ZNF738

Summary

ZNF738 (zinc finger protein 738, HGNC:32469) is a protein-coding gene on chromosome 19p12, encoding Zinc finger protein 738 (Q8NE65). May be involved in transcriptional regulation.

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleus.

Source: NCBI Gene 148203 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 25 total
• MANE Select transcript: NM_001355237

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32469
Approved symbol	ZNF738
Name	zinc finger protein 738
Location	19p12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172687
Ensembl biotype	protein_coding
Entrez	148203

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 nonsense_mediated_decay

ENST00000311015, ENST00000380870, ENST00000594245, ENST00000597492, ENST00000597810, ENST00000683779, ENST00000915175

RefSeq mRNA: 4 — MANE Select: NM_001355237 NM_001355237, NM_001355239, NM_001355240, NM_001355241

CCDS: CCDS86732, CCDS86733, CCDS92573

Canonical transcript exons

ENST00000683779 — 5 exons

Exon	Start	End
ENSE00001765206	21375869	21375964
ENSE00003473888	21375238	21375364
ENSE00003606307	21361766	21361858
ENSE00003916555	21359000	21359143
ENSE00003916857	21382866	21388582

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 98.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.1245 / max 530.2786, expressed in 1619 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174886	11.3733	1603
174885	0.4125	201
174887	0.3388	159

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	98.19	gold quality
secondary oocyte	CL:0000655	96.41	gold quality
embryo	UBERON:0000922	94.46	gold quality
ganglionic eminence	UBERON:0004023	94.46	gold quality
buccal mucosa cell	CL:0002336	94.05	gold quality
ventricular zone	UBERON:0003053	90.91	gold quality
cortical plate	UBERON:0005343	89.11	gold quality
thymus	UBERON:0002370	87.05	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.94	gold quality
tibia	UBERON:0000979	84.68	gold quality
cerebellar hemisphere	UBERON:0002245	84.66	gold quality
cerebellar cortex	UBERON:0002129	84.61	gold quality
germinal epithelium of ovary	UBERON:0001304	84.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.20	gold quality
cerebellum	UBERON:0002037	84.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.90	gold quality
endometrium	UBERON:0001295	83.37	gold quality
pigmented layer of retina	UBERON:0001782	83.32	gold quality
corpus callosum	UBERON:0002336	82.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.48	gold quality
amniotic fluid	UBERON:0000173	82.35	gold quality
adrenal tissue	UBERON:0018303	82.09	gold quality
spinal cord	UBERON:0002240	81.67	gold quality
ovary	UBERON:0000992	81.47	gold quality
endothelial cell	CL:0000115	80.98	gold quality
epithelium of nasopharynx	UBERON:0001951	80.76	gold quality
cerebellar vermis	UBERON:0004720	80.69	silver quality
ileal mucosa	UBERON:0000331	80.45	gold quality
left ovary	UBERON:0002119	80.16	gold quality
metanephros	UBERON:0000081	80.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.36

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp738	ENSMUSG00000048280
mus_musculus	Zfp457	ENSMUSG00000055341
mus_musculus	Zfp595	ENSMUSG00000057842
mus_musculus	Zfp953	ENSMUSG00000098905
rattus_norvegicus	AABR07009105.1	ENSRNOG00000053325

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 738 — Q8NE65 (reviewed: Q8NE65)

All UniProt accessions (6): Q8NE65, A0A804HJ59, E9PE46, M0R024, M0R0N2, M0R3I0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Miscellaneous. Gene prediction based on partial EST data.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NE65-1	1	yes
Q8NE65-2	2

RefSeq proteins (4): NP_001342166, NP_001342168, NP_001342169, NP_001342170 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050752	C2H2-ZF_domain	Family

Pfam: PF00096, PF01352

UniProt features (11 total): zinc finger region 7, splice variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NE65-F1	61.96	0.07

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 47 (showing top): LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN, chr19p12, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_PROTEIN_POLYUBIQUITINATION, LEE_RECENT_THYMIC_EMIGRANT, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, JOHNSTONE_PARVB_TARGETS_3_DN, ZWANG_DOWN_BY_2ND_EGF_PULSE, KIM_MYCN_AMPLIFICATION_TARGETS_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ASH1L_TARGET_GENES, HSD17B8_TARGET_GENES, LHX9_TARGET_GENES

GO Biological Process (2): protein polyubiquitination (GO:0000209), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (4): DNA binding (GO:0003677), ubiquitin-protein transferase activity (GO:0004842), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein ubiquitination	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
ubiquitin-like protein transferase activity	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

388 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF738	UBALD2	Q8IYN6	434
ZNF738	CCDC150	Q8NCX0	433
ZNF738	SPATA31D1	Q6ZQQ2	419
ZNF738	ZNF781	Q8N8C0	417
ZNF738	SLC66A2	Q8N2U9	404
ZNF738	SOWAHB	A6NEL2	399
ZNF738	NKAIN3	Q8N8D7	397
ZNF738	ZNF200	P98182	392
ZNF738	CCDC77	Q9BR77	390
ZNF738	ZNF260	Q3ZCT1	373
ZNF738	HROB	Q8N3J3	373
ZNF738	TMEM182	Q6ZP80	371
ZNF738	FAM72B	Q86X60	371
ZNF738	SKIDA1	Q1XH10	367
ZNF738	ZNF266	Q14584	359

