ZNF764

Summary

ZNF764 (zinc finger protein 764, HGNC:28200) is a protein-coding gene on chromosome 16p11.2, encoding Zinc finger protein 764 (Q96H86). Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR.

Enables transcription coregulator activity. Involved in cellular response to glucocorticoid stimulus. Is active in nucleus.

Source: NCBI Gene 92595 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_001172679

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28200
Approved symbol	ZNF764
Name	zinc finger protein 764
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC13138
Ensembl gene	ENSG00000169951
Ensembl biotype	protein_coding
OMIM	619524
Entrez	92595

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 retained_intron

ENST00000252797, ENST00000395091, ENST00000568333, ENST00000952475

RefSeq mRNA: 2 — MANE Select: NM_001172679 NM_001172679, NM_033410

CCDS: CCDS10683, CCDS54001

Canonical transcript exons

ENST00000395091 — 3 exons

Exon	Start	End
ENSE00000895848	30557733	30557846
ENSE00001520569	30553764	30556107
ENSE00002603753	30557987	30558374

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 82.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.8558 / max 108.5483, expressed in 1687 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157065	3.7154	1516
157064	0.8187	484
157066	0.7015	363
157063	0.6203	356

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.96	gold quality
apex of heart	UBERON:0002098	78.16	gold quality
body of stomach	UBERON:0001161	77.55	gold quality
cortical plate	UBERON:0005343	77.42	gold quality
granulocyte	CL:0000094	77.20	gold quality
ganglionic eminence	UBERON:0004023	77.01	gold quality
germinal epithelium of ovary	UBERON:0001304	76.55	gold quality
heart left ventricle	UBERON:0002084	76.23	gold quality
amniotic fluid	UBERON:0000173	76.03	gold quality
stromal cell of endometrium	CL:0002255	75.67	gold quality
cardiac ventricle	UBERON:0002082	75.54	gold quality
stomach	UBERON:0000945	75.38	gold quality
hair follicle	UBERON:0002073	75.15	silver quality
ventricular zone	UBERON:0003053	74.97	gold quality
ovary	UBERON:0000992	74.94	gold quality
left ovary	UBERON:0002119	74.89	gold quality
mucosa of transverse colon	UBERON:0004991	74.80	gold quality
transverse colon	UBERON:0001157	74.79	gold quality
secondary oocyte	CL:0000655	74.74	gold quality
right lobe of liver	UBERON:0001114	74.72	gold quality
right atrium auricular region	UBERON:0006631	74.72	gold quality
right ovary	UBERON:0002118	74.58	gold quality
bronchial epithelial cell	CL:0002328	74.48	gold quality
tibia	UBERON:0000979	74.22	gold quality
body of uterus	UBERON:0009853	74.18	gold quality
endocervix	UBERON:0000458	74.11	gold quality
right adrenal gland	UBERON:0001233	74.07	gold quality
blood	UBERON:0000178	74.03	gold quality
left adrenal gland	UBERON:0001234	73.82	gold quality
right adrenal gland cortex	UBERON:0035827	73.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.33

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

54 targeting ZNF764, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-671-5P	99.52	67.11	1277
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-508-5P	99.41	64.25	1248

Literature-anchored findings (GeneRIF, showing 1)

• effect of ZNF764 on the glucocorticoid receptor transcriptional activity was mediated through cooperation with a general nuclear hormone receptor coactivator, transcriptional intermediary factor 1 (PMID:22577170)

