ZNF772

Summary

ZNF772 (zinc finger protein 772, HGNC:33106) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 772 (Q68DY9). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 400720 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001144068

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33106
Approved symbol	ZNF772
Name	zinc finger protein 772
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp686I1569
Ensembl gene	ENSG00000197128
Ensembl biotype	protein_coding
Entrez	400720

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 nonsense_mediated_decay

ENST00000343280, ENST00000356584, ENST00000425074, ENST00000427512, ENST00000450712, ENST00000600175, ENST00000601768, ENST00000610548

RefSeq mRNA: 3 — MANE Select: NM_001144068 NM_001024596, NM_001144068, NM_001330613

CCDS: CCDS33133, CCDS46210, CCDS82406

Canonical transcript exons

ENST00000356584 — 4 exons

Exon	Start	End
ENSE00002243719	57477277	57477566
ENSE00003472627	57476634	57476672
ENSE00003579857	57469586	57474421
ENSE00003679792	57475660	57475786

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 87.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.5300 / max 69.3169, expressed in 1579 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182907	5.5300	1579

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	87.89	gold quality
adrenal tissue	UBERON:0018303	82.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.32	gold quality
cortical plate	UBERON:0005343	80.87	gold quality
ganglionic eminence	UBERON:0004023	80.63	gold quality
ventricular zone	UBERON:0003053	80.04	gold quality
skeletal muscle tissue	UBERON:0001134	79.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.95	gold quality
islet of Langerhans	UBERON:0000006	78.67	gold quality
calcaneal tendon	UBERON:0003701	78.22	gold quality
muscle of leg	UBERON:0001383	76.46	gold quality
gastrocnemius	UBERON:0001388	76.44	gold quality
muscle tissue	UBERON:0002385	76.19	gold quality
stromal cell of endometrium	CL:0002255	76.02	gold quality
heart left ventricle	UBERON:0002084	74.94	gold quality
cerebellum	UBERON:0002037	74.82	gold quality
cerebellar cortex	UBERON:0002129	74.73	gold quality
placenta	UBERON:0001987	74.67	gold quality
cerebellar hemisphere	UBERON:0002245	74.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.08	gold quality
endometrium	UBERON:0001295	73.72	gold quality
adrenal gland	UBERON:0002369	73.63	gold quality
heart	UBERON:0000948	73.57	gold quality
prefrontal cortex	UBERON:0000451	73.40	gold quality
adenohypophysis	UBERON:0002196	72.96	gold quality
pituitary gland	UBERON:0000007	72.73	gold quality
left adrenal gland	UBERON:0001234	72.49	gold quality
tonsil	UBERON:0002372	72.46	gold quality
right adrenal gland	UBERON:0001233	72.21	gold quality
right lobe of thyroid gland	UBERON:0001119	72.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.24

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2529.1	ZNF772	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

miRNA regulators (miRDB)

152 targeting ZNF772, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3910	99.95	71.13	2227

Literature-anchored findings (GeneRIF, showing 1)

• [Correlation between DNA Methylation of ZNF772 Promoter Region and Cervical Cancer]. (PMID:32385021)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zfx	ENSDARG00000074453
danio_rerio		ENSDARG00000098424
mus_musculus	Zfy2	ENSMUSG00000000103
mus_musculus	Zfy1	ENSMUSG00000053211
rattus_norvegicus	Zfy1	ENSRNOG00000053042

Paralogs (38): ZFX (ENSG00000005889), ZBTB11 (ENSG00000066422), ZFAT (ENSG00000066827), ZFY (ENSG00000067646), ZNF586 (ENSG00000083828), IKZF5 (ENSG00000095574), ZNF419 (ENSG00000105136), ZNF549 (ENSG00000121406), ZSCAN20 (ENSG00000121903), ZNF304 (ENSG00000131845), PRDM15 (ENSG00000141956), ZNF660 (ENSG00000144792), ZNF711 (ENSG00000147180), ZNF773 (ENSG00000152439), ZNF256 (ENSG00000152454), ZNF837 (ENSG00000152475), ZNF691 (ENSG00000164011), ZNF610 (ENSG00000167554), E4F1 (ENSG00000167967), ZNF562 (ENSG00000171466), ZNF561 (ENSG00000171469), ZNF584 (ENSG00000171574), ZIK1 (ENSG00000171649), ZNF570 (ENSG00000171827), ZSCAN2 (ENSG00000176371), ZNF552 (ENSG00000178935), ZNF154 (ENSG00000179909), ZNF792 (ENSG00000180884), ZNF793 (ENSG00000188227), ZNF548 (ENSG00000188785), ZNF79 (ENSG00000196152), ZNF418 (ENSG00000196724), ZNF583 (ENSG00000198440), ZNF480 (ENSG00000198464), ZNF551 (ENSG00000204519), ZNF134 (ENSG00000213762), ZNF587B (ENSG00000269343), ZNF8 (ENSG00000278129)

