ZNF765

Summary

ZNF765 (zinc finger protein 765, HGNC:25092) is a protein-coding gene on chromosome 19q13.42, encoding Zinc finger protein 765 (Q7L2R6). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 91661 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 92 total
• MANE Select transcript: NM_001040185

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25092
Approved symbol	ZNF765
Name	zinc finger protein 765
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196417
Ensembl biotype	protein_coding
Entrez	91661

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000396408, ENST00000504146, ENST00000504235, ENST00000505866, ENST00000507045, ENST00000594030, ENST00000594627, ENST00000596086, ENST00000933978, ENST00000963919

RefSeq mRNA: 2 — MANE Select: NM_001040185 NM_001040185, NM_001350495

CCDS: CCDS46171

Canonical transcript exons

ENST00000396408 — 4 exons

Exon	Start	End
ENSE00001524825	53407698	53412009
ENSE00002055262	53395149	53395193
ENSE00003283638	53402065	53402191
ENSE00003557175	53397943	53398030

Expression profiles

Bgee: expression breadth ubiquitous, 246 present calls, max score 90.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.3438 / max 57.4145, expressed in 1190 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177325	6.1489	1654
177324	3.3438	1190

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	90.92	gold quality
germinal epithelium of ovary	UBERON:0001304	90.50	gold quality
secondary oocyte	CL:0000655	89.75	gold quality
thymus	UBERON:0002370	87.80	gold quality
epithelium of nasopharynx	UBERON:0001951	87.75	gold quality
palpebral conjunctiva	UBERON:0001812	84.54	gold quality
mucosa of paranasal sinus	UBERON:0005030	84.18	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.52	gold quality
adrenal tissue	UBERON:0018303	82.52	gold quality
jejunal mucosa	UBERON:0000399	82.37	gold quality
mucosa of sigmoid colon	UBERON:0004993	82.12	gold quality
parietal pleura	UBERON:0002400	81.56	gold quality
amniotic fluid	UBERON:0000173	81.37	gold quality
tibia	UBERON:0000979	81.21	gold quality
colonic mucosa	UBERON:0000317	81.10	gold quality
visceral pleura	UBERON:0002401	80.94	gold quality
gingival epithelium	UBERON:0001949	80.84	gold quality
lower lobe of lung	UBERON:0008949	80.84	gold quality
placenta	UBERON:0001987	80.69	gold quality
ganglionic eminence	UBERON:0004023	80.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.08	gold quality
ovary	UBERON:0000992	79.97	gold quality
trabecular bone tissue	UBERON:0002483	79.57	gold quality
calcaneal tendon	UBERON:0003701	79.54	gold quality
esophagus squamous epithelium	UBERON:0006920	79.54	gold quality
oral cavity	UBERON:0000167	79.46	gold quality
right adrenal gland cortex	UBERON:0035827	79.23	gold quality
gingiva	UBERON:0001828	79.00	gold quality
bone marrow	UBERON:0002371	78.89	gold quality
islet of Langerhans	UBERON:0000006	78.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.69

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. (PMID:32713259)

Cross-species orthologs

0 orthologs

Paralogs (11): ZNF761 (ENSG00000160336), ZNF701 (ENSG00000167562), ZNF816 (ENSG00000180257), ZNF766 (ENSG00000196214), ZNF860 (ENSG00000197385), ZNF813 (ENSG00000198346), ZNF525 (ENSG00000203326), ZNF468 (ENSG00000204604), ZNF888 (ENSG00000213793), ZNF578 (ENSG00000258405), (ENSG00000269825)

Protein

Protein identifiers

Zinc finger protein 765 — Q7L2R6 (reviewed: Q7L2R6)

All UniProt accessions (3): Q7L2R6, D6RF03, E9PDE6

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q7L2R6-1	1	yes
Q7L2R6-2	2
Q7L2R6-3	3

RefSeq proteins (2): NP_001035275, NP_001337424 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050758	Znf_C2H2-type	Family

Pfam: PF00096, PF01352

UniProt features (25 total): zinc finger region 11, sequence conflict 6, splice variant 4, chain 1, domain 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L2R6-F1	63.84	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 205

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins

MSigDB gene sets: 66 (showing top): LIAO_METASTASIS, MODULE_544, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, JOHNSTONE_PARVB_TARGETS_3_DN, MODULE_481, REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ELF2_TARGET_GENES, ZNF350_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P, MIR4698, MIR23A_3P_MIR23B_3P, MIR23C

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nuclear lumen (GO:0031981)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Regulation of endogenous retroelements	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nucleus	1
intracellular organelle lumen	1

Protein interactions and networks

STRING

484 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF765	FAAH2	Q6GMR7	525
ZNF765	PDXDC1	Q6P996	516
ZNF765	PDHB	P11177	359
ZNF765	VOPP1	Q96AW1	322
ZNF765	STAU1	O95793	305
ZNF765	ADAP1	O75689	299
ZNF765	BAIAP3	O94812	277
ZNF765	ABHD3	Q8WU67	276
ZNF765	N4BP2L2	Q92802	269
ZNF765	ENOPH1	Q9UHY7	267
ZNF765	CEP295	Q9C0D2	263
ZNF765	HOOK2	Q96ED9	251
ZNF765	MED11	Q9P086	250
ZNF765	C9orf153	Q5TBE3	248
ZNF765	RAX2	Q96IS3	248

IntAct

22 interactions, top by confidence:

A	B	Type	Score
ZNF765	TRIM28	psi-mi:“MI:0915”(physical association)	0.620
ZNF765	REL	psi-mi:“MI:0915”(physical association)	0.560
DZIP3	ZNF765	psi-mi:“MI:0915”(physical association)	0.560
USHBP1	ZNF765	psi-mi:“MI:0915”(physical association)	0.560
REL	ZNF765	psi-mi:“MI:0915”(physical association)	0.560
ZNF765	DZIP3	psi-mi:“MI:0915”(physical association)	0.560
ZNF765	USHBP1	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
ZNF765	IPO7	psi-mi:“MI:0915”(physical association)	0.500
tax	ZNF765	psi-mi:“MI:0915”(physical association)	0.490
ZNF765	tax	psi-mi:“MI:0915”(physical association)	0.490
M		psi-mi:“MI:0914”(association)	0.350
ZNF765	TRIM24	psi-mi:“MI:0914”(association)	0.350
ZNF467	ZNF320	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
CUL9	NVL	psi-mi:“MI:0914”(association)	0.350

BioGRID (23): ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Affinity Capture-MS), ZNF765 (Affinity Capture-RNA), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ZNF765 (Two-hybrid), ARID5A (Two-hybrid)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A2RRD8, A2VDQ7, A6NHJ4, A6NK75, A6NN14, A6NNF4, A6NP11, B4DX44, B4DXR9, E9PW05, O14628, O43345, O75290, O75346, O75373, O75820, P0CB33, P0CJ79, P0DKX0, P10755, P17032, P17035, P52738, Q02386, Q03923, Q03936, Q05481, Q08AN1, Q09FC8, Q0VGE8, Q14586, Q14593, Q147U1, Q15928, Q3MIS6, Q3SXZ3, Q494X3, Q4R6C2, Q5HY98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

92 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

679 predictions. Top by Δscore:

Variant	Effect	Δscore
19:53395190:GCGG:G	donor_gain	1.0000
19:53395192:GG:G	donor_gain	1.0000
19:53395192:GGGTG:G	donor_loss	1.0000
19:53395193:GG:G	donor_gain	1.0000
19:53395194:G:GA	donor_loss	1.0000
19:53395194:G:GG	donor_gain	1.0000
19:53395195:T:A	donor_loss	1.0000
19:53402152:G:T	donor_gain	1.0000
19:53395189:CGCGG:C	donor_gain	0.9900
19:53395190:GCGGG:G	donor_gain	0.9900
19:53395191:CGG:C	donor_gain	0.9900
19:53395192:GGG:G	donor_gain	0.9900
19:53398029:AGGT:A	donor_loss	0.9900
19:53398030:GGTGA:G	donor_loss	0.9900
19:53398031:G:GA	donor_loss	0.9900
19:53398032:T:G	donor_loss	0.9900
19:53397940:CA:C	acceptor_loss	0.9800
19:53397941:A:AG	acceptor_gain	0.9800
19:53397942:G:GG	acceptor_gain	0.9800
19:53397942:GGATT:G	acceptor_gain	0.9800
19:53402190:GG:G	donor_gain	0.9800
19:53402191:GG:G	donor_gain	0.9800
19:53402197:G:GT	donor_gain	0.9800
19:53402215:G:GT	donor_gain	0.9800
19:53404549:TTC:T	donor_gain	0.9800
19:53397941:AG:A	acceptor_gain	0.9700
19:53397942:GG:G	acceptor_gain	0.9700
19:53402152:G:GT	donor_gain	0.9700
19:53402215:G:T	donor_gain	0.9700
19:53402059:T:G	acceptor_loss	0.9600

AlphaMissense

3523 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:53408561:T:C	F336L	0.993
19:53408563:T:A	F336L	0.993
19:53408563:T:G	F336L	0.993
19:53408645:T:C	F364L	0.990
19:53408647:T:A	F364L	0.990
19:53408647:T:G	F364L	0.990
19:53408729:T:C	F392L	0.989
19:53408731:T:A	F392L	0.989
19:53408731:T:G	F392L	0.989
19:53408393:T:C	F280L	0.988
19:53408395:C:A	F280L	0.988
19:53408395:C:G	F280L	0.988
19:53408477:T:C	F308L	0.985
19:53408479:C:A	F308L	0.985
19:53408479:C:G	F308L	0.985
19:53408978:T:C	F475L	0.983
19:53408980:C:A	F475L	0.983
19:53408980:C:G	F475L	0.983
19:53408652:G:C	R366P	0.975
19:53408580:T:C	L342P	0.974
19:53409062:T:C	F503L	0.968
19:53409064:C:A	F503L	0.968
19:53409064:C:G	F503L	0.968
19:53402089:G:C	A14P	0.967
19:53408588:C:G	H345D	0.967
19:53402098:T:C	F17L	0.964
19:53402100:C:A	F17L	0.964
19:53402100:C:G	F17L	0.964
19:53408562:T:C	F336S	0.963
19:53408590:T:A	H345Q	0.963

dbSNP variants (sampled 300 via entrez): RS1000217926 (19:53414615 T>G), RS1000246805 (19:53398593 T>C), RS1000273355 (19:53414189 C>G,T), RS1000380595 (19:53419529 G>A,T), RS1000445332 (19:53425132 C>G,T), RS1000472790 (19:53417100 G>A,T), RS1000563417 (19:53413201 T>A,C), RS1000615744 (19:53413001 T>C), RS1000672592 (19:53418626 G>A,C), RS1000769842 (19:53423890 C>T), RS1000822298 (19:53423497 C>T), RS1001008866 (19:53419925 A>G), RS1001127224 (19:53418442 C>T), RS1001132975 (19:53398437 G>A), RS1001277612 (19:53415525 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	2
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
avobenzone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
jinfukang	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Succimer	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases expression	1
Particulate Matter	decreases expression, increases abundance	1
Magnetite Nanoparticles	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.