ZNF737

Summary

ZNF737 (zinc finger protein 737, HGNC:32468) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 737 (O75373). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.

Source: NCBI Gene 100129842 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_001159293

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32468
Approved symbol	ZNF737
Name	zinc finger protein 737
Location	19p12
Locus type	gene with protein product
Status	Approved
Aliases	ZNF102
Ensembl gene	ENSG00000237440
Ensembl biotype	protein_coding
OMIM	603984
Entrez	100129842

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 nonsense_mediated_decay

ENST00000427401, ENST00000594419, ENST00000596530, ENST00000596797, ENST00000597940, ENST00000865229

RefSeq mRNA: 1 — MANE Select: NM_001159293 NM_001159293

CCDS: CCDS54238

Canonical transcript exons

ENST00000427401 — 4 exons

Exon	Start	End
ENSE00002317806	20565638	20565781
ENSE00002718568	20537992	20545976
ENSE00003678582	20553709	20553835
ENSE00003687476	20552475	20552570

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 93.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4176 / max 127.0339, expressed in 1545 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180193	9.1166	1502
180192	0.4119	232
180196	0.3590	188
180194	0.3335	167
180195	0.1967	89

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	93.28	gold quality
ganglionic eminence	UBERON:0004023	90.54	gold quality
cortical plate	UBERON:0005343	88.47	gold quality
endometrium	UBERON:0001295	86.96	gold quality
calcaneal tendon	UBERON:0003701	86.70	gold quality
adrenal tissue	UBERON:0018303	86.60	gold quality
right lobe of thyroid gland	UBERON:0001119	86.13	gold quality
islet of Langerhans	UBERON:0000006	85.93	gold quality
lymph node	UBERON:0000029	85.42	gold quality
thyroid gland	UBERON:0002046	85.23	gold quality
left lobe of thyroid gland	UBERON:0001120	84.44	gold quality
right adrenal gland cortex	UBERON:0035827	83.98	gold quality
right adrenal gland	UBERON:0001233	83.31	gold quality
pancreas	UBERON:0001264	82.89	gold quality
ovary	UBERON:0000992	82.60	gold quality
adrenal gland	UBERON:0002369	82.55	gold quality
superior frontal gyrus	UBERON:0002661	82.33	gold quality
left ovary	UBERON:0002119	82.06	gold quality
left adrenal gland	UBERON:0001234	81.42	gold quality
tonsil	UBERON:0002372	81.33	gold quality
body of pancreas	UBERON:0001150	81.08	gold quality
left adrenal gland cortex	UBERON:0035825	81.01	gold quality
urinary bladder	UBERON:0001255	80.48	gold quality
right ovary	UBERON:0002118	80.41	gold quality
cortex of kidney	UBERON:0001225	80.04	gold quality
rectum	UBERON:0001052	79.38	gold quality
ventricular zone	UBERON:0003053	79.33	gold quality
right uterine tube	UBERON:0001302	79.16	gold quality
nucleus accumbens	UBERON:0001882	79.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.87
E-GEOD-111727	no	290.01

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000099025

Paralogs (18): ZNF430 (ENSG00000118620), ZNF92 (ENSG00000146757), ZNF66 (ENSG00000160229), ZNF22 (ENSG00000165512), ZNF680 (ENSG00000173041), ZNF114 (ENSG00000178150), ZFP41 (ENSG00000181638), ZNF730 (ENSG00000183850), ZNF479 (ENSG00000185177), ZNF626 (ENSG00000188171), ZNF431 (ENSG00000196705), ZNF100 (ENSG00000197020), ZNF257 (ENSG00000197134), ZNF98 (ENSG00000197360), ZNF675 (ENSG00000197372), ZNF273 (ENSG00000198039), ZNF253 (ENSG00000256771), ZNF723 (ENSG00000268696)

Protein

Protein identifiers

Zinc finger protein 737 — O75373 (reviewed: O75373)

Alternative names: Zinc finger protein 102

All UniProt accessions (5): O75373, M0QZS4, M0R1D1, M0R1M3, M0R1M8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001152765* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (19 total): zinc finger region 13, sequence variant 4, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75373-F1	75.30	0.22

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 72 (showing top): chr19p12, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CBX5_TARGET_GENES, HMGA1_TARGET_GENES, ZNF10_TARGET_GENES, ZNF274_TARGET_GENES, ZNF350_TARGET_GENES, ZNF597_TARGET_GENES, ZNF92_TARGET_GENES, MIR3662, MIR607, MIR12136

GO Biological Process (2): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

332 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF737	ZNF277	Q9NRM2	370
ZNF737	OR8J3	Q8NGG0	369
ZNF737	OR5F1	O95221	349
ZNF737	OR5D16	Q8NGK9	348
ZNF737	OR4A15	Q8NGL6	336
ZNF737	OR8I2	Q8N0Y5	329
ZNF737	OR5T2	Q8NGG2	325
ZNF737	OR5D14	Q8NGL3	324
ZNF737	OR8H2	Q8N162	322
ZNF737	OR11H2	Q8NH07	321
ZNF737	OR5AS1	Q8N127	315
ZNF737	TEX38	Q6PEX7	300
ZNF737	OR4C16	Q8NGL9	300
ZNF737	OR8H3	Q8N146	298
ZNF737	OR5W2	Q8NH69	297