Cross-species orthologs

19 orthologs

Organism	Symbol	Gene ID
danio_rerio	znf646	ENSDARG00000061424
danio_rerio	si:dkey-89b17.4	ENSDARG00000075545
danio_rerio	zgc:66472	ENSDARG00000075916
danio_rerio	si:ch211-148l7.4	ENSDARG00000094469
danio_rerio	znf576.1	ENSDARG00000097819
mus_musculus	Zfp764	ENSMUSG00000045757
mus_musculus	Zfp764l1	ENSMUSG00000078580
rattus_norvegicus	Zfp764	ENSRNOG00000031003
rattus_norvegicus	Zfp764l1	ENSRNOG00000046480
drosophila_melanogaster	az2	FBGN0025185
drosophila_melanogaster	CG2129	FBGN0030008
drosophila_melanogaster	CG1602	FBGN0033186
drosophila_melanogaster	CG18011	FBGN0033491
drosophila_melanogaster	CG12942	FBGN0033569
drosophila_melanogaster	indra	FBGN0035213
drosophila_melanogaster	CG30020	FBGN0050020
drosophila_melanogaster	mld	FBGN0263490
caenorhabditis_elegans	ztf-15	WBGENE00011066
caenorhabditis_elegans		WBGENE00015649

Paralogs (36): ZNF302 (ENSG00000089335), ZNF184 (ENSG00000096654), CTCF (ENSG00000102974), ZNF574 (ENSG00000105732), ZBTB24 (ENSG00000112365), ZNF142 (ENSG00000115568), CTCFL (ENSG00000124092), ZNF473 (ENSG00000142528), ZNF827 (ENSG00000151612), ZNF689 (ENSG00000156853), ZNF208 (ENSG00000160321), ZNF91 (ENSG00000167232), ZNF526 (ENSG00000167625), ZNF747 (ENSG00000169955), ZNF282 (ENSG00000170265), ZNF160 (ENSG00000170949), ZNF497 (ENSG00000174586), ZBTB34 (ENSG00000177125), ZNF771 (ENSG00000179965), ZNF48 (ENSG00000180035), ZNF594 (ENSG00000180626), ZBTB37 (ENSG00000185278), ZFP92 (ENSG00000189420), ZNF107 (ENSG00000196247), ZNF729 (ENSG00000196350), ZNF569 (ENSG00000196437), ZNF420 (ENSG00000197050), ZNF785 (ENSG00000197162), ZNF665 (ENSG00000197497), ZNF181 (ENSG00000197841), ZNF347 (ENSG00000197937), ZNF84 (ENSG00000198040), ZBTB48 (ENSG00000204859), ZNF845 (ENSG00000213799), ZNF99 (ENSG00000213973), ZNF688 (ENSG00000229809)

Protein

Protein identifiers

Zinc finger protein 764 — Q96H86 (reviewed: Q96H86)

All UniProt accessions (1): Q96H86

UniProt curated annotations — full annotation on UniProt →

Function. Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR. Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes.

Subunit / interactions. Interacts (via KRAB domain) with NR3C1/GR (via NR LBD domain); the interaction regulates transcription factor activity of NR3C1 by directing its actions toward certain biologic pathways.

Subcellular location. Nucleus.

Domain organisation. The KRAB domain and the zinc finger domain are both necessary for the regulation of NR3C1/GR transcriptional activity.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96H86-1	1	yes
Q96H86-2	2

RefSeq proteins (2): NP_001166150, NP_219363 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (13 total): zinc finger region 7, chain 1, domain 1, splice variant 1, sequence variant 1, sequence conflict 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96H86-F1	70.94	0.33

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 99 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_RESPONSE_TO_CORTICOSTEROID, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS, chr16p11, GOBP_RESPONSE_TO_STEROID_HORMONE, GOBP_RESPONSE_TO_HORMONE, GOBP_RESPONSE_TO_LIPID, GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS, GCCATNTTG_YY1_Q6, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MODULE_37, GOMF_TRANSCRIPTION_COREGULATOR_ACTIVITY

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), cellular response to glucocorticoid stimulus (GO:0071385), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), transcription coregulator activity (GO:0003712), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
response to glucocorticoid	1
cellular response to corticosteroid stimulus	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

