ZNF766

Summary

ZNF766 (zinc finger protein 766, HGNC:28063) is a protein-coding gene on chromosome 19q13.41, encoding Zinc finger protein 766 (Q5HY98). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus.

Source: NCBI Gene 90321 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 62 total — 1 pathogenic
• MANE Select transcript: NM_001010851

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28063
Approved symbol	ZNF766
Name	zinc finger protein 766
Location	19q13.41
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196214
Ensembl biotype	protein_coding
Entrez	90321

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 retained_intron

ENST00000439461, ENST00000593612, ENST00000593703, ENST00000595000, ENST00000595149, ENST00000599581, ENST00000600016, ENST00000600821, ENST00000601711, ENST00000950441

RefSeq mRNA: 1 — MANE Select: NM_001010851 NM_001010851

CCDS: CCDS46163

Canonical transcript exons

ENST00000439461 — 4 exons

Exon	Start	End
ENSE00001424793	52290066	52296046
ENSE00001742857	52269587	52269631
ENSE00003479006	52282111	52282237
ENSE00003677138	52283285	52283413

Expression profiles

Bgee: expression breadth ubiquitous, 251 present calls, max score 96.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.5773 / max 230.9802, expressed in 1759 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177296	10.5557	1746
177295	0.7442	469
177294	0.2633	102
208917	0.0141	4

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	96.20	gold quality
calcaneal tendon	UBERON:0003701	92.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.97	gold quality
epithelial cell of pancreas	CL:0000083	87.90	silver quality
tendon	UBERON:0000043	87.84	gold quality
secondary oocyte	CL:0000655	85.75	gold quality
colonic epithelium	UBERON:0000397	85.49	gold quality
islet of Langerhans	UBERON:0000006	84.80	gold quality
tendon of biceps brachii	UBERON:0008188	84.75	gold quality
amniotic fluid	UBERON:0000173	84.73	gold quality
palpebral conjunctiva	UBERON:0001812	84.45	gold quality
ganglionic eminence	UBERON:0004023	84.21	gold quality
cortical plate	UBERON:0005343	83.93	gold quality
bone marrow cell	CL:0002092	83.69	gold quality
upper leg skin	UBERON:0004262	83.58	gold quality
testis	UBERON:0000473	83.20	gold quality
right testis	UBERON:0004534	83.01	gold quality
tibia	UBERON:0000979	82.85	gold quality
cartilage tissue	UBERON:0002418	82.79	gold quality
endothelial cell	CL:0000115	82.60	silver quality
left testis	UBERON:0004533	82.49	gold quality
cardiac muscle of right atrium	UBERON:0003379	82.31	silver quality
leukocyte	CL:0000738	82.30	gold quality
bone marrow	UBERON:0002371	82.23	gold quality
monocyte	CL:0000576	82.12	gold quality
adrenal tissue	UBERON:0018303	82.01	gold quality
stromal cell of endometrium	CL:0002255	81.77	gold quality
parietal pleura	UBERON:0002400	81.74	gold quality
left ventricle myocardium	UBERON:0006566	81.45	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6379	no	1019.54
E-GEOD-111727	no	245.48
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2098.1	ZNF766	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:22955616

miRNA regulators (miRDB)

40 targeting ZNF766, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-520F-5P	99.34	70.40	1632
HSA-MIR-324-3P	99.26	66.31	1034
HSA-MIR-6843-3P	99.26	66.42	915
HSA-MIR-6504-3P	99.17	69.31	2891
HSA-MIR-10399-5P	99.17	69.87	2610
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-29A-5P	99.08	68.59	1813
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-138-2-3P	98.91	68.33	1643
HSA-MIR-6715B-3P	98.80	68.07	1204
HSA-MIR-8060	98.61	66.93	1187
HSA-MIR-147A	98.33	66.40	795
HSA-MIR-6509-3P	98.32	67.33	1343
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-197-3P	98.09	69.23	1004
HSA-MIR-6072	98.00	66.47	804
HSA-MIR-6511B-5P	97.98	65.64	823
HSA-MIR-6811-5P	97.98	64.96	848
HSA-MIR-6810-3P	97.96	64.57	1023
HSA-MIR-3159	97.94	66.79	1098
HSA-MIR-1271-3P	97.56	64.85	865
HSA-MIR-550A-3-5P	97.56	65.35	823