Protein

Protein identifiers

Zinc finger protein 772 — Q68DY9 (reviewed: Q68DY9)

All UniProt accessions (6): A0A087WTB1, C9J1S5, C9JFF8, Q68DY9, M0R084, M0R156

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q68DY9-1	1	yes
Q68DY9-2	2
Q68DY9-3	3

RefSeq proteins (3): NP_001019767, NP_001137540, NP_001317542 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352

UniProt features (17 total): zinc finger region 10, splice variant 2, sequence variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q68DY9-F1	65.42	0.12

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 31 (showing top): TGCCTTA_MIR124A, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, CEBPZ_TARGET_GENES, MIR520D_5P, MIR524_5P, MIR5582_3P, MIR95_5P, MIR548AW, MIR3688_3P, MIR6873_3P, MIR510_3P, MIR6508_5P, MIR4760_3P, MIR12124

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

402 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF772	VN1R1	Q9GZP7	952
ZNF772	ZNF487	B1APH4	512
ZNF772	OR4D9	Q8NGE8	503
ZNF772	OR1K1	Q8NGR3	496
ZNF772	AVPR2	P30518	493
ZNF772	OR52W1	Q6IF63	488
ZNF772	OR2AT4	A6NND4	445
ZNF772	KRTAP4-5	Q9BYR2	434
ZNF772	SLCO1B7	G3V0H7	417
ZNF772	RDM1	Q8NG50	414
ZNF772	GOLPH3L	Q9H4A5	410
ZNF772	STK31	Q9BXU1	409
ZNF772	TMEM121	Q9BTD3	403
ZNF772	DNAJC12	Q9UKB3	399
ZNF772	THOC5	Q13769	398

IntAct

9 interactions, top by confidence:

A	B	Type	Score
PEX5	ZNF772	psi-mi:“MI:0915”(physical association)	0.560
ZNF772	PEX5	psi-mi:“MI:0915”(physical association)	0.560
ZNF772	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
ECE1	ZNF772	psi-mi:“MI:0915”(physical association)	0.370
ZNF772	TRIM24	psi-mi:“MI:0914”(association)	0.350
ZNF772	MEOX2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): ZNF772 (Two-hybrid), ZNF772 (Affinity Capture-RNA), ZNF772 (Affinity Capture-RNA), ZNF772 (Two-hybrid), ZNF772 (Affinity Capture-MS), ZNF772 (Affinity Capture-MS), ZNF772 (Affinity Capture-RNA), ZNF772 (Affinity Capture-MS)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A1YF12, A1YG88, A2T759, B2RUI1, D3ZVT0, O43296, P0CG31, P10072, P17020, P17097, P51814, Q08ER8, Q13398, Q14590, Q3KQV3, Q3SY52, Q4V8A8, Q571J5, Q5CZA5, Q5RBX0, Q5RCD9, Q5RCX4, Q61116, Q61967, Q68DY9, Q6NX49, Q6PK81, Q80YP6, Q86UD4, Q8BFS8, Q8BV42, Q8IVP9, Q8IZ26, Q8NEK5, Q8TAU3, Q8TAW3, Q8TF47, Q8WTR7

Diamond homologs: A6NDX5, A6NN14, A6QLU5, A7MBI1, A8MQ14, B4DU55, B4DX44, O43296, O60765, O75290, O75346, O75437, O95780, P10072, P10078, P17014, P17030, P17032, P17097, P17098, P51523, P51814, P52736, P52738, P52742, Q05481, Q06730, Q06732, Q14586, Q14929, Q15928, Q16587, Q29RZ4, Q2KI58, Q3KNS6, Q3V080, Q3ZCX4, Q49AA0, Q4R6C2, Q4V8A8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