622 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF764	ZNF654	Q8IZM8	540
ZNF764	GTF3C1	Q12789	509
ZNF764	BEST2	Q8NFU1	504
ZNF764	GPR153	Q6NV75	499
ZNF764	PAFAH1B3	Q15102	491
ZNF764	BRICD5	Q6PL45	446
ZNF764	BEST1	O76090	421
ZNF764	SETDB1	Q15047	405
ZNF764	CCDC61	Q9Y6R9	400
ZNF764	NRIP1	P48552	395
ZNF764	TIMELESS	Q9UNS1	349
ZNF764	GABPA	Q06546	343
ZNF764	ZNF592	Q92610	333
ZNF764	TSKS	Q9UJT2	324
ZNF764	ARK2N	Q96B23	323

IntAct

106 interactions, top by confidence:

A	B	Type	Score
ZNF764	SUFU	psi-mi:“MI:0915”(physical association)	0.880
SUFU	ZNF764	psi-mi:“MI:0915”(physical association)	0.880
ZNF764	MDFI	psi-mi:“MI:0915”(physical association)	0.670
MDFI	ZNF764	psi-mi:“MI:0915”(physical association)	0.670
ZNF764	ZNF316	psi-mi:“MI:0914”(association)	0.640
ZNF764	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	ZRANB1	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	PICK1	psi-mi:“MI:0915”(physical association)	0.560
CCDC125	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
CBY2	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-3	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	ZNF408	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	MID2	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	HOOK1	psi-mi:“MI:0915”(physical association)	0.560
ZNF837	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	KRTAP4-4	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
KPNA3	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
DVL3	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
KRTAP12-2	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	ZNF330	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
HNRNPF	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
CLK2	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
ZNF764	ARMC7	psi-mi:“MI:0915”(physical association)	0.560
DTX2	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
FHL5	ZNF764	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (127): ZNF764 (Two-hybrid), ZNF764 (Two-hybrid), ZNF764 (Two-hybrid), ZNF764 (Two-hybrid), ZNF764 (Two-hybrid), ZNF764 (Synthetic Growth Defect), SH3PXD2A (Affinity Capture-MS), NEBL (Affinity Capture-MS), SUFU (Affinity Capture-MS), ZNF764 (Affinity Capture-MS), SH3PXD2B (Affinity Capture-MS), TRIM39 (Affinity Capture-MS), USP34 (Affinity Capture-MS), GNE (Affinity Capture-MS), SMARCAD1 (Affinity Capture-MS)

ESM2 similar proteins: A2CE44, A6NFI3, A6NM28, A8K8V0, O15370, O70218, O95201, P0CJ78, P10075, P10754, P28698, P70338, Q04890, Q07120, Q14V87, Q19A40, Q569E7, Q58DK7, Q5DWN0, Q5FWU5, Q5RJR4, Q5T619, Q5TEC3, Q6DD87, Q6IQX8, Q6PD29, Q6PGE4, Q6ZMY9, Q7Z7K2, Q80VM4, Q8BIF9, Q8JZL0, Q8N8E2, Q8NAF0, Q8NCA9, Q8TD94, Q8WUU4, Q96C55, Q96H86, Q96MX3

Diamond homologs: A0JPL0, A2A761, A3KN32, A3KN36, A6NFI3, A6NM28, A6QLU5, A6QPT6, A7MBI1, A8MTY0, B2RXC5, B4DU55, E9PYI1, O14978, O60765, O75467, O75820, O95780, P0C7X2, P0DKX0, P0DPD5, P10072, P15622, P16374, P17014, P17023, P17032, P17098, P51523, P51786, P52738, P52742, Q02975, Q06732, Q08DG8, Q08ER8, Q0VCB0, Q14590, Q14929, Q29RZ4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 45 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	6	15.2×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

393 predictions. Top by Δscore:

