ZNF782

Summary

ZNF782 (zinc finger protein 782, HGNC:33110) is a protein-coding gene on chromosome 9q22.33, encoding Zinc finger protein 782 (Q6ZMW2). May be involved in transcriptional regulation.

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 158431 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 97 total
• MANE Select transcript: NM_001001662

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33110
Approved symbol	ZNF782
Name	zinc finger protein 782
Location	9q22.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ16636
Ensembl gene	ENSG00000196597
Ensembl biotype	protein_coding
Entrez	158431

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000289032, ENST00000466833, ENST00000478850, ENST00000481138, ENST00000485322, ENST00000498811, ENST00000535338, ENST00000893217, ENST00000893218, ENST00000893219, ENST00000917517

RefSeq mRNA: 4 — MANE Select: NM_001001662 NM_001001662, NM_001346991, NM_001346993, NM_001346995

CCDS: CCDS35075

Canonical transcript exons

ENST00000481138 — 6 exons

Exon	Start	End
ENSE00001635162	96854088	96854514
ENSE00001642217	96852853	96853069
ENSE00001707228	96844890	96845016
ENSE00001837263	96816269	96819778
ENSE00003549908	96851947	96852005
ENSE00003694541	96827080	96827181

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 85.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2761 / max 86.1217, expressed in 1479 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101607	4.2519	1479
101608	0.0146	6
205572	0.0097	4

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.76	gold quality
calcaneal tendon	UBERON:0003701	81.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.32	gold quality
ganglionic eminence	UBERON:0004023	75.99	gold quality
cortical plate	UBERON:0005343	75.99	gold quality
bone marrow cell	CL:0002092	75.67	gold quality
colonic epithelium	UBERON:0000397	75.54	gold quality
body of pancreas	UBERON:0001150	75.37	gold quality
ventricular zone	UBERON:0003053	75.36	gold quality
adrenal tissue	UBERON:0018303	74.68	gold quality
tendon	UBERON:0000043	74.61	gold quality
pancreas	UBERON:0001264	73.49	gold quality
stromal cell of endometrium	CL:0002255	72.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.27	gold quality
islet of Langerhans	UBERON:0000006	70.70	gold quality
monocyte	CL:0000576	70.60	gold quality
leukocyte	CL:0000738	70.46	gold quality
left ovary	UBERON:0002119	70.36	gold quality
smooth muscle tissue	UBERON:0001135	70.33	gold quality
rectum	UBERON:0001052	70.32	gold quality
cerebellar cortex	UBERON:0002129	70.23	gold quality
cerebellar hemisphere	UBERON:0002245	70.13	gold quality
right coronary artery	UBERON:0001625	70.05	gold quality
cerebellum	UBERON:0002037	69.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.80	gold quality
right ovary	UBERON:0002118	69.76	gold quality
endocervix	UBERON:0000458	69.59	gold quality
popliteal artery	UBERON:0002250	69.58	gold quality
tibial artery	UBERON:0007610	69.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.35

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

75 targeting ZNF782, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-5002-5P	99.76	70.84	1763
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-26A-1-3P	99.64	66.81	788
HSA-MIR-26A-2-3P	99.64	66.82	786
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-892A	99.54	68.16	1141
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-3171	99.49	69.06	776
HSA-MIR-4441	99.49	66.56	3216

Literature-anchored findings (GeneRIF, showing 1)

• The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese. (PMID:19030899)

Cross-species orthologs

0 orthologs

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 782 — Q6ZMW2 (reviewed: Q6ZMW2)

All UniProt accessions (3): Q6ZMW2, C9J9Y8, F8WEU9

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (4): NP_001001662, NP_001333920, NP_001333922, NP_001333924 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (22 total): zinc finger region 15, sequence variant 4, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZMW2-F1	60.77	0.28

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 45 (showing top): chr9q22, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, E2F3_UP.V1_DN, SRC_UP.V1_DN, RBM34_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF423_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR4729, MIR8068, MIR7159_5P, MIR664A_3P, MIR539_5P

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): DNA binding (GO:0003677), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

452 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZNF782	OR2A2	Q6IF42	593
ZNF782	GXYLT1	Q4G148	563
ZNF782	FREY1	C9JXX5	543
ZNF782	TSTD2	Q5T7W7	522
ZNF782	ZDHHC24	Q6UX98	491
ZNF782	EFCAB14	O75071	480
ZNF782	EXD1	Q8NHP7	471
ZNF782	PCYOX1L	Q8NBM8	457
ZNF782	ZNF518A	Q6AHZ1	448
ZNF782	CATSPERB	Q9H7T0	444
ZNF782	PGAP2	Q9UHJ9	433
ZNF782	H2AJ	Q9BTM1	425
ZNF782	STARD9	Q9P2P6	419
ZNF782	UTP14C	Q5TAP6	419
ZNF782	STON2	Q8WXE9	418

