ZNF761

Summary

ZNF761 (zinc finger protein 761, HGNC:23179) is a protein-coding gene on chromosome 19q13.42, encoding Zinc finger protein 761 (Q86XN6). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 388561 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 30 total
• MANE Select transcript: NM_001289951

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23179
Approved symbol	ZNF761
Name	zinc finger protein 761
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Aliases	KIAA2033, FLJ16231, FLJ35333
Ensembl gene	ENSG00000160336
Ensembl biotype	protein_coding
Entrez	388561

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000334095, ENST00000432094, ENST00000610928, ENST00000613950, ENST00000651864, ENST00000684525, ENST00000870656, ENST00000962991

RefSeq mRNA: 5 — MANE Select: NM_001289951 NM_001008401, NM_001289951, NM_001289952, NM_001289953, NM_001350496

CCDS: CCDS77353

Canonical transcript exons

ENST00000684525 — 5 exons

Exon	Start	End
ENSE00001638380	53454650	53458261
ENSE00003849099	53431984	53432028
ENSE00003904241	53446227	53446337
ENSE00003906296	53447196	53447283
ENSE00003908682	53449512	53449638

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 90.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9979 / max 104.1038, expressed in 1773 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177326	10.9979	1773

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prostate gland	UBERON:0002367	90.42	gold quality
right adrenal gland cortex	UBERON:0035827	85.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.50	gold quality
body of pancreas	UBERON:0001150	85.08	gold quality
right adrenal gland	UBERON:0001233	84.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.75	gold quality
endometrium	UBERON:0001295	84.41	gold quality
pancreas	UBERON:0001264	84.19	gold quality
right ovary	UBERON:0002118	84.10	gold quality
left adrenal gland cortex	UBERON:0035825	84.10	gold quality
placenta	UBERON:0001987	84.08	gold quality
left ovary	UBERON:0002119	84.01	gold quality
right lung	UBERON:0002167	83.89	gold quality
islet of Langerhans	UBERON:0000006	83.72	gold quality
ovary	UBERON:0000992	83.46	gold quality
left adrenal gland	UBERON:0001234	83.46	gold quality
adrenal gland	UBERON:0002369	83.21	gold quality
left uterine tube	UBERON:0001303	82.37	gold quality
cortical plate	UBERON:0005343	82.16	gold quality
omental fat pad	UBERON:0010414	82.03	gold quality
calcaneal tendon	UBERON:0003701	81.72	gold quality
fundus of stomach	UBERON:0001160	81.08	gold quality
adipose tissue	UBERON:0001013	80.99	gold quality
minor salivary gland	UBERON:0001830	80.88	gold quality
body of stomach	UBERON:0001161	80.86	gold quality
vagina	UBERON:0000996	80.71	gold quality
ganglionic eminence	UBERON:0004023	80.69	gold quality
saliva-secreting gland	UBERON:0001044	80.66	gold quality
pituitary gland	UBERON:0000007	80.58	gold quality
fallopian tube	UBERON:0003889	80.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

92 targeting ZNF761, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4698	99.84	71.41	4303

Cross-species orthologs

0 orthologs

Paralogs (11): ZNF701 (ENSG00000167562), ZNF816 (ENSG00000180257), ZNF766 (ENSG00000196214), ZNF765 (ENSG00000196417), ZNF860 (ENSG00000197385), ZNF813 (ENSG00000198346), ZNF525 (ENSG00000203326), ZNF468 (ENSG00000204604), ZNF888 (ENSG00000213793), ZNF578 (ENSG00000258405), (ENSG00000269825)

Protein

Protein identifiers

Zinc finger protein 761 — Q86XN6 (reviewed: Q86XN6)

All UniProt accessions (5): Q86XN6, A0A087WXU7, A0A087WYY7, A0A494C1D2, Q6IQ01

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (5): NP_001008401, NP_001276880, NP_001276881, NP_001276882, NP_001337425 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352, PF13465, PF13912

UniProt features (28 total): zinc finger region 19, sequence variant 5, chain 1, domain 1, cross-link 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86XN6-F1	67.61	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 205

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 39 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, HAND1_TARGET_GENES, ZNF350_TARGET_GENES, MIR4698, MIR6809_3P, MIR4482_3P, MIR6833_3P, MIR6873_3P, MIR587, MIR4768_5P, MIR580_5P, MIR3182, MIR155_5P, MIR3065_3P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

10 interactions, top by confidence:

A	B	Type	Score
CUL9	TP53	psi-mi:“MI:0914”(association)	0.920
TRIM44	ODAD3	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
CUL9	NVL	psi-mi:“MI:0914”(association)	0.350
RBM4B	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (10): ZNF761 (Affinity Capture-RNA), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS), ZNF761 (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

986 predictions. Top by Δscore:

Variant	Effect	Δscore
19:53449599:G:T	donor_gain	1.0000
19:53447192:TCA:T	acceptor_loss	0.9900
19:53447193:CAGG:C	acceptor_loss	0.9900
19:53447194:A:T	acceptor_loss	0.9900
19:53447195:GGATT:G	acceptor_gain	0.9900
19:53449508:TCA:T	acceptor_loss	0.9900
19:53449510:AG:A	acceptor_gain	0.9900
19:53449511:GG:G	acceptor_gain	0.9900
19:53449511:GGGT:G	acceptor_gain	0.9900
19:53449599:G:GT	donor_gain	0.9900
19:53449637:GG:G	donor_gain	0.9900
19:53449638:GG:G	donor_gain	0.9900
19:53449638:GGTGA:G	donor_loss	0.9900
19:53449639:G:GG	donor_gain	0.9900
19:53449640:T:TG	donor_loss	0.9900
19:53449641:G:GG	donor_loss	0.9900
19:53454647:TAGA:T	acceptor_loss	0.9900
19:53454648:A:AG	acceptor_gain	0.9900
19:53454649:G:GG	acceptor_gain	0.9900
19:53454649:GAT:G	acceptor_gain	0.9900
19:53454649:GATAT:G	acceptor_gain	0.9900
19:53447194:A:AG	acceptor_gain	0.9800
19:53447195:G:GG	acceptor_gain	0.9800
19:53447282:AG:A	donor_loss	0.9800
19:53447283:GG:G	donor_loss	0.9800
19:53447284:GTGA:G	donor_loss	0.9800
19:53447285:T:A	donor_loss	0.9800
19:53449622:G:GT	donor_gain	0.9800
19:53449644:GA:G	donor_gain	0.9800
19:53454649:GATA:G	acceptor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000025290 (19:53441829 G>A), RS1000307740 (19:53450131 C>A,T), RS1000583663 (19:53446270 C>A,G), RS1000672889 (19:53449698 T>C,G), RS1000889538 (19:53453206 G>A,T), RS1000972814 (19:53445345 C>A,G,T), RS1001079638 (19:53433190 A>T), RS1001183829 (19:53447476 G>A), RS1001615153 (19:53447202 C>T), RS1001706192 (19:53431228 A>G), RS1002052085 (19:53431447 C>T), RS1002085422 (19:53434028 A>G), RS1002245931 (19:53438371 G>A,T), RS1002656471 (19:53432158 A>G), RS1002703323 (19:53438036 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	increases expression	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	increases abundance, affects cotreatment, decreases expression	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ozone	affects cotreatment, decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Triclosan	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin M1	decreases expression	1
Cadmium Chloride	increases expression	1
Volatile Organic Compounds	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.