Cross-species orthologs

0 orthologs

Paralogs (11): ZNF761 (ENSG00000160336), ZNF701 (ENSG00000167562), ZNF816 (ENSG00000180257), ZNF765 (ENSG00000196417), ZNF860 (ENSG00000197385), ZNF813 (ENSG00000198346), ZNF525 (ENSG00000203326), ZNF468 (ENSG00000204604), ZNF888 (ENSG00000213793), ZNF578 (ENSG00000258405), (ENSG00000269825)

Protein

Protein identifiers

Zinc finger protein 766 — Q5HY98 (reviewed: Q5HY98)

All UniProt accessions (8): A0A0B4J2B2, G3XAE0, M0QXI4, M0R139, M0R1P9, M0R2P3, M0R2R1, Q5HY98

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_001010851* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352, PF13465

UniProt features (18 total): zinc finger region 10, cross-link 4, chain 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5HY98-F1	66.08	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 75, 157, 179, 367

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 40 (showing top): GOCC_MICROTUBULE_ORGANIZING_CENTER, GOCC_CENTROSOME, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, FIGUEROA_AML_METHYLATION_CLUSTER_1_UP, FIGUEROA_AML_METHYLATION_CLUSTER_4_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CBX5_TARGET_GENES, HES2_TARGET_GENES, ZNF350_TARGET_GENES, MIR1236_3P, MIR1227_3P, GSE13485_CTRL_VS_DAY21_YF17D_VACCINE_PBMC_UP, SAFB2_TARGET_GENES, POU2AF1_TARGET_GENES, DESCARTES_MAIN_FETAL_CORNEAL_AND_CONJUNCTIVAL_EPITHELIAL_CELLS

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

506 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF766	CCDC97	Q96F63	400
ZNF766	ZSWIM5	Q9P217	391
ZNF766	TRIM28	Q13263	374
ZNF766	MRPL36	Q9P0J6	357
ZNF766	ONECUT3	O60422	335
ZNF766	MRPL42	Q9Y6G3	325
ZNF766	SH3BP4	Q9P0V3	288
ZNF766	ZRANB2	O95218	265
ZNF766	ZBED1	O96006	265
ZNF766	SETDB1	Q15047	261
ZNF766	FOXN2	P32314	260
ZNF766	RNF138	Q8WVD3	258
ZNF766	GEMIN5	Q8TEQ6	248
ZNF766	IL5RA	Q01344	246
ZNF766	RPL28	P46779	230

IntAct

12 interactions, top by confidence:

A	B	Type	Score
ZNF766	FHL5	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
CPSF7	WWP2	psi-mi:“MI:0914”(association)	0.350
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.350
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL13	POLRMT	psi-mi:“MI:0914”(association)	0.350
ZNF766	FHL5	psi-mi:“MI:0915”(physical association)	0.000
MDM2	ZNF766	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (12): ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Two-hybrid), ZNF766 (Affinity Capture-RNA), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-MS), ZNF766 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1W2PQL4, A0JPL0, A2RRD8, A6NHJ4, A6NP11, B4DX44, O75346, O95780, P0CB33, P21506, P51508, P52738, Q0D2J5, Q0VGE8, Q12901, Q13360, Q14593, Q15973, Q2M218, Q2M3X9, Q2VY69, Q3SXZ3, Q5HY98, Q5RCJ2, Q5VIY5, Q6J6I6, Q7L2R6, Q86XU0, Q86Y25, Q8IW36, Q8IYN0, Q8IYX0, Q8N782, Q8N883, Q8N9Z0, Q8NDP4, Q95K49, Q969W8, Q96H40, Q96N58

Diamond homologs: A0A1W2PQL4, A6NK75, A6NN14, A6NNF4, A6NP11, A8MQ14, A8MTY0, A8MUV8, A8MXY4, B4DX44, B4DXR9, E9PYI1, O14628, O43345, O75290, O75346, O75373, O75437, O95780, P0CB33, P0DKX0, P0DPD5, P16373, P17019, P17038, P21506, P35789, P52736, P52738, P52744, Q03923, Q03924, Q03936, Q03938, Q05481, Q14586, Q14593, Q14929, Q15928, Q3KNS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	52
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3779559	NM_001010851.3(ZNF766):c.274+2804_274+2806del	Pathogenic

SpliceAI

618 predictions. Top by Δscore:

