ZNF763

Summary

ZNF763 (zinc finger protein 763, HGNC:27614) is a protein-coding gene on chromosome 19p13.2, encoding Zinc finger protein 763 (Q0D2J5). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 284390 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001367172

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27614
Approved symbol	ZNF763
Name	zinc finger protein 763
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	ZNF440L
Ensembl gene	ENSG00000197054
Ensembl biotype	protein_coding
Entrez	284390

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000343949, ENST00000358987, ENST00000481745, ENST00000586494, ENST00000592625

RefSeq mRNA: 4 — MANE Select: NM_001367172 NM_001012753, NM_001367172, NM_001367173, NM_001367174

CCDS: CCDS45982, CCDS92522

Canonical transcript exons

ENST00000358987 — 4 exons

Exon	Start	End
ENSE00001411647	11978116	11980617
ENSE00001708936	11965040	11965211
ENSE00003481030	11977038	11977164
ENSE00003527623	11977371	11977431

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 87.49.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6083 / max 28.7072, expressed in 901 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173972	1.6083	901
173975	1.4562	583

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.49	gold quality
granulocyte	CL:0000094	75.94	gold quality
bronchial epithelial cell	CL:0002328	75.36	gold quality
buccal mucosa cell	CL:0002336	74.99	silver quality
left ovary	UBERON:0002119	74.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.51	gold quality
calcaneal tendon	UBERON:0003701	74.32	gold quality
mucosa of stomach	UBERON:0001199	73.98	gold quality
bronchus	UBERON:0002185	73.80	gold quality
right ovary	UBERON:0002118	73.79	gold quality
metanephros cortex	UBERON:0010533	73.50	gold quality
body of pancreas	UBERON:0001150	73.48	gold quality
ventricular zone	UBERON:0003053	73.35	gold quality
jejunal mucosa	UBERON:0000399	73.17	gold quality
ovary	UBERON:0000992	72.99	gold quality
right lobe of thyroid gland	UBERON:0001119	72.71	gold quality
pancreas	UBERON:0001264	72.53	gold quality
islet of Langerhans	UBERON:0000006	72.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.40	gold quality
lower esophagus	UBERON:0013473	72.35	gold quality
spleen	UBERON:0002106	72.12	gold quality
cortex of kidney	UBERON:0001225	72.06	gold quality
leukocyte	CL:0000738	71.90	gold quality
ganglionic eminence	UBERON:0004023	71.86	gold quality
cortical plate	UBERON:0005343	71.84	gold quality
right adrenal gland	UBERON:0001233	71.67	gold quality
apex of heart	UBERON:0002098	71.67	gold quality
monocyte	CL:0000576	71.53	gold quality
blood	UBERON:0000178	71.53	gold quality
left lobe of thyroid gland	UBERON:0001120	71.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.91

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF

miRNA regulators (miRDB)

77 targeting ZNF763, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-548AN	99.97	70.91	2817
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-3156-3P	99.76	66.72	939

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp78	ENSMUSG00000055150
rattus_norvegicus		ENSRNOG00000083797
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZFP90 (ENSG00000184939), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300)

Protein

Protein identifiers

Zinc finger protein 763 — Q0D2J5 (reviewed: Q0D2J5)

All UniProt accessions (4): Q0D2J5, K7EJ80, K7EJF3, K7ESF6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q0D2J5-1	1	yes
Q0D2J5-2	2
Q0D2J5-3	3

RefSeq proteins (4): NP_001012771, NP_001354101, NP_001354102, NP_001354103 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13912

UniProt features (14 total): zinc finger region 8, splice variant 2, sequence variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q0D2J5-F1	67.53	0.25

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 49 (showing top): OSMAN_BLADDER_CANCER_DN, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, STK33_SKM_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF22_TARGET_GENES, MIR6809_3P, MIR6833_3P, MIR6873_3P, MIR203A_3P, MIR1827, MIR4768_5P, MIR7154_5P, MIR605_3P, GSE11057_NAIVE_VS_EFF_MEMORY_CD4_TCELL_UP

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

12 interactions, top by confidence:

A	B	Type	Score
	ZNF763	psi-mi:“MI:0915”(physical association)	0.560
GADD45G	ZNF763	psi-mi:“MI:0915”(physical association)	0.560
ZNF763	SUFU	psi-mi:“MI:0915”(physical association)	0.560
ZNF763	CSNK2A2	psi-mi:“MI:0914”(association)	0.350
ZNF69	ZNF763	psi-mi:“MI:0914”(association)	0.350
SUFU	ZNF763	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): KRTAP10-3 (Two-hybrid), ZNF763 (Synthetic Growth Defect), ZNF763 (Two-hybrid), ZNF763 (Two-hybrid), ZNF763 (Affinity Capture-MS), ZNF763 (Affinity Capture-MS), ZNF763 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0JPK3, A8MT65, C9JN71, E9QAG8, G3X9G7, O75820, P16373, P16374, P16415, P17017, P17024, P17025, P51815, P52737, Q08AG5, Q08ER8, Q0D2J5, Q15973, Q2M218, Q3KP31, Q3V080, Q494X3, Q4R4C7, Q5MYW4, Q5R9F0, Q5R9S5, Q5REI6, Q5REK1, Q68EA5, Q6P560, Q6P5C7, Q6ZQV5, Q7L945, Q86T29, Q8BGV5, Q8C6P8, Q8IYI8, Q8IZC7, Q8N7K0, Q8N972

