ZNF726

Summary

ZNF726 (zinc finger protein 726, HGNC:32462) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 726 (A6NNF4). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 730087 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 7 total
• MANE Select transcript: NM_001244038

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32462
Approved symbol	ZNF726
Name	zinc finger protein 726
Location	19p12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000213967
Ensembl biotype	protein_coding
Entrez	730087

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000334589, ENST00000525354, ENST00000531821, ENST00000575986, ENST00000594466

RefSeq mRNA: 4 — MANE Select: NM_001244038 NM_001244038, NM_001348687, NM_001348688, NM_001348689

CCDS: CCDS54241, CCDS59372, CCDS86738, CCDS86739

Canonical transcript exons

ENST00000594466 — 4 exons

Exon	Start	End
ENSE00002228793	23919987	23920082
ENSE00002288660	23919373	23919499
ENSE00003181723	23932343	23934484
ENSE00003202939	23914886	23914997

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 83.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.0577 / max 194.6576, expressed in 1193 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174925	3.9492	1040
174926	2.1085	732

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.77	gold quality
ventricular zone	UBERON:0003053	81.07	gold quality
ganglionic eminence	UBERON:0004023	81.03	gold quality
endometrium	UBERON:0001295	80.19	gold quality
mucosa of transverse colon	UBERON:0004991	75.39	gold quality
lower esophagus mucosa	UBERON:0035834	75.25	gold quality
skin of abdomen	UBERON:0001416	73.56	gold quality
vagina	UBERON:0000996	73.32	gold quality
endocervix	UBERON:0000458	72.80	gold quality
zone of skin	UBERON:0000014	72.48	gold quality
adrenal tissue	UBERON:0018303	72.32	gold quality
placenta	UBERON:0001987	72.25	gold quality
rectum	UBERON:0001052	72.04	gold quality
lymph node	UBERON:0000029	72.03	gold quality
cerebellar hemisphere	UBERON:0002245	71.77	gold quality
skin of leg	UBERON:0001511	71.74	gold quality
cerebellar cortex	UBERON:0002129	71.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.63	gold quality
esophagus mucosa	UBERON:0002469	71.55	gold quality
uterine cervix	UBERON:0000002	71.52	gold quality
cerebellum	UBERON:0002037	71.51	gold quality
cortical plate	UBERON:0005343	71.40	gold quality
metanephros cortex	UBERON:0010533	71.36	gold quality
corpus callosum	UBERON:0002336	71.33	gold quality
cortex of kidney	UBERON:0001225	71.10	gold quality
thymus	UBERON:0002370	70.14	gold quality
ectocervix	UBERON:0012249	70.12	gold quality
stromal cell of endometrium	CL:0002255	69.74	gold quality
body of stomach	UBERON:0001161	69.49	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-36552	no	29.17
E-ANND-3	no	4.56

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2527.1	ZNF726	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 726 — A6NNF4 (reviewed: A6NNF4)

All UniProt accessions (5): A0A8I5GK09, A6NNF4, E9PLI7, F1T0F3, J3KNQ9

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
A6NNF4-3	3	yes
A6NNF4-2	2

RefSeq proteins (4): NP_001230967, NP_001335616, NP_001335617, NP_001335618 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050826	Krueppel_C2H2_ZnFinger	Family

Pfam: PF00096, PF01352

UniProt features (20 total): zinc finger region 16, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NNF4-F1	74.01	0.07

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 22 (showing top): chr19p12, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, CEBPZ_TARGET_GENES, HSD17B8_TARGET_GENES, PRKDC_TARGET_GENES, ZNF350_TARGET_GENES, MANNE_COVID19_NONICU_VS_HEALTHY_DONOR_PLATELETS_DN, BARX2_TARGET_GENES, GAUTAM_EYE_CORNEA_MONOCYTES, HE_LIM_SUN_FETAL_LUNG_C5_LARGE_PRE_B_CELL, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

182 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF726	J3QRE1	J3QRE1	608
ZNF726	DEFB115	Q30KQ5	440
ZNF726	NXPE4	Q6UWF7	402
ZNF726	REP15	Q6BDI9	400
ZNF726	ZNF638	Q14966	395
ZNF726	PTCHD4	Q6ZW05	391
ZNF726	FAM135A	Q9P2D6	370
ZNF726	CNN3	Q15417	357
ZNF726	AMER2	Q8N7J2	355
ZNF726	MAFG	O15525	348
ZNF726	ASB7	Q9H672	323
ZNF726	ZNF346	Q9UL40	321
ZNF726	ZC3H12D	A2A288	301
ZNF726	XKR6	Q5GH73	290
ZNF726	PARD6G	Q9BYG4	255

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ZNF726	TRIM24	psi-mi:“MI:0914”(association)	0.350
ZNF726	ZNF716	psi-mi:“MI:0914”(association)	0.350
INSR	RIMOC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): ZNF726 (Synthetic Lethality), ZNF726 (Two-hybrid), ZNF492 (Affinity Capture-MS), TRIM24 (Affinity Capture-MS), ZNF430 (Affinity Capture-MS), TRIM39 (Affinity Capture-MS), DCAF10 (Affinity Capture-MS), TRIM28 (Affinity Capture-MS), ZNF716 (Affinity Capture-MS), CBX5 (Affinity Capture-MS), ZNF726 (Affinity Capture-MS), ZNF726 (Affinity Capture-MS), ZNF726 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

664 predictions. Top by Δscore:

Variant	Effect	Δscore
19:23919368:TCCA:T	acceptor_loss	1.0000
19:23919369:CCA:C	acceptor_loss	1.0000
19:23919370:CA:C	acceptor_loss	1.0000
19:23919371:A:AC	acceptor_loss	1.0000
19:23919371:A:AG	acceptor_gain	1.0000
19:23919371:AG:A	acceptor_gain	1.0000
19:23919371:AGG:A	acceptor_gain	1.0000
19:23919372:G:GC	acceptor_gain	1.0000
19:23919372:GG:G	acceptor_gain	1.0000
19:23919372:GGG:G	acceptor_gain	1.0000
19:23919372:GGGA:G	acceptor_gain	1.0000
19:23919372:GGGAC:G	acceptor_gain	1.0000
19:23919460:A:T	donor_gain	1.0000
19:23919496:CTGGG:C	donor_loss	1.0000
19:23919498:GG:G	donor_gain	1.0000
19:23919498:GGGTG:G	donor_loss	1.0000
19:23919499:GG:G	donor_gain	1.0000
19:23919500:G:GG	donor_gain	1.0000
19:23919500:GTG:G	donor_loss	1.0000
19:23919501:T:G	donor_loss	1.0000
19:23919505:GA:G	donor_gain	1.0000
19:23919980:A:AG	acceptor_gain	1.0000
19:23919985:A:G	acceptor_loss	1.0000
19:23919986:G:GA	acceptor_loss	1.0000
19:23919986:GGT:G	acceptor_gain	1.0000
19:23919361:T:TA	acceptor_gain	0.9900
19:23919364:A:AG	acceptor_gain	0.9900
19:23919981:A:G	acceptor_gain	0.9900
19:23919985:A:AG	acceptor_gain	0.9900
19:23919986:G:GG	acceptor_gain	0.9900

AlphaMissense

4102 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:23933836:T:C	F574L	0.983
19:23933838:T:A	F574L	0.983
19:23933838:T:G	F574L	0.983
19:23933584:T:C	F490L	0.982
19:23933586:T:A	F490L	0.982
19:23933586:T:G	F490L	0.982
19:23933248:T:C	F378L	0.980
19:23933250:T:A	F378L	0.980
19:23933250:T:G	F378L	0.980
19:23933920:T:C	F602L	0.978
19:23933922:T:A	F602L	0.978
19:23933922:T:G	F602L	0.978
19:23933332:T:C	F406L	0.977
19:23933334:T:A	F406L	0.977
19:23933334:T:G	F406L	0.977
19:23933668:T:C	F518L	0.977
19:23933670:T:A	F518L	0.977
19:23933670:T:G	F518L	0.977
19:23933164:T:C	F350L	0.976
19:23933166:T:A	F350L	0.976
19:23933166:T:G	F350L	0.976
19:23933752:T:C	F546L	0.974
19:23933754:T:A	F546L	0.974
19:23933754:T:G	F546L	0.974
19:23933416:T:C	F434L	0.973
19:23933418:T:A	F434L	0.973
19:23933418:T:G	F434L	0.973
19:23933843:G:C	R576P	0.973
19:23933500:T:C	F462L	0.969
19:23933502:T:A	F462L	0.969

dbSNP variants (sampled 300 via entrez): RS1000150617 (19:23926318 G>T), RS1000164484 (19:23926378 C>T), RS1000329483 (19:23931624 G>A,T), RS1000402922 (19:23931349 T>C), RS1000561162 (19:23924952 C>G), RS1000599279 (19:23916266 T>G), RS1000711632 (19:23915994 A>G), RS1000873594 (19:23931527 T>C), RS1000900725 (19:23941137 C>A), RS1000932019 (19:23925223 T>G), RS1001115953 (19:23921728 A>C), RS1001199081 (19:23939545 G>T), RS1001433962 (19:23915706 T>C), RS1001535448 (19:23921399 G>A,T), RS1001566479 (19:23921242 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004713_10	Testicular germ cell tumor	2.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methyleugenol	increases expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	increases expression	1
Oxygen	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vanadates	decreases expression	1
Okadaic Acid	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.