IntAct

3 interactions, top by confidence:

A	B	Type	Score
S100A9	ZNF737	psi-mi:“MI:0915”(physical association)	0.370
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): ZNF737 (Affinity Capture-MS), ZNF737 (Affinity Capture-MS), ZNF737 (Affinity Capture-RNA)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	101
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

717 predictions. Top by Δscore:

Variant	Effect	Δscore
19:20545972:CGTAA:C	acceptor_gain	1.0000
19:20545977:C:CC	acceptor_gain	1.0000
19:20553703:TCTCA:T	donor_loss	1.0000
19:20553704:CTCA:C	donor_loss	1.0000
19:20553705:TCA:T	donor_loss	1.0000
19:20553706:CA:C	donor_loss	1.0000
19:20553707:A:T	donor_loss	1.0000
19:20553708:C:G	donor_loss	1.0000
19:20553748:T:A	donor_gain	1.0000
19:20553831:GGCCC:G	acceptor_gain	1.0000
19:20553832:GCCC:G	acceptor_gain	1.0000
19:20553833:CCC:C	acceptor_gain	1.0000
19:20553833:CCCC:C	acceptor_gain	1.0000
19:20553834:CC:C	acceptor_gain	1.0000
19:20553834:CCC:C	acceptor_gain	1.0000
19:20553835:CC:C	acceptor_gain	1.0000
19:20553835:CCTG:C	acceptor_loss	1.0000
19:20553836:C:A	acceptor_loss	1.0000
19:20553836:C:CC	acceptor_gain	1.0000
19:20553837:T:A	acceptor_loss	1.0000
19:20545973:GTAA:G	acceptor_gain	0.9900
19:20545974:TAA:T	acceptor_gain	0.9900
19:20545974:TAAC:T	acceptor_loss	0.9900
19:20545975:AA:A	acceptor_gain	0.9900
19:20545976:ACT:A	acceptor_loss	0.9900
19:20545977:C:CA	acceptor_loss	0.9900
19:20545978:T:G	acceptor_loss	0.9900
19:20552470:CCTA:C	donor_loss	0.9900
19:20552471:CTA:C	donor_loss	0.9900
19:20552472:TAC:T	donor_loss	0.9900

AlphaMissense

3566 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:20545573:G:C	F210L	0.980
19:20545573:G:T	F210L	0.980
19:20545575:A:G	F210L	0.980
19:20545321:A:C	F294L	0.978
19:20545321:A:T	F294L	0.978
19:20545323:A:G	F294L	0.978
19:20545069:G:C	F378L	0.976
19:20545069:G:T	F378L	0.976
19:20545071:A:G	F378L	0.976
19:20545405:A:C	F266L	0.976
19:20545405:A:T	F266L	0.976
19:20545407:A:G	F266L	0.976
19:20545489:A:C	F238L	0.974
19:20545489:A:T	F238L	0.974
19:20545491:A:G	F238L	0.974
19:20544817:G:C	F462L	0.970
19:20544817:G:T	F462L	0.970
19:20544819:A:G	F462L	0.970
19:20545153:A:C	F350L	0.968
19:20545153:A:T	F350L	0.968
19:20545155:A:G	F350L	0.968
19:20544985:A:C	F406L	0.956
19:20544985:A:T	F406L	0.956
19:20544987:A:G	F406L	0.956
19:20545657:A:C	F182L	0.956
19:20545657:A:T	F182L	0.956
19:20545659:A:G	F182L	0.956
19:20544733:A:C	F490L	0.955
19:20544733:A:T	F490L	0.955
19:20544735:A:G	F490L	0.955

dbSNP variants (sampled 300 via entrez): RS1000152511 (19:20553270 T>C), RS1000359452 (19:20546944 T>C), RS1000684851 (19:20543066 C>A), RS1000904893 (19:20537171 T>C), RS1000966429 (19:20548325 C>T), RS1001082880 (19:20554603 T>G), RS1001157820 (19:20554866 T>A,C), RS1001335205 (19:20548049 G>A,C), RS1002028897 (19:20537976 C>T), RS1002059855 (19:20538309 T>A), RS1002426968 (19:20548535 A>G), RS1002458051 (19:20548834 C>A), RS1003028224 (19:20539318 A>G,T), RS1003235516 (19:20544457 T>C), RS1003670196 (19:20556676 T>A)

Disease associations

OMIM: gene MIM:603984 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003901_5	Cognitive decline (age-related)	7.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
arsenite	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	increases expression	1
di-n-butylphosphoric acid	affects expression	1
bisphenol S	decreases methylation	1
Air Pollutants	increases abundance, affects expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Doxorubicin	decreases expression	1
Methapyrilene	increases methylation	1
Nicotine	increases expression	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	decreases expression	1
Vanadates	decreases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.