Variant	Effect	Δscore
16:30557981:TCTCA:T	donor_loss	1.0000
16:30557982:CTCAC:C	donor_loss	1.0000
16:30557983:TCAC:T	donor_loss	1.0000
16:30557984:CACCG:C	donor_loss	1.0000
16:30557985:A:AC	donor_gain	1.0000
16:30557985:A:T	donor_loss	1.0000
16:30557986:C:A	donor_loss	1.0000
16:30557986:C:CC	donor_gain	1.0000
16:30557986:C:CG	donor_loss	1.0000
16:30555200:ACACT:A	donor_gain	0.9900
16:30555201:CACTC:C	donor_gain	0.9900
16:30555334:A:AC	donor_gain	0.9900
16:30555335:C:CC	donor_gain	0.9900
16:30556105:AATC:A	acceptor_loss	0.9900
16:30556106:AT:A	acceptor_loss	0.9900
16:30556106:ATCTG:A	acceptor_gain	0.9900
16:30556107:TCTGC:T	acceptor_gain	0.9900
16:30556108:C:CG	acceptor_loss	0.9900
16:30556108:CTG:C	acceptor_gain	0.9900
16:30556108:CTGCT:C	acceptor_gain	0.9900
16:30556109:T:G	acceptor_loss	0.9900
16:30556111:C:CC	acceptor_gain	0.9900
16:30557729:C:CA	donor_gain	0.9900
16:30556107:TCTG:T	acceptor_loss	0.9800
16:30556108:CTGC:C	acceptor_loss	0.9800
16:30556109:TGCTG:T	acceptor_loss	0.9800
16:30556110:GC:G	acceptor_loss	0.9800
16:30556111:C:A	acceptor_loss	0.9800
16:30556112:T:G	acceptor_loss	0.9800
16:30557602:AG:A	donor_gain	0.9800

AlphaMissense

2620 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:30555449:G:C	F324L	0.999
16:30555449:G:T	F324L	0.999
16:30555451:A:G	F324L	0.999
16:30555533:G:C	F296L	0.999
16:30555533:G:T	F296L	0.999
16:30555535:A:G	F296L	0.999
16:30555617:G:C	F268L	0.999
16:30555617:G:T	F268L	0.999
16:30555619:A:G	F268L	0.999
16:30555701:G:C	F240L	0.999
16:30555701:G:T	F240L	0.999
16:30555703:A:G	F240L	0.999
16:30555785:G:C	F212L	0.999
16:30555785:G:T	F212L	0.999
16:30555787:A:G	F212L	0.999
16:30555869:A:C	F184L	0.999
16:30555869:A:T	F184L	0.999
16:30555871:A:G	F184L	0.999
16:30555618:A:G	F268S	0.998
16:30555674:G:C	H249Q	0.998
16:30555674:G:T	H249Q	0.998
16:30555830:G:C	H197Q	0.998
16:30555830:G:T	H197Q	0.998
16:30555365:A:C	F352L	0.997
16:30555365:A:T	F352L	0.997
16:30555367:A:G	F352L	0.997
16:30555410:G:C	H337Q	0.997
16:30555410:G:T	H337Q	0.997
16:30555662:G:C	H253Q	0.997
16:30555662:G:T	H253Q	0.997

dbSNP variants (sampled 300 via entrez): RS1000507027 (16:30556394 C>A), RS1000960590 (16:30557147 A>T), RS1001727539 (16:30556653 T>C), RS1002504999 (16:30554273 G>A), RS1002800907 (16:30557525 CAG>C), RS1003100927 (16:30557785 A>T), RS1003199830 (16:30553841 T>C), RS1003694715 (16:30558611 C>T), RS1003790302 (16:30557760 C>A), RS1004234925 (16:30558469 C>G,T), RS1005093548 (16:30553968 C>T), RS1005228289 (16:30560348 A>C,G), RS1006009604 (16:30555515 CAGGTCCG>C), RS1006229108 (16:30559028 T>C), RS1006285564 (16:30560121 C>T)

Disease associations

OMIM: gene MIM:619524 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
Silicon Dioxide	decreases expression, increases expression	2
Valproic Acid	affects expression, decreases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
dicrotophos	increases expression	1
methylmercuric chloride	decreases expression	1
titanium dioxide	decreases expression	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
cobaltous chloride	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
ferrous chloride	decreases expression	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Sunitinib	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Formaldehyde	decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	increases expression	1
Zinc Sulfate	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TZ46	HAP1 ZNF764 (-) 1	Cancer cell line	Male
CVCL_TZ47	HAP1 ZNF764 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.