ZNF714

Summary

ZNF714 (zinc finger protein 714, HGNC:27124) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 714 (Q96N38). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 148206 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 24 total
• MANE Select transcript: NM_182515

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27124
Approved symbol	ZNF714
Name	zinc finger protein 714
Location	19p12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000160352
Ensembl biotype	protein_coding
Entrez	148206

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 14 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000425625, ENST00000456283, ENST00000596053, ENST00000600535, ENST00000610902, ENST00000613286, ENST00000616183, ENST00000618008, ENST00000618422, ENST00000620627, ENST00000904346, ENST00000904347, ENST00000904348, ENST00000931179, ENST00000968193, ENST00000968194, ENST00000968195

RefSeq mRNA: 1 — MANE Select: NM_182515 NM_182515

CCDS: CCDS54239

Canonical transcript exons

ENST00000456283 — 5 exons

Exon	Start	End
ENSE00001177597	21083978	21084069
ENSE00003669539	21098185	21098311
ENSE00003719382	21116807	21125094
ENSE00003735317	21098812	21098910
ENSE00003752082	21082203	21082348

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 87.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.6498 / max 455.4540, expressed in 1583 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174880	10.7270	1518
174881	2.2236	768
174879	0.6992	375

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	87.48	gold quality
adrenal tissue	UBERON:0018303	87.22	gold quality
ganglionic eminence	UBERON:0004023	85.89	gold quality
ventricular zone	UBERON:0003053	85.07	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.24	gold quality
lower esophagus mucosa	UBERON:0035834	81.24	gold quality
endometrium	UBERON:0001295	79.20	gold quality
corpus callosum	UBERON:0002336	79.07	gold quality
thymus	UBERON:0002370	77.77	gold quality
calcaneal tendon	UBERON:0003701	77.32	gold quality
ovary	UBERON:0000992	77.17	gold quality
bone marrow	UBERON:0002371	77.09	gold quality
left ovary	UBERON:0002119	76.20	gold quality
stromal cell of endometrium	CL:0002255	75.14	gold quality
right ovary	UBERON:0002118	74.70	gold quality
sural nerve	UBERON:0015488	74.69	gold quality
cerebellum	UBERON:0002037	74.59	gold quality
cerebellar cortex	UBERON:0002129	74.58	gold quality
esophagus mucosa	UBERON:0002469	74.54	gold quality
cerebellar vermis	UBERON:0004720	74.48	gold quality
cerebellar hemisphere	UBERON:0002245	74.43	gold quality
monocyte	CL:0000576	74.01	gold quality
thyroid gland	UBERON:0002046	73.99	gold quality
adrenal gland	UBERON:0002369	73.96	gold quality
lymph node	UBERON:0000029	73.87	gold quality
leukocyte	CL:0000738	73.77	gold quality
superior frontal gyrus	UBERON:0002661	73.74	gold quality
colonic epithelium	UBERON:0000397	73.57	gold quality
islet of Langerhans	UBERON:0000006	73.54	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.78
E-MTAB-6142	no	78.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

291 targeting ZNF714, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-433-3P	99.98	69.37	1203

Literature-anchored findings (GeneRIF, showing 1)

• ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells. (PMID:37958512)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631), ZNF3 (ENSG00000166526)

Protein

Protein identifiers

Zinc finger protein 714 — Q96N38 (reviewed: Q96N38)

All UniProt accessions (7): A0A087WU35, A0A087WV13, A0A087WX89, A0A087X1X4, A0A087X1Z8, I3L2D0, M0QY60

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96N38-1	1	yes
Q96N38-2	2
Q96N38-3	3

RefSeq proteins (1): NP_872321* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF13465

UniProt features (24 total): zinc finger region 14, splice variant 3, sequence variant 3, sequence conflict 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96N38-F1	68.35	0.19

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 69 (showing top): chr19p12, FISCHER_DREAM_TARGETS, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ZWANG_DOWN_BY_2ND_EGF_PULSE, NFE2L2.V2, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ARID5B_TARGET_GENES, ASH1L_TARGET_GENES, PAX3_TARGET_GENES, PRKDC_TARGET_GENES, ZNF10_TARGET_GENES, ZNF2_TARGET_GENES, ZNF350_TARGET_GENES, ZNF711_TARGET_GENES, MIR12136

GO Biological Process (1): regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

486 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF714	ATAD3C	Q5T2N8	615
ZNF714	CYB5D2	Q8WUJ1	462
ZNF714	ICA1L	Q8NDH6	450
ZNF714	CYP20A1	Q6UW02	449
ZNF714	GK5	Q6ZS86	447
ZNF714	ANAPC16	Q96DE5	442
ZNF714	C17orf75	Q9HAS0	427
ZNF714	DCAF10	Q5QP82	426
ZNF714	ERICH1	Q86X53	417
ZNF714	KRT38	O76015	398
ZNF714	ARL11	Q969Q4	398
ZNF714	SSH1	Q8WYL5	398
ZNF714	PABIR3	Q6P4D5	398
ZNF714	CIAO1	O76071	380
ZNF714	FKBP14	Q9NWM8	377

