ZNF773

Summary

ZNF773 (zinc finger protein 773, HGNC:30487) is a protein-coding gene on chromosome 19q13.43, encoding Zinc finger protein 773 (Q6PK81). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 374928 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 90 total
• MANE Select transcript: NM_198542

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30487
Approved symbol	ZNF773
Name	zinc finger protein 773
Location	19q13.43
Locus type	gene with protein product
Status	Approved
Aliases	MGC4728
Ensembl gene	ENSG00000152439
Ensembl biotype	protein_coding
Entrez	374928

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000282292, ENST00000593916, ENST00000597061, ENST00000598770, ENST00000599847, ENST00000601958

RefSeq mRNA: 5 — MANE Select: NM_198542 NM_001304334, NM_001304335, NM_001304336, NM_001304337, NM_198542

CCDS: CCDS33134, CCDS77368, CCDS77369

Canonical transcript exons

ENST00000282292 — 4 exons

Exon	Start	End
ENSE00001418741	57499938	57500113
ENSE00001420077	57506358	57508229
ENSE00002500029	57505302	57505400
ENSE00003599160	57504657	57504786

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 84.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2920 / max 80.5681, expressed in 1665 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
177779	7.2920	1665

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.53	gold quality
ventricular zone	UBERON:0003053	77.75	gold quality
cortical plate	UBERON:0005343	77.67	gold quality
left adrenal gland cortex	UBERON:0035825	77.41	gold quality
left lobe of thyroid gland	UBERON:0001120	77.37	gold quality
right adrenal gland cortex	UBERON:0035827	77.36	gold quality
left adrenal gland	UBERON:0001234	77.33	gold quality
thyroid gland	UBERON:0002046	77.27	gold quality
right lobe of thyroid gland	UBERON:0001119	77.17	gold quality
pituitary gland	UBERON:0000007	77.00	gold quality
adrenal gland	UBERON:0002369	76.93	gold quality
stromal cell of endometrium	CL:0002255	76.90	gold quality
right adrenal gland	UBERON:0001233	76.87	gold quality
adenohypophysis	UBERON:0002196	76.67	gold quality
granulocyte	CL:0000094	76.37	gold quality
ganglionic eminence	UBERON:0004023	76.20	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.18	gold quality
lower esophagus	UBERON:0013473	76.16	gold quality
apex of heart	UBERON:0002098	76.13	gold quality
cerebellar hemisphere	UBERON:0002245	75.96	gold quality
cerebellar cortex	UBERON:0002129	75.91	gold quality
cerebellum	UBERON:0002037	75.90	gold quality
islet of Langerhans	UBERON:0000006	75.88	gold quality
lymph node	UBERON:0000029	75.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.29	gold quality
spleen	UBERON:0002106	75.26	gold quality
skin of leg	UBERON:0001511	75.17	gold quality
zone of skin	UBERON:0000014	75.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.00

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2530.1	ZNF773	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

miRNA regulators (miRDB)

23 targeting ZNF773, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-377-5P	99.70	65.28	712
HSA-MIR-6086	99.70	65.38	699
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-653-5P	99.46	67.35	1300
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-1245B-5P	98.88	66.55	576
HSA-MIR-3142	98.88	66.09	529
HSA-MIR-4299	98.28	66.96	850
HSA-MIR-4289	98.26	66.90	810
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-876-5P	97.99	68.49	1345
HSA-MIR-1279	97.83	67.50	1898
HSA-MIR-6865-3P	97.54	64.67	684
HSA-MIR-1226-3P	97.51	66.32	1063
HSA-MIR-3167	96.81	67.09	1236
HSA-MIR-6777-3P	95.35	64.30	699
HSA-MIR-4694-5P	94.62	65.39	532
HSA-MIR-6879-3P	93.93	64.00	759

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zfx	ENSDARG00000074453
danio_rerio		ENSDARG00000098424
mus_musculus	Zfy2	ENSMUSG00000000103
mus_musculus	Zfy1	ENSMUSG00000053211
rattus_norvegicus	Zfy1	ENSRNOG00000053042

