ZNF770

Summary

ZNF770 (zinc finger protein 770, HGNC:26061) is a protein-coding gene on chromosome 15q14, encoding Zinc finger protein 770 (Q6IQ21). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 54989 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 91 total
• MANE Select transcript: NM_014106

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26061
Approved symbol	ZNF770
Name	zinc finger protein 770
Location	15q14
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20582, PRO1914
Ensembl gene	ENSG00000198146
Ensembl biotype	protein_coding
Entrez	54989

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

ENST00000356321, ENST00000559564, ENST00000901401, ENST00000901402, ENST00000901403, ENST00000901404, ENST00000901405, ENST00000901406, ENST00000932527, ENST00000955893, ENST00000955894

RefSeq mRNA: 1 — MANE Select: NM_014106 NM_014106

CCDS: CCDS10042

Canonical transcript exons

ENST00000356321 — 3 exons

Exon	Start	End
ENSE00001402305	34988116	34988287
ENSE00001402805	34987557	34987673
ENSE00001403333	34978341	34983490

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 98.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.5100 / max 237.0806, expressed in 1813 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149305	32.5100	1813

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper arm skin	UBERON:0004263	98.84	gold quality
corpus epididymis	UBERON:0004359	98.49	gold quality
gingival epithelium	UBERON:0001949	98.39	gold quality
gingiva	UBERON:0001828	98.20	gold quality
penis	UBERON:0000989	97.92	gold quality
kidney epithelium	UBERON:0004819	96.78	gold quality
esophagus squamous epithelium	UBERON:0006920	96.71	gold quality
caput epididymis	UBERON:0004358	96.54	gold quality
superior surface of tongue	UBERON:0007371	96.46	gold quality
pharyngeal mucosa	UBERON:0000355	96.24	gold quality
tongue	UBERON:0001723	96.11	gold quality
renal medulla	UBERON:0000362	95.75	gold quality
body of tongue	UBERON:0011876	95.69	gold quality
oral cavity	UBERON:0000167	95.55	gold quality
cerebellar vermis	UBERON:0004720	95.34	gold quality
cauda epididymis	UBERON:0004360	95.19	gold quality
mammalian vulva	UBERON:0000997	95.14	gold quality
germinal epithelium of ovary	UBERON:0001304	95.03	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	95.01	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.97	gold quality
epithelial cell of pancreas	CL:0000083	94.84	gold quality
thymus	UBERON:0002370	94.80	gold quality
nipple	UBERON:0002030	94.79	gold quality
epithelium of nasopharynx	UBERON:0001951	94.74	gold quality
left ventricle myocardium	UBERON:0006566	94.49	gold quality
biceps brachii	UBERON:0001507	94.31	gold quality
upper leg skin	UBERON:0004262	94.10	gold quality
quadriceps femoris	UBERON:0001377	94.07	gold quality
vastus lateralis	UBERON:0001379	93.93	gold quality
deltoid	UBERON:0001476	93.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.81

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2099.1	ZNF770	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:22955616

miRNA regulators (miRDB)

149 targeting ZNF770, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	plagx	ENSDARG00000036855
danio_rerio	ovol1a	ENSDARG00000076472
danio_rerio	plagl2	ENSDARG00000076657
danio_rerio	ovol1b	ENSDARG00000078256
mus_musculus	Zfp770	ENSMUSG00000040321
rattus_norvegicus	Zfp770	ENSRNOG00000043037
drosophila_melanogaster	hb	FBGN0001180
drosophila_melanogaster	CG12391	FBGN0033581
caenorhabditis_elegans		WBGENE00001824
caenorhabditis_elegans		WBGENE00003033
caenorhabditis_elegans		WBGENE00012385

Paralogs (29): ZNF446 (ENSG00000083838), REST (ENSG00000084093), ZNF174 (ENSG00000103343), OVOL3 (ENSG00000105261), PLAGL1 (ENSG00000118495), ZSCAN18 (ENSG00000121413), ZNF576 (ENSG00000124444), OVOL2 (ENSG00000125850), PLAGL2 (ENSG00000126003), ZSCAN5A (ENSG00000131848), ZSCAN29 (ENSG00000140265), ZSCAN32 (ENSG00000140987), ZSCAN1 (ENSG00000152467), ZNF18 (ENSG00000154957), ZKSCAN2 (ENSG00000155592), ZNF496 (ENSG00000162714), ZNF202 (ENSG00000166261), ZNF641 (ENSG00000167528), ZNF444 (ENSG00000167685), SCAND1 (ENSG00000171222), ZNF274 (ENSG00000171606), ZNF131 (ENSG00000172262), OVOL1 (ENSG00000172818), ZNF518A (ENSG00000177853), ZNF518B (ENSG00000178163), PLAG1 (ENSG00000181690), ZSCAN5B (ENSG00000197213), PEG3 (ENSG00000198300), ZSCAN5C (ENSG00000204532)

