ZNF775

Summary

ZNF775 (zinc finger protein 775, HGNC:28501) is a protein-coding gene on chromosome 7q36.1, encoding Zinc finger protein 775 (Q96BV0). May be involved in transcriptional regulation.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 285971 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_173680

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28501
Approved symbol	ZNF775
Name	zinc finger protein 775
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC33584
Ensembl gene	ENSG00000196456
Ensembl biotype	protein_coding
Entrez	285971

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 protein_coding

ENST00000329630, ENST00000478789, ENST00000490973, ENST00000937963, ENST00000937964, ENST00000937965, ENST00000937966, ENST00000937967, ENST00000937968, ENST00000937969, ENST00000968864, ENST00000968865, ENST00000968866, ENST00000968867, ENST00000968868, ENST00000968869

RefSeq mRNA: 1 — MANE Select: NM_173680 NM_173680

CCDS: CCDS43678

Canonical transcript exons

ENST00000329630 — 3 exons

Exon	Start	End
ENSE00001330710	150396513	150398630
ENSE00001900789	150379330	150379392
ENSE00003863569	150388422	150388501

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 91.83.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6655 / max 9.6722, expressed in 370 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81936	5.0716	1602
81930	0.6655	370

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	91.83	gold quality
medial globus pallidus	UBERON:0002477	87.60	gold quality
globus pallidus	UBERON:0001875	86.21	gold quality
ganglionic eminence	UBERON:0004023	84.11	gold quality
upper arm skin	UBERON:0004263	83.97	gold quality
ventricular zone	UBERON:0003053	82.94	gold quality
buccal mucosa cell	CL:0002336	82.93	gold quality
cortical plate	UBERON:0005343	81.77	gold quality
mucosa of transverse colon	UBERON:0004991	81.00	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.88	gold quality
cardiac muscle of right atrium	UBERON:0003379	80.83	gold quality
spinal cord	UBERON:0002240	80.62	gold quality
left ventricle myocardium	UBERON:0006566	80.33	gold quality
inferior vagus X ganglion	UBERON:0005363	80.18	gold quality
lateral globus pallidus	UBERON:0002476	79.86	silver quality
ventral tegmental area	UBERON:0002691	79.65	silver quality
putamen	UBERON:0001874	79.30	gold quality
transverse colon	UBERON:0001157	79.22	gold quality
subthalamic nucleus	UBERON:0001906	78.89	silver quality
substantia nigra	UBERON:0002038	78.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.83	gold quality
midbrain	UBERON:0001891	78.81	gold quality
vena cava	UBERON:0004087	78.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.58	gold quality
lower esophagus	UBERON:0013473	78.53	gold quality
dorsal plus ventral thalamus	UBERON:0001897	78.52	silver quality
substantia nigra pars reticulata	UBERON:0001966	78.42	gold quality
prefrontal cortex	UBERON:0000451	78.41	gold quality
body of tongue	UBERON:0011876	78.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.93

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2531.1	ZNF775	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605320

miRNA regulators (miRDB)

4 targeting ZNF775, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-532-3P	99.34	65.76	1195
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-1291	96.28	65.89	1224
HSA-MIR-6775-3P	95.76	65.91	982

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp719	ENSMUSG00000030469
mus_musculus	Zfp141	ENSMUSG00000092416
mus_musculus	B020011L13Rik	ENSMUSG00000101303
drosophila_melanogaster	Meics	FBGN0025874

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 775 — Q96BV0 (reviewed: Q96BV0)

All UniProt accessions (3): C9JAM7, C9JVG2, Q96BV0

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_775951* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (18 total): zinc finger region 11, region of interest 2, compositionally biased region 2, chain 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96BV0-F1	63.77	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 533

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 78 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, TGACCTY_ERR1_Q2, CACCAGC_MIR138, CCATCCA_MIR432, LEF1_Q6, OSF2_Q6, YOSHIMURA_MAPK8_TARGETS_DN, TCANNTGAY_SREBP1_01, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, PR_01, KOYAMA_SEMA3B_TARGETS_DN, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ARID5B_TARGET_GENES

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

500 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF775	GIMAP8	Q8ND71	507
ZNF775	GIMAP2	Q9UG22	500
ZNF775	A0A087WTJ2	A0A087WTJ2	493
ZNF775	GIMAP7	Q8NHV1	483
ZNF775	TMEM176B	Q3YBM2	482
ZNF775	SYCE1L	A8MT33	450
ZNF775	GIMAP6	Q6P9H5	449
ZNF775	C7orf33	Q8WU49	448
ZNF775	DRC11L	A6NCM1	445
ZNF775	GIMAP5	Q96F15	440
ZNF775	TMEM120A	Q9BXJ8	425
ZNF775	URB2	Q14146	400
ZNF775	ZBED10P	Q96FA7	398
ZNF775	DENND2C	Q68D51	385
ZNF775	TTLL8	A6PVC2	381

IntAct

45 interactions, top by confidence:

A	B	Type	Score
ZNF775	ZRANB1	psi-mi:“MI:0915”(physical association)	0.560
CEP70	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
ZNF775	CARD10	psi-mi:“MI:0915”(physical association)	0.560
ZNF775	EHMT2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
ZNF775	TSPYL2	psi-mi:“MI:0915”(physical association)	0.560
DVL3	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
FAM9A	ZNF775	psi-mi:“MI:0915”(physical association)	0.560
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF775	DAP3	psi-mi:“MI:0915”(physical association)	0.400
FES	ZNF775	psi-mi:“MI:0915”(physical association)	0.370
ZNF775	MAPK6	psi-mi:“MI:0915”(physical association)	0.370
OSGEP	ZNF775	psi-mi:“MI:0915”(physical association)	0.370
PPP2CB	ZNF775	psi-mi:“MI:0915”(physical association)	0.370
ZNF775	RPS6KA5	psi-mi:“MI:0915”(physical association)	0.370
MAP3K20	ZNF775	psi-mi:“MI:0915”(physical association)	0.370
NOTCH2	ZNF320	psi-mi:“MI:0914”(association)	0.350
LTBP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
PTX3	POLRMT	psi-mi:“MI:0914”(association)	0.350
TRIM63	ZNF775	psi-mi:“MI:0915”(physical association)	0.000
TRIM55	ZNF775	psi-mi:“MI:0915”(physical association)	0.000
ZNF775	ZRANB1	psi-mi:“MI:0915”(physical association)	0.000
ZNF775	CEP70	psi-mi:“MI:0915”(physical association)	0.000
ZNF775	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.000
ZNF775	CARD10	psi-mi:“MI:0915”(physical association)	0.000
ZNF775	TSPYL2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (28): ZNF775 (Affinity Capture-MS), ZNF775 (Affinity Capture-MS), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid), CYSRT1 (Two-hybrid), EHMT2 (Two-hybrid), ZNF775 (Proximity Label-MS), ZNF775 (Two-hybrid), ZNF775 (Two-hybrid)

ESM2 similar proteins: A3KN32, A6NM28, A8K8V0, E9PYI1, O75467, O95201, P10072, P10075, P10078, P10754, P28698, P30373, P52736, Q0VCC5, Q14929, Q16587, Q17QR7, Q29RZ4, Q3KNW1, Q3TDE8, Q3US17, Q58DK7, Q5RJR4, Q5T619, Q5TEC3, Q5U4E2, Q62396, Q68H95, Q6AW86, Q6PGE4, Q6ZMY9, Q7Z398, Q7Z7K2, Q8BI73, Q8BIF9, Q8BIQ3, Q8BKK5, Q8JZL0, Q8N393, Q8R0T2

Diamond homologs: P17041, P18732, Q08AN1, Q3US17, Q80V23, Q86T29, Q8CF60, Q8TBZ5, Q96BV0, Q96EG3, Q9H4T2, Q9H7R5, Q9HAH1, O15090, O43167, P18744, P18747, Q5EBL2, Q62255, Q80X44, Q8CJ78, Q8K083, Q9BXA9, Q9ER74, Q9NSC2, Q9UDV7, B0K011, P23803, P41995, P60319, P86413, Q08DS3, Q0IHB8, Q32NK7, Q3T135, Q567J8, Q5XJQ7, Q66JF8, Q6AY34, Q7PN68

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	110
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1407 predictions. Top by Δscore:

Variant	Effect	Δscore
7:150396501:T:A	acceptor_gain	1.0000
7:150396507:T:TA	acceptor_gain	1.0000
7:150368937:CAGAG:C	donor_loss	0.9900
7:150368938:AGAGG:A	donor_loss	0.9900
7:150368939:GAG:G	donor_gain	0.9900
7:150368940:AGGT:A	donor_loss	0.9900
7:150368941:GGTA:G	donor_loss	0.9900
7:150368942:GTAC:G	donor_loss	0.9900
7:150368943:T:A	donor_loss	0.9900
7:150369867:GG:G	donor_gain	0.9900
7:150369868:GG:G	donor_gain	0.9900
7:150369869:G:T	donor_gain	0.9900
7:150370349:G:GT	donor_gain	0.9900
7:150371226:A:AG	acceptor_gain	0.9900
7:150371227:G:GG	acceptor_gain	0.9900
7:150371227:GCA:G	acceptor_gain	0.9900
7:150379387:TCAA:T	donor_gain	0.9900
7:150379388:CAAAG:C	donor_loss	0.9900
7:150379390:AAGGT:A	donor_loss	0.9900
7:150379392:GGTAT:G	donor_loss	0.9900
7:150379394:T:G	donor_loss	0.9900
7:150396497:C:CA	acceptor_gain	0.9900
7:150396508:G:A	acceptor_gain	0.9900
7:150396509:GCAG:G	acceptor_loss	0.9900
7:150396510:CAG:C	acceptor_loss	0.9900
7:150396512:G:GT	acceptor_loss	0.9900
7:150396512:GGA:G	acceptor_gain	0.9900
7:150369800:G:GT	donor_gain	0.9800
7:150394454:T:TA	acceptor_gain	0.9800
7:150396511:A:AG	acceptor_gain	0.9800

AlphaMissense

3475 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:150396827:T:C	F116L	1.000
7:150396829:C:A	F116L	1.000
7:150396829:C:G	F116L	1.000
7:150397844:T:C	F455L	1.000
7:150397846:C:A	F455L	1.000
7:150397846:C:G	F455L	1.000
7:150397928:T:C	F483L	1.000
7:150397930:C:A	F483L	1.000
7:150397930:C:G	F483L	1.000
7:150396854:C:G	H125D	0.999
7:150396911:T:C	F144L	0.999
7:150396913:C:A	F144L	0.999
7:150396913:C:G	F144L	0.999
7:150396995:T:C	F172L	0.999
7:150396997:C:A	F172L	0.999
7:150396997:C:G	F172L	0.999
7:150397349:T:C	F290L	0.999
7:150397350:T:C	F290S	0.999
7:150397351:C:A	F290L	0.999
7:150397351:C:G	F290L	0.999
7:150397376:C:G	H299D	0.999
7:150397433:T:C	F318L	0.999
7:150397434:T:C	F318S	0.999
7:150397435:C:A	F318L	0.999
7:150397435:C:G	F318L	0.999
7:150397517:T:C	F346L	0.999
7:150397519:C:A	F346L	0.999
7:150397519:C:G	F346L	0.999
7:150397871:C:G	H464D	0.999
7:150397929:T:C	F483S	0.999

dbSNP variants (sampled 300 via entrez): RS1000213400 (7:150388546 C>T), RS1000265621 (7:150388268 A>G), RS1000375585 (7:150382803 C>T), RS1000786037 (7:150386171 G>A), RS1000827637 (7:150381804 C>T), RS1000930555 (7:150380249 G>A,C), RS1001037010 (7:150391405 G>A), RS1001114317 (7:150381414 T>A), RS1001248142 (7:150398745 G>A), RS1001278147 (7:150385156 G>A,T), RS1001305243 (7:150398455 G>A), RS1001490193 (7:150390384 C>T), RS1001737832 (7:150381546 G>A,C), RS1001832999 (7:150391488 A>G), RS1001864169 (7:150395071 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004765_15	Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes	2.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007806	total cholesterol change measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Zoledronic Acid	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Methapyrilene	increases methylation	1
Plant Extracts	decreases expression, affects cotreatment	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	increases expression	1
Valproic Acid	decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Copper Sulfate	decreases expression	1
Genistein	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.