Paralogs (38): ZFX (ENSG00000005889), ZBTB11 (ENSG00000066422), ZFAT (ENSG00000066827), ZFY (ENSG00000067646), ZNF586 (ENSG00000083828), IKZF5 (ENSG00000095574), ZNF419 (ENSG00000105136), ZNF549 (ENSG00000121406), ZSCAN20 (ENSG00000121903), ZNF304 (ENSG00000131845), PRDM15 (ENSG00000141956), ZNF660 (ENSG00000144792), ZNF711 (ENSG00000147180), ZNF256 (ENSG00000152454), ZNF837 (ENSG00000152475), ZNF691 (ENSG00000164011), ZNF610 (ENSG00000167554), E4F1 (ENSG00000167967), ZNF562 (ENSG00000171466), ZNF561 (ENSG00000171469), ZNF584 (ENSG00000171574), ZIK1 (ENSG00000171649), ZNF570 (ENSG00000171827), ZSCAN2 (ENSG00000176371), ZNF552 (ENSG00000178935), ZNF154 (ENSG00000179909), ZNF792 (ENSG00000180884), ZNF793 (ENSG00000188227), ZNF548 (ENSG00000188785), ZNF79 (ENSG00000196152), ZNF418 (ENSG00000196724), ZNF772 (ENSG00000197128), ZNF583 (ENSG00000198440), ZNF480 (ENSG00000198464), ZNF551 (ENSG00000204519), ZNF134 (ENSG00000213762), ZNF587B (ENSG00000269343), ZNF8 (ENSG00000278129)

Protein

Protein identifiers

Zinc finger protein 773 — Q6PK81 (reviewed: Q6PK81)

Alternative names: Zinc finger protein 419B

All UniProt accessions (3): Q6PK81, M0QX16, M0QYZ8

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6PK81-1	1	yes
Q6PK81-2	2

RefSeq proteins (5): NP_001291263, NP_001291264, NP_001291265, NP_001291266, NP_940944* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050589	Ikaros_C2H2-ZF	Family

Pfam: PF00096, PF01352

UniProt features (12 total): zinc finger region 9, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6PK81-F1	70.52	0.35

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 55 (showing top): GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ARID5B_TARGET_GENES, CEBPZ_TARGET_GENES, HDAC4_TARGET_GENES, PER1_TARGET_GENES, YBX1_TARGET_GENES, ZNF597_TARGET_GENES, MIR4262, MIR181A_5P_MIR181B_5P, MIR181D_5P, MIR181C_5P, MIR519E_5P, MIR3692_3P, MIR515_5P

GO Biological Process (4): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355), regulation of macromolecule metabolic process (GO:0060255), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of metabolic process	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
macromolecule metabolic process	1
primary metabolic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

592 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF773	OR6S1	Q8NH40	581
ZNF773	ZNF395	Q9H8N7	437
ZNF773	TCEANC2	Q96MN5	400
ZNF773	VSTM2B	A6NLU5	370
ZNF773	C9J5N1	C9J5N1	357
ZNF773	Q32Q12	Q32Q12	357
ZNF773	AARSD1	Q9BTE6	349
ZNF773	CCDC181	Q5TID7	325
ZNF773	BEND4	Q6ZU67	317
ZNF773	TC2N	Q8N9U0	317
ZNF773	RABL2A	Q9UBK7	313
ZNF773	MRPL52	Q86TS9	305
ZNF773	WASF2	Q9Y6W5	295
ZNF773	ENDOV	Q8N8Q3	290
ZNF773	ZNF644	Q9H582	280

IntAct

11 interactions, top by confidence:

A	B	Type	Score
TLK1	ZNF773	psi-mi:“MI:0915”(physical association)	0.560
TRIM41	ZNF773	psi-mi:“MI:0915”(physical association)	0.560
ZNF773	TLK1	psi-mi:“MI:0915”(physical association)	0.560
ZNF773	TRIM41	psi-mi:“MI:0915”(physical association)	0.560
ECE1	ZNF773	psi-mi:“MI:0915”(physical association)	0.370
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350
ZNF773	IPO8	psi-mi:“MI:0914”(association)	0.350
ZNF773	JUNB	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): ZNF773 (Affinity Capture-MS), ZNF773 (Affinity Capture-RNA), ZNF773 (Two-hybrid), TLK1 (Two-hybrid), GSG2 (Affinity Capture-MS), SOX13 (Affinity Capture-MS), IPO8 (Affinity Capture-MS), ZNF689 (Affinity Capture-MS), ZNF629 (Affinity Capture-MS), TRIM28 (Affinity Capture-MS), TRIM39 (Affinity Capture-MS), ZNF773 (Affinity Capture-MS), ZNF773 (Affinity Capture-MS)

ESM2 similar proteins: A0JNB1, A1YF12, A1YG88, A2T759, A3KN32, B2RUI1, O43296, O75123, P10072, P17020, P17097, P51814, P52736, P52740, Q07230, Q08ER8, Q13398, Q14590, Q32KN0, Q3KQV3, Q3MIS6, Q4V8A8, Q5CZA5, Q5RBQ3, Q5RBX0, Q5RCD9, Q5RCX4, Q6GQR8, Q6NX45, Q6P9A3, Q6PK81, Q7TSH9, Q7TSI0, Q7Z7L9, Q86UD4, Q8BFS8, Q8BLB0, Q8IVP9, Q8IZ26, Q8N9F8