IntAct

0 interactions, top by confidence:

BioGRID (39): ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation), ZNF782 (Co-fractionation)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

97 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

891 predictions. Top by Δscore:

Variant	Effect	Δscore
9:96844889:CCCA:C	donor_gain	1.0000
9:96854083:CTTA:C	donor_loss	1.0000
9:96854084:TTAC:T	donor_loss	1.0000
9:96854085:TACC:T	donor_loss	1.0000
9:96854086:AC:A	donor_gain	1.0000
9:96854086:ACCC:A	donor_loss	1.0000
9:96854087:CC:C	donor_gain	1.0000
9:96844892:A:AC	donor_gain	0.9900
9:96844893:C:CC	donor_gain	0.9900
9:96854086:A:AC	donor_gain	0.9900
9:96854087:C:CC	donor_gain	0.9900
9:96854087:CCCG:C	donor_gain	0.9900
9:96854087:CCCGG:C	donor_gain	0.9900
9:96852001:CTCAG:C	acceptor_gain	0.9800
9:96854086:ACC:A	donor_gain	0.9800
9:96854087:CCC:C	donor_gain	0.9800
9:96844888:AC:A	donor_gain	0.9700
9:96844889:CC:C	donor_gain	0.9700
9:96852003:CAG:C	acceptor_gain	0.9700
9:96852006:C:CC	acceptor_gain	0.9700
9:96854442:T:A	donor_gain	0.9700
9:96819776:CTT:C	acceptor_gain	0.9600
9:96844881:TGTGC:T	donor_loss	0.9600
9:96844882:GTGC:G	donor_loss	0.9600
9:96844883:TGCT:T	donor_loss	0.9600
9:96844884:GCTCA:G	donor_loss	0.9600
9:96844885:C:CG	donor_loss	0.9600
9:96844886:TCAC:T	donor_loss	0.9600
9:96844887:C:CA	donor_loss	0.9600
9:96844888:A:AA	donor_loss	0.9600

AlphaMissense

4690 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:96818058:G:C	F655L	0.999
9:96818058:G:T	F655L	0.999
9:96818060:A:G	F655L	0.999
9:96818110:C:G	R638P	0.999
9:96818142:G:C	F627L	0.999
9:96818142:G:T	F627L	0.999
9:96818144:A:G	F627L	0.999
9:96818310:G:C	F571L	0.999
9:96818310:G:T	F571L	0.999
9:96818312:A:G	F571L	0.999
9:96818394:G:C	F543L	0.999
9:96818394:G:T	F543L	0.999
9:96818396:A:G	F543L	0.999
9:96818562:G:C	F487L	0.999
9:96818562:G:T	F487L	0.999
9:96818564:A:G	F487L	0.999
9:96817974:G:C	F683L	0.998
9:96817974:G:T	F683L	0.998
9:96817976:A:G	F683L	0.998
9:96818041:A:G	L661P	0.998
9:96818053:T:G	Q657P	0.998
9:96818125:A:G	L633P	0.998
9:96818209:A:G	L605P	0.998
9:96818221:T:G	Q601P	0.998
9:96818226:G:C	F599L	0.998
9:96818226:G:T	F599L	0.998
9:96818228:A:G	F599L	0.998
9:96818293:A:G	L577P	0.998
9:96818377:A:G	L549P	0.998
9:96818478:G:C	F515L	0.998

dbSNP variants (sampled 300 via entrez): RS1000106211 (9:96889103 G>A,C,T), RS1000128441 (9:96913597 C>T), RS1000131643 (9:96851556 C>A), RS1000155350 (9:96861102 T>A,G), RS1000165982 (9:96904812 T>C,G), RS1000197430 (9:96865146 C>T), RS1000202978 (9:96855370 G>T), RS1000233602 (9:96887675 C>T), RS1000265692 (9:96817270 G>C), RS1000274948 (9:96858472 C>G,T), RS1000281601 (9:96904140 G>C), RS1000304914 (9:96872250 G>A,T), RS1000340002 (9:96928627 T>C), RS1000372402 (9:96823625 C>G), RS1000399098 (9:96851183 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	2
Valproic Acid	decreases methylation, decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
Arsenic	increases methylation	1
Dimethyl Sulfoxide	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Rifampin	decreases expression	1
Urethane	increases expression	1
Particulate Matter	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.