Variant	Effect	Δscore
19:52269628:GCGC:G	donor_gain	1.0000
19:52269630:GC:G	donor_gain	1.0000
19:52269632:G:GG	donor_gain	1.0000
19:52282238:G:GA	donor_loss	1.0000
19:52282238:G:GG	donor_gain	1.0000
19:52282239:T:TC	donor_loss	1.0000
19:52269627:GGCGC:G	donor_gain	0.9900
19:52269628:GCGCG:G	donor_gain	0.9900
19:52269629:CGC:C	donor_gain	0.9900
19:52269630:GCG:G	donor_gain	0.9900
19:52269631:CG:C	donor_loss	0.9900
19:52269632:G:GA	donor_loss	0.9900
19:52269633:T:A	donor_loss	0.9900
19:52269634:G:GC	donor_loss	0.9900
19:52282236:GG:G	donor_gain	0.9900
19:52282237:GG:G	donor_gain	0.9900
19:52283362:A:T	donor_gain	0.9900
19:52269635:A:AC	donor_loss	0.9800
19:52282109:A:AG	acceptor_gain	0.9800
19:52282110:G:GG	acceptor_gain	0.9800
19:52282110:GGGAC:G	acceptor_gain	0.9800
19:52282198:G:T	donor_gain	0.9800
19:52269629:C:T	donor_gain	0.9700
19:52269636:G:C	donor_loss	0.9700
19:52282107:TTA:T	acceptor_loss	0.9700
19:52282109:AG:A	acceptor_gain	0.9700
19:52282109:AGG:A	acceptor_gain	0.9700
19:52282109:AGGG:A	acceptor_loss	0.9700
19:52282110:GG:G	acceptor_gain	0.9700
19:52282110:GGG:G	acceptor_gain	0.9700

AlphaMissense

3125 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:52291049:T:C	F420L	0.991
19:52291051:C:A	F420L	0.991
19:52291051:C:G	F420L	0.991
19:52290965:T:C	F392L	0.990
19:52290967:C:A	F392L	0.990
19:52290967:C:G	F392L	0.990
19:52290881:T:C	F364L	0.987
19:52290883:T:A	F364L	0.987
19:52290883:T:G	F364L	0.987
19:52290990:G:C	R400P	0.981
19:52291056:A:C	Q422P	0.980
19:52290994:T:A	H401Q	0.979
19:52290994:T:G	H401Q	0.979
19:52290996:A:C	Q402P	0.978
19:52291006:C:A	H405Q	0.976
19:52291006:C:G	H405Q	0.976
19:52290992:C:G	H401D	0.974
19:52291078:T:A	H429Q	0.974
19:52291078:T:G	H429Q	0.974
19:52291080:A:C	Q430P	0.974
19:52282144:T:C	F18L	0.972
19:52282146:C:A	F18L	0.972
19:52282146:C:G	F18L	0.972
19:52290797:T:C	F336L	0.972
19:52290799:T:A	F336L	0.972
19:52290799:T:G	F336L	0.972
19:52291050:T:C	F420S	0.971
19:52290966:T:C	F392S	0.969
19:52290629:T:C	F280L	0.967
19:52290631:C:A	F280L	0.967

dbSNP variants (sampled 300 via entrez): RS1000000713 (19:52278160 A>G), RS1000102521 (19:52289399 A>C,G,T), RS1000245302 (19:52273278 G>T), RS1000456929 (19:52268079 A>G), RS1000653812 (19:52274976 C>A), RS1000660289 (19:52275294 CAAG>C), RS1000783893 (19:52269483 G>A), RS1000912388 (19:52294196 G>A,C), RS1000928570 (19:52292848 T>C), RS1000979133 (19:52269746 C>T), RS1001237471 (19:52268596 T>A,C), RS1001253671 (19:52295356 G>T), RS1001290991 (19:52283549 T>A), RS1001445723 (19:52273371 T>C), RS1001484731 (19:52278812 C>T)

Disease associations

OMIM: gene `` | disease phenotypes: MIM:143880

GenCC curated gene-disease

Mondo (1): hypercalcemia, infantile, 1 (MONDO:0020739)

Orphanet (1): Autosomal recessive infantile hypercalcemia (Orphanet:300547)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002916_14	Cannabis use (initiation)	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007586	Cannabis use initiation

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Cyclosporine	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression	1
MT19c compound	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Atrazine	increases expression	1
Cadmium	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Phthalic Acids	decreases methylation	1
Potassium Chloride	decreases expression, decreases response to substance	1
Dronabinol	decreases response to substance, decreases expression	1
Valproic Acid	decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HA09	K562 eGFP-ZNF766	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.