ZNF723

Summary

ZNF723 (zinc finger protein 723, HGNC:32286) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 723 (P0DPD5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 646864 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001349726

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32286
Approved symbol	ZNF723
Name	zinc finger protein 723
Location	19p12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000268696
Ensembl biotype	protein_coding
Entrez	646864

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000600766

RefSeq mRNA: 1 — MANE Select: NM_001349726 NM_001349726

CCDS: CCDS86735

Canonical transcript exons

ENST00000600766 — 4 exons

Exon	Start	End
ENSE00001673752	22857118	22858667
ENSE00002993203	22849198	22849293
ENSE00003084768	22848261	22848387
ENSE00003121959	22832291	22832382

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 77.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1286 / max 52.8953, expressed in 22 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174906	0.0882	18
174907	0.0404	10

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.08	gold quality
testis	UBERON:0000473	56.20	gold quality
right testis	UBERON:0004534	54.61	gold quality
left testis	UBERON:0004533	54.59	gold quality
sural nerve	UBERON:0015488	48.62	silver quality
granulocyte	CL:0000094	43.88	silver quality
ganglionic eminence	UBERON:0004023	43.08	silver quality
placenta	UBERON:0001987	41.90	gold quality
cortical plate	UBERON:0005343	40.79	silver quality
endometrium	UBERON:0001295	39.20	gold quality
bone marrow	UBERON:0002371	38.82	gold quality
bone marrow cell	CL:0002092	38.71	gold quality
stromal cell of endometrium	CL:0002255	38.49	gold quality
islet of Langerhans	UBERON:0000006	37.88	gold quality
duodenum	UBERON:0002114	37.21	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
muscle tissue	UBERON:0002385	36.28	silver quality
pancreas	UBERON:0001264	36.14	gold quality
smooth muscle tissue	UBERON:0001135	36.08	gold quality
monocyte	CL:0000576	35.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.59	gold quality
vermiform appendix	UBERON:0001154	35.25	gold quality
mucosa of transverse colon	UBERON:0004991	34.90	gold quality
skeletal muscle tissue	UBERON:0001134	34.81	gold quality
adrenal tissue	UBERON:0018303	34.79	silver quality
tonsil	UBERON:0002372	34.44	gold quality
urinary bladder	UBERON:0001255	33.86	silver quality
left adrenal gland cortex	UBERON:0035825	33.15	silver quality
adrenal gland	UBERON:0002369	32.60	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.13
E-GEOD-99795	no	0.83

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000099025

Paralogs (18): ZNF430 (ENSG00000118620), ZNF92 (ENSG00000146757), ZNF66 (ENSG00000160229), ZNF22 (ENSG00000165512), ZNF680 (ENSG00000173041), ZNF114 (ENSG00000178150), ZFP41 (ENSG00000181638), ZNF730 (ENSG00000183850), ZNF479 (ENSG00000185177), ZNF626 (ENSG00000188171), ZNF431 (ENSG00000196705), ZNF100 (ENSG00000197020), ZNF257 (ENSG00000197134), ZNF98 (ENSG00000197360), ZNF675 (ENSG00000197372), ZNF273 (ENSG00000198039), ZNF737 (ENSG00000237440), ZNF253 (ENSG00000256771)

Protein

Protein identifiers

Zinc finger protein 723 — P0DPD5 (reviewed: P0DPD5)

All UniProt accessions (1): P0DPD5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001336655* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (14 total): zinc finger region 12, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DPD5-F1	74.20	0.32

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 7 (showing top): chr19p12, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, DESCARTES_FETAL_PLACENTA_SYNCYTIOTROPHOBLASTS_AND_VILLOUS_CYTOTROPHOBLASTS, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

60 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF723	TMEM178B	H3BS89	608
ZNF723	ADGRF2P	Q8IZF7	571
ZNF723	LYPD1	Q8N2G4	431
ZNF723	FXYD2	P54710	397
ZNF723	SLFN11	Q7Z7L1	375
ZNF723	ARNT2	Q9HBZ2	363
ZNF723	RELN	P78509	271
ZNF723	LIPC	P11150	270
ZNF723	PLCG2	P16885	224
ZNF723	AXIN2	Q9Y2T1	193
ZNF723	MAPK1	P28482	172
ZNF723	MST1R	Q04912	134
ZNF723	MVK	Q03426	64
ZNF723	NME8	Q8N427	62
ZNF723	MED14	O60244	57
ZNF723	JUN	P05412	57

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ZNF723	ECE1	psi-mi:“MI:0915”(physical association)	0.370

ESM2 similar proteins: A6NK75, A6NNF4, A6NP11, A8MTY0, A8MUV8, B4DXR9, C9JN71, O75346, O75373, O95780, P0CJ79, P0DKX0, P0DPD5, P17019, P17035, P35789, Q03923, Q03938, Q08AN1, Q14593, Q15928, Q3SXZ3, Q3ZCX4, Q5MCW4, Q5R9S5, Q5RER9, Q68DY1, Q6JLC9, Q6ZMV8, Q6ZN06, Q6ZN08, Q6ZNA1, Q76KX8, Q86T29, Q86V71, Q8IYN0, Q8N4W9, Q8N7M2, Q8NEM1, Q8TD23

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

3441 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:22858107:T:C	F406L	0.987
19:22858109:T:A	F406L	0.987
19:22858109:T:G	F406L	0.987
19:22858191:T:C	F434L	0.987
19:22858193:T:A	F434L	0.987
19:22858193:T:G	F434L	0.987
19:22857603:T:C	F238L	0.979
19:22857605:T:A	F238L	0.979
19:22857605:T:G	F238L	0.979
19:22857855:T:C	F322L	0.979
19:22857857:T:A	F322L	0.979
19:22857857:T:G	F322L	0.979
19:22857771:T:C	F294L	0.977
19:22857773:T:A	F294L	0.977
19:22857773:T:G	F294L	0.977
19:22857687:T:C	F266L	0.974
19:22857689:T:A	F266L	0.974
19:22857689:T:G	F266L	0.974
19:22858023:T:C	F378L	0.974
19:22858025:T:A	F378L	0.974
19:22858025:T:G	F378L	0.974
19:22858275:T:C	F462L	0.974
19:22858277:T:A	F462L	0.974
19:22858277:T:G	F462L	0.974
19:22857939:T:C	F350L	0.956
19:22857941:C:A	F350L	0.956
19:22857941:C:G	F350L	0.956
19:22858126:T:C	L412P	0.946
19:22858359:T:C	F490L	0.945
19:22858361:T:A	F490L	0.945

dbSNP variants (sampled 300 via entrez): RS1000052728 (19:22835278 G>C), RS1000058749 (19:22817246 T>C), RS1000103258 (19:22835454 A>G), RS1000111501 (19:22853178 T>C), RS1000163658 (19:22853451 C>T), RS1000170077 (19:22848223 T>C), RS1000330877 (19:22812363 C>T), RS1000401654 (19:22854956 A>C), RS1000498008 (19:22846888 G>A), RS1000500219 (19:22854845 C>G,T), RS1000630664 (19:22811939 G>A,T), RS1000663218 (19:22813665 C>T), RS1000745310 (19:22813163 G>A), RS1000751627 (19:22854657 A>G), RS1001059631 (19:22840458 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.