ZNF736

Summary

ZNF736 (zinc finger protein 736, HGNC:32467) is a protein-coding gene on chromosome 7q11.21, encoding Zinc finger protein 736 (B4DX44). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 728927 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001170905

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32467
Approved symbol	ZNF736
Name	zinc finger protein 736
Location	7q11.21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000234444
Ensembl biotype	protein_coding
Entrez	728927

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 3 protein_coding, 3 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000355095, ENST00000423484, ENST00000438373, ENST00000465343, ENST00000488621, ENST00000492322, ENST00000493036, ENST00000606716

RefSeq mRNA: 2 — MANE Select: NM_001170905 NM_001170905, NM_001294255

CCDS: CCDS55114

Canonical transcript exons

ENST00000423484 — 4 exons

Exon	Start	End
ENSE00001713499	64348090	64356634
ENSE00001804551	64313961	64314153
ENSE00002432757	64336887	64336982
ENSE00003519206	64336259	64336385

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 90.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.7606 / max 181.2170, expressed in 1499 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
78797	11.8151	1470
78793	1.4268	506
78798	0.6412	343
78794	0.4243	209
78795	0.3520	209
78796	0.1014	33

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	90.02	gold quality
right testis	UBERON:0004534	86.84	gold quality
left testis	UBERON:0004533	86.82	gold quality
epithelium of nasopharynx	UBERON:0001951	85.97	gold quality
testis	UBERON:0000473	85.36	gold quality
oviduct epithelium	UBERON:0004804	84.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.15	gold quality
endothelial cell	CL:0000115	83.98	gold quality
calcaneal tendon	UBERON:0003701	83.80	gold quality
adrenal tissue	UBERON:0018303	83.72	gold quality
bone marrow cell	CL:0002092	82.83	gold quality
germinal epithelium of ovary	UBERON:0001304	82.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.21	gold quality
right uterine tube	UBERON:0001302	82.13	gold quality
left ovary	UBERON:0002119	81.98	gold quality
colonic epithelium	UBERON:0000397	81.95	gold quality
adenohypophysis	UBERON:0002196	81.78	gold quality
right lobe of thyroid gland	UBERON:0001119	81.72	gold quality
ovary	UBERON:0000992	81.71	gold quality
left lobe of thyroid gland	UBERON:0001120	81.57	gold quality
thyroid gland	UBERON:0002046	81.54	gold quality
pituitary gland	UBERON:0000007	81.53	gold quality
right ovary	UBERON:0002118	80.94	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.51	gold quality
secondary oocyte	CL:0000655	80.04	gold quality
endocervix	UBERON:0000458	79.75	gold quality
tibia	UBERON:0000979	79.73	gold quality
ganglionic eminence	UBERON:0004023	79.67	gold quality
tibial nerve	UBERON:0001323	79.63	gold quality
sural nerve	UBERON:0015488	79.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

256 targeting ZNF736, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4682	100.00	68.89	1258
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp738	ENSMUSG00000048280
mus_musculus	Zfp457	ENSMUSG00000055341
mus_musculus	Zfp595	ENSMUSG00000057842
mus_musculus	Zfp953	ENSMUSG00000098905
rattus_norvegicus	AABR07009105.1	ENSRNOG00000053325

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 736 — B4DX44 (reviewed: B4DX44)

All UniProt accessions (2): B4DX44, A0A1D5RMN6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (2): NP_001164376, NP_001281184 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13912

UniProt features (13 total): zinc finger region 10, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-B4DX44-F1	72.70	0.27

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 74 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, LIAO_METASTASIS, chr7q11, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, CEBPZ_TARGET_GENES, HSD17B8_TARGET_GENES, KAT5_TARGET_GENES, SIX1_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF184_TARGET_GENES, ZNF711_TARGET_GENES

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

248 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF736	TRIM60	Q495X7	594
ZNF736	OR52E4	Q8NGH9	486
ZNF736	SMIM8	Q96KF7	431
ZNF736	UBTFL1	P0CB47	420
ZNF736	SPIDR	Q14159	418
ZNF736	FNTA	P49354	396
ZNF736	HGSNAT	Q68CP4	396
ZNF736	HOOK3	Q86VS8	391
ZNF736	POMK	Q9H5K3	383
ZNF736	KANSL1L	A0AUZ9	380
ZNF736	TMEM52	Q8NDY8	380
ZNF736	GKAP1	Q5VSY0	374
ZNF736	TLNRD1	Q9H1K6	370
ZNF736	CCDC200	A0A1B0GVQ3	366
ZNF736	MCM4	P33991	353
ZNF736	PRKDC	P78527	353