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

674 predictions. Top by Δscore:

Variant	Effect	Δscore
19:11978115:GGA:G	acceptor_gain	1.0000
19:11965207:A:T	donor_gain	0.9900
19:11977023:T:G	acceptor_gain	0.9900
19:11978106:C:G	acceptor_gain	0.9900
19:11978110:T:TA	acceptor_gain	0.9900
19:11978111:GACA:G	acceptor_loss	0.9900
19:11978114:A:AG	acceptor_gain	0.9900
19:11978114:AG:A	acceptor_gain	0.9900
19:11978115:G:GA	acceptor_loss	0.9900
19:11978115:G:GG	acceptor_gain	0.9900
19:11978115:GG:G	acceptor_gain	0.9900
19:11978115:GGAGT:G	acceptor_gain	0.9900
19:11965206:G:GT	donor_gain	0.9800
19:11977022:ATGT:A	acceptor_gain	0.9800
19:11977164:GGT:G	donor_loss	0.9800
19:11977164:GGTA:G	donor_loss	0.9800
19:11977165:G:GC	donor_loss	0.9800
19:11977166:T:A	donor_loss	0.9800
19:11977367:TTAGG:T	acceptor_loss	0.9800
19:11977368:TA:T	acceptor_loss	0.9800
19:11977369:AG:A	acceptor_gain	0.9800
19:11977370:G:GA	acceptor_loss	0.9800
19:11977370:GG:G	acceptor_gain	0.9800
19:11977427:TTCAG:T	donor_loss	0.9800
19:11977428:TCAG:T	donor_loss	0.9800
19:11977429:CAGG:C	donor_loss	0.9800
19:11977430:AGGTA:A	donor_loss	0.9800
19:11977431:GG:G	donor_loss	0.9800
19:11977432:G:GC	donor_loss	0.9800
19:11977433:T:G	donor_loss	0.9800

AlphaMissense

2641 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:11978969:T:C	F349L	0.983
19:11978971:C:A	F349L	0.983
19:11978971:C:G	F349L	0.983
19:11978633:T:C	F237L	0.978
19:11978635:T:A	F237L	0.978
19:11978635:T:G	F237L	0.978
19:11978717:T:C	F265L	0.972
19:11978719:C:A	F265L	0.972
19:11978719:C:G	F265L	0.972
19:11978801:T:C	F293L	0.968
19:11978803:C:A	F293L	0.968
19:11978803:C:G	F293L	0.968
19:11978885:T:C	F321L	0.965
19:11978887:C:A	F321L	0.965
19:11978887:C:G	F321L	0.965
19:11977071:T:C	F13L	0.964
19:11977073:C:A	F13L	0.964
19:11977073:C:G	F13L	0.964
19:11977072:T:C	F13S	0.943
19:11978900:T:C	S326P	0.931
19:11977109:G:C	Q25H	0.924
19:11977109:G:T	Q25H	0.924
19:11978984:T:C	S354P	0.923
19:11978842:C:A	H306Q	0.922
19:11978842:C:G	H306Q	0.922
19:11978926:C:A	H334Q	0.919
19:11978926:C:G	H334Q	0.919
19:11978732:T:C	S270P	0.916
19:11978674:C:A	H250Q	0.911
19:11978674:C:G	H250Q	0.911

dbSNP variants (sampled 300 via entrez): RS1000031080 (19:11974612 C>G,T), RS1000307814 (19:11963343 C>G,T), RS1000711128 (19:11963142 T>TGCA), RS1000948702 (19:11972766 T>C), RS1001060725 (19:11967010 G>A), RS1001139525 (19:11967132 C>T), RS1001285468 (19:11964235 C>G), RS1001508907 (19:11966959 T>A), RS1001534800 (19:11975600 T>C), RS1001586926 (19:11975836 C>T), RS1001601021 (19:11967683 G>A), RS1001813890 (19:11969839 A>T), RS1001859868 (19:11979868 G>A,C), RS1001871898 (19:11974523 C>T), RS1001924228 (19:11974662 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008839_35	Height	2.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	4
trichostatin A	affects cotreatment, decreases expression	3
entinostat	affects cotreatment, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
methylmercuric chloride	decreases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Vorinostat	increases expression	1
Leflunomide	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Lead	affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	increases abundance, increases expression	1
Asbestos, Crocidolite	decreases expression, increases methylation	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.