959 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57475654:CCTT:C	donor_loss	0.9900
19:57475655:CTTAC:C	donor_loss	0.9900
19:57475656:TTA:T	donor_loss	0.9900
19:57475657:TACC:T	donor_loss	0.9900
19:57475658:A:AC	donor_gain	0.9900
19:57475658:A:C	donor_loss	0.9900
19:57475658:A:G	donor_loss	0.9900
19:57475658:AC:A	donor_gain	0.9900
19:57475659:C:CA	donor_loss	0.9900
19:57475659:C:CC	donor_gain	0.9900
19:57475659:CC:C	donor_gain	0.9900
19:57475783:GCCC:G	acceptor_gain	0.9900
19:57475784:CCCC:C	acceptor_gain	0.9900
19:57475791:C:CT	acceptor_gain	0.9900
19:57475791:C:T	acceptor_gain	0.9900
19:57475784:CCC:C	acceptor_gain	0.9800
19:57475785:CCC:C	acceptor_gain	0.9800
19:57475797:C:CT	acceptor_gain	0.9800
19:57476630:TCACC:T	donor_loss	0.9800
19:57476633:C:CT	donor_loss	0.9800
19:57476669:GAACC:G	acceptor_loss	0.9800
19:57476670:AACC:A	acceptor_loss	0.9800
19:57476670:AACCT:A	acceptor_loss	0.9800
19:57476671:ACCT:A	acceptor_loss	0.9800
19:57476672:CCT:C	acceptor_loss	0.9800
19:57476673:CT:C	acceptor_loss	0.9800
19:57476673:CTGTG:C	acceptor_loss	0.9800
19:57476674:T:C	acceptor_loss	0.9800
19:57476674:T:G	acceptor_loss	0.9800
19:57475782:TGCCC:T	acceptor_gain	0.9700

AlphaMissense

3033 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57473331:G:C	F471L	0.999
19:57473331:G:T	F471L	0.999
19:57473333:A:G	F471L	0.999
19:57473415:A:C	F443L	0.999
19:57473415:A:T	F443L	0.999
19:57473417:A:G	F443L	0.999
19:57473482:A:G	L421P	0.998
19:57473751:A:C	F331L	0.998
19:57473751:A:T	F331L	0.998
19:57473753:A:G	F331L	0.998
19:57473388:A:C	H452Q	0.997
19:57473388:A:T	H452Q	0.997
19:57473416:A:G	F443S	0.997
19:57473712:G:C	H344Q	0.997
19:57473712:G:T	H344Q	0.997
19:57473722:T:G	Q341P	0.997
19:57473734:A:G	L337P	0.997
19:57473314:A:G	L477P	0.996
19:57473376:G:C	H456Q	0.996
19:57473376:G:T	H456Q	0.996
19:57473390:G:C	H452D	0.996
19:57473398:A:G	L449P	0.996
19:57473472:A:C	H424Q	0.996
19:57473472:A:T	H424Q	0.996
19:57473499:A:C	F415L	0.996
19:57473499:A:T	F415L	0.996
19:57473501:A:G	F415L	0.996
19:57473724:A:C	H340Q	0.996
19:57473724:A:T	H340Q	0.996
19:57473835:A:C	F303L	0.996

dbSNP variants (sampled 300 via entrez): RS1000274871 (19:57470535 A>G), RS1000279280 (19:57474746 G>A,T), RS1000718337 (19:57469712 T>C), RS1000750879 (19:57469967 A>G), RS1000787461 (19:57477389 G>C,T), RS1001150241 (19:57478385 T>G), RS1001503476 (19:57473051 T>C), RS1001592989 (19:57476815 C>G), RS1001958957 (19:57476987 G>A,C), RS1002323643 (19:57478015 C>T), RS1002403421 (19:57471518 C>G,T), RS1003205131 (19:57471919 G>A), RS1003411443 (19:57470235 C>A,T), RS1003493872 (19:57478189 G>C), RS1003604000 (19:57478552 A>C,G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	2
methacrylaldehyde	affects cotreatment, decreases expression, increases oxidation, increases abundance	2
Acrolein	increases abundance, affects cotreatment, decreases expression, increases oxidation	2
Ozone	decreases expression, increases oxidation, increases abundance, affects cotreatment	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	decreases expression, increases oxidation, increases abundance, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Temozolomide	increases expression	1
Air Pollutants	decreases expression, increases abundance, increases oxidation, affects cotreatment	1
Benzo(a)pyrene	affects methylation	1
Cadmium	increases abundance, increases expression	1
Potassium Chloride	decreases expression, decreases response to substance	1
Dronabinol	decreases expression, decreases response to substance	1
Urethane	decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Volatile Organic Compounds	affects cotreatment, decreases expression, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.