Diamond homologs: A0JPL0, A2A761, A3KN32, A3KN36, A6NFI3, A6NM28, A6QLU5, A6QPT6, A7MBI1, A8MTY0, B2RXC5, B4DU55, E9PYI1, O14978, O60765, O75467, O75820, O95780, P0C7X2, P0DKX0, P0DPD5, P10072, P15622, P16374, P17014, P17023, P17032, P17098, P51523, P51786, P52738, P52742, Q02975, Q06732, Q08DG8, Q08ER8, Q0VCB0, Q14590, Q14929, Q29RZ4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

90 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

738 predictions. Top by Δscore:

Variant	Effect	Δscore
19:57500112:AGGT:A	donor_loss	1.0000
19:57500113:GGTG:G	donor_loss	1.0000
19:57500114:GTGA:G	donor_loss	1.0000
19:57504655:A:AG	acceptor_gain	1.0000
19:57504655:AGCAG:A	acceptor_gain	1.0000
19:57504656:G:GA	acceptor_gain	1.0000
19:57504656:GCA:G	acceptor_gain	1.0000
19:57504656:GCAGG:G	acceptor_gain	1.0000
19:57504785:GG:G	donor_gain	1.0000
19:57504786:GG:G	donor_gain	1.0000
19:57504786:GGTA:G	donor_loss	1.0000
19:57504787:G:GG	donor_gain	1.0000
19:57504787:GTAAG:G	donor_loss	1.0000
19:57505373:G:GT	donor_gain	1.0000
19:57505373:G:T	donor_gain	1.0000
19:57500114:G:GG	donor_gain	0.9900
19:57504650:A:AG	acceptor_gain	0.9900
19:57504653:TTAGC:T	acceptor_loss	0.9900
19:57504659:GGGCT:G	acceptor_gain	0.9900
19:57504786:GGTAA:G	donor_loss	0.9900
19:57504787:G:GA	donor_loss	0.9900
19:57504788:T:A	donor_loss	0.9900
19:57505300:A:AG	acceptor_gain	0.9900
19:57505301:G:GG	acceptor_gain	0.9900
19:57505397:AGAG:A	donor_loss	0.9900
19:57505398:GAG:G	donor_gain	0.9900
19:57505399:AG:A	donor_loss	0.9900
19:57505400:GGT:G	donor_loss	0.9900
19:57506357:GGTA:G	acceptor_gain	0.9900
19:57504656:GC:G	acceptor_gain	0.9800

AlphaMissense

2953 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:57506861:T:C	F256L	0.998
19:57506863:T:A	F256L	0.998
19:57506863:T:G	F256L	0.998
19:57506945:T:C	F284L	0.998
19:57506947:C:A	F284L	0.998
19:57506947:C:G	F284L	0.998
19:57506868:G:C	R258P	0.996
19:57506880:T:C	L262P	0.996
19:57506777:T:C	F228L	0.995
19:57506779:T:A	F228L	0.995
19:57506779:T:G	F228L	0.995
19:57504694:T:C	F24S	0.994
19:57506890:C:A	H265Q	0.994
19:57506890:C:G	H265Q	0.994
19:57506946:T:C	F284S	0.994
19:57507029:T:C	F312L	0.994
19:57507031:T:A	F312L	0.994
19:57507031:T:G	F312L	0.994
19:57507147:G:C	R351P	0.994
19:57504693:T:C	F24L	0.993
19:57504695:C:A	F24L	0.993
19:57504695:C:G	F24L	0.993
19:57506918:T:C	F275L	0.993
19:57506920:T:A	F275L	0.993
19:57506920:T:G	F275L	0.993
19:57506964:T:C	L290P	0.993
19:57506974:T:A	H293Q	0.993
19:57506974:T:G	H293Q	0.993
19:57507132:T:C	L346P	0.993
19:57507142:T:A	H349Q	0.993

dbSNP variants (sampled 300 via entrez): RS1000029379 (19:57515467 C>G), RS1000232633 (19:57518268 G>T), RS1000619595 (19:57508230 A>G), RS1000674773 (19:57515056 C>T), RS1000770757 (19:57514775 G>C), RS1001511722 (19:57513375 G>A), RS1001681654 (19:57518667 G>A), RS1001801532 (19:57514663 T>G), RS1002242026 (19:57517152 T>C), RS1002279801 (19:57504026 A>G), RS1002311068 (19:57503801 G>A,T), RS1002565156 (19:57512092 A>C), RS1002946749 (19:57501509 A>C), RS1003004341 (19:57507026 T>A,C), RS1003019938 (19:57501284 T>TC)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009193_16	Pars opercularis volume	8.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
ferrous chloride	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	affects expression	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation, affects methylation	1
Cisplatin	increases expression	1
Estradiol	affects expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1
Tunicamycin	increases expression	1
Aflatoxin B1	increases methylation	1
Acrylamide	increases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.