, TAL1ALPHAE47_01, MORF_ESR1, GGGTGGRR_PAX4_03, AAAYRNCTG_UNKNOWN, AATGGAG_MIR136, CAGCTG_AP4_Q5, EFC_Q6, NF1_Q6_01, TCF11_01

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

910 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF710	RPS6KL1	Q9Y6S9	667
ZNF710	ZNF541	Q9H0D2	512
ZNF710	SNRPN	P14648	499
ZNF710	POLD1	P28340	489
ZNF710	RHBDL2	Q9NX52	466
ZNF710	CCL27	Q9Y4X3	438
ZNF710	ADK	P55263	422
ZNF710	FAM241B	Q96D05	416
ZNF710	MED22	Q15528	397
ZNF710	IGSF9	Q9P2J2	382
ZNF710	SYCE1L	A8MT33	377
ZNF710	CIB4	A0PJX0	367
ZNF710	TTC22	Q5TAA0	348
ZNF710	NAA35	Q5VZE5	348
ZNF710	TRIM7	Q9C029	348

IntAct

54 interactions, top by confidence:

A	B	Type	Score
DYNLL1	BLTP3B	psi-mi:“MI:0914”(association)	0.730
DYNLL1	ZNF710	psi-mi:“MI:0915”(physical association)	0.700
ZNF710	DYNLL1	psi-mi:“MI:0915”(physical association)	0.700
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
SUOX	ZNF710	psi-mi:“MI:0915”(physical association)	0.560
POGZ	ZNF710	psi-mi:“MI:0915”(physical association)	0.560
	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL1	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL11	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL22	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL26	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL3	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL3L1	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL4L1	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL5	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CCL8	ZNF710	psi-mi:“MI:0915”(physical association)	0.370
CXCL10	ZNF710	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (4): ZNF710 (Two-hybrid), POGZ (Two-hybrid), ZNF710 (Affinity Capture-MS), ZNF710 (Affinity Capture-MS)

ESM2 similar proteins: A1L1J6, A2A5K6, A2APF3, D3ZUU2, E9Q8T2, G3V893, G5E8B9, O43167, O70237, O95625, P10074, P22227, P52739, P57071, P98169, Q05516, Q13105, Q1H9T6, Q3B725, Q3B7N9, Q3U288, Q3UH06, Q4VBD9, Q5DU09, Q5EAC5, Q5R633, Q5VTD9, Q60821, Q6DDV0, Q6GL52, Q6NS86, Q6YND2, Q6ZSB9, Q7TS63, Q80X44, Q8BKX7, Q8BXX2, Q8C8V1, Q8CCE9, Q8N1W2

Diamond homologs: Q3U288, Q6NS86, Q8N1W2, Q8N895

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Chemokine receptors bind chemokines	10	81.4×	7e-16
Interleukin-10 signaling	5	50.7×	1e-06
Class A/1 (Rhodopsin-like receptors)	5	16.1×	2e-04
Peptide ligand-binding receptors	5	16.1×	2e-04
GPCR ligand binding	5	13.9×	2e-04
Signaling by GPCR	6	10.4×	2e-04
G alpha (i) signalling events	6	10.2×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
eosinophil chemotaxis	8	209.3×	6e-16
chemokine-mediated signaling pathway	12	138.9×	1e-21
antimicrobial humoral immune response mediated by antimicrobial peptide	12	69.5×	4e-18
neutrophil chemotaxis	5	51.0×	1e-06
chemotaxis	9	43.7×	1e-11
cell chemotaxis	6	39.7×	2e-07
cellular response to virus	5	35.8×	6e-06
cell-cell signaling	11	27.4×	4e-12

Disease & clinical

Clinical variants and AI predictions

ClinVar

93 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	85
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1267 predictions. Top by Δscore:

Variant	Effect	Δscore
15:90001613:GG:G	donor_gain	1.0000
15:90001614:GG:G	donor_gain	1.0000
15:90009115:T:TA	acceptor_gain	1.0000
15:90009116:G:A	acceptor_gain	1.0000
15:90067109:GCGAT:G	acceptor_gain	1.0000
15:90068594:AGGTA:A	donor_loss	1.0000
15:90068596:G:A	donor_loss	1.0000
15:90068597:T:G	donor_loss	1.0000
15:90073068:CA:C	acceptor_loss	1.0000
15:90073069:A:AC	acceptor_loss	1.0000
15:90073069:A:AG	acceptor_gain	1.0000
15:90073069:AG:A	acceptor_gain	1.0000
15:90073070:G:GG	acceptor_gain	1.0000
15:90073070:G:GT	acceptor_loss	1.0000
15:90073070:GG:G	acceptor_gain	1.0000
15:90073070:GGGC:G	acceptor_gain	1.0000
15:90073259:CAAG:C	donor_loss	1.0000
15:90073260:AAGGT:A	donor_loss	1.0000
15:90073261:AGGTA:A	donor_loss	1.0000
15:90074112:CTAG:C	acceptor_loss	1.0000
15:90074113:TAGGT:T	acceptor_loss	1.0000
15:90074115:G:GC	acceptor_loss	1.0000
15:90074115:GGT:G	acceptor_gain	1.0000
15:90079657:CA:C	acceptor_loss	1.0000
15:90079658:A:AG	acceptor_gain	1.0000
15:90079658:AG:A	acceptor_loss	1.0000
15:90079659:G:C	acceptor_loss	1.0000
15:90079659:G:GT	acceptor_gain	1.0000
15:90001612:AGGG:A	donor_loss	0.9900
15:90001615:G:GA	donor_loss	0.9900

AlphaMissense

4431 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:90068020:T:A	W295R	1.000
15:90068020:T:C	W295R	1.000
15:90068022:G:C	W295C	1.000
15:90068022:G:T	W295C	1.000
15:90068026:T:A	C297S	1.000
15:90068026:T:C	C297R	1.000
15:90068027:G:C	C297S	1.000
15:90068035:T:A	C300S	1.000
15:90068035:T:C	C300R	1.000
15:90068036:G:A	C300Y	1.000
15:90068036:G:C	C300S	1.000
15:90068037:C:G	C300W	1.000
15:90068047:T:G	Y304D	1.000
15:90068053:T:C	S306P	1.000
15:90068064:C:A	N309K	1.000
15:90068064:C:G	N309K	1.000
15:90068066:T:C	L310P	1.000
15:90068074:C:A	H313N	1.000
15:90068074:C:G	H313D	1.000
15:90068075:A:G	H313R	1.000
15:90068076:C:A	H313Q	1.000
15:90068076:C:G	H313Q	1.000
15:90068081:T:C	L315P	1.000
15:90068086:C:G	H317D	1.000
15:90068088:C:A	H317Q	1.000
15:90068088:C:G	H317Q	1.000
15:90068110:T:C	C325R	1.000
15:90068111:G:A	C325Y	1.000
15:90068112:C:G	C325W	1.000
15:90068119:T:C	C328R	1.000

dbSNP variants (sampled 300 via entrez): RS1000013312 (15:90001393 C>T), RS1000083223 (15:90003337 A>G), RS1000124990 (15:90047685 AATG>A), RS1000138131 (15:90061461 C>T), RS1000145046 (15:90011888 G>A), RS1000231480 (15:90032702 C>T), RS1000243141 (15:90076486 A>G), RS1000258780 (15:90026704 G>A), RS1000268626 (15:90018915 A>G), RS1000288223 (15:90038926 G>A), RS1000291385 (15:90026334 A>C,G), RS1000352547 (15:90074009 A>C), RS1000410055 (15:90000428 C>T), RS1000422964 (15:90013193 C>T), RS1000534747 (15:90034147 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST010989_1	Body size at age 10	4.000000e-11
GCST90002388_158	Lymphocyte count	3.000000e-16
GCST90002389_303	Lymphocyte percentage of white cells	3.000000e-09
GCST90002395_180	Mean platelet volume	1.000000e-16
GCST90002395_181	Mean platelet volume	4.000000e-43
GCST90002401_102	Platelet distribution width	2.000000e-09
GCST90002401_103	Platelet distribution width	2.000000e-14
GCST90002402_170	Platelet count	8.000000e-19

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0009819	comparative body size at age 10, self-reported
EFO:0004587	lymphocyte count
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007984	platelet component distribution width
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation, affects cotreatment	6
Benzo(a)pyrene	affects methylation, decreases expression	2
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
Allergens	increases expression	1
Amiodarone	increases expression	1
Arsenic	increases methylation	1
Doxorubicin	decreases expression	1
Lead	decreases expression	1
Methylcholanthrene	affects binding, increases reaction	1
Silicon Dioxide	increases expression	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	increases expression	1
Topotecan	affects response to substance	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.