Protein

Protein identifiers

Zinc finger protein 770 — Q6IQ21 (reviewed: Q6IQ21)

All UniProt accessions (2): Q6IQ21, H0YM59

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_054825* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (22 total): zinc finger region 11, cross-link 8, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IQ21-F1	55.24	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 11, 112, 121, 146, 262, 420, 437, 683

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 138 (showing top): XU_GH1_AUTOCRINE_TARGETS_UP, chr15q14, MODULE_331, BASAKI_YBX1_TARGETS_DN, ZHANG_BREAST_CANCER_PROGENITORS_UP, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, BENPORATH_ES_1, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, MARTENS_TRETINOIN_RESPONSE_DN, WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D, DELACROIX_RAR_BOUND_ES, GCM_RAB10, ATF6_TARGET_GENES, GSE10240_IL22_VS_IL17_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP, BARX1_TARGET_GENES

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

886 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF770	NUS1	Q96E22	507
ZNF770	NUP58	Q9BVL2	507
ZNF770	LRRC2	Q9BYS8	507
ZNF770	ZNF654	Q8IZM8	490
ZNF770	DARS1	P14868	455
ZNF770	TSTD2	Q5T7W7	443
ZNF770	KMT2D	O14686	420
ZNF770	METAP1	P53582	413
ZNF770	RNF166	Q96A37	406
ZNF770	ZC3HC1	Q86WB0	404
ZNF770	MRM2	Q9UI43	401
ZNF770	E2F4	Q16254	395
ZNF770	ZBED5	Q49AG3	393
ZNF770	E2F3	O00716	387
ZNF770	CCDC12	Q8WUD4	387

IntAct

114 interactions, top by confidence:

A	B	Type	Score
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MRPS34	ZZEF1	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
NIFK	RSL1D1	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL7A	NVL	psi-mi:“MI:0914”(association)	0.530
ZNF770	GGH	psi-mi:“MI:0915”(physical association)	0.400
CFTR	ZNF770	psi-mi:“MI:0915”(physical association)	0.370
Set	ZKSCAN1	psi-mi:“MI:0914”(association)	0.350
MPHOSPH8	HCFC1	psi-mi:“MI:0914”(association)	0.350
MRPS34	CIBAR1	psi-mi:“MI:0914”(association)	0.350
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
C6orf11	RRP8	psi-mi:“MI:0914”(association)	0.350
NIFK	RRP8	psi-mi:“MI:0914”(association)	0.350

BioGRID (112): ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), ZNF770 (Affinity Capture-MS), GGH (Proximity Label-MS)

ESM2 similar proteins: A0A0A6YYL3, A5PK30, A7KBS4, B3NP26, B4GBA9, B4HMH2, B4P8I0, B4QIJ9, B7ZQJ9, E1JH25, G3X9G7, H3BUK9, P10925, P18853, P20662, P98182, Q09377, Q0VCB0, Q10127, Q19203, Q290S5, Q2EI20, Q2EI21, Q4R6J4, Q5NVT2, Q5PPG4, Q5SVQ8, Q5T5D7, Q5UR86, Q65XX7, Q6IQ21, Q6NRM8, Q7JUR5, Q7K4M4, Q7Z142, Q8BIQ8, Q8C0P7, Q8IRH5, Q8NAP3, Q8T053

Diamond homologs: A0JC51, A2ANX9, O15391, O57311, O57415, O60481, O62836, O73689, O95409, P08048, P0C6P6, P10925, P17010, P17012, P18747, P20662, P22227, P25490, P34694, P46684, P80944, Q00899, Q10RP4, Q12145, Q15915, Q29419, Q2FAY8, Q3TTC2, Q3UH06, Q3US17, Q3Y4E1, Q52V16, Q5NVT2, Q5R782, Q5RJ54, Q61467, Q61624, Q62520, Q62521, Q62806

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 127 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	27	42.3×	5e-36
Viral mRNA Translation	27	42.3×	5e-36
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	27	41.8×	5e-36
Selenocysteine synthesis	27	40.1×	1e-35
Eukaryotic Translation Termination	27	40.1×	1e-35
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	27	39.2×	2e-35
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	27	39.2×	2e-35
Formation of a pool of free 40S subunits	27	37.3×	6e-35

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	28	46.3×	2e-37
ribosomal large subunit biogenesis	8	31.7×	2e-08
translation	29	26.6×	2e-31
ribosomal small subunit biogenesis	8	16.3×	3e-06
rRNA processing	10	12.6×	8e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

91 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

661 predictions. Top by Δscore:

Variant	Effect	Δscore
15:34983356:ATGG:A	donor_gain	1.0000
15:34988145:C:A	donor_gain	1.0000
15:34988164:T:TA	donor_gain	1.0000
15:34988003:T:TA	donor_gain	0.9900
15:34988139:G:GT	donor_gain	0.9800
15:34988144:T:TA	donor_gain	0.9800
15:34987673:CCTAA:C	acceptor_loss	0.9700
15:34987674:C:A	acceptor_loss	0.9700
15:34987675:T:A	acceptor_loss	0.9700
15:34988071:CAGGA:C	donor_gain	0.9700
15:34988072:AGGAA:A	donor_gain	0.9700
15:34988111:GGCAC:G	donor_loss	0.9700
15:34988112:GCAC:G	donor_loss	0.9700
15:34988113:CACCT:C	donor_loss	0.9700
15:34988114:A:AC	donor_loss	0.9700
15:34988115:C:T	donor_loss	0.9700
15:34983488:TGT:T	acceptor_gain	0.9600
15:34983491:C:CC	acceptor_gain	0.9600
15:34988116:C:G	donor_loss	0.9600
15:34983490:TC:T	acceptor_loss	0.9500
15:34983491:CT:C	acceptor_loss	0.9500
15:34983492:T:A	acceptor_loss	0.9500
15:34988187:T:TA	donor_gain	0.9500
15:34987552:CTGA:C	donor_loss	0.9400
15:34987553:TGA:T	donor_loss	0.9400
15:34987554:GA:G	donor_loss	0.9400
15:34987555:ACCTC:A	donor_loss	0.9400
15:34987556:CC:C	donor_loss	0.9400
15:34988158:TC:T	donor_gain	0.9400
15:34988159:CC:C	donor_gain	0.9400

AlphaMissense

4621 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:34981424:G:C	H671D	0.999
15:34981449:G:C	F662L	0.999
15:34981449:G:T	F662L	0.999
15:34981451:A:G	F662L	0.999
15:34981899:A:C	F512L	0.999
15:34981899:A:T	F512L	0.999
15:34981901:A:G	F512L	0.999
15:34982760:A:C	F225L	0.999
15:34982760:A:T	F225L	0.999
15:34982762:A:G	F225L	0.999
15:34982819:G:C	H206D	0.999
15:34982844:A:C	F197L	0.999
15:34982844:A:T	F197L	0.999
15:34982846:A:G	F197L	0.999
15:34981422:A:C	H671Q	0.998
15:34981422:A:T	H671Q	0.998
15:34981450:A:G	F662S	0.998
15:34981472:A:G	C655R	0.998
15:34981506:G:C	H643Q	0.998
15:34981506:G:T	H643Q	0.998
15:34981533:G:C	F634L	0.998
15:34981533:G:T	F634L	0.998
15:34981535:A:G	F634L	0.998
15:34981900:A:G	F512S	0.998
15:34982743:A:G	L231P	0.998
15:34982761:A:G	F225S	0.998
15:34982845:A:G	F197S	0.998
15:34983243:A:C	F64L	0.998
15:34983243:A:T	F64L	0.998
15:34983245:A:G	F64L	0.998

dbSNP variants (sampled 300 via entrez): RS1000546953 (15:34989947 C>G,T), RS1000783648 (15:34982785 T>C,G), RS1001134146 (15:34982235 A>C,G,T), RS1001618515 (15:34987278 C>A,T), RS1001833659 (15:34987048 T>A), RS1002221554 (15:34988432 A>C,G), RS1002573831 (15:34988263 A>G), RS1002721221 (15:34989414 T>G), RS1002882776 (15:34986056 C>G,T), RS1003134625 (15:34985497 T>C), RS1003165945 (15:34985125 G>T), RS1003520359 (15:34978856 T>G), RS1004344309 (15:34984482 A>C), RS1004512149 (15:34979535 C>T), RS1005140367 (15:34985607 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002104_23	Bronchopulmonary dysplasia	9.000000e-06
GCST004047_3	Optic nerve measurement (cup-to-disc ratio)	1.000000e-06
GCST008477_24	Emphysema annual change measurement in smokers (adjusted lung density)	9.000000e-06
GCST010002_165	Refractive error	2.000000e-245

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006939	cup-to-disc ratio measurement
EFO:0007626	emphysema imaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	decreases expression, increases expression	3
Air Pollutants	affects expression, increases abundance, increases expression	2
Valproic Acid	increases expression, decreases expression, decreases methylation	2
TAK-243	increases sumoylation	1
geldanamycin	increases expression	1
triphenyl phosphate	affects expression	1
perfluoro-n-nonanoic acid	increases expression	1
ICG 001	increases expression	1
Grape Seed Proanthocyanidins	increases expression, affects cotreatment	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
MT19c compound	increases expression	1
Resveratrol	affects cotreatment, decreases expression, increases expression	1
Vorinostat	decreases expression	1
Leflunomide	increases expression	1
Acetaminophen	decreases expression	1
Atrazine	decreases expression	1
Catechin	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression, increases expression	1
Silicon Dioxide	decreases expression	1
Testosterone	decreases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Vanadates	decreases expression	1
Aflatoxin M1	decreases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XW82	HEK293 eGFP-ZNF770	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.