IntAct

12 interactions, top by confidence:

A	B	Type	Score
ZNF223	CENPB	psi-mi:“MI:0914”(association)	0.530
PCBD1	ZNF714	psi-mi:“MI:0915”(physical association)	0.370
LZTR1	ZNF714	psi-mi:“MI:0915”(physical association)	0.370
ZNF714	ECE1	psi-mi:“MI:0915”(physical association)	0.370
S100B	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
RPL27A	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF460	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
ZNF550	MEIOC	psi-mi:“MI:0914”(association)	0.350
RPL15	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
ZNF48	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350

BioGRID (20): ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-RNA), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Affinity Capture-MS), ZNF714 (Positive Genetic), ZNF714 (Proximity Label-MS)

ESM2 similar proteins: A6NK75, A6NNF4, A6NP11, A8MTY0, A8MUV8, B4DXR9, C9JN71, O75346, O75373, O95780, P0CJ79, P0DKX0, P0DPD5, P17019, P17035, P35789, Q03923, Q03938, Q08AN1, Q14593, Q15928, Q3SXZ3, Q3ZCX4, Q5MCW4, Q5R9S5, Q5RER9, Q68DY1, Q6JLC9, Q6ZMV8, Q6ZN06, Q6ZN08, Q6ZNA1, Q76KX8, Q86T29, Q86V71, Q8IYN0, Q8N4W9, Q8N7M2, Q8NEM1, Q8TD23

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1028 predictions. Top by Δscore:

Variant	Effect	Δscore
19:21084039:G:GT	donor_gain	1.0000
19:21116806:GCT:G	acceptor_gain	1.0000
19:21116806:GCTAT:G	acceptor_gain	1.0000
19:21082315:C:G	donor_gain	0.9900
19:21082347:TGGT:T	donor_loss	0.9900
19:21082349:GT:G	donor_loss	0.9900
19:21098179:TTTCA:T	acceptor_loss	0.9900
19:21098180:TTCA:T	acceptor_loss	0.9900
19:21098181:TCA:T	acceptor_loss	0.9900
19:21098182:CA:C	acceptor_loss	0.9900
19:21098184:G:A	acceptor_loss	0.9900
19:21098184:GGA:G	acceptor_gain	0.9900
19:21098307:CTTGG:C	donor_loss	0.9900
19:21098308:TTGGG:T	donor_loss	0.9900
19:21098309:TGGGT:T	donor_loss	0.9900
19:21098310:GG:G	donor_gain	0.9900
19:21098311:GG:G	donor_gain	0.9900
19:21098311:GGTG:G	donor_loss	0.9900
19:21098312:G:GG	donor_gain	0.9900
19:21098312:GTG:G	donor_loss	0.9900
19:21098313:T:TC	donor_loss	0.9900
19:21098314:G:GC	donor_loss	0.9900
19:21116801:TTTCA:T	acceptor_loss	0.9900
19:21116802:TTCA:T	acceptor_loss	0.9900
19:21116804:CA:C	acceptor_loss	0.9900
19:21116805:A:AG	acceptor_gain	0.9900
19:21116805:A:G	acceptor_loss	0.9900
19:21116806:G:GG	acceptor_gain	0.9900
19:21116806:GCTA:G	acceptor_gain	0.9900
19:21082335:G:GT	donor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000059832 (19:21114569 A>G), RS1000112467 (19:21099270 T>G), RS1000157519 (19:21090266 G>A,C,T), RS1000259438 (19:21114622 A>C,G), RS1000359138 (19:21101775 T>A), RS1000368200 (19:21107822 C>T), RS1000408806 (19:21089084 T>A,C), RS1000538965 (19:21120793 G>A,T), RS1000563822 (19:21083292 C>G), RS1000706944 (19:21097779 G>GGA), RS1000772753 (19:21096650 A>G), RS1000958696 (19:21097297 C>G), RS1001114066 (19:21114310 C>G), RS1001162850 (19:21088571 A>G), RS1001215232 (19:21088201 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	increases expression, increases methylation	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	increases expression	1
benzo(e)pyrene	increases methylation	1
methacrylaldehyde	decreases expression, increases abundance, affects cotreatment	1
perfluorooctane sulfonic acid	decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Allergens	increases expression	1
Vehicle Emissions	decreases expression, decreases reaction	1
Coal	increases abundance, decreases expression	1
Gallic Acid	increases expression	1
Methapyrilene	increases methylation	1
Ozone	affects cotreatment, decreases expression, increases abundance	1
Smoke	decreases expression, increases abundance	1
Tetrachlorodibenzodioxin	affects expression	1
Tobacco Smoke Pollution	decreases expression	1
Vanadates	decreases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	increases expression	1
Particulate Matter	decreases expression, decreases reaction	1
Volatile Organic Compounds	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.