IntAct

8 interactions, top by confidence:

A	B	Type	Score
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF738	TRIM28	psi-mi:“MI:0914”(association)	0.530
ECE1	ZNF738	psi-mi:“MI:0915”(physical association)	0.370
ZNF738	KRBA1	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0JPL0, A1L1L7, A7MBI1, A8MT65, B2RXC5, G3X9G7, P0CG31, P21506, P52738, Q02525, Q2KI58, Q2M3W8, Q49AA0, Q4R6J4, Q5FWF6, Q5RB33, Q5RCJ2, Q5RE50, Q5REF1, Q5T5D7, Q5VIY5, Q6V9R5, Q6ZMW2, Q6ZN11, Q6ZNG0, Q86TJ5, Q86XU0, Q8BGV5, Q8N782, Q8N859, Q8N883, Q8N9Z0, Q8NC26, Q8NE65, Q95K49, Q96N20, Q96NG8, Q96NJ3, Q96SR6, Q9BSK1

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1257 predictions. Top by Δscore:

Variant	Effect	Δscore
19:21375325:A:T	donor_gain	1.0000
19:21359109:C:G	donor_gain	0.9900
19:21359142:TGG:T	donor_loss	0.9900
19:21359143:GGTGA:G	donor_loss	0.9900
19:21359144:G:C	donor_loss	0.9900
19:21359144:G:GG	donor_gain	0.9900
19:21359145:T:G	donor_loss	0.9900
19:21361764:A:AG	acceptor_gain	0.9900
19:21361765:G:GG	acceptor_gain	0.9900
19:21375232:TTTCA:T	acceptor_loss	0.9900
19:21375233:TTCA:T	acceptor_loss	0.9900
19:21375236:A:T	acceptor_loss	0.9900
19:21375237:G:T	acceptor_loss	0.9900
19:21375864:ATCAG:A	acceptor_loss	0.9900
19:21375865:TCAGG:T	acceptor_loss	0.9900
19:21375866:CAGGT:C	acceptor_loss	0.9900
19:21375867:A:G	acceptor_loss	0.9900
19:21359130:G:GT	donor_gain	0.9800
19:21361628:AT:A	donor_gain	0.9800
19:21361760:CCATA:C	acceptor_loss	0.9800
19:21361761:CATA:C	acceptor_loss	0.9800
19:21361762:ATAGG:A	acceptor_loss	0.9800
19:21361763:TA:T	acceptor_loss	0.9800
19:21361765:G:T	acceptor_loss	0.9800
19:21361854:AAAAG:A	donor_loss	0.9800
19:21361855:AAAGG:A	donor_loss	0.9800
19:21361856:AAG:A	donor_loss	0.9800
19:21361857:AGGTA:A	donor_loss	0.9800
19:21361858:GGTA:G	donor_loss	0.9800
19:21361859:GT:G	donor_loss	0.9800

AlphaMissense

2502 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:21375271:T:C	F44L	0.975
19:21375273:C:A	F44L	0.975
19:21375273:C:G	F44L	0.975
19:21375272:T:C	F44S	0.956
19:21375250:T:C	F37L	0.942
19:21375252:T:A	F37L	0.942
19:21375252:T:G	F37L	0.942
19:21375309:G:C	Q56H	0.917
19:21375309:G:T	Q56H	0.917
19:21375358:T:C	F73L	0.913
19:21375360:C:A	F73L	0.913
19:21375360:C:G	F73L	0.913
19:21375342:C:A	N67K	0.903
19:21375342:C:G	N67K	0.903
19:21375319:T:G	Y60D	0.898
19:21375272:T:G	F44C	0.897
19:21375288:G:C	W49C	0.891
19:21375288:G:T	W49C	0.891
19:21375286:T:A	W49R	0.889
19:21375286:T:C	W49R	0.889
19:21375296:T:C	L52P	0.871
19:21375333:G:A	M64I	0.866
19:21375333:G:C	M64I	0.866
19:21375333:G:T	M64I	0.866
19:21375343:T:C	F68L	0.864
19:21375345:C:A	F68L	0.864
19:21375345:C:G	F68L	0.864
19:21375338:A:T	E66V	0.863
19:21375308:A:C	Q56P	0.852
19:21375353:T:C	L71P	0.847

dbSNP variants (sampled 300 via entrez): RS1000096284 (19:21388998 C>T), RS1000127592 (19:21379368 C>T), RS1000310246 (19:21373045 C>A), RS1000450139 (19:21380919 C>G), RS1000493599 (19:21383972 G>A,T), RS1000610067 (19:21379660 A>G), RS1000698551 (19:21387646 C>T), RS1000773763 (19:21359121 G>A), RS1000888876 (19:21368445 T>C), RS1001020174 (19:21365207 T>A), RS1001048268 (19:21374539 T>C), RS1001109556 (19:21383672 T>A,G), RS1001113691 (19:21367856 T>C), RS1001211642 (19:21378168 T>C), RS1001402320 (19:21363920 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010118_72	Type 2 diabetes	2.000000e-13

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
bisphenol F	affects cotreatment, decreases expression	1
methylmercuric chloride	decreases expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chloropicrin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Asbestos, Crocidolite	decreases expression	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.