IntAct

4 interactions, top by confidence:

A	B	Type	Score
ZNF736	EPB41L2	psi-mi:“MI:0915”(physical association)	0.400
M		psi-mi:“MI:0914”(association)	0.350
ZNF736	PPM1G	psi-mi:“MI:0914”(association)	0.350

BioGRID (4): EPB41L2 (Proximity Label-MS), ZNF736 (Negative Genetic), ZNF736 (Affinity Capture-MS), ZNF736 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

763 predictions. Top by Δscore:

Variant	Effect	Δscore
7:64336253:TTCCA:T	acceptor_loss	1.0000
7:64336254:TCCA:T	acceptor_loss	1.0000
7:64336255:CCA:C	acceptor_loss	1.0000
7:64336256:CAG:C	acceptor_loss	1.0000
7:64336257:A:C	acceptor_loss	1.0000
7:64336258:G:GT	acceptor_loss	1.0000
7:64336258:GGGA:G	acceptor_gain	1.0000
7:64336382:TTGGG:T	donor_loss	1.0000
7:64336386:GT:G	donor_loss	1.0000
7:64336387:T:A	donor_loss	1.0000
7:64336256:CAGGG:C	acceptor_gain	0.9900
7:64336257:A:AG	acceptor_gain	0.9900
7:64336257:AG:A	acceptor_gain	0.9900
7:64336257:AGGGA:A	acceptor_gain	0.9900
7:64336258:G:GG	acceptor_gain	0.9900
7:64336258:GG:G	acceptor_gain	0.9900
7:64336258:GGGAG:G	acceptor_gain	0.9900
7:64336333:GC:G	donor_gain	0.9900
7:64336346:G:T	donor_gain	0.9900
7:64336384:GG:G	donor_gain	0.9900
7:64336385:GG:G	donor_gain	0.9900
7:64336386:G:GG	donor_gain	0.9900
7:64336388:GAGAA:G	donor_loss	0.9900
7:64348088:AGCT:A	acceptor_gain	0.9900
7:64348089:GCTG:G	acceptor_gain	0.9900
7:64336257:AGG:A	acceptor_gain	0.9800
7:64336258:GGG:G	acceptor_gain	0.9800
7:64337089:GTTTC:G	donor_gain	0.9800
7:64337090:TTTCT:T	donor_gain	0.9800
7:64336330:GCAGC:G	donor_gain	0.9700

AlphaMissense

2868 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:64348659:T:C	F266L	0.987
7:64348661:T:A	F266L	0.987
7:64348661:T:G	F266L	0.987
7:64348575:T:C	F238L	0.985
7:64348577:T:A	F238L	0.985
7:64348577:T:G	F238L	0.985
7:64348827:T:C	F322L	0.984
7:64348829:T:A	F322L	0.984
7:64348829:T:G	F322L	0.984
7:64348678:T:C	L272P	0.980
7:64348491:T:C	F210L	0.974
7:64348493:T:A	F210L	0.974
7:64348493:T:G	F210L	0.974
7:64348911:T:C	F350L	0.968
7:64348913:T:A	F350L	0.968
7:64348913:T:G	F350L	0.968
7:64348700:T:A	H279Q	0.965
7:64348700:T:G	H279Q	0.965
7:64348688:T:A	H275Q	0.964
7:64348688:T:G	H275Q	0.964
7:64348686:C:G	H275D	0.956
7:64336292:T:C	F13L	0.951
7:64336294:C:A	F13L	0.951
7:64336294:C:G	F13L	0.951
7:64348995:T:C	F378L	0.947
7:64348997:T:A	F378L	0.947
7:64348997:T:G	F378L	0.947
7:64348713:C:T	P284S	0.944
7:64348716:T:G	Y285D	0.943
7:64348762:T:C	L300P	0.943

dbSNP variants (sampled 300 via entrez): RS1000100291 (7:64353055 C>A,G,T), RS1000298872 (7:64335630 T>C), RS1000358994 (7:64330225 T>C), RS1000603300 (7:64312025 G>A,C), RS1000632256 (7:64341653 A>G), RS1001105682 (7:64354579 C>T), RS1001272515 (7:64317107 T>G), RS1001450444 (7:64347074 A>C,G), RS1001794297 (7:64324188 A>AT), RS1001973194 (7:64335685 A>G), RS1002093775 (7:64312280 A>C), RS1002129048 (7:64316830 A>G), RS1002175965 (7:64312378 C>T), RS1002532447 (7:64331730 G>C), RS1002900500 (7:64350455 AT>A,ATT)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation, increases methylation	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
Doxorubicin	decreases expression	1
Niclosamide	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.