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ZNF727

gene
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Summary

ZNF727 (zinc finger protein 727, HGNC:22785) is a protein-coding gene on chromosome 7q11.21, encoding Zinc finger protein 727 (A8MUV8). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 442319 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 85 total
  • MANE Select transcript: NM_001159522

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:22785
Approved symbolZNF727
Namezinc finger protein 727
Location7q11.21
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000214652
Ensembl biotypeprotein_coding
Entrez442319

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000456806, ENST00000715348, ENST00000889950, ENST00000889951

RefSeq mRNA: 1 — MANE Select: NM_001159522 NM_001159522

CCDS: CCDS55113

Canonical transcript exons

ENST00000456806 — 4 exons

ExonStartEnd
ENSE000016186856407727664085339
ENSE000034994246406951464069609
ENSE000036769456406889164069017
ENSE000040265716404543464045624

Expression profiles

Bgee: expression breadth ubiquitous, 209 present calls, max score 84.77.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6179 / max 180.7664, expressed in 321 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter IDTPM avgSamples expressed
787902.6179321

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
oviduct epitheliumUBERON:000480484.77gold quality
germinal epithelium of ovaryUBERON:000130482.41gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099181.75gold quality
endothelial cellCL:000011578.90gold quality
secondary oocyteCL:000065578.87gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047378.18gold quality
corpus epididymisUBERON:000435978.11gold quality
buccal mucosa cellCL:000233676.05silver quality
mammary ductUBERON:000176575.28gold quality
epithelium of mammary glandUBERON:000324475.13gold quality
caput epididymisUBERON:000435874.27gold quality
thoracic mammary glandUBERON:000520073.13gold quality
mammary glandUBERON:000191173.01gold quality
parietal pleuraUBERON:000240072.86gold quality
entorhinal cortexUBERON:000272871.09gold quality
postcentral gyrusUBERON:000258170.68gold quality
bronchial epithelial cellCL:000232870.18gold quality
ovaryUBERON:000099270.14gold quality
cauda epididymisUBERON:000436069.92gold quality
skin of hipUBERON:000155469.73gold quality
tibiaUBERON:000097969.67gold quality
superior frontal gyrusUBERON:000266169.01gold quality
bronchusUBERON:000218568.83gold quality
visceral pleuraUBERON:000240168.80gold quality
fallopian tubeUBERON:000388968.63gold quality
left ovaryUBERON:000211968.51gold quality
islet of LangerhansUBERON:000000668.11gold quality
middle temporal gyrusUBERON:000277167.69gold quality
Brodmann (1909) area 23UBERON:001355467.27gold quality
parietal lobeUBERON:000187266.75gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no5.47

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
mus_musculusZfp738ENSMUSG00000048280
mus_musculusZfp457ENSMUSG00000055341
mus_musculusZfp595ENSMUSG00000057842
mus_musculusZfp953ENSMUSG00000098905
rattus_norvegicusAABR07009105.1ENSRNOG00000053325

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 727 — A8MUV8 (reviewed: A8MUV8)

All UniProt accessions (1): A8MUV8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001152994* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001909KRABDomain
IPR013087Znf_C2H2_typeDomain
IPR036051KRAB_dom_sfHomologous_superfamily
IPR036236Znf_C2H2_sfHomologous_superfamily
IPR050527

Pfam: PF00096, PF01352, PF13894

UniProt features (13 total): zinc finger region 11, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-A8MUV8-F170.120.16

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-212436Generic Transcription Pathway

MSigDB gene sets: 20 (showing top): BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, chr7q11, GOCC_NUCLEOLUS, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, OUILLETTE_CLL_13Q14_DELETION_DN, THUM_SYSTOLIC_HEART_FAILURE_UP, GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY, GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING, PULVER_FOREY_PERTURB_ACCUMULATION_G2_M, PULVER_FOREY_PERTURB_ATTRITION_M_EG1, KORKOLA_CORRELATED_WITH_POU5F1, GOMF_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), double-stranded DNA binding (GO:0003690), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleolus (GO:0005730), microtubule cytoskeleton (GO:0015630), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
RNA Polymerase II Transcription1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
regulation of transcription by RNA polymerase II2
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
transcription by RNA polymerase II1
negative regulation of DNA-templated transcription1
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
transition metal ion binding1
nucleic acid binding1
DNA binding1
cation binding1
nuclear lumen1
intracellular membraneless organelle1
cytoskeleton1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

148 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZNF727CFAP68Q9H5F2576
ZNF727C16orf87Q6PH81571
ZNF727DEFB115Q30KQ5507
ZNF727FAM135AQ9P2D6434
ZNF727ANKRD9Q96BM1419
ZNF727ASB7Q9H672391
ZNF727TSPAN17Q96FV3380
ZNF727RBBP4P31149375
ZNF727NFXL1Q6ZNB6374
ZNF727ZGPATQ8N5A5370
ZNF727SEC14L6B5MCN3370
ZNF727TRIM52Q96A61356
ZNF727TMEM163Q8TC26348
ZNF727RNF144AP50876348
ZNF727UBR7Q8N806338

IntAct

2 interactions, top by confidence:

ABTypeScore
ZNF727ECE1psi-mi:“MI:0915”(physical association)0.370

BioGRID (3): ZNF727 (Affinity Capture-MS), ZNF727 (Affinity Capture-MS), CALR (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A6NK75, A6NNF4, A6NP11, A8MTY0, A8MUV8, B4DXR9, C9JN71, O75346, O75373, O95780, P0CJ79, P0DKX0, P0DPD5, P17019, P17035, P35789, Q03923, Q03938, Q08AN1, Q14593, Q15928, Q3SXZ3, Q3ZCX4, Q5MCW4, Q5R9S5, Q5RER9, Q68DY1, Q6JLC9, Q6ZMV8, Q6ZN06, Q6ZN08, Q6ZNA1, Q76KX8, Q86T29, Q86V71, Q8IYN0, Q8N4W9, Q8N7M2, Q8NEM1, Q8TD23

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance71
Likely benign5
Benign5

Top pathogenic / likely-pathogenic (0)

SpliceAI

753 predictions. Top by Δscore:

VariantEffectΔscore
7:64045623:TGGTG:Tdonor_loss1.0000
7:64045624:GGTG:Gdonor_loss1.0000
7:64045625:G:Tdonor_loss1.0000
7:64045626:T:Gdonor_loss1.0000
7:64057454:G:GTdonor_gain1.0000
7:64068890:GCGA:Gacceptor_gain1.0000
7:64045625:G:GGdonor_gain0.9900
7:64045627:GAGT:Gdonor_loss0.9900
7:64068321:A:Tdonor_gain0.9900
7:64068885:TTTCA:Tacceptor_loss0.9900
7:64068888:CA:Cacceptor_loss0.9900
7:64068889:A:AGacceptor_gain0.9900
7:64068889:AGC:Aacceptor_gain0.9900
7:64068890:G:GGacceptor_gain0.9900
7:64068890:G:GTacceptor_loss0.9900
7:64068890:GC:Gacceptor_gain0.9900
7:64068890:GCG:Gacceptor_gain0.9900
7:64069016:GG:Gdonor_gain0.9900
7:64069016:GGGTG:Gdonor_loss0.9900
7:64069017:GG:Gdonor_gain0.9900
7:64069018:G:GGdonor_gain0.9900
7:64069018:GT:Gdonor_loss0.9900
7:64069019:T:Gdonor_loss0.9900
7:64069020:GAGAA:Gdonor_loss0.9900
7:64077270:TTTCA:Tacceptor_loss0.9900
7:64077272:TCA:Tacceptor_loss0.9900
7:64077273:CAG:Cacceptor_loss0.9900
7:64077274:A:AGacceptor_gain0.9900
7:64077274:AGCT:Aacceptor_gain0.9900
7:64077274:AGCTG:Aacceptor_gain0.9900

AlphaMissense

3332 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:64078094:T:CF349L0.994
7:64078096:T:AF349L0.994
7:64078096:T:GF349L0.994
7:64077842:T:CF265L0.993
7:64077844:T:AF265L0.993
7:64077844:T:GF265L0.993
7:64078262:T:CF405L0.993
7:64078264:T:AF405L0.993
7:64078264:T:GF405L0.993
7:64077926:T:CF293L0.991
7:64077928:T:AF293L0.991
7:64077928:T:GF293L0.991
7:64078178:T:CF377L0.991
7:64078180:T:AF377L0.991
7:64078180:T:GF377L0.991
7:64078346:T:CF433L0.991
7:64078348:T:AF433L0.991
7:64078348:T:GF433L0.991
7:64078430:T:CF461L0.990
7:64078432:T:AF461L0.990
7:64078432:T:GF461L0.990
7:64078010:T:CF321L0.989
7:64078012:T:AF321L0.989
7:64078012:T:GF321L0.989
7:64078197:T:CL383P0.988
7:64078205:C:GH386D0.985
7:64078207:T:AH386Q0.984
7:64078207:T:GH386Q0.984
7:64078219:C:AH390Q0.984
7:64078219:C:GH390Q0.984

dbSNP variants (sampled 300 via entrez): RS1000097312 (7:64073496 A>G), RS1000258034 (7:64073308 T>TG), RS1000288701 (7:64049660 G>A), RS1000415597 (7:64043955 G>A), RS1000549975 (7:64062696 A>G), RS1000680166 (7:64049964 A>G), RS1000901646 (7:64062965 A>G), RS1000919954 (7:64081918 G>A), RS1000983967 (7:64068759 C>G), RS1001190993 (7:64052321 G>A), RS1001261129 (7:64073925 G>A), RS1001286348 (7:64061924 A>T), RS1001374589 (7:64081618 A>G), RS1001448405 (7:64068436 G>T), RS1001499057 (7:64075071 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

ChemicalActions (top 5)PubMed papers
TAK-243increases sumoylation1
Benzo(a)pyreneaffects methylation1
Aflatoxin